메뉴 건너뛰기




Volumn 39, Issue 6, 2007, Pages 679-689

DNA vaccines for cervical cancer: From bench to bedside

Author keywords

Antigen presenting cells; Dendritic cells; Human papillomavirus type 16; Oncogene protein E7; Papillomavirus vaccines; Vaccination; Vaccines, DNA

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENDRITIC CELL VACCINE; DNA VACCINE; EPIGALLOCATECHIN GALLATE; HEAT SHOCK PROTEIN 70; IMIQUIMOD; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN E6; PROTEIN E7; WART VIRUS VACCINE;

EID: 38049174711     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2007.74     Document Type: Review
Times cited : (73)

References (68)
  • 2
    • 33847401888 scopus 로고    scopus 로고
    • Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: An update on implications for chronic infections and tumor evasion
    • Blank C, Mackensen A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion. Cancer Immunol Immunother 2007;56:739-45
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 739-745
    • Blank, C.1    Mackensen, A.2
  • 6
    • 0034003977 scopus 로고    scopus 로고
    • Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines
    • Chen CH, Wang TL, Hung CF, Pardoll DM, Wu TC. Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines. Vaccine 2000b;18:2015-22
    • (2000) Vaccine , vol.18 , pp. 2015-2022
    • Chen, C.H.1    Wang, T.L.2    Hung, C.F.3    Pardoll, D.M.4    Wu, T.C.5
  • 7
    • 0034788572 scopus 로고    scopus 로고
    • Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen
    • Cheng WF, Hung CF, Chai CY, Hsu KF, He L, Ling M, Wu TC. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J Clin Invest 2001;108:669-78
    • (2001) J Clin Invest , vol.108 , pp. 669-678
    • Cheng, W.F.1    Hung, C.F.2    Chai, C.Y.3    Hsu, K.F.4    He, L.5    Ling, M.6    Wu, T.C.7
  • 9
    • 0028313992 scopus 로고
    • Assembly, transport, and function of MHC class II molecules
    • Cresswell P. Assembly, transport, and function of MHC class II molecules. Annual review of immunology 1994;12:259-93
    • (1994) Annual review of immunology , vol.12 , pp. 259-293
    • Cresswell, P.1
  • 10
    • 0024412885 scopus 로고
    • Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras
    • Crook T, Morgenstern JP, Crawford L, Banks L. Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras. Embo J 1989;8:513-9
    • (1989) Embo J , vol.8 , pp. 513-519
    • Crook, T.1    Morgenstern, J.P.2    Crawford, L.3    Banks, L.4
  • 13
    • 0032896455 scopus 로고    scopus 로고
    • Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22
    • Dilber MS, Phelan A, Aints A, Mohamed AJ, Elliott G, Smith CI, O'Hare P. Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22. Gene Ther 1999;6:12-21
    • (1999) Gene Ther , vol.6 , pp. 12-21
    • Dilber, M.S.1    Phelan, A.2    Aints, A.3    Mohamed, A.J.4    Elliott, G.5    Smith, C.I.6    O'Hare, P.7
  • 15
    • 0033825002 scopus 로고    scopus 로고
    • Marek's disease virus (MDV) homologues of herpes simplex virus type 1 UL49 (VP22) and UL48 (VP16) genes: High-level expression and characterization of MDV-1 VP22 and VP16
    • Dorange F, El Mehdaoui S, Pichon C, Coursaget P, Vautherot JF. Marek's disease virus (MDV) homologues of herpes simplex virus type 1 UL49 (VP22) and UL48 (VP16) genes: high-level expression and characterization of MDV-1 VP22 and VP16. J Gen Virol 2000;81 Pt 9:2219-30
