Bcl2 enhances induced hematopoietic differentiation of murine embryonic stem cells

Experimental Hematology

Volumn 36, Issue 2, 2008, Pages 128-139

  Wang, Yan Yi ^a   Deng, Xingming ^a   Xu, Lijun ^a   Gao, Fengqin ^a   Flagg, Tammy ^a   May, W Stratford ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN BCL 2; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; COLONY FORMING UNIT; EMBRYO; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE SILENCING; HEMATOPOIESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; STEM CELL TRANSPLANTATION; WESTERN BLOTTING;

ANIMALS; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; EMBRYONIC STEM CELLS; G0 PHASE; G1 PHASE; GENES, DOMINANT; HEMATOPOIETIC STEM CELLS; MICE; MUTATION; NIH 3T3 CELLS; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; STEM CELL TRANSPLANTATION; UP-REGULATION;

MURINAE;

EID: 38149000936     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.09.004     Document Type: Article

References (37)

1. Townsend K.J., Zhou P., Qian L., et al. Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. J Biol Chem 274 (1999) 1801-1813
2. Kozopas K.M., Yang T., Buchan H.L., et al. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Natl Acad Sci U S A 90 (1993) 3516-3520
3. Zhang K.Z., Westberg J.A., Holtta E., et al. BCL2 regulates neural differentiation. Proc Natl Acad Sci U S A 93 (1996) 4504-4508
4. Rolletschek A., Chang H., Guan K., et al. Differentiation of embryonic stem cell-derived dopaminergic neurons is enhanced by survival-promoting factors. Mech Dev 105 (2001) 93-104
5. Middleton G., Pinon L.G., Wyatt S., et al. Bcl-2 accelerates the maturation of early sensory neurons. J Neurosci 18 (1998) 3344-3350
6. Haughn L., Hawley R.G., Morrison D.K., et al. BCL-2 and BCL-XL restrict lineage choice during hematopoietic differentiation. J Biol Chem 278 (2003) 25158-25165
7. Marone M., Bonanno G., Rutella S., et al. Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21. Leuk Lymphoma 43 (2002) 51-57
8. Lu Q.L., Poulsom R., Wong L., et al. Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J Pathol 169 (1993) 431-437
9. Domen J., Gandy K.L., and Weissman I.L. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood 91 (1998) 2272-2282
10. Park J.R., Bernstein I.D., and Hockenbery D.M. Primitive human hematopoietic precursors express Bcl-x but not Bcl-2. Blood 86 (1995) 868-876
11. Deng X., Gao F., Flagg T., et al. Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc Natl Acad Sci U S A 101 (2004) 153-158
12. Korhonen L., Belluardo N., Mudo G., et al. Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain. Eur J Neurosci 18 (2003) 1121-1134
13. Deng X., Gao F., and May Jr. W.S. Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood 102 (2003) 3179-3185
14. Youn C.K., Cho H.J., Kim S.H., et al. Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity. Nat Cell Biol 7 (2005) 137-147
15. Jin Z., May W.S., Gao F., et al. Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity. J Biol Chem 281 (2006) 14446-14456
16. Ruvolo P.P., Deng X., and May W.S. Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia 15 (2001) 515-522
17. May W.S., Tyler P.G., Ito T., et al. Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis. J Biol Chem 269 (1994) 26865-26870
18. Ito T., Deng X., Carr B., et al. Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272 (1997) 11671-11673
19. Deng X., Ruvolo P., Carr B., et al. Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci U S A 97 (2000) 1578-1583
20. Horiuchi M., Hayashida W., Kambe T., et al. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 272 (1997) 19022-19026
21. Pear W.S., Miller J.P., Xu L., et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 92 (1998) 3780-3792
22. Pear W.S., Nolan G.P., Scott M.L., et al. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A 90 (1993) 8392-8396
23. Helgason C.D., Sauvageau G., Lawrence H.J., et al. Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro. Blood 87 (1996) 2740-2749
24. Keller G., Kennedy M., Papayannopoulou T., et al. Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 13 (1993) 473-486
25. Kyba M., Perlingeiro R.C., Hoover R.R., et al. Enhanced hematopoietic differentiation of embryonic stem cells conditionally expressing Stat5. Proc Natl Acad Sci U S A 100 Suppl 1 (2003) 11904-11910
26. Mitjavila-Garcia M.T., Cailleret M., Godin I., et al. Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development 129 (2002) 2003-2013
27. Mikkola H.K., Fujiwara Y., Schlaeger T.M., et al. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood 101 (2003) 508-516
28. Deng X., Ito T., Carr B., et al. Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. J Biol Chem 273 (1998) 34157-34163
29. Chiang C.W., Harris G., Ellig C., et al. Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation. Blood 97 (2001) 1289-1297
30. Sasaki K., Tamura S., Tachibana H., et al. Expression and role of p27(kip1) in neuronal differentiation of embryonal carcinoma cells. Brain Res Mol Brain Res 77 (2000) 209-221
31. Drissi H., Hushka D., Aslam F., et al. The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts. Cancer Res 59 (1999) 3705-3711
32. Casaccia-Bonnefil P., Tikoo R., Kiyokawa H., et al. Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. Genes Dev 11 (1997) 2335-2346
33. Carruthers S., Mason J., and Papalopulu N. Depletion of the cell-cycle inhibitor p27(Xic1) impairs neuronal differentiation and increases the number of ElrC(+) progenitor cells in Xenopus tropicalis. Mech Dev 120 (2003) 607-616
34. Preclikova H., Bryja V., Pachernik J., et al. Early cycling-independent changes to p27, cyclin D2, and cyclin D3 in differentiating mouse embryonal carcinoma cells. Cell Growth Differ 13 (2002) 421-430
35. Bahrami A.R., Matin M.M., and Andrews P.W. The CDK inhibitor p27 enhances neural differentiation in pluripotent NTERA2 human EC cells, but does not permit differentiation of 2102Ep nullipotent human EC cells. Mech Dev 122 (2005) 1034-1042
36. Hauser P.J., Agrawal D., Flanagan M., et al. The role of p27kip1 in the in vitro differentiation of murine keratinocytes. Cell Growth Differ 8 (1997) 203-211
37. Baldassarre G., Barone M.V., Belletti B., et al. Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation. Oncogene 18 (1999) 6241-6251