메뉴 건너뛰기




Volumn 38, Issue 2, 2008, Pages 123-131

Ursodeoxycholic acid: Mechanism of action and novel clinical applications

Author keywords

Bile acids; Cholestatic liver diseases; Colon cancer; Non alcoholic steatohepatitis; Ursodeoxycholic acid

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; CHENODEOXYCHOLIC ACID; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; INSULIN; MIFEPRISTONE; PIROXICAM; PLACEBO; TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

EID: 38049109883     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2007.00297.x     Document Type: Review
Times cited : (104)

References (80)
  • 1
    • 0016765162 scopus 로고
    • Dissolution of cholesterol gallstones by long-term administration of ursodeoxycholic acid
    • (In Japanese) [Nippon Shokakibyo Gakkai Zasshi]
    • Makino I, Shinozaki K, Yoshino K, Nakagawa S. [Dissolution of cholesterol gallstones by long-term administration of ursodeoxycholic acid]. J Jpn Soc Gastroenterol [Nippon Shokakibyo Gakkai Zasshi] 1975; 72: 690-702. (In Japanese)
    • (1975) J Jpn Soc Gastroenterol , vol.72 , pp. 690-702
    • Makino, I.1    Shinozaki, K.2    Yoshino, K.3    Nakagawa, S.4
  • 2
    • 0025829205 scopus 로고
    • Treatment of cholesterol gallstones with litholytic bile acids
    • Salen G, Tint GS, Shefer S. Treatment of cholesterol gallstones with litholytic bile acids. Gastroenterol Clin North Am 1991; 20: 171-82.
    • (1991) Gastroenterol Clin North Am , vol.20 , pp. 171-182
    • Salen, G.1    Tint, G.S.2    Shefer, S.3
  • 3
    • 0019155977 scopus 로고
    • Mesophase formation during cholesterol dissolution in ursodeoxycholate-lecithin solutions: New mechanism for gallstone dissolution in humans
    • Corrigan OI, Su CC, Higuchi WI, Hofmann AF. Mesophase formation during cholesterol dissolution in ursodeoxycholate-lecithin solutions: New mechanism for gallstone dissolution in humans. J Pharm Sci 1980; 69: 869-71.
    • (1980) J Pharm Sci , vol.69 , pp. 869-871
    • Corrigan, O.I.1    Su, C.C.2    Higuchi, W.I.3    Hofmann, A.F.4
  • 4
    • 0020318866 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part I
    • Bachrach WH, Hofmann AF. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part I. Dig Dis Sci 1982; 27: 737-61.
    • (1982) Part I. Dig Dis Sci , vol.27 , pp. 737-761
    • Bachrach, W.H.1    Hofmann, A.F.2
  • 5
    • 0025203619 scopus 로고
    • Gallbladder motility in cholesterol gallstone disease. Effect of ursodeoxycholic acid administration and gallstone dissolution
    • Festi D, Frabboni R, Bazzoli F et al. Gallbladder motility in cholesterol gallstone disease. Effect of ursodeoxycholic acid administration and gallstone dissolution. Gastroenterology 1990; 99: 1779-85.
    • (1990) Gastroenterology , vol.99 , pp. 1779-1785
    • Festi, D.1    Frabboni, R.2    Bazzoli, F.3
  • 8
    • 0033036447 scopus 로고    scopus 로고
    • Long-term ursodeoxycholic acid therapy is associated with reduced risk of biliary pain and acute cholecystitis in patients with gallbladder stones: A cohort analysis
    • Tomida S, Abei M, Yamaguchi T et al. Long-term ursodeoxycholic acid therapy is associated with reduced risk of biliary pain and acute cholecystitis in patients with gallbladder stones: A cohort analysis. Hepatology 1999; 30: 6-13.
    • (1999) Hepatology , vol.30 , pp. 6-13
    • Tomida, S.1    Abei, M.2    Yamaguchi, T.3
  • 9
    • 33745538347 scopus 로고    scopus 로고
    • Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy
    • Venneman NG, Besselink MG, Keulemans YC et al. Ursodeoxycholic acid exerts no beneficial effect in patients with symptomatic gallstones awaiting cholecystectomy. Hepatology 2006; 43: 1276-83.
