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Volumn 75, Issue 3, 2008, Pages 639-648

Compensatory effects of the human nucleoside transporters on the response to nucleoside-derived drugs in breast cancer MCF7 cells

Author keywords

5 DFUR; Breast cancer; hCNT1; Inhibitor; Nucleoside analogues; Nucleoside transport

Indexed keywords

CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 2; DOXIFLURIDINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2; NUCLEOSIDE TRANSPORTER; UNCLASSIFIED DRUG;

EID: 38049058351     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.10.005     Document Type: Article
Times cited : (26)

References (31)
  • 1
    • 1242340288 scopus 로고    scopus 로고
    • The concentrative nucleoside transporter family, SLC28
    • Gray J.H., Owen R.P., and Giacomini K.M. The concentrative nucleoside transporter family, SLC28. Pflugers Arch 447 (2004) 728-734
    • (2004) Pflugers Arch , vol.447 , pp. 728-734
    • Gray, J.H.1    Owen, R.P.2    Giacomini, K.M.3
  • 3
    • 33745792969 scopus 로고    scopus 로고
    • Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma
    • Marce S., Molina-Arcas M., Villamor N., Casado F.J., Campo E., Pastor-Anglada M., et al. Expression of human equilibrative nucleoside transporter 1 (hENT1) and its correlation with gemcitabine uptake and cytotoxicity in mantle cell lymphoma. Haematologica 91 (2006) 895-902
    • (2006) Haematologica , vol.91 , pp. 895-902
    • Marce, S.1    Molina-Arcas, M.2    Villamor, N.3    Casado, F.J.4    Campo, E.5    Pastor-Anglada, M.6
  • 5
    • 19944427083 scopus 로고    scopus 로고
    • Equilibrative nucleoside transporter-2 (hENT2) protein expression correlates with ex vivo sensitivity to fludarabine in chronic lymphocytic leukemia (CLL) cells
    • Molina-Arcas M., Marce S., Villamor N., Huber-Ruano I., Casado F.J., Bellosillo B., et al. Equilibrative nucleoside transporter-2 (hENT2) protein expression correlates with ex vivo sensitivity to fludarabine in chronic lymphocytic leukemia (CLL) cells. Leukemia 19 (2005) 64-68
    • (2005) Leukemia , vol.19 , pp. 64-68
    • Molina-Arcas, M.1    Marce, S.2    Villamor, N.3    Huber-Ruano, I.4    Casado, F.J.5    Bellosillo, B.6
  • 6
    • 33746656174 scopus 로고    scopus 로고
    • Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer
    • Gloeckner-Hofmann K., Guillen-Gomez E., Schmidtgen C., Porstmann R., Ziegler R., Stoss O., et al. Expression of the high-affinity fluoropyrimidine-preferring nucleoside transporter hCNT1 correlates with decreased disease-free survival in breast cancer. Oncology 70 (2006) 238-244
    • (2006) Oncology , vol.70 , pp. 238-244
    • Gloeckner-Hofmann, K.1    Guillen-Gomez, E.2    Schmidtgen, C.3    Porstmann, R.4    Ziegler, R.5    Stoss, O.6
  • 7
    • 33645731188 scopus 로고    scopus 로고
    • Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
    • Giovannetti E., Del Tacca M., Mey V., Funel N., Nannizzi S., Ricci S., et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 66 (2006) 3928-3935
    • (2006) Cancer Res , vol.66 , pp. 3928-3935
    • Giovannetti, E.1    Del Tacca, M.2    Mey, V.3    Funel, N.4    Nannizzi, S.5    Ricci, S.6
  • 8
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin J., Sangha R., Glubrecht D., Dabbagh L., Young J.D., Dumontet C., et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 10 (2004) 6956-6961
    • (2004) Clin Cancer Res , vol.10 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3    Dabbagh, L.4    Young, J.D.5    Dumontet, C.6
  • 9
    • 2442655506 scopus 로고    scopus 로고
    • p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis
    • Kho P.S., Wang Z., Zhuang L., Li Y., Chew J.L., Ng H.H., et al. p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem 279 (2004) 21183-21192
    • (2004) J Biol Chem , vol.279 , pp. 21183-21192
    • Kho, P.S.1    Wang, Z.2    Zhuang, L.3    Li, Y.4    Chew, J.L.5    Ng, H.H.6
  • 10
    • 33746437215 scopus 로고    scopus 로고
    • Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53
    • Hernandez-Vargas H., Ballestar E., Carmona-Saez P., von Kobbe C., Banon-Rodriguez I., Esteller M., et al. Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer 119 (2006) 1164-1175