    • (2000) J Gen Virol , vol.81 , Issue.PART 9 , pp. 2219-2230
    • Dorange, F.1    El Mehdaoui, S.2    Pichon, C.3    Coursaget, P.4    Vautherot, J.F.5
  • 16
    • 0031471203 scopus 로고    scopus 로고
    • Intercellular trafficking and protein delivery by a herpesvirus structural protein
    • Elliott G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 1997;88:223-33
    • (1997) Cell , vol.88 , pp. 223-233
    • Elliott, G.1    O'Hare, P.2
  • 18
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
    • Gorelik L, Flavell RA. Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med 2001;7:1118-22
    • (2001) Nat Med , vol.7 , pp. 1118-1122
    • Gorelik, L.1    Flavell, R.A.2
  • 19
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh V, Wu J, Yee C, Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 2002;419:734-8
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 22
    • 0034014715 scopus 로고    scopus 로고
    • Distinctions between bovine herpesvirus 1 and herpes simplex virus type 1 VP22 tegument protein subcellular associations
    • Harms JS, Ren X, Oliveira SC, Splitter GA. Distinctions between bovine herpesvirus 1 and herpes simplex virus type 1 VP22 tegument protein subcellular associations. J Virol 2000;74:3301-12
    • (2000) J Virol , vol.74 , pp. 3301-3312
    • Harms, J.S.1    Ren, X.2    Oliveira, S.C.3    Splitter, G.A.4
  • 23
    • 0141625683 scopus 로고    scopus 로고
    • Augmentation of DNA vaccine potency through secretory heat shock protein-mediated antigen targeting
    • Hauser H, Chen SY. Augmentation of DNA vaccine potency through secretory heat shock protein-mediated antigen targeting. Methods 2003;31:225-31
    • (2003) Methods , vol.31 , pp. 225-231
    • Hauser, H.1    Chen, S.Y.2
  • 24
    • 2942748077 scopus 로고    scopus 로고
    • Secretory heat-shock protein as a dendritic cell-targeting molecule: A new strategy to enhance the potency of genetic vaccines
    • Hauser H, Shen L, Gu QL, Krueger S, Chen SY. Secretory heat-shock protein as a dendritic cell-targeting molecule: a new strategy to enhance the potency of genetic vaccines. Gene Ther 2004;11:924-32
    • (2004) Gene Ther , vol.11 , pp. 924-932
    • Hauser, H.1    Shen, L.2    Gu, Q.L.3    Krueger, S.4    Chen, S.Y.5
  • 25
    • 23744472184 scopus 로고    scopus 로고
    • Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope
    • Huang CH, Peng S, He L, Tsai YC, Boyd DA, Hansen TH, Wu TC, Hung CF. Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope. Gene Ther 2005;12:1180-6
    • (2005) Gene Ther , vol.12 , pp. 1180-1186
    • Huang, C.H.1    Peng, S.2    He, L.3    Tsai, Y.C.4    Boyd, D.A.5    Hansen, T.H.6    Wu, T.C.7    Hung, C.F.8
  • 26
    • 0035340174 scopus 로고    scopus 로고
    • Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen
    • Hung C-F, Cheng W-F, Chai C-Y, Hsu K-F, He L, Ling M, Wu T-C. Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen. J Immunol 2001a;166:5733-40
    • (2001) J Immunol , vol.166 , pp. 5733-5740
    • Hung, C.-F.1    Cheng, W.-F.2    Chai, C.-Y.3    Hsu, K.-F.4    He, L.5    Ling, M.6    Wu, T.-C.7
  • 27
    • 0035328523 scopus 로고    scopus 로고
    • Cancer immunotherapy using a DNA vaccine encoding the translocation domain of a bacterial toxin linked to a tumor antigen