    • (2006) Hepatology , vol.43 , pp. 1276-1283
    • Venneman, N.G.1    Besselink, M.G.2    Keulemans, Y.C.3
  • 10
    • 1642338852 scopus 로고    scopus 로고
    • Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease
    • vi
    • Paumgartner G, Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. Clin Liver Dis 2004; 8: 67-81, vi.
    • (2004) , vol.8 , pp. 67-81
    • Paumgartner, G.1    Beuers, U.2
  • 12
    • 0033604026 scopus 로고    scopus 로고
    • Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: A meta-analysis
    • Goulis J, Leandro G, Burroughs AK. Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: A meta-analysis. Lancet 1999; 354: 1053-60.
    • (1999) Lancet , vol.354 , pp. 1053-1060
    • Goulis, J.1    Leandro, G.2    Burroughs, A.K.3
  • 13
    • 0034077201 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for primary biliary cirrhosis: Lessons from the past - Issues for the future
    • Poupon RE. Ursodeoxycholic acid for primary biliary cirrhosis: Lessons from the past - issues for the future. J Hepatology 2000; 32: 685-8.
    • (2000) J Hepatology , vol.32 , pp. 685-688
    • Poupon, R.E.1
  • 14
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner M, Boyer JL. Bile salt transporters: Molecular characterization, function, and regulation. Physiol Rev 2003; 83: 633-71.
    • (2003) Physiol Rev , vol.83 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 15
    • 0028084463 scopus 로고
    • Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid
    • Jazrawi RP, de Caestecker JS, Goggin PM etal. Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid. Gastroenterology 1994; 106: 134-42.
    • (1994) Gastroenterology , vol.106 , pp. 134-142
    • Jazrawi, R.P.1    de Caestecker, J.S.2    Goggin, P.M.3
  • 16
    • 0031021891 scopus 로고    scopus 로고
    • Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis
    • Medina JF, Martinez A, Vazquez JJ, Prieto J. Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology 1997; 25: 12-17.
    • (1997) Hepatology , vol.25 , pp. 12-17
    • Medina, J.F.1    Martinez, A.2    Vazquez, J.J.3    Prieto, J.4
  • 17
    • 23244465392 scopus 로고    scopus 로고
    • Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
    • Marschall HU, Wagner M, Zollner G et al. Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. Gastroenterology 2005; 129: 476-85.
    • (2005) Gastroenterology , vol.129 , pp. 476-485
    • Marschall, H.U.1    Wagner, M.2    Zollner, G.3
  • 18
    • 0034949811 scopus 로고    scopus 로고
    • Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver
    • Fickert P, Zollner G, Fuchsbichler A et al. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology 2001; 121: 170-83.
    • (2001) Gastroenterology , vol.121 , pp. 170-183
    • Fickert, P.1    Zollner, G.2    Fuchsbichler, A.3
  • 19
    • 0035038177 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
    • Beuers U, Bilzer M, Chittattu A et al. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 2001; 33: 1206-16.
    • (2001) Hepatology , vol.33 , pp. 1206-1216
    • Beuers, U.1    Bilzer, M.2    Chittattu, A.3
  • 20
    • 0034910937 scopus 로고    scopus 로고
    • Tauroursodeoxycholate-induced choleresis involves p38 (MAPK) activation and translocation of the bile salt export pump in rats
    • Kurz AK, Graf D, Schmitt M, Vom Dahl S, Haussinger D. Tauroursodeoxycholate-induced choleresis involves p38 (MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 2001; 121: 407-19.
    • (2001) Gastroenterology , vol.121 , pp. 407-419
    • Kurz, A.K.1    Graf, D.2    Schmitt, M.3    Vom Dahl, S.4    Haussinger, D.5
  • 21
    • 30944462200 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver
    • Dombrowski F, Stieger B, Beuers U. Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. Lab Invest 2006; 86: 166-74.
    • (2006) Lab Invest , vol.86 , pp. 166-174
    • Dombrowski, F.1    Stieger, B.2    Beuers, U.3
  • 22
    • 0842299393 scopus 로고    scopus 로고
    • Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase
    • Kubitz R, Sutfels G, Kuhlkamp T, Kolling R, Haussinger D. Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Gastroenterology 2004; 126: 541-53.
