First clinical trial of cat soft tissue sarcomas treatment by electrochemotherapy

British Journal of Cancer

Volumn 76, Issue 12, 1997, Pages 1617-1622

  Mir, L M ^a   Devauchelle, P ^b   Quintin Colonna, F ^b   Delisle, F ^b   Doliger, S ^b   Fradelizi, D ^c   Belehradek Jr , J ^a   Orlowski, S ^d  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^c Institut Cochin   (France)

^d CEA SACLAY   (France)

Author keywords

Bleomycin; Electric pulse; Electrochemotherapy; Interleukin 2; Soft tissue sarcoma

Indexed keywords

BLEOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL DESTRUCTION; CAT; CELL MEMBRANE PERMEABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG TOLERANCE; ELECTROCHEMOTHERAPY; FIBROSIS; HISTOLOGY; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RELAPSE; SALVAGE THERAPY; SKIN ELECTRODE; SOFT TISSUE SARCOMA; SOLID TUMOR;

EID: 0030690094     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.606     Document Type: Article

References (23)

1. Belehradek Jr J, Orlowski S, Poddevin B, Paoletti C and Mir LM (1991) Electrochemotherapy of spontaneous mammary tumours in mice. Eur J Cancer 27: 73-76
2. Belehradek Jr J, Orlowski S, Ramirez LH, Pron G, Poddevin B and Mir LM (1994) Electropermeabilization of cells in tissues assessed by the qualitative and quantitative electroloading of bleomycin. Biochim Biophys Acta 1190: 155-163
3. Belehradek M, Domenge C, Luboinski B, Orlowski S, Belehradek Jr J and Mir LM (1993) Electrochemotherapy, a new antitumour treatment, first clinical phase I-II trial. Cancer 72: 3694-3700
4. Bostock DE and Dye MT (1979) Prognosis after surgical excision of fibrosarcomas in cats. J Am Vet Med Assoc 175: 727-728
5. Brown NO, Patnaik AK, Mooney S, Hayes A, Harvey HJ and MacEwen EG (1978) Soft tissue sarcomas in the cat. J Am Vet Med Assoc 173: 744-749
6. Chang DC, Chassy BM, Saunders JA and Sowers AE (1992) Guide to Electroporation and Electrofusion. Academic Press: San Diego
7. Domenge C, Orlowski S, Luboinski B, De Baere T, Schwaab G, Belehradek Jr J and Mir LM (1996) Antitumor electrochemotherapy: new advances in the clinical protocol. Cancer 77: 956-963
8. Ferrara P, Pecceu F, Marchese H, Vita N, Roskam W and Lupker J (1987) Characterization of recombinant glycosylated human interleukin-2 produced by a recombinant plasmid transformed CHO cell line. FEBS Lett 226: 47-52
9. Heller R, Jaroszeski M, Leo-Messina J, Perrot R, Van Voorhis N, Reintgen D and Gilbert R (1994) Treatment of B16 mouse melanoma with the combination of electropermeabilization and chemotherapy. Bioelectrochem Bioenerg 36: 83-87
10. Hilmas DE and Guette EL (1976) Radiotherapy of spontaneous fibrous connective-tissue sarcomas in animals. J Natl Cancer Inst 56: 365-368
11. MacEwen EG, Mooney S, Brown NO and Hayes AA (1987) Management of feline neoplasms: surgery, immunotherapy and chemotherapy. In Diseases of the Cat: Medicine and Surgery, Vol. 1, Holzworth (ed.), pp. 597 606. WB Saunders: Philadelphia
12. Mir LM, Banoun H and Paoletti C (1988) Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: direct access to the cytosol. Exp Cell Res 175: 15-25
13. Mir LM, Orlowski S, Belehradek Jr J and Paoletti C (1991) Electrochemotherapy: potentiation of antitumour effect of bleomycin by local electric pulses. Eur J Cancer 27: 68-72
14. Mir LM, Orlowski S, Poddevin B and Belehradek Jr J (1992) Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host's defenses. Eur Cytokine Netw 3: 331-334
15. Mir LM, Roth C, Orlowski S, Quintin-Colonna F, Fradelizi D, Belehradek Jr J and Kourilsky P (1995) Systemic antitumor effects of electrochemotherapy combined with histoincompatible cells secreting interleukin-2. J Immunother 17: 30-38
16. Orlowski S and Mir LM (1993) Cell electropermeabilization: a new tool for biochemical and pharmacological studies. Biochim Biophys Acta 1154: 51-63
17. Orlowski S, Belehradek Jr J, Paoletti C and Mir LM (1988) Transient electropermeabilization of cells in culture: increase of the cytotoxicity of anticancer drugs. Biochem Pharmacol 37: 4727-4733
18. Poddevin B, Orlowski S, Belehradek Jr J and Mir LM (1991) Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture. Biochem Pharmacol 42(S): 67-75
19. Roth C, Mir LM, Cressent M, Quinlin-Colonna F, Ley V, Fradelizi D and Kourilsky P (1992) Inhibition of tumor growth by histoincompatible cells expressing interleukin-2. Int Immunol 4: 1429-1436
20. Salford LG, Persson BRR, Brun A, Ceberg CP, Konstad PC and Mir LM (1993) A new brain tumour therapy combining bleomycin with in vivo electropermeabilization. Biochem Biophys Res Commun 194: 938-943
21. Serša G, Čemazar M, Miklavčič D and Mir LM (1994) Electrochemotherapy: variable anti-tumor effect on different tumor models. Bioelectrochem Bioenerg 35: 23-27
22. Tounekti O, Pron G, Belehradek Jr J and Mir LM (1993) Bleomycin, an apoptosis-mimetic drug that induces two types of cell death depending on the number of molecules internalized. Cancer Res 53: 5462-5469
23. Yamaguchi O, Irisawa C, Baba K, Ogihara M, Yokota T and Shiraiwa Y (1994) Potentiation of antitumor effect of bleomycin by local electric pulses in mouse bladder tumor. Tohoku J Exp Med 172: 291-293