Inhibitory effects of ursodeoxycholic acid on N-methylnitrosourea- induced colon carcinogenesis and colonic mucosal telomerase activity in F344 rats

Journal of Experimental and Clinical Cancer Research

Volumn 18, Issue 2, 1999, Pages 259-266

  Narisawa, T ^a   Fukaura, Y ^a   Terada, K ^b   Sekiguchi, H ^c  

^a AKITA UNIVERSITY   (Japan)

^b AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Ashikaga Plant   (Japan)

Author keywords

Aberrant crypt; Carcinogenesis; Chemoprevention; Colon; Telomerase; Ursodeoxycholic acid

Indexed keywords

CHENODEOXYCHOLIC ACID; METHYLNITROSOUREA; TELOMERASE; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INCIDENCE; CANCER INHIBITION; COLON CARCINOGENESIS; COLON CARCINOMA; COLON MUCOSA; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HISTOPATHOLOGY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOGENS; COLON; COLONIC NEOPLASMS; ENZYME INHIBITORS; FEMALE; GASTROINTESTINAL AGENTS; INTESTINAL MUCOSA; METHYLNITROSOUREA; RATS; RATS, INBRED F344; TELOMERASE; URSODEOXYCHOLIC ACID;

EID: 0032768209     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Potter J. D., Slattery M. L., Bostick R. M., Gapstur S. M.: Colon cancer: A review of the epidemiology. Epidemiol. Rev. 15:499-545,1993.
2. Weisburger J. H. : Causes, relevant mechanims, and prevention of large bowel cancer. Semin. Oncol. 18:316-336, 1991.
3. Narisawa T., Magadia N. E., Weisburger J. H., Wynder E. L.: Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats. J. Natl. Cancer Inst. 53:1093-1097, 1974.
4. Reddy B. S., Watanabe K., Weisburger J. H., Wynder E. L.: Promoting effect of bile acids in colon carcinogenesis in germfree and conventional F344 rats. Cancer Res. 37:3238-3242, 1977.
5. Sarwal A. N., Cohen B. I., Raicht R. F., Takahashi M., Fazzini E.: Effect of dietary administration of chenodeoxycholic acid on N-methyl-N-nitrosourea-induced colon cancer in rats. Biochem. Biophys. Acta 574:423-432, 1979.
6. Cohen B. I., Raicht R. F., Deschner E. E., Takahashi M., Sarwal A. N., Fazzini E.: Effect of cholic acid feeding on N-methyl-N-nitrosourea-induced colon tumors and cell kinetics in rats. J. Natl. Cancer Inst. 64:573-578, 1980.
7. Czygan P., Seitz H., Stiehl W. A., Raedsch R., Kommerell B.: Chenodeoxycholic acid but not ursodeoxycholic acid enhances colonie carcinogenesis in rats. In: Paumgartner G., Stiehl A., Gerok G., eds. Bile Acid and Cholesterol in Health and Disease. Lancaster : MTP Press, 1983:393-395.
8. Earnest D. L., Holubec H., Wali R. K., Jolley C. S. et al. Chemoprevention of azoxymethane-induced colonie carcinogenesis by supplemental dietary ursodeoxycholic acid. Cancer Res. 54:5071-5074,1994.
9. Bird R. P.: Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93:55-71, 1995.
10. Seraj M. J., Umemoto A., Kajikawa A. et al.: Effects of dietary bile acids on formation of azoxymethane-induced aberrant crypt foci in F344 rats. Cancer Lett. 15:97-103, 1997.
11. Kim N. W., Piatyszek M. A., Prowse K. R. et al.: Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015, 1994.
12. Kannan S., Tahara H., Yokozaki H. et al.: Telomerase activity in premalignant and malignant lesions of human oral mucosa. Cancer Epidemiol. Biomarkers Prevent. 6:413-420, 1997.
13. Mao L., El-Naggar A. K., Fan Y. H. et al.: Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues. Cancer Res. 56:5600-5604, 1996.
14. Tahara H., Kuniyasu H., Yokozaki H. et al.: Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions. Clin. Cancer Res. 1:1245-1251, 1995.
15. Yashima K., Litzky L. A., Kaiser L. et al.: Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. Cancer Res. 57:2373-2377, 1997.
16. Tahara H., Nakanishi T., Kitamoto M.: Telomerase activity in human liver tissues: Comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res. 55:2734-2736, 1995.
17. Ikeguchi M., Kaibara N.: Telomerase activity in familial adenomatous polyposis. J. Jpn. Soc. Gastroenterol. Carcinogenesis 9:85-88, 1997 (Japanese).
18. Chadeneau C., Hay K., Hirte H. W., Gallinger S., Bacchetti S.: Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res. 55:2533-2536, 1995.
19. Miura M., Karasaki Y., Abe T., Higashi K., Ikemura K., Gotoh S.: Prompt activation of telomerase by chemical carcinogens in rats detected with a modified TRAP assay. Biochem. Biophys. Res. Comm. 246:13-19, 1998.
20. Bednarek A., Budunova I., Slaga T. J., Aldaz C. M.: Increased telomerase activity in mouse skin premalignant progression. Cancer Res. 55:4566-4569, 1995.
21. Yoshimi M., Ino N., Suzuki M. et al.: Telomerase activity of normal tissues and neoplasms in rat colon carcinogenesis induced by methylazoxymethanol acetate and its differene from that of human colon tissues. Mol. Carcinogenesis 16:1-5, 1996.
22. Varon D., Jiang C., Hedican C. et al.: Telomerase activity in normal and neoplastic rat mammary gland. Cancer Res. 57:5605-5609, 1997.
23. Tsujiuchi T., Tsutsumi M., Konishi Y.: Increasing of telomerase activity in rat hepatocarcinogenesis. J. Jpn. Soc. Gastroenterol. Carcinogenesis 9:73-75, 1997 (Japanese).
24. Takahashi M., Totsuka Y., Masuda M. et al.: Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA). Carcinogenesis 18:1937-1941, 1997.
25. Narisawa T., Fukaura Y., Terada K., Sekiguchi H.: Prevention of N-methylnitrosourea-induced colon tumorigenesis by ursodeoxycholic acid in F344 rats. Jpn. J. Cancer Res. 89:1009-1013, 1998.
26. Batta A. K., Salen G., Holubec H., Brasitus T. A., Earnest A. D.: Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps. Cancer Res. 58:1684-1687, 1998.
27. Koutsos K. I., Shiff S. J., Rigas B.: The effect of ursodeoxycholic and lithocholic acid on cell cycle and apoptosis in human colon adenocarcinoma cells. Gastroenterology 108:A492, 1995.
28. Martinez J. D., Stratagoules E.D., LaRue J. M. et al.: Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr. Cancer 31:111-118, 1998.
29. Wali R. K., Frawley B. P. Jr., Hartmann S. et al.: Mechanism of action of chemopreventive ursodeoxycholate in the azoxymethane model of rat colonie carcinogenesis : Potential roles of protein kinase C-a, -bII, and -z. Cancer Res. 55:5257-5264, 1995.
30. Narisawa T.: An overview on chemoprevention of colorectal cancer. J. Jpn. Surg. Soc. 99:362-367, 1998 (Japanese).