Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin

British Journal of Cancer

Volumn 87, Issue 9, 2002, Pages 1047-1054

  Sersa, G ^a   Krzic, M ^b   Sentjurc, M ^b   Ivanusa, T ^c   Beravs, K ^b   Kotnik, V ^c   Coer, A ^c   Swartz, H M ^d   Cemazar, M ^a  

^a INSTITUTE OF ONCOLOGY   (Slovenia)

^b JO EF STEFAN INSTITUTE   (Slovenia)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Blood flow; Cisplatin; Electrochemotherapy; Electroporation; Fibrosarcoma; Oxygen pressure

Indexed keywords

CISPLATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER INHIBITION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CYTOTOXICITY; ELECTROCHEMOTHERAPY; FEMALE; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIMETRY; OXYGEN TENSION; OXYGENATION; PRIORITY JOURNAL; SKIN TUMOR; TUMOR BLOOD FLOW; TUMOR NECROSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOOD FLOW VELOCITY; CELL RESPIRATION; CISPLATIN; COMBINED MODALITY THERAPY; ELECTRIC STIMULATION THERAPY; FEMALE; FIBROSARCOMA; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED A; NECROSIS; OXYGEN;

EID: 0037152638     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600606     Document Type: Article

References (33)

1. Belehradek Jr J, Orlowski S, Ramirez LH, Pron G, Poddevin B, Mir LM (1994) Electropermeabilization of cells in tissues assessed by the qualitative and quantitative electroloading of bleomycin. BBA Biomembranes 1190: 155-163
2. Beravs K, Ivanusa T, Medic J, Sersa I, Sersa G, Jevtic V, Demsar F (2000) MRI macromolecular contrast agents as indicators of tumor starvation. In Proceedings of the ISMRM ISMRM (ed) p 1054 Denver, Colorado: ISMRM
3. Cemazar M, Miklavcic D, Scancar J, Dolzan V, Golouh R, Sersa G (1999) Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin. Br J Cancer 79: 1386-1391
4. Cemazar M, Parkins CS, Holder AL, Chaplin DJ, Tozer GM, Sersa G (2001) Electroporation of human microvascular endothelial cells: Evidence for an anti-vascular mechanism of electrochemotherapy. Br J Cancer 84: 565-570
5. Chaplin DJ, Hill SA, Bell KM, Tozer GM (1998) Modification of tumor blood flow: Current status and future directions. Semin Radiat Oncol 8: 151-163
6. Demsar F, Roberts TP, Schwickert HC, Shames DM, van Dijke CF, Mann JS, Saeed M, Brasch RC (1997) A MRI spatial mapping technique for microvascular permeability and tissue blood volume based on macromolecular contrast agent distribution. Magn Resort Med 37: 236-242
7. Denekamp J, Hill SA, Hobson B (1983) Vascular occlusion and tumour cell death. Eur J Cancer Clin Oncol 19: 271-275
8. Gehl J, Geertsen PF (2000) Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy. Melanoma Res 10: 585-589
9. Gehl J, Skovsgaard T, Mir LM (2002) Vascular reactions to in vivo electro-poration: Characterization and consequences for drug and gene delivery. Biochim Biophys Acta 1569: 51-58
10. Heller R, Gilbert R, Jaroszeski MJ (2000) Clinical trials for solid tumors using electrochemotherapy. In: Electrochemotherapy, Electrogenetherapy and Transdermal Drug Delivery. Electrically Mediated Delivery of Molecules to Cells Jaroszeski MJ, Heller R, Gilbert R (eds) pp 137-156 Totowa, New Jersey: Humana Press
11. Jaroszeski MJ, Dang V, Pottinger C, Hickey J, Gilbert R, Heller R (2000) Toxicity of anticancer agents mediated by electroporation in vitro. Anti-cancer Drugs 11: 201-208
12. Jordan P, Carmo-Fonseca M (2000) Molecular mechanisms involved in cisplatin cytotoxicity. Cell Mol Life Sci 57: 1229-1235
13. Krzic M, Sentjurc M, Kristl J (2001) Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry. J Control Release 70: 203-211
14. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A (1995) Tumor necrosis factor - Induced hepatocyte apoptosis precedes liver failure in experimental murine shoch models. Am J Pathol 146: 1220-1234
