Developmental expression of LC3α and β: Absence of fibronectin or autophagy phenotype in LC3β knockout mice

Developmental Dynamics

Volumn 237, Issue 1, 2008, Pages 187-195

  Cann, Gordon M ^a   Guignabert, Christophe ^a   Ying, Lihua ^a   Deshpande, Niru ^a   Bekker, Janine M ^a   Wang, Lingli ^a   Zhou, Bin ^b   Rabinovitch, Marlene ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Fibronectin; LC3; RNA binding protein; Transgenic mouse

Indexed keywords

CAVEOLIN 1; FIBRONECTIN; MATRIX METALLOPROTEINASE; RNA BINDING PROTEIN; ISOPROTEIN; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FETUS DEVELOPMENT; KNOCKOUT MOUSE; LIGHT CHAIN; MOUSE; NONHUMAN; PERINATAL DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; CELL CULTURE; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IN SITU HYBRIDIZATION; MESODERM; METABOLISM; MOUSE MUTANT; NERVOUS SYSTEM; PHYSIOLOGY; PRENATAL DEVELOPMENT; SURVIVAL; WESTERN BLOTTING;

MURINAE; MUS; MUS MUSCULUS;

ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; CAVEOLIN 1; CELLS, CULTURED; FIBROBLASTS; FIBRONECTINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IN SITU HYBRIDIZATION; MATRIX METALLOPROTEINASES; MESODERM; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NERVOUS SYSTEM; PHENOTYPE; PROTEIN ISOFORMS; SURVIVAL ANALYSIS;

EID: 38149098485     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21392     Document Type: Article

References (36)

1. Boudreau N, Turley E, Rabinovitch M. 1991. Fibronectin, hyaluronan, and a hyaluronan binding protein contribute to increased ductus arteriosus smooth muscle cell migration. Dev Biol 143:235-247.
2. Feiner L, Webber AL, Brown CB, Lu MM, Jia L, Feinstein P, Mombaerts P, Epstein JA, Raper JA. 2001. Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development 128:3061-3070.
3. Furuta S, Miura K, Copeland T, Shang WH, Oshima A, Kamata T. 2002. Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling. Oncogene 21:7060-7066.
4. Hammarback JA, Obar RA, Hughes SM, Vallee RB. 1991. MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain. Neuron 7:129-139.
5. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441:885-889.
6. He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, Zhao S, Liu JO, Yu L. 2003. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem 278:29278-29287.
7. Hemelaar J, Lelyveld VS, Kessler BM, Ploegh HL. 2003. A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem 278:51841-51850.
8. Jackson WT, Giddings TH Jr, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, Kirkegaard K. 2005. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol 3:e156.
9. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. 2000. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J 19:5720-5728.
10. Kabeya Y, Mizushima N, Yamamoto A, Oshitani-Okamoto S, Ohsumi Y, Yoshimori T. 2004. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 117:2805-2812.
11. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169:425-434.
12. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. 2006. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441:880-884.
13. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. 2004. The role of autophagy during the early neonatal starvation period. Nature 432:1032-1036.
14. Kuznetsov SA, Gelfand VI. 1987. 18 kDa microtubule-associated protein: identification as a new light chain (LC-3) of microtubule-associated protein 1 (MAP-1). FEBS Lett 212:145-148.
15. Langkopf A, Hammarback JA, Muller R, Vallee RB, Garner CC. 1992. Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA. J Biol Chem 267:16561-16566.
16. Levine B, Klionsky DJ. 2004. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6:463-477.
17. Mann SS, Hammarback JA. 1994. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. J Biol Chem 269:11492-11497.
18. Mann SS, Hammarback JA. 1996. Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B. J Neurosci Res 43:535-544.
19. Mason CA, Bigras JL, O'Blenes SB, Zhou B, McIntyre B, Nakamura N, Kaneda Y, Rabinovitch M. 1999a. Gene transfer in utero biologically engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal formation. Nat Med 5:176-182.
20. Mason CA, Chang P, Fallery C, Rabinovitch M. 1999b. Nitric oxide mediates LC-3-dependent regulation of fibronectin in ductus arteriosus intimal cushion formation. Faseb J 13:1423-1434.
21. Meyers G, Stoll D, Gunn M. 1998. Insertion of a sequence encoding light chain 3 of microtubule-associated proteins 1A and 1B in a pestivirus genome: connection with virus cytopathogenicity and induction of lethal disease in cattle. J Virol 72:4139-4148.
22. Mizushima N, Sugita H, Yoshimori T, Ohsumi Y. 1998. A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. J Biol Chem 273:33889-33892.
23. Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, Tokuhisa T, Ohsumi Y, Yoshimori T. 2001. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 152:657-668.
24. Muyrers JP, Zhang Y, Testa G, Stewart AF. 1999. Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res 27:1555-1557.
25. O'Blenes CA, Kinnear C, Rabinovitch M. 2001. Tumor necrosis factor-alpha induces fibronectin synthesis in coronary artery smooth muscle cells by a nitric oxide-dependent posttranscriptional mechanism. Circ Res 89:26-32.
26. Sagiv Y, Legesse-Miller A, Porat A, Elazar Z. 2000. GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28. Embo J 19:1494-1504.
27. Salicioni AM, Mizelle KS, Loukinova E, Mikhailenko I, Strickland DK, Gonias SL. 2002. The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces. J Biol Chem 277:16160-16166.
28. Seidenbecher CI, Landwehr M, Smalla KH, Kreutz M, Dieterich DC, Zuschratter W, Reissner C, Hammarback JA, Bockers TM, Gundelfinger ED, Kreutz MR. 2004. Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins. J Mol Biol 336:957-970.
29. Sottile J, Chandler J. 2005. Fibronectin matrix turnover occurs through a caveolin-1-dependent process. Mol Biol Cell 16:757-768.
30. Sou YS, Tanida I, Komatsu M, Ueno T, Kominami E. 2006. Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem 281:3017-3024.
31. Tanida I, Ueno T, Kominami E. 2004. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. J Biol Chem 279:47704-47710.
32. Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW. 1999. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature 397:69-72.
33. Wrana JL, Maeno M, Hawrylyshyn B, Yao KL, Domenicucci C, Sodek J. 1988. Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations. J Cell Biol 106:915-924.
34. Yorimitsu T, Klionsky DJ. 2005. Autophagy: molecular machinery for self-eating. Cell Death Differ 12(Suppl 2):1542-1552.
35. Zhou B, Rabinovitch M. 1998. Microtubule involvement in translational regulation of fibronectin expression by light chain 3 of microtubule-associated protein 1 in vascular smooth muscle cells. Circ Res 83:481-489.
36. Zhou B, Boudreau N, Coulber C, Hammarback J, Rabinovitch M. 1997. Microtubule-associated protein 1 light chain 3 is a fibronectin mRNA-binding protein linked to mRNA translation in lamb vascular smooth muscle cells. J Clin Invest 100:3070-3082.