    • (2004) Gastroenterology , vol.126 , pp. 541-553
    • Kubitz, R.1    Sutfels, G.2    Kuhlkamp, T.3    Kolling, R.4    Haussinger, D.5
  • 23
    • 30144441515 scopus 로고    scopus 로고
    • Biliary transport systems: Short-term regulation
    • Kubitz R, Helmer A, Haussinger D. Biliary transport systems: Short-term regulation. Methods Enzymol 2005; 400: 542-57.
    • (2005) Methods Enzymol , vol.400 , pp. 542-557
    • Kubitz, R.1    Helmer, A.2    Haussinger, D.3
  • 24
    • 0031979439 scopus 로고    scopus 로고
    • Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
    • Roelofsen H, Soroka CJ, Keppler D, Boyer JL. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci 1998; 111: 1137-45.
    • (1998) J Cell Sci , vol.111 , pp. 1137-1145
    • Roelofsen, H.1    Soroka, C.J.2    Keppler, D.3    Boyer, J.L.4
  • 25
    • 0033369266 scopus 로고    scopus 로고
    • Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp
    • Webster CR, Anwer MS. Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp. Am J Physiol 1999; 277: G1165-72.
    • (1999) Am J Physiol , vol.277
    • Webster, C.R.1    Anwer, M.S.2
  • 26
    • 0028954737 scopus 로고
    • Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: A role for PKC
    • Bouscarel B, Gettys TW, Fromm H, Dubner H. Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: A role for PKC. Am J Physiol 1995; 268: G300-10.
    • (1995) Am J Physiol , vol.268
    • Bouscarel, B.1    Gettys, T.W.2    Fromm, H.3    Dubner, H.4
  • 27
    • 0030841172 scopus 로고    scopus 로고
    • Effect of cholestasis on regulation of cAMP synthesis by glucagon and bile acids in isolated hepatocytes
    • Matsuzaki Y, Bouscarel B, Le M et al. Effect of cholestasis on regulation of cAMP synthesis by glucagon and bile acids in isolated hepatocytes. Am J Physiol 1997; 273: G164-74.
    • (1997) Am J Physiol , vol.273
    • Matsuzaki, Y.1    Bouscarel, B.2    Le, M.3
  • 28
    • 33751258265 scopus 로고    scopus 로고
    • Decreased glucagon responsiveness by bile acids: A role for protein kinase C-alpha and glucagon receptor phosphorylation
    • Ikegami T, Krilov L, Meng J, Patel B, Chapin-Kennedy K, Bouscarel B. Decreased glucagon responsiveness by bile acids: A role for protein kinase C-alpha and glucagon receptor phosphorylation. Endocrinology 2006; 147: 5294-302.
    • (2006) Endocrinology , vol.147 , pp. 5294-5302
    • Ikegami, T.1    Krilov, L.2    Meng, J.3    Patel, B.4    Chapin-Kennedy, K.5    Bouscarel, B.6
  • 29
    • 0024318186 scopus 로고
    • Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions
    • Heuman DM. Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions. J Lipid Res 1989; 30: 719-30.
    • (1989) J Lipid Res , vol.30 , pp. 719-730
    • Heuman, D.M.1
  • 30
    • 0027963209 scopus 로고
    • A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C
    • Takano S, Ito Y, Yokosuka O et al. A multicenter randomized controlled dose study of ursodeoxycholic acid for chronic hepatitis C. Hepatology 1994; 20: 558-64.
    • (1994) Hepatology , vol.20 , pp. 558-564
    • Takano, S.1    Ito, Y.2    Yokosuka, O.3
  • 31
    • 36749040213 scopus 로고    scopus 로고
    • A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C
    • Omata M, Yoshida H, Toyota J et al. A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C. Gut 2007; 56: 1747-53.
    • (2007) Gut , vol.56 , pp. 1747-1753
    • Omata, M.1    Yoshida, H.2    Toyota, J.3
  • 32
    • 0032919402 scopus 로고    scopus 로고
    • Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
    • Faubion WA, Guicciardi ME, Miyoshi H et al. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest 1999; 103: 137-45.
    • (1999) J Clin Invest , vol.103 , pp. 137-145
    • Faubion, W.A.1    Guicciardi, M.E.2    Miyoshi, H.3
  • 33
    • 0041322990 scopus 로고    scopus 로고
    • Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation
    • Reinehr R, Graf D, Haussinger D. Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation. Gastroenterology 2003; 125: 839-53.