15. Meyn RE, Stephens LC, Hunter NR, Milas L (1995) Kinetics of cisplatin-induced apoptosis in murine mammary and ovarian adenocarcinomas. Int J Cancer 60: 725-729
16. Mir LM (2000) Therapeutic perspectives of in vivo cell electropermeabilization. Bioelectrochemistry 53: 1-10
17. Mir LM, Glass LF, Sersa G, Teissie J, Domenge C, Mildavcic D, Jaroszeski MJ, Orlowski S, Reintgen DS, Rudolf Z, Belehradek M, Gilbert R, Rols MP, Belehradek Jr J, Bachaud JM, DeConti R, Stabuc B, Cemazar M, Coninx P, Heller R (1998) Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer 77: 2336-2342
18. Mir LM, Orlowski S (1999) Mechanisms of electrochemotherapy. Adv Drug Deliv Rev 35: 107-118
19. Mir LM, Orlowski S, Poddevin B, Belehradek Jr J (1992) Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses. Eur Cytokine Netw 3: 331-334
20. O'Hara JA, Blumenthal RD, Grinberg OY, Demidenko E, Grinberg S, Wilmot CM, Taylor AM, Goldenberg DM, Swartz HM (2001) Response to radio-immunotherapy correlates with tumor pO2 measured by EPR oximetry in human tumor xenografts. Rad Res 155: 466-473
21. Ramirez LH, Orlowski S, An D, Bindoula G, Dzodic R, Ardouin P, Bognel C, Belehradek Jr J, Munck JN, Mir LM (1998) Electrochemotherapy on liver tumours in rabbits. Br J Cancer 77: 2104-2111
22. Rols MP, Golzio M, Delteil C, Teissie J (2000) In vitro delivery of drugs and other molecules to cells. In: Electrochemotherapy, Electrogenetherapy and Transdermal Drug Delivery. Electrically Mediated Delivery of Molecules to Cells Jaroszeski MJ, Heller R, Gilbert R (eds) pp 83-97 Totowa, New Jersey: Humana Press
23. Sapistein LA (1985) Regional blood flow by fraction distribution of indicators. Am J Physiol 193: 161-168
24. Sersa G (2000a) Electrochemotherapy: Animal work review. In:. Electrochemotherapy, Electrogenetherapy and Transdermal Drug Delivery. Electrically Mediated Delivery of Molecules to Cells, Jaroszeski MJ, Heller R, Gilbert R (eds) pp 119-1136 Totowa, New Jersey: Humana Press
25. Sersa G, Cemazar M, Miklavcic D (1995) Antitumor effectiveness of electrochemotherapy with cis- diamminedichloroplatinum(II) in mice. Cancer Res 55: 3450-3455
26. Sersa G, Cemazar M, Miklavcic D, Chaplin DJ (1999b) Tumor blood flow modifying effect of electrochemotherapy with bleomycin. Anticancer Res 19: 4017-4022
27. Sersa G, Cemazar M, Parkins CS, Chaplin DJ (1999a) Tumour blood flow changes induced by application of electric pulses. Eur J Cancer 35: 672-677
28. Sersa G, Krzic M, Sentjurc M, Ivanusa T, Beravs K, Cemazar M, Auersperg M, Swartz HM (2001) Reduced tumor oxygenation by treatment with vinblastine. Cancer Res 61: 4266-4271
29. Sersa G, Miklavcic D, Cemazar M, Belehradek Jr J, Jarm T, Mir LM (1997) Electrochemotherapy with CDDP on LPB sarcoma: Comparison of the anti-tumor effectiveness in immunocompetent and immunodeficient mice. Bioelectroch Bioenerg 43: 279-283
30. Sersa G, Stabuc B, Cemazar M, Mildavcic D, Rudolf Z (2000b) Electrochemotherapy with cisplatin: Clinical experience in malignant melanoma patients. Clin Cancer Res 6: 863-867
31. Swartz HM, Boyer S, Brown D, Chang K, Gast P, Glockner HH, Liu J, Moussavi M, Nilges M, Norby SW, Smirnov A, Vahidi N, Walzcak T, Wu M, Clarkson RB (1993) The use of EPR for the measurement of the concentration of oxygen in vivo in tissues under physiologically pertinent conditions and concentrations. In: Oxygen Transport to Tissue XIV, Nemoto M and La Mana C (eds) pp 221-228 New York: Plenum Press
32. Swartz HM, Clarkson RB (1998) The measurement of oxygen in vivo using EPR techniques. Phys Med Biol 43: 1957-1975
33. Workman P, Twentyman P, Balkwill F, Balmain A, Chaplin D, Double J, Embleton J, Newell D, Raymond R, Stables J, Stephens T, Wallace J (1998) United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) guidelines for the welfare of animals in experimental neoplasis (Second edition). Br J Cancer 77: 1-10