Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 2, 2008, Pages 614-618

  Piergentili, Alessandro ^a   Quaglia, Wilma ^a   Giannella, Mario ^a   Del Bello, Fabio ^a   Buccioni, Michela ^a   Nesi, Marta ^b   Matucci, Rosanna ^b  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

1,4 Dioxane nucleus; Muscarinic agonists; Muscarinic receptors; Receptor enantioselectivity; Stereoselective synthesis; Subtype selectivity

Indexed keywords

MUSCARINIC AGENT; MUSCARINIC RECEPTOR; N,N,N TRIMETHYL (6 METHYL 1,4 DIOXAN 2 YL)METHANAMINIUM IODIDE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIRALITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ISOMER; NONHUMAN; OPTICAL ROTATION; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIOXANES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MUSCARINIC AGONISTS; RABBITS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38149048456     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.073     Document Type: Article

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