    • (2003) Gastroenterology , vol.125 , pp. 839-853
    • Reinehr, R.1    Graf, D.2    Haussinger, D.3
  • 34
    • 0031950282 scopus 로고    scopus 로고
    • Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
    • (Cambridge, Mass)
    • Rodrigues CM, Fan G, Wong PY, Kren BT, Steer CJ. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med (Cambridge, Mass) 1998; 4: 165-78.
    • (1998) Mol Med , vol.4 , pp. 165-178
    • Rodrigues, C.M.1    Fan, G.2    Wong, P.Y.3    Kren, B.T.4    Steer, C.J.5
  • 35
    • 0032846812 scopus 로고    scopus 로고
    • Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
    • Rodrigues CM, Ma X, Linehan-Stieers C, Fan G, Kren BT, Steer CJ. Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation. Cell Death Differ 1999; 6: 842-54.
    • (1999) Cell Death Differ , vol.6 , pp. 842-854
    • Rodrigues, C.M.1    Ma, X.2    Linehan-Stieers, C.3    Fan, G.4    Kren, B.T.5    Steer, C.J.6
  • 36
    • 17344370605 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes
    • Webster CR, Anwer MS. Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. Hepatology 1998; 27: 1324-31.
    • (1998) Hepatology , vol.27 , pp. 1324-1331
    • Webster, C.R.1    Anwer, M.S.2
  • 37
    • 0032808154 scopus 로고    scopus 로고
    • Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
    • Kennedy SG, Kandel ES, Cross TK, Hay N. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol 1999; 19: 5800-10.
    • (1999) Mol Cell Biol , vol.19 , pp. 5800-5810
    • Kennedy, S.G.1    Kandel, E.S.2    Cross, T.K.3    Hay, N.4
  • 38
    • 0035525733 scopus 로고    scopus 로고
    • Cellular stress response and apoptosis in cancer therapy
    • Herr I, Debatin KM. Cellular stress response and apoptosis in cancer therapy. Blood 2001; 98: 2603-14.
    • (2001) Blood , vol.98 , pp. 2603-2614
    • Herr, I.1    Debatin, K.M.2
  • 39
    • 2442662132 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
    • Schoemaker MH, Conde de la Rosa L, Buist-Homan M etal. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology 2004; 39: 1563-73.
    • (2004) Hepatology , vol.39 , pp. 1563-1573
    • Schoemaker, M.H.1    Conde de la Rosa, L.2    Buist-Homan, M.3
  • 40
    • 25844516609 scopus 로고    scopus 로고
    • Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes
    • Sola S, Amaral JD, Castro RE et al. Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes. Hepatology 2005; 42: 925-34.
    • (2005) Hepatology , vol.42 , pp. 925-934
    • Sola, S.1    Amaral, J.D.2    Castro, R.E.3
  • 41
    • 0034671410 scopus 로고    scopus 로고
    • Potentiation of photodynamic therapy by ursodeoxycholic acid
    • Kessel D, Caruso JA, Reiners JJ Jr. Potentiation of photodynamic therapy by ursodeoxycholic acid. Cancer Res 2000; 60: 6985-8.
    • (2000) Cancer Res , vol.60 , pp. 6985-6988
    • Kessel, D.1    Caruso, J.A.2    Reiners Jr., J.J.3
  • 43
    • 0036211298 scopus 로고    scopus 로고
    • Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes
    • Qiao L, Yacoub A, Studer E et al. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 2002; 35: 779-89.
    • (2002) Hepatology , vol.35 , pp. 779-789
    • Qiao, L.1    Yacoub, A.2    Studer, E.3
  • 45
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid. Hepatology 1990; 11: 12-15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 46
    • 0030043423 scopus 로고    scopus 로고
    • Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway
    • Tanaka H, Makino Y, Miura T et al. Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway. J Immunol 1996; 156: 1601-8.
    • (1996) J Immunol , vol.156 , pp. 1601-1608
    • Tanaka, H.1    Makino, Y.2    Miura, T.3
  • 48
    • 16344364151 scopus 로고    scopus 로고
    • Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells
    • Ikegami T, Matsuzaki Y, Fukushima S et al. Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells. Hepatology 2005; 41: 896-905.