    • (2006) Int J Cancer , vol.119 , pp. 1164-1175
    • Hernandez-Vargas, H.1    Ballestar, E.2    Carmona-Saez, P.3    von Kobbe, C.4    Banon-Rodriguez, I.5    Esteller, M.6
  • 11
    • 33751085679 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells
    • Molina-Arcas M., Moreno-Bueno G., Cano-Soldado P., Hernandez-Vargas H., Casado F.J., Palacios J., et al. Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells. Biochem Pharmacol 72 (2006) 1646-1656
    • (2006) Biochem Pharmacol , vol.72 , pp. 1646-1656
    • Molina-Arcas, M.1    Moreno-Bueno, G.2    Cano-Soldado, P.3    Hernandez-Vargas, H.4    Casado, F.J.5    Palacios, J.6
  • 12
    • 8644236778 scopus 로고    scopus 로고
    • Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors
    • Farre X., Guillen-Gomez E., Sanchez L., Hardisson D., Plaza Y., Lloberas J., et al. Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. Int J Cancer 112 (2004) 959-966
    • (2004) Int J Cancer , vol.112 , pp. 959-966
    • Farre, X.1    Guillen-Gomez, E.2    Sanchez, L.3    Hardisson, D.4    Plaza, Y.5    Lloberas, J.6
  • 13
    • 0034984732 scopus 로고    scopus 로고
    • Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug
    • Mata J.F., Garcia-Manteiga J.M., Lostao M.P., Fernandez-Veledo S., Guillen-Gomez E., Larrayoz I.M., et al. Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. Mol Pharmacol 59 (2001) 1542-1548
    • (2001) Mol Pharmacol , vol.59 , pp. 1542-1548
    • Mata, J.F.1    Garcia-Manteiga, J.M.2    Lostao, M.P.3    Fernandez-Veledo, S.4    Guillen-Gomez, E.5    Larrayoz, I.M.6
  • 14
    • 4644286859 scopus 로고    scopus 로고
    • Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells
    • Fernandez-Veledo S., Valdes R., Wallenius V., Casado F.J., and Pastor-Anglada M. Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells. J Hepatol 41 (2004) 538-544
    • (2004) J Hepatol , vol.41 , pp. 538-544
    • Fernandez-Veledo, S.1    Valdes, R.2    Wallenius, V.3    Casado, F.J.4    Pastor-Anglada, M.5
  • 15
    • 0034666069 scopus 로고    scopus 로고
    • Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes
    • Lostao M.P., Mata J.F., Larrayoz I.M., Inzillo S.M., Casado F.J., and Pastor-Anglada M. Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes. FEBS Lett 481 (2000) 137-140
    • (2000) FEBS Lett , vol.481 , pp. 137-140
    • Lostao, M.P.1    Mata, J.F.2    Larrayoz, I.M.3    Inzillo, S.M.4    Casado, F.J.5    Pastor-Anglada, M.6
  • 16
    • 1542365250 scopus 로고    scopus 로고
    • Electrophysiological characterization of the human Na(+)/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function
    • Larrayoz I.M., Casado F.J., Pastor-Anglada M., and Lostao M.P. Electrophysiological characterization of the human Na(+)/nucleoside cotransporter 1 (hCNT1) and role of adenosine on hCNT1 function. J Biol Chem 279 (2004) 8999-9007
    • (2004) J Biol Chem , vol.279 , pp. 8999-9007
    • Larrayoz, I.M.1    Casado, F.J.2    Pastor-Anglada, M.3    Lostao, M.P.4
  • 17
    • 11144260100 scopus 로고    scopus 로고
    • Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1)
    • Cano-Soldado P., Lorrayoz I.M., Molina-Arcas M., Casado F.J., Martinez-Picado J., Lostao M.P., et al. Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1). Antivir Ther 9 (2004) 993-1002
    • (2004) Antivir Ther , vol.9 , pp. 993-1002
    • Cano-Soldado, P.1    Lorrayoz, I.M.2    Molina-Arcas, M.3    Casado, F.J.4    Martinez-Picado, J.5    Lostao, M.P.6
  • 18
    • 1342308339 scopus 로고    scopus 로고
    • Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1
    • Chang C., Swaan P.W., Ngo L.Y., Lum P.Y., Patil S.D., and Unadkat J.D. Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1. Mol Pharmacol 65 (2004) 558-570
    • (2004) Mol Pharmacol , vol.65 , pp. 558-570
    • Chang, C.1    Swaan, P.W.2    Ngo, L.Y.3    Lum, P.Y.4    Patil, S.D.5    Unadkat, J.D.6
  • 20
    • 34548203759 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 expression predicts nonresponse to gemcitabine-containing chemotherapy in non-small cell lung cancer