    • Hung C-F, Cheng W-F, Hsu K-F, Chai C-Y, He L, Ling M, Wu T-C. Cancer immunotherapy using a DNA vaccine encoding the translocation domain of a bacterial toxin linked to a tumor antigen. Cancer Research 2001b;61:3698-703
    • (2001) Cancer Research , vol.61 , pp. 3698-3703
    • Hung, C.-F.1    Cheng, W.-F.2    Hsu, K.-F.3    Chai, C.-Y.4    He, L.5    Ling, M.6    Wu, T.-C.7
  • 28
    • 0035110962 scopus 로고    scopus 로고
    • Enhancement of DNA vaccine potency by linkage of antigen gene to a gene encoding the extracellular domain of Flt3-ligand
    • Hung C-F, Hsu K-F, Cheng W-F, Chai CY, He L, Ling M, Wu T-C. Enhancement of DNA vaccine potency by linkage of antigen gene to a gene encoding the extracellular domain of Flt3-ligand. Cancer Research 2001c;61:1080-8
    • (2001) Cancer Research , vol.61 , pp. 1080-1088
    • Hung, C.-F.1    Hsu, K.-F.2    Cheng, W.-F.3    Chai, C.Y.4    He, L.5    Ling, M.6    Wu, T.-C.7
  • 29
    • 0036184794 scopus 로고    scopus 로고
    • Improving DNA vaccine potency by linking Marek's disease virus type 1 VP22 to an antigen
    • Hung CF, He L, Juang J, Lin TJ, Ling M, Wu TC. Improving DNA vaccine potency by linking Marek's disease virus type 1 VP22 to an antigen. J Virol 2002;76:2676-82
    • (2002) J Virol , vol.76 , pp. 2676-2682
    • Hung, C.F.1    He, L.2    Juang, J.3    Lin, T.J.4    Ling, M.5    Wu, T.C.6
  • 30
    • 0038520125 scopus 로고    scopus 로고
    • Enhancing major histocompatibility complex class I antigen presentation by targeting antigen to centrosomes
    • Hung CF, Cheng WF, He L, Ling M, Juang J, Lin CT, Wu TC. Enhancing major histocompatibility complex class I antigen presentation by targeting antigen to centrosomes. Cancer Res 2003;63:2393-8
    • (2003) Cancer Res , vol.63 , pp. 2393-2398
    • Hung, C.F.1    Cheng, W.F.2    He, L.3    Ling, M.4    Juang, J.5    Lin, C.T.6    Wu, T.C.7
  • 31
    • 0037299740 scopus 로고    scopus 로고
    • Improving DNA vaccine potency via modification of professional antigen presenting cells
    • Hung CF, Wu TC. Improving DNA vaccine potency via modification of professional antigen presenting cells. Curr Opin Mol Ther 2003;5:20-4
    • (2003) Curr Opin Mol Ther , vol.5 , pp. 20-24
    • Hung, C.F.1    Wu, T.C.2
  • 32
    • 33845219775 scopus 로고    scopus 로고
    • Hung C-F, Calizo R, Tsai YC, He L, Wu T-C. A DNA vaccine encoding a single-chain trimer of HLA-A2 linked to human mesothelin peptide generates anti-tumor effects against human mesothelin-expressing tumors. Vaccine 2007a;25:127-35
    • Hung C-F, Calizo R, Tsai YC, He L, Wu T-C. A DNA vaccine encoding a single-chain trimer of HLA-A2 linked to human mesothelin peptide generates anti-tumor effects against human mesothelin-expressing tumors. Vaccine 2007a;25:127-35
  • 33
    • 34247232184 scopus 로고    scopus 로고
    • DNA vaccines encoding Ii-PADRE generates potent PADRE-specific CD4(+) T-cell immune responses and enhances vaccine potency
    • Hung CF, Tsai YC, He L, Wu TC. DNA vaccines encoding Ii-PADRE generates potent PADRE-specific CD4(+) T-cell immune responses and enhances vaccine potency. Mol Ther 2007b;15:1211-9
    • (2007) Mol Ther , vol.15 , pp. 1211-1219
    • Hung, C.F.1    Tsai, Y.C.2    He, L.3    Wu, T.C.4
  • 34
    • 0033589811 scopus 로고    scopus 로고
    • Targeting HPV-16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine HPV-16 E7-expressing tumors