    • (2005) Hepatology , vol.41 , pp. 896-905
    • Ikegami, T.1    Matsuzaki, Y.2    Fukushima, S.3
  • 49
    • 0028062702 scopus 로고
    • The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development
    • Rigas B, Tsioulias GJ, Allan C, Wali RK, Brasitus TA. The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development. Immunology 1994; 83: 319-23.
    • (1994) Immunology , vol.83 , pp. 319-323
    • Rigas, B.1    Tsioulias, G.J.2    Allan, C.3    Wali, R.K.4    Brasitus, T.A.5
  • 50
    • 0028072163 scopus 로고
    • Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid
    • Earnest DL, Holubec H, Wali RK et al. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res 1994; 54: 5071-4.
    • (1994) Cancer Res , vol.54 , pp. 5071-5074
    • Earnest, D.L.1    Holubec, H.2    Wali, R.K.3
  • 51
    • 0032418162 scopus 로고    scopus 로고
    • The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: Suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue
    • Ikegami T, Matsuzaki Y, Shoda J, Kano M, Hirabayashi N, Tanaka N. The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: Suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue. Cancer Lett 1998; 134: 129-39.
    • (1998) Cancer Lett , vol.134 , pp. 129-139
    • Ikegami, T.1    Matsuzaki, Y.2    Shoda, J.3    Kano, M.4    Hirabayashi, N.5    Tanaka, N.6
  • 52
    • 0031751777 scopus 로고    scopus 로고
    • Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation
    • Martinez JD, Stratagoules ED, LaRue JM et al. Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr Cancer 1998; 31: 111-18.
    • (1998) Nutr Cancer , vol.31 , pp. 111-118
    • Martinez, J.D.1    Stratagoules, E.D.2    LaRue, J.M.3
  • 53
    • 0031787679 scopus 로고    scopus 로고
    • Prevention of N-methylnitrosourea-induced colon tumorigenesis by ursodeoxycholic acid in F344 rats
    • Narisawa T, Fukaura Y, Terada K, Sekiguchi H. Prevention of N-methylnitrosourea-induced colon tumorigenesis by ursodeoxycholic acid in F344 rats. Jpn J Cancer Res 1998; 89: 1009-13.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 1009-1013
    • Narisawa, T.1    Fukaura, Y.2    Terada, K.3    Sekiguchi, H.4
  • 54
    • 0032768209 scopus 로고    scopus 로고
    • Inhibitory effects of ursodeoxycholic acid on N-methylnitrosourea-induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats
    • Narisawa T, Fukaura Y, Terada K, Sekiguchi H. Inhibitory effects of ursodeoxycholic acid on N-methylnitrosourea-induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats. J Exp Clin Cancer Res 1999; 18: 259-66.
    • (1999) J Exp Clin Cancer Res , vol.18 , pp. 259-266
    • Narisawa, T.1    Fukaura, Y.2    Terada, K.3    Sekiguchi, H.4
  • 55
    • 0017413089 scopus 로고
    • Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps
    • Reddy BS, Wynder EL. Metabolic epidemiology of colon cancer. Fecal bile acids and neutral sterols in colon cancer patients and patients with adenomatous polyps. Cancer 1977; 39: 2533-9.
    • (1977) Cancer , vol.39 , pp. 2533-2539
    • Reddy, B.S.1    Wynder, E.L.2
  • 57
    • 0034685773 scopus 로고    scopus 로고
    • Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling
    • Qiao D, Chen W, Stratagoules ED, Martinez JD. Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling. J Biol Chem 2000; 275: 15090-8.
    • (2000) J Biol Chem , vol.275 , pp. 15090-15098
    • Qiao, D.1    Chen, W.2    Stratagoules, E.D.3    Martinez, J.D.4
  • 58
    • 0031915460 scopus 로고    scopus 로고
    • Dihydroxy bile acids activate the transcription of cyclooxygenase-2
    • Zhang F, Subbaramaiah K, Altorki N, Dannenberg AJ. Dihydroxy bile acids activate the transcription of cyclooxygenase-2. J Biol Chem 1998; 273: 2424-8.
