Mutational analysis of the FXNPXY motif within LDL receptor-related protein 1 (LRP1) reveals the functional importance of the tyrosine residues in cell growth regulation and signal transduction

Biochemical Journal

Volumn 409, Issue 1, 2008, Pages 53-64

  Zhang, Hongyu ^a   Lee, Jonathan M ^a   Wang, Yuwei ^a   Dong, Li ^a   Ko, Kerry W S ^a   Pelletier, Louise ^a   Yao, Zemin ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Cell growth inhibition; Extracellular signal regulated kinase (ERK); FXNPXY motif; Low density lipoprotein receptor related protein 1 (LRP1); Mutational analysis; Tumorigenesis

Indexed keywords

CELL GROWTH; MUTAGENESIS; SIGNAL TRANSDUCTION; TUMORS;

CELL GROWTH INHIBITION; EXTRACELLULAR-SIGNAL-REGULATED KINASE (ERK); MUTATIONAL ANALYSIS; TUMORIGENESIS;

PROTEINS;

ADAPTOR PROTEIN; ALANINE; BETA CATENIN; CADHERIN; CYCLIN D1; FOCAL ADHESION KINASE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLALANINE; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CAVEOLA; CELL GROWTH; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOARCHITECTURE; CYTOPLASM; DISEASE COURSE; EMBRYO; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; ANIMAL; CANCER TRANSPLANTATION; CELL PROLIFERATION; CHEMISTRY; CHO CELL; CRICETULUS; GENETICS; HAMSTER; METABOLISM; NUDE MOUSE; PHYSIOLOGY;

CRICETINAE; MUS; MUS MUSCULUS;

ALANINE; AMINO ACID MOTIFS; ANIMALS; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; CYTOPLASM; DNA MUTATIONAL ANALYSIS; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SIGNAL TRANSDUCTION; TYROSINE;

EID: 38149087715     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071127     Document Type: Article

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