    • Ji H, Wang T-L, Chen C-H, Hung C-F, Pai S, Lin K-Y, Kurman RJ, Pardoll DM, Wu T-C. Targeting HPV-16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine HPV-16 E7-expressing tumors. Hum Gene Ther 1999;10:2727-40
    • (1999) Hum Gene Ther , vol.10 , pp. 2727-2740
    • Ji, H.1    Wang, T.-L.2    Chen, C.-H.3    Hung, C.-F.4    Pai, S.5    Lin, K.-Y.6    Kurman, R.J.7    Pardoll, D.M.8    Wu, T.-C.9
  • 36
    • 36148987257 scopus 로고    scopus 로고
    • Enhancing DNA Vaccine Potency by Combining a Strategy to Prolong Dendritic Cell Life and Intracellular Targeting Strategies with a Strategy to Boost CD4+ T cells
    • Kim D, Hoory T, Wu T-C, Hung CF. Enhancing DNA Vaccine Potency by Combining a Strategy to Prolong Dendritic Cell Life and Intracellular Targeting Strategies with a Strategy to Boost CD4+ T cells. Human Gene Therapy 2007;18:1129-40
    • (2007) Human Gene Therapy , vol.18 , pp. 1129-1140
    • Kim, D.1    Hoory, T.2    Wu, T.-C.3    Hung, C.F.4
  • 39
    • 84984550385 scopus 로고    scopus 로고
    • Vaccination with a DNA vaccine encoding herpes simplex virus type 1 VP22 linked to antigen generates long-term antigen-specific CD8-positive memory T cells and protective immunity
    • Kim TW, Hung CF, Kim JW, Juang J, Chen PJ, He L, Boyd DA, Wu TC. Vaccination with a DNA vaccine encoding herpes simplex virus type 1 VP22 linked to antigen generates long-term antigen-specific CD8-positive memory T cells and protective immunity. Hum Gene Ther 2004b;15:167-77
    • (2004) Hum Gene Ther , vol.15 , pp. 167-177
    • Kim, T.W.1    Hung, C.F.2    Kim, J.W.3    Juang, J.4    Chen, P.J.5    He, L.6    Boyd, D.A.7    Wu, T.C.8
  • 40
    • 11244319876 scopus 로고    scopus 로고
    • Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency
    • Kim TW, Lee JH, He L, Boyd DA, Hardwick JM, Hung CF, Wu TC. Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency. Cancer Res 2005;65:309-16
    • (2005) Cancer Res , vol.65 , pp. 309-316
    • Kim, T.W.1    Lee, J.H.2    He, L.3    Boyd, D.A.4    Hardwick, J.M.5    Hung, C.F.6    Wu, T.C.7
  • 41
    • 0029163631 scopus 로고
    • Identification and characterization of a cDNA clone derived from the Marek's disease tumour cell line RPL1 encoding a homologue of alpha-transinducing factor (VP16) of HSV-1
    • Koptidesova D, Kopacek J, Zelnik V, Ross NL, Pastorekova S, Pastorek J. Identification and characterization of a cDNA clone derived from the Marek's disease tumour cell line RPL1 encoding a homologue of alpha-transinducing factor (VP16) of HSV-1. Arch Virol 1995;140:355-62
    • (1995) Arch Virol , vol.140 , pp. 355-362
    • Koptidesova, D.1    Kopacek, J.2    Zelnik, V.3    Ross, N.L.4    Pastorekova, S.5    Pastorek, J.6
  • 42
    • 33745684793 scopus 로고    scopus 로고
    • A DNA vaccine encoding a codon-optimized human papillomavirus type 16 E6 gene enhances CTL response and anti-tumor activity
    • Lin CT, Tsai YC, He L, Calizo R, Chou HH, Chang TC, Soong YK, Hung CF, Lai CH. A DNA vaccine encoding a codon-optimized human papillomavirus type 16 E6 gene enhances CTL response and anti-tumor activity. J Biomed Sci 2006;13:481-8
    • (2006) J Biomed Sci , vol.13 , pp. 481-488
    • Lin, C.T.1    Tsai, Y.C.2    He, L.3    Calizo, R.4    Chou, H.H.5    Chang, T.C.6    Soong, Y.K.7    Hung, C.F.8    Lai, C.H.9
  • 43
    • 0034910022 scopus 로고    scopus 로고
    • Is VP22 nuclear homing an artifact?