    • (1998) J Biol Chem , vol.273 , pp. 2424-2428
    • Zhang, F.1    Subbaramaiah, K.2    Altorki, N.3    Dannenberg, A.J.4
  • 59
    • 0024235005 scopus 로고
    • Differing effect of chenodeoxycholic acid and ursodeoxycholic acid on bile acids in rat colonic wall and contents
    • Kurtz WJ, Guldutuna S, Leuschner U. Differing effect of chenodeoxycholic acid and ursodeoxycholic acid on bile acids in rat colonic wall and contents. Tokai J Exp Clin Med 1988; 13: 91-7.
    • (1988) Tokai J Exp Clin Med , vol.13 , pp. 91-97
    • Kurtz, W.J.1    Guldutuna, S.2    Leuschner, U.3
  • 60
    • 0028842929 scopus 로고
    • The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation
    • Rodrigues CM, Kren BT, Steer CJ, Setchell KD. The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation. Gastroenterology 1995; 109: 1835-44.
    • (1995) Gastroenterology , vol.109 , pp. 1835-1844
    • Rodrigues, C.M.1    Kren, B.T.2    Steer, C.J.3    Setchell, K.D.4
  • 61
    • 0032522615 scopus 로고    scopus 로고
    • Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps
    • Batta AK, Salen G, Holubec H, Brasitus TA, Alberts D, Earnest DL. Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps. Cancer Res 1998; 58: 1684-7.
    • (1998) Cancer Res , vol.58 , pp. 1684-1687
    • Batta, A.K.1    Salen, G.2    Holubec, H.3    Brasitus, T.A.4    Alberts, D.5    Earnest, D.L.6
  • 62
    • 0035135599 scopus 로고    scopus 로고
    • Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis
    • Qiao D, Stratagouleas ED, Martinez JD. Activation and role of mitogen-activated protein kinases in deoxycholic acid-induced apoptosis. Carcinogenesis 2001; 22: 35-41.
    • (2001) Carcinogenesis , vol.22 , pp. 35-41
    • Qiao, D.1    Stratagouleas, E.D.2    Martinez, J.D.3
  • 63
    • 0942301272 scopus 로고    scopus 로고
    • Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells
    • Im E, Martinez JD. Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells. J Nutr 2004; 134: 483-6.
    • (2004) J Nutr , vol.134 , pp. 483-486
    • Im, E.1    Martinez, J.D.2
  • 64
    • 14944350350 scopus 로고    scopus 로고
    • Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling
    • Im E, Akare S, Powell A, Martinez JD. Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling. Nutr Cancer 2005; 51: 110-16.
    • (2005) Nutr Cancer , vol.51 , pp. 110-116
    • Im, E.1    Akare, S.2    Powell, A.3    Martinez, J.D.4
  • 65
    • 0028868935 scopus 로고
    • Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: Potential roles of protein kinase C-alpha-beta II, and - Zeta
    • Wali RK, Frawley BP Jr, Hartmann S etal. Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: Potential roles of protein kinase C-alpha-beta II, and - zeta. Cancer Res 1995; 55: 5257-64.
    • (1995) Cancer Res , vol.55 , pp. 5257-5264
    • Wali, R.K.1    Frawley Jr., B.P.2    Hartmann, S.3
  • 66
    • 0029035299 scopus 로고
    • Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam
    • Roy HK, Bissonnette M, Frawley BP Jr et al. Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam. FEBS Lett 1995; 366: 143-5.
    • (1995) FEBS Lett , vol.366 , pp. 143-145
    • Roy, H.K.1    Bissonnette, M.2    Frawley Jr., B.P.3
  • 67
    • 0038121949 scopus 로고    scopus 로고
    • Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: An observational study
    • Serfaty L, De Leusse A, Rosmorduc O et al. Ursodeoxycholic acid therapy and the risk of colorectal adenoma in patients with primary biliary cirrhosis: An observational study. Hepatology 2003; 38: 203-9.
    • (2003) Hepatology , vol.38 , pp. 203-209
    • Serfaty, L.1    De Leusse, A.2    Rosmorduc, O.3
  • 68
    • 0035895263 scopus 로고    scopus 로고
    • Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis
    • Tung BY, Emond MJ, Haggitt RC et al. Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. Ann Intern Med 2001; 134: 89-95.
    • (2001) Ann Intern Med , vol.134 , pp. 89-95
    • Tung, B.Y.1    Emond, M.J.2    Haggitt, R.C.3
  • 69
    • 0037382288 scopus 로고    scopus 로고
    • Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis
    • Pardi DS, Loftus EV Jr, Kremers WK, Keach J, Lindor KD. Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 2003; 124: 889-93.