    • Oguri T., Achiwa H., Muramatsu H., Ozasa H., Sato S., Shimizu S., et al. The absence of human equilibrative nucleoside transporter 1 expression predicts nonresponse to gemcitabine-containing chemotherapy in non-small cell lung cancer. Cancer Lett 256 (2007) 112-119
    • (2007) Cancer Lett , vol.256 , pp. 112-119
    • Oguri, T.1    Achiwa, H.2    Muramatsu, H.3    Ozasa, H.4    Sato, S.5    Shimizu, S.6
  • 21
    • 16444383188 scopus 로고    scopus 로고
    • Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry
    • Chow L., Lai R., Dabbagh L., Belch A., Young J.D., Cass C.E., et al. Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry. Mod Pathol 18 (2005) 558-564
    • (2005) Mod Pathol , vol.18 , pp. 558-564
    • Chow, L.1    Lai, R.2    Dabbagh, L.3    Belch, A.4    Young, J.D.5    Cass, C.E.6
  • 22
    • 0036152443 scopus 로고    scopus 로고
    • Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers
    • Mackey J.R., Jennings L.L., Clarke M.L., Santos C.L., Dabbagh L., Vsianska M., et al. Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers. Clin Cancer Res 8 (2002) 110-116
    • (2002) Clin Cancer Res , vol.8 , pp. 110-116
    • Mackey, J.R.1    Jennings, L.L.2    Clarke, M.L.3    Santos, C.L.4    Dabbagh, L.5    Vsianska, M.6
  • 23
    • 85047685004 scopus 로고    scopus 로고
    • Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease
    • Reiman T., Clarke M.L., Dabbagh L., Vsianska M., Coupland R.W., Belch A.R., et al. Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease. Leuk Lymphoma 43 (2002) 1435-1440
    • (2002) Leuk Lymphoma , vol.43 , pp. 1435-1440
    • Reiman, T.1    Clarke, M.L.2    Dabbagh, L.3    Vsianska, M.4    Coupland, R.W.5    Belch, A.R.6
  • 24
    • 0035001331 scopus 로고    scopus 로고
    • Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine
    • Ngo L.Y., Patil S.D., and Unadkat J.D. Ontogenic and longitudinal activity of Na(+)-nucleoside transporters in the human intestine. Am J Physiol Gastrointest Liver Physiol 280 (2001) G475-G481
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280
    • Ngo, L.Y.1    Patil, S.D.2    Unadkat, J.D.3
  • 25
    • 0242637653 scopus 로고    scopus 로고
    • Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney
    • Mangravite L.M., Badagnani I., and Giacomini K.M. Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. Eur J Pharmacol 479 (2003) 269-281
    • (2003) Eur J Pharmacol , vol.479 , pp. 269-281
    • Mangravite, L.M.1    Badagnani, I.2    Giacomini, K.M.3
  • 28
    • 0036440576 scopus 로고    scopus 로고
    • Concentrative nucleoside transporter (rCNT1) is targeted to the apical membrane through the hepatic transcytotic pathway
    • Duflot S., Calvo M., Casado F.J., Enrich C., and Pastor-Anglada M. Concentrative nucleoside transporter (rCNT1) is targeted to the apical membrane through the hepatic transcytotic pathway. Exp Cell Res 281 (2002) 77-85
    • (2002) Exp Cell Res , vol.281 , pp. 77-85
    • Duflot, S.1    Calvo, M.2    Casado, F.J.3    Enrich, C.4    Pastor-Anglada, M.5
  • 29
    • 33645768125 scopus 로고    scopus 로고
    • Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells
    • Fernandez-Veledo S., Huber-Ruano I., Aymerich I., Duflot S., Casado F.J., and Pastor-Anglada M. Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. Biochem J 395 (2006) 337-344
    • (2006) Biochem J , vol.395 , pp. 337-344
    • Fernandez-Veledo, S.1    Huber-Ruano, I.2    Aymerich, I.3    Duflot, S.4    Casado, F.J.5    Pastor-Anglada, M.6
  • 31
    • 0036736594 scopus 로고    scopus 로고
    • Mechanisms of resistance to nucleoside analogue chemotherapy in mantle cell lymphoma: a molecular case study
    • Reiman T., Graham K.A., Wong J., Belch A.R., Coupland R., Young J., et al. Mechanisms of resistance to nucleoside analogue chemotherapy in mantle cell lymphoma: a molecular case study. Leukemia 16 (2002) 1886-1887
    • (2002) Leukemia , vol.16 , pp. 1886-1887
    • Reiman, T.1    Graham, K.A.2    Wong, J.3    Belch, A.R.4    Coupland, R.5    Young, J.6


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