    • Lundberg M, Johansson M. Is VP22 nuclear homing an artifact? Nat Biotechnol 2001;19:713-4
    • (2001) Nat Biotechnol , vol.19 , pp. 713-714
    • Lundberg, M.1    Johansson, M.2
  • 44
  • 45
    • 23044469104 scopus 로고    scopus 로고
    • Enhancement of antigen acquisition by dendritic cells and MHC class II-restricted epitope presentation to CD4+ T cells using VP22 DNA vaccine vectors that promote intercellular spreading following initial transfection
    • Mwangi W, Brown WC, Splitter GA, Zhuang Y, Kegerreis K, Palmer GH. Enhancement of antigen acquisition by dendritic cells and MHC class II-restricted epitope presentation to CD4+ T cells using VP22 DNA vaccine vectors that promote intercellular spreading following initial transfection. J Leukoc Biol 2005;78:401-11
    • (2005) J Leukoc Biol , vol.78 , pp. 401-411
    • Mwangi, W.1    Brown, W.C.2    Splitter, G.A.3    Zhuang, Y.4    Kegerreis, K.5    Palmer, G.H.6
  • 47
    • 0034913965 scopus 로고    scopus 로고
    • A genetic immunization adjuvant system based on BVP22-antigen fusion
    • Oliveira SC, Harms JS, Afonso RR, Splitter GA. A genetic immunization adjuvant system based on BVP22-antigen fusion. Hum Gene Ther 2001;12:1353-9
    • (2001) Hum Gene Ther , vol.12 , pp. 1353-1359
    • Oliveira, S.C.1    Harms, J.S.2    Afonso, R.R.3    Splitter, G.A.4
  • 49
    • 0036819778 scopus 로고    scopus 로고
    • Particle-mediated DNA vaccination of mice, monkeys and men: Looking beyond the dogma
    • Payne LG, Fuller DH, Haynes JR. Particle-mediated DNA vaccination of mice, monkeys and men: looking beyond the dogma. Curr Opin Mol Ther 2002;4:459-66
    • (2002) Curr Opin Mol Ther , vol.4 , pp. 459-466
    • Payne, L.G.1    Fuller, D.H.2    Haynes, J.R.3
  • 50
    • 33644659256 scopus 로고    scopus 로고
    • Principles and use of anti-CTLA4 antibody in human cancer immunotherapy
    • Peggs KS, Quezada SA, Korman AJ, Allison JP. Principles and use of anti-CTLA4 antibody in human cancer immunotherapy. Curr Opin Immunol 2006;18:206-13
    • (2006) Curr Opin Immunol , vol.18 , pp. 206-213
    • Peggs, K.S.1    Quezada, S.A.2    Korman, A.J.3    Allison, J.P.4
  • 51
    • 27744556963 scopus 로고    scopus 로고
    • Characterization of HPV-16 E6 DNA vaccines employing intracellular targeting and intercellular spreading strategies
    • Peng S, Trimble C, Ji H, He L, Tsai YC, Macaes B, Hung CF, Wu TC. Characterization of HPV-16 E6 DNA vaccines employing intracellular targeting and intercellular spreading strategies. J Biomed Sci 2005;12:689-700
    • (2005) J Biomed Sci , vol.12 , pp. 689-700
    • Peng, S.1    Trimble, C.2    Ji, H.3    He, L.4    Tsai, Y.C.5    Macaes, B.6    Hung, C.F.7    Wu, T.C.8
  • 53
    • 0031953510 scopus 로고    scopus 로고
    • Intercellular delivery of functional p53 by the herpesvirus protein VP22
    • Phelan A, Elliott G, O'Hare P. Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nat Biotechnol 1998;16:440-3
    • (1998) Nat Biotechnol , vol.16 , pp. 440-443
    • Phelan, A.1    Elliott, G.2    O'Hare, P.3
  • 54
    • 0032555907 scopus 로고    scopus 로고
    • Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization
    • Porgador A, Irvine KR, Iwasaki A, Barber BH, Restifo NP, Germain RN. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med 1998;188:1075-82
    • (1998) J Exp Med , vol.188 , pp. 1075-1082
    • Porgador, A.1    Irvine, K.R.2    Iwasaki, A.3    Barber, B.H.4    Restifo, N.P.5    Germain, R.N.6
  • 55
    • 33748988471 scopus 로고    scopus 로고
    • Roden R, Wu TC. How will HPV vaccines affect cervical cancer? Nat Rev Cancer 2006;6:753-63
    • Roden R, Wu TC. How will HPV vaccines affect cervical cancer? Nat Rev Cancer 2006;6:753-63
  • 58
    • 0037062508 scopus 로고    scopus 로고
    • Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection
    • Sciortino MT, Taddeo B, Poon AP, Mastino A, Roizman B. Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection. Proc Natl Acad Sci USA 2002;99:8318-23
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8318-8323
    • Sciortino, M.T.1    Taddeo, B.2    Poon, A.P.3    Mastino, A.4    Roizman, B.5
  • 59
    • 34250324345 scopus 로고    scopus 로고
    • Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
    • Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med 2007;204:1441-51
    • (2007) J Exp Med , vol.204 , pp. 1441-1451
    • Stary, G.1    Bangert, C.2    Tauber, M.3    Strohal, R.4    Kopp, T.5    Stingl, G.6
  • 60
    • 0025735629 scopus 로고
    • The dendritic cell system and its role in immunogenicity
    • Steinman RM. The dendritic cell system and its role in immunogenicity. Annual review of immunology 1991;9:271-96
    • (1991) Annual review of immunology , vol.9 , pp. 271-296
    • Steinman, R.M.1
  • 61
    • 10744223658 scopus 로고    scopus 로고
    • Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe
    • Trimble C, Lin CT, Hung CF, Pai S, Juang J, He L, Gillison M, Pardoll D, Wu L, Wu TC. Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine 2003;21:4036-42
    • (2003) Vaccine , vol.21 , pp. 4036-4042
    • Trimble, C.1    Lin, C.T.2    Hung, C.F.3    Pai, S.4    Juang, J.5    He, L.6    Gillison, M.7    Pardoll, D.8    Wu, L.9    Wu, T.C.10
  • 62
    • 17644370329 scopus 로고    scopus 로고
    • Cell biology of antigen processing in vitro and in vivo
    • Trombetta ES, Mellman I. Cell biology of antigen processing in vitro and in vivo. Annual review of immunology 2005;23:975-1028
    • (2005) Annual review of immunology , vol.23 , pp. 975-1028
    • Trombetta, E.S.1    Mellman, I.2
  • 66
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 67
    • 0030950036 scopus 로고    scopus 로고
    • Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules
    • Yue FY, Dummer R, Geertsen R, Hofbauer G, Laine E, Manolio S, Burg G. Interleukin-10 is a growth factor for human melanoma cells and down-regulates HLA class-I, HLA class-II and ICAM-1 molecules. Int J Cancer 1997;71:630-7
    • (1997) Int J Cancer , vol.71 , pp. 630-637
    • Yue, F.Y.1    Dummer, R.2    Geertsen, R.3    Hofbauer, G.4    Laine, E.5    Manolio, S.6    Burg, G.7
  • 68
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002;2:342-50
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.