    • (2003) Gastroenterology , vol.124 , pp. 889-893
    • Pardi, D.S.1    Loftus Jr., E.V.2    Kremers, W.K.3    Keach, J.4    Lindor, K.D.5
  • 70
    • 20544476450 scopus 로고    scopus 로고
    • Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence
    • Alberts DS, Martinez ME, Hess LM et al. Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence. J Natl Cancer Inst 2005; 97: 846-53.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 846-853
    • Alberts, D.S.1    Martinez, M.E.2    Hess, L.M.3
  • 71
    • 0035085858 scopus 로고    scopus 로고
    • Treatment of nonalcoholic fatty liver: Present and emerging therapies
    • Angulo P, Lindor KD. Treatment of nonalcoholic fatty liver: Present and emerging therapies. Semin Liver Dis 2001; 21: 81-8.
    • (2001) Semin Liver Dis , vol.21 , pp. 81-88
    • Angulo, P.1    Lindor, K.D.2
  • 72
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial
    • Lindor KD, Kowdley KV, Heathcote EJ et al. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: Results of a randomized trial. Hepatology 2004; 39: 770-8.
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1    Kowdley, K.V.2    Heathcote, E.J.3
  • 73
    • 17444454145 scopus 로고    scopus 로고
    • Cholate inhibits high-fat diet-induced hyperglycemia and obesity with acyl-CoA synthetase mRNA decrease
    • Ikemoto S, Takahashi M, Tsunoda N et al. Cholate inhibits high-fat diet-induced hyperglycemia and obesity with acyl-CoA synthetase mRNA decrease. Am J Physiol 1997; 273: E37-45.
    • (1997) Am J Physiol , vol.273
    • Ikemoto, S.1    Takahashi, M.2    Tsunoda, N.3
  • 74
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    • Watanabe M, Houten SM, Wang L et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004; 113: 1408-18.
    • (2004) J Clin Invest , vol.113 , pp. 1408-1418
    • Watanabe, M.1    Houten, S.M.2    Wang, L.3
  • 75
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006; 439: 484-9.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3
  • 76
    • 12444301770 scopus 로고    scopus 로고
    • Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
    • Zollner G, Fickert P, Fuchsbichler A et al. Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J Hepatol 2003; 39: 480-8.
    • (2003) J Hepatol , vol.39 , pp. 480-488
    • Zollner, G.1    Fickert, P.2    Fuchsbichler, A.3
  • 78
    • 32944463445 scopus 로고    scopus 로고
    • Intrahepatic cholestasis of pregnancy: A randomized controlled trial comparing dexamethasone and ursodeoxycholic acid
    • Glantz A, Marschall HU, Lammert F, Mattsson LA. Intrahepatic cholestasis of pregnancy: A randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology 2005; 42: 1399-405.
    • (2005) Hepatology , vol.42 , pp. 1399-1405
    • Glantz, A.1    Marschall, H.U.2    Lammert, F.3    Mattsson, L.A.4
  • 79
    • 19144371795 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for liver disease associated with cystic fibrosis: A double-blind multicenter trial. The Italian Group for the Study of Ursodeoxycholic Acid in Cystic Fibrosis
    • Colombo C, Battezzati PM, Podda M, Bettinardi N, Giunta A. Ursodeoxycholic acid for liver disease associated with cystic fibrosis: a double-blind multicenter trial. The Italian Group for the Study of Ursodeoxycholic Acid in Cystic Fibrosis. Hepatology 1996; 23: 1484-90.
    • (1996) Hepatology , vol.23 , pp. 1484-1490
    • Colombo, C.1    Battezzati, P.M.2    Podda, M.3    Bettinardi, N.4    Giunta, A.5
  • 80
    • 0031049399 scopus 로고    scopus 로고
    • Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis
    • Jacquemin E, Hermans D, Myara A et al. Ursodeoxycholic acid therapy in pediatric patients with progressive familial intrahepatic cholestasis. Hepatology 1997; 25: 519-23.
    • (1997) Hepatology , vol.25 , pp. 519-523
    • Jacquemin, E.1    Hermans, D.2    Myara, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.