The "bald Mill Hill" mutation in the mouse is associated with an abnormal, mislocalized HR bmh protein

Journal of Investigative Dermatology

Volumn 128, Issue 2, 2008, Pages 311-321

  Brancaz Bouvier, Maud Virginie ^a,b   Folco, Eric J G ^a   Salameire, Dimitri ^a   Romero, Yannick ^a,c   Iratni, Rabah ^a   Nonchev, Stefan ^a  

^a INSTITUT ALBERT BONNIOT   (France)

^b ERYTECH PHARMA   (France)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CELL PROTEIN; MESSENGER RNA; MUTANT PROTEIN; PROTEIN HR BMH; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CODON; CONTROLLED STUDY; EPIDERMIS; GENE MUTATION; GENETIC TRANSFECTION; HAIR FOLLICLE; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

EID: 38149061181     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700998     Document Type: Article

References (33)

1. Arata Y, Kouike H, Zhang Y, Herman MA, Okano H, Sawa H (2006) Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans. Dev Cell 11:105-15
2. Beaudoin GMJ III, Sisk JM, Coulombe PA, Thompson CC (2005) Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci USA 102:14653-8
3. Bernard BA (2002) Hairless and genetic disorders of hair. Med. Sci. 18:276-80
4. Bikle D, Teichert A, Hawker N, Xie Z, Oda Y (2007) Sequential regulation of keratinocyte differentiation by 1, 25(OH)(2)D(3), VDR, and its coregulators. J Steroid Biochem Mol Biol 103:396-404
5. Bikle DD, Elalieh H, Chang S, Xie Z, Sundberg JP (2006) Development and progression of alopecia in the vitamin D receptor null mouse. J Cell Physiol 207:340-53
6. Brancaz MV, Iratni R, Morrison A, Mancini SJ, Marche P, Sundberg J et al. (2004) A new allele of the mouse hairless gene interferes with Hox/LacZ transgene regulation in hair follicle primordia. Exp Mol Pathol 76:173-81
7. Cachon-Gonzalez MB, San-Jose I, Cano A, Vega JA, Garcia N, Freeman T et al. (1999) The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype. Dev Dyn 216:113-26
8. Djabali K, Aita VM, Christiano AM (2001) Hairless is translocated to the nucleus via a novel bipartite nuclear localization signal and is associated with the nuclear matrix. J Cell Sci 114:367-76
9. Hsieh JC, Sisk JM, Jurutka PW, Haussler CA, Slater SA, Haussler MR et al. (2003) Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling. J Biol Chem 278:38665-74
10. Itasaki N, Jones CM, Mercurio S, Rowe A, Domingos PM, Smith JC et al. (2003) Wise, a context-dependent activator and inhibitor of Wnt signalling. Development 130:4295-305
11. Khochbin S, Verdel A, Lemercier C, Seigneurin-Berny D (2001) Functional significance of histone deacetylase diversity. Curr Opin Genet Dev 11:162-6
12. Klose RJ, Kallin EM, Zhang Y (2006) JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet 7:715-27
13. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R et al. (1997) Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-5
14. Miller J, Djabali K, Chen T, Liu Y, Ioffreda M, Lyle S et al. (2001) Atrichia caused by mutations in the vitamin D receptor gene is a phenocopy of generalized atrichia caused by mutations in the hairless gene. J Invest Dermatol 117:612-7
15. Moraitis AN, Giguere V, Thompson CC (2002) Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants. Mol Cell Biol 22:6831-41
16. Nonchev S, Brancaz MV, Folco E, Romero Y, Iratni R (2006) [The mouse hairless gene: its function in hair root and at the heart of a subtle pleiotropy]. Med Sci (Paris) 22:525-30
17. Nordstrom U, Maier E, Jessell TM, Edlund T (2006) An early role for Wnt signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity. PLoS Biol 4:e252
18. O'Shaughnessy RF, Yeo W, Gautier J, Jahoda CA, Christiano AM (2004) The WNT signalling modulator, wise, is expressed in an interaction-dependent manner during hair-follicle cycling. J Invest Dermatol 123:613-21
19. Panteleyev AA, Ahmad W, Malashenko AM, Ignatieva EL, Paus R, Sundberg JP et al. (1998a) Molecular basis for the rhino Yurlovo (hr(rhY)) phenotype: severe skin abnormalities and female reproductive defects associated with an insertion in the hairless gene. Exp Dermatol 7:281-8
20. Panteleyev AA, Paus R, Ahmad W, Sundberg JP, Christiano AM (1998b) Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans. Exp Dermatol 7:249-67
21. Panteleyev AA, van der Veen C, Rosenbach T, Muller-Rover S, Sokolov VE, Paus R (1998c) Towards defining the pathogenesis of the hairless phenotype. J Invest Dermatol 110:902-7
22. Potter GB, Beaudoin GM III, DeRenzo CL, Zarach JM, Chen SH, Thompson CC (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev 15:2687-701
23. Potter GB, Zarach JM, Sisk JM, Thompson CC (2002) The thyroid hormone-regulated corepressor hairless associates with histone deacetylases in neonatal rat brain. Mol Endocrinol 16:2547-60
24. San Jose I, Garcia-Suarez O, Hannestad J, Cabo R, Gauna L, Represa J et al. (2001) The thymus of the hairless rhino-j (hr/rh-j) mice. J Anat 198:399-406
25. Takeuchi T, Watanabe Y, Takano-Shimizu T, Kondo S (2006) Roles of jumonji and jumonji family genes in chromatin regulation and development. Dev Dyn 235:2449-59
26. Thompson CC, Bottcher MC (1997) The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proc Natl Acad Sci USA 94:8527-32
27. Thompson CC, Sisk JM, Beaudoin GM III (2006) Hairless and Wnt signaling: allies in epithelial stem cell differentiation. Cell Cycle 17:1913-7
28. Wilkinson DG, Nieto MA (1993) Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol 225:361-73
29. Xie Z, Chang S, Oda Y, Bikle DD (2006) Hairless suppresses vitamin D receptor transactivation in human keratinocytes. Endocrinology 147:314-23
30. Xu L, Wilkinson D (1998) In situ hybridisation of mRNA with hapten labelled probes. In: In Situ Hybridisation: A Practical Approach (Wilkinson DG, ed, 2nd ed), Oxford University Press: Oxford, UK, 87-106
31. Yang XJ, Gregoire S (2005) Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol 25:2873-84
32. Zarach JM, Beaudoin GM III, Coulombe PA, Thompson CC (2004) The corepressor hairless has a role in epithelial cell differentiation in the skin. Development 131:4189-200
33. Zhang J, Fang S, Wang CY (2005) A novel nonsense mutation and polymorphisms in mouse hairless gene. J Invest Dermatol 124:1200-5