Genetic alterations on 3p,11q13, and 18q in nonfamilial and MEN 1- associated pancreatic endocrine tumors

Genes Chromosomes and Cancer

Volumn 26, Issue 3, 1999, Pages 258-264

  Hessman, Ola ^a   Lindberg, Daniel ^a   Einarsson, Annika ^a   Lillhager, Peter ^a   Carling, Tobias ^a   Grimelius, Lars ^a   Eriksson, Barbro ^a   Åkerström, Göran ^a   Westin, Gunnar ^a   Skogseid, Britt ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER GENETICS; CHROMOSOME 11Q; CHROMOSOME 18Q; CHROMOSOME 3P; CHROMOSOME ABERRATION; CLINICAL ARTICLE; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HOMOZYGOSITY; HUMAN; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL;

CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 18; CHROMOSOMES, HUMAN, PAIR 3; GENETIC MARKERS; HUMANS; LOSS OF HETEROZYGOSITY; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; PANCREATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0032869951     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199911)26:3<258::AID-GCC11>3.0.CO;2-2     Document Type: Article

References (21)

1. Böttger T, Seidl C, Seifert JK, Heintz A, Bretz B, Junginger T. 1997. Value of quantitative DNA analysis in endocrine tumors of the pancreas. Oncology 54:318-323.
2. Byström C, Larsson C, Blomberg C, Sandelin K, Falkmer U, Skogseid B, Öberg K, Werner S, Nordenskjöld M. 1990. Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA 87:1968-1972.
3. Chakrabarti R, Srivatsan ES, Wood TF, Eubanks PJ, Ebrahimi SA, Gatti RA, Passaro E Jr, Sawicki MP. 1998. Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13. Genes Chromosomes Cancer 22:130-137.
4. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ. 1997. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276:404-407.
5. Chung DC, Smith AP, Louis DN, Graeme Cook F, Warshaw AL, Arnold A. 1997. A novel pancreatic endocrine tumor suppressor gene locus on chromosome 3p with clinical prognostic implications. J Clin Invest 100:404-410.
6. Chung DC, Brown SB, Graeme-Cook F, Tillotson LG, Warshaw AL, Jensen RT, Arnold A. 1998. Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors. Cancer Res 58:3706-3711.
7. Debelenko LV, Zhuang Z, Emmert-Buck MR, Chandrasekharappa SC, Manickam P, Guru SC, Marx SJ, Skarulis MC, Spiegel AM, Collins FS, Jensen RT, Liotta LA, Lubensky IA. 1997. Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. Cancer Res 57:2238-2243.
8. Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L. 1996. MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86:543-552.
9. European Consortium on MEN1. 1997. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene: the European Consortium on MEN1. Hum Mol Genet 6:1177-1183.
10. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thomas G, Kinzler KW, et al. 1990. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247:49-56.
11. Fero ML, Randel E, Gurlcy KE, Roberts JM, Kemp CJ. 1998. The murine gene p27Kipl is haplo-insufficient for tumour suppression. Nature 396:177-180.
12. Hessman O, Lindberg D, Skogseid B, Carling T, Hellman P, Rastad J, Åkerstrom G, Westin G. 1998. Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas. Cancer Res 58:377-379.
13. Kong XT, Choi SH, Inoue A, Xu F, Chen T, Takita J, Yokota J, Bessho F, Yanagisawa M, Hanada R, Yamamoto K, Hayashi Y. 1997. Expression and mutational analysis of the DCC, DPC4, and MADR2/JV18-1 genes in neuroblastoma. Cancer Res 57:3772-3778.
14. Pelosi G, Bresaola E, Bogina G, Pasini F, Rodella S, Castelli P, Iacono C, Serio G, Zamboni G. 1996. Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy: a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum Pathol 27:1124-1134.
15. Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, Goodman SN, Sohn TA, Hruban RH, Yeo CJ, Kern SE. 1997. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 57:1731-1734.
16. Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H. Sidransky D, Casero RA Jr, Meltzer PS, Hahn SA, Kern SE. 1996. DPC4 gene in various tumor types. Cancer Res 56:2527-2530.
17. Skogseid B, Larsson C, Lindgren PG, Kvanta E, Rastad J, Theodorsson E, Wide L, Wilander E, Öberg K. 1992. Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 75:76-81.
18. Skogseid B, Öberg K, Eriksson B, Juhlin C, Granberg D, Åkerstrom G, Rastad J. 1996. Surgery for asymptomatic pancreatic lesion in multiple endocrine neoplasia type I. World J Surg 20:872-876.
19. Uchida K, Nagatake M, Osada H, Yatabe Y, Kondo M. Mitsudomi T, Masuda A, Takahashi T, Takahashi T. 1996. Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers. Cancer Res 56:5583-5585.
20. Wang EH, Ebrahimi SA, Wu AY, Kashefi C, Passaro E Jr, Sawicki MP. 1998. Mutation of the MENIN gene in sporadic pancreatic endocrine tumors. Cancer Res 58:4417-4420.
21. Zhuang Z, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang C, Park WS, Aganval SK, Debelenko LV, Rester M, Guru SC, Manickam P, Olufemi SE, Yu F. Heppner C, Crabtree JS, Skarulis MC, Yenzon DJ, Emmert-Buck MR, Spiegel AM, Chandrasekharappa SC, Collins FS, Burns AL, Marx SJ, Lubensky IA. 1997. Somatic mutations of the MENI tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res 57:4682-4686.