Role of TLR1 and TLR6 in the host defense against disseminated candidiasis

FEMS Immunology and Medical Microbiology

Volumn 52, Issue 1, 2008, Pages 118-123

  Netea, Mihai G ^a   Van De Veerdonk, Frank ^a   Verschueren, Ineke ^a   Van Der Meer, Jos W M ^a   Kullberg, Bart Jan ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Candida albicans; Cytokines; TLR1; TLR6

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE MODEL; DISEASE PREDISPOSITION; HOST RESISTANCE; INVASIVE CANDIDIASIS; KNOCKOUT MOUSE; MONOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; TH1 CELL; TH2 CELL;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CELLS, CULTURED; COLONY COUNT, MICROBIAL; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-6; KIDNEY; MACROPHAGES, PERITONEAL; MICE; MICE, KNOCKOUT; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38149036671     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2007.00353.x     Document Type: Article

References (34)

1. Akira S, Uematsu S Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124 : 783 801.
2. Bellocchio S, Montagnoli C, Bozza S et al 2004) The contribution of Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol 172 : 3059 3069.
3. Brown GD, Taylor PR, Reid DM et al 2002) Dectin-1 is a major beta-glucan receptor on macrophages. J Exp Med 196 : 407 412.
4. Dillon S, Agrawal S, Banerjee K et al 2006) Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest 116 : 916 928.
5. Gantner BN, Simmons RM, Canavera SJ, Akira S Underhill DM (2003) Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 197 : 1107 1117.
6. Gudlaugsson O, Gillespie S, Lee K et al 2003) Attributable mortality of nosocomial candidemia, revisited. Clin Infect Dis 37 : 1172 1177.
7. Jouault T, Ibata-Ombetta S, Takeuchi O et al 2003) Candida albicans phospholipomannan is sensed through Toll-like receptors. J Infect Dis 188 : 165 172.
8. Jouault T, El Abed-El Behi M, Martinez-Esparza M et al 2006) Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J Immunol 177 : 4679 4687.
9. Kaposzta R, Tree P, Marodi L Gordon S (1998) Characteristics of invasive candidiasis in gamma interferon- and interleukin-4-deficient mice: role of macrophages in host defense against Candida albicans. Infect Immun 66 : 1708 1717.
10. Kesh S, Mensah NY, Peterlongo P et al 2005) TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci 1062 : 95 103.
11. Kullberg BJ, Van't Wout JW Van Furth R (1990) Role of granulocytes in enhanced host resistance to Candida albicans induced by recombinant interleukin-1. Infect Immun 58 : 3319 3324.
12. Kullberg BJ, Van't Wout JW, Hoogstraten C Van Furth R (1993) Recombinant interferon-γ enhances resistance to acute disseminated Candida albicans infection in mice. J Infect Dis 168 : 436 443.
13. Lehrer RI Cline MJ (1969) Interactions of Candida albicans with human leukocytes and serum. J Bacteriol 98 : 996 1004.
14. Mestas J Hughes CC (2004) Of mice and not men: differences between mouse and human immunology. J Immunol 172 : 2731 2738.
15. Nair PK, Melnick SJ, Ramachandran R, Escalon E Ramachandran C (2006) Mechanism of macrophage activation by (1,4)-alpha-D-glucan isolated from Tinospora cordifolia. Int Immunopharmacol 6 : 1815 1824.
16. Netea MG, Demacker PNM, Kullberg BJ et al 1996) Low-density-lipoprotein receptor deficient mice are protected against lethal endotoxinemia and severe Gram-negative infections. J Clin Invest 97 : 1366 1372.
17. Netea MG, Van Tits LJH, Curfs JHAJ et al 1999) The increased susceptibility of TNFaLTa double knock-out mice to systemic candidiasis is due to defective recruitment and phagocytosis by neutrophils. J Immunol 163 : 1498 1505.
18. Netea MG, de Graaf C, Vonk A, Verschueren I, Van der Meer JWM Kullberg BJ (2002) The role of Toll-like receptors in the defense against disseminated candidiasis. J Infect Dis 185 : 1483 1489.
19. Netea MG, Sutmuller R, Hermann C et al 2004) Toll-like receptor 2 inhibits cellular responses against Candida albicans through pathways mediated by IL-10 and CD4+CD25+regulatory T cells. J Immunol 172 : 3712 3718.
20. Netea MG, Gow NA, Munro CA et al 2006) Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest 116 : 1642 1650.
21. Ozinsky A, Underhill DM, Fontenot JD et al 2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad, Sci USA 97 : 13766 13771.
22. Razonable RR, Henault M, Lee LN et al 2005) Secretion of proinflammatory cytokines and chemokines during amphotericin B exposure is mediated by coactivation of toll-like receptors 1 and 2. Antimicrob Agents Chemother 49 : 1617 1621.
23. Romani L (2004) Immunity to fungal infections. Nature Rev Immunol 4 : 1 13.
24. Tada H, Nemoto E, Shimauki H et al 2002) Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner. Microbiol Immunol 2002 : 503 512.
25. Takeuchi O, Kawai T, Muhlradt PF et al 2001) Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol 13 : 933 940.
26. Takeuchi O, Sato S, Horiuchi T et al 2002) Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 169 : 10 14.
27. Taylor PR, Tsoni SV, Willment JA et al 2007) Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol 8 : 31 38.
28. Tonnetti L, Spaccapelo R, Cenci E et al 1995) Interleukin-4 and -10 exacerbate candidiasis in mice. Eur J Immunol 25 : 1559 1565.
29. Triantafilou M Triantafilou K (2002) Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol 23 : 301 304.
30. Triantafilou M, Gamper FG, Haston RM et al 2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem 281 : 31002 31011.
31. Villamon E, Gozalbo D, Roig P et al 2004a) Myeloid differentiation factor 88 (MyD88) is required for murine resistance to Candida albicans and is critically involved in Candida -induced production of cytokines. Eur Cytokine Netw 15 : 263 271.
32. Villamon E, Gozalbo D, Roig P, O'Connor JE, Fradelizi D Gil ML (2004b) Toll-like receptor-2 is essential in murine defenses against Candida albicans infections. Microbes Infect 6 : 1 7.
33. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP Edmond MB (2004) Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 39 : 309 317.
34. Yamamoto Y, Klein TW Friedman H (1997) Involvement of mannose receptor in cytokine interleukin-1beta (IL-1beta), IL-6, and granulocyte-macrophage colony-stimulating factor responses, but not in chemokine macrophage inflammatory protein 1beta (MIP-1beta), MIP-2, and KC responses, caused by attachment of Candida albicans to macrophages. Infect Immun 65 : 1077 1082.