Concentrative nucleoside transporter (rCNT1) is targeted to the apical membrane through the hepatic transcytotic pathway

Experimental Cell Research

Volumn 281, Issue 1, 2002, Pages 77-85

  Duflot, Sylvie ^a   Calvo, Maria ^a   Casado, F Javier ^a   Enrich, Carlos ^a   Pastor Anglada, Marçal ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Caveolin; Concentrative nucleoside transporter (CNT); Endocytosis; Endosome; Hepatocyte; Transcytosis

Indexed keywords

CARRIER PROTEIN; CAVEOLIN; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 2; ISOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOSOME; LIVER CELL; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RAT; TRANSCYTOSIS;

EID: 0036440576     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5641     Document Type: Article

References (40)

1. Griffith, D. A., and Jarvis, S. M. (1996). Nucleoside and nucleobase transport systems of mammalian cells. Biochim. Biophys. Biochim. Biophys. Acta 1286, 153-181.
2. Wang, J., Schaner, M. E., Thomassen, S., Su, S. F., Piquette-Miller, M., and Giacomini, K. M. (1997). Functional and molecular characteristics of Na(+)-dependent nucleoside transporters. Pharm. Res. 14, 1524-1532.
3. Pastor-Anglada, M., Felipe, A., and Casado, F. J. (1998). Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies. Trends Pharmacol. Sci. 19, 424-430.
4. Baldwin, S. A., Mackay, J. R., Cass, C. E. and Young, J. D. (1999). Nucleoside transporters: Molecular biology and implications for therapeutic development Mol. Med. Today 5, 216-224.
5. Felipe, A., Valdés, R., del Santo, B., Lloberas, J., Casado, J. and Pastor-Anglada, M. (1998). Na+-dependent nucleoside transport in liver: Two different isoforms from the same gene family are expressed in liver cells. Biochem. J. 330, 997-1001.
6. del Santo, B., Valdés, R., Mata, J., Felipe, A., Casado, F. J. and Pastor-Anglada, M. (1998). Differential expression and regulation of nucleoside transport systems in rat liver parenchymal and hepatoma cells. Hepatology 28, 1504-1511.
7. Ritzel, M. W. L., Ng, A. M. L., Yao, S. Y. M., Graham, K., Loewen, S. K., Smith, K. M., Ritzel, R. G., Mowles, D. A., Carpenter, A., Chen, X. Z., Karpinski, E., Hyde, R. J., Baldwin, S. A., Cass, C. E., and Young, J. D. (2001). Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: Identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J. Biol. Chem. 276, 2914-2927.
8. Evans, W. H. (1980). A biochemical dissection of the functional polarity of the plasma membrane of the hepatocyte. Biochim. Biophys. Acta 604, 27-64.
9. Bartles, J. R., Feracci, H. M., Stieger, B., and Hubbard, A. L. (1987). Biogenesis of the rat hepatocyte plasma membrane in vivo: Comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation. J. Cell Biol. 105, 1241-1251.
10. Schell, M. J., Maurice, M., Stieger, B., and Hubbard, A. L. (1992). 5′ nucleotidase is sorted to the apical domain of hepatocytes via an indirect route. J. Cell Biol. 119, 1173-1182.
11. Kipp, H., and Arias, I. M. (2000). Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J. Biol. Chem. 275, 15917-15925.
12. Che, M., Nishida, T., Gatmaitzan, Z., and Arias, I. M. (1995). Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. J. Biol. Chem. 270, 13596-13599.
13. Hamilton, S. R., Yao, S. Y. M., Ingram, J. C., Hadden, D. A., Ritzel, M. W. L., Gallagher, M. P., Henderson, P. F., Cass, C. E., Young, J. D. and Baldwin, S. A. (2001). Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1. J. Biol. Chem. 276, 27981-2798.
14. Ohno, H., Tomemori, T., Nakatsu, F., Okasaki, Y., Aguilar, R. C., Foelsch, H., mellman, I., Saito, T., Shirasawa, T., and Bonifacino, J. S. (1999). Mu 1B, a novel adaptor medium chain expressed in polarized epithelial cells. FEBS Lett. 449, (2-3), 215-220.
15. Koivisto, U-M., Hubbart, A. L., and Mellman, I. (2001). A novel cellular phenotype for familial hypercholesteriolemia due to a defect in polarized targetting of LDL receptor. Cell 105, 575-585.
16. Pastor-Anglada, M., Remesar, X., and Bourdel, G. (1987). Alanine uptake by liver at midpregnancy in rats. Am. J. Physiol. 252, E408-E413.
17. Neville, D. M., Jr. (1960). The isolation of a cell membrane fraction from a rat liver. J. Biophys. Biochem. Cytol. 8, 413-422.
18. Belcher, J. D., Hamilton, R. L., Brady, S. E., Jäckle, S., Schneider, W. J. and Havel, R. J. (1987). Isolation and characterization of three endosomal fractions from the liver of estradiol-treated rats. Proc. Natl. Acad. Sci. USA 84, 6785-6789.
19. Calvo, M., and Enrich, C. (2000). Biochemical analysis of a caveolae-enriched plasma membrane fraction from rat liver. Electrophoresis 21, 3386-3395.
20. Jäckle, S., Runquist, E. A., Miranda-Brady, S., and Havel, R. J. (1991). Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions. J. Biol. Chem. 266, 1396-1402.
21. Ruiz-Montasell, B., Casado, F. J., Felipe, A., and Pastor-Anglada, M. (1992). Uridine transport in basolateral plasma membrane vesicles from rat liver. J. Membrane Biol. 128, 227-233.
22. Dragan, Y., Valdés, R., Gómez-Angelats, M., Felipe, A., Casado, F. J., Pitot, H. C., and Pastor-Anglada, M. (2000). Selective loss of nucleoside carrier expression in rat hepatocarcinomas. Hepatology 32, 239-246.
23. Pol, A., Ortega, D., and Enrich, C. (1997). Identification and distribution of proteins in isolated endosomal fractions of rat liver: Involvement in endocytosis, recycling and transcytosis. Biochem. J. 323, 435-443.
24. Stieger, B., Hagenbuch, B., Landmann, L., Hochli, M., Schroeder, A., and Meier, P. J. (1994). In situ localization of the hepatocytic Na+/taurocholate cotransporting polypeptide in rat liver. Gastroenterology 107, 1781-1787.
25. Pol, A., Calvo, M., Lu, A., and Enrich, C. (1999). The "early-sorting" endocytic compartment of rat hepatocytes is involved in the intracellular pathway of caveolin-1 (VIP-21). Hepatology 29, 1848-1857.
26. Babbit J., Trigatti, B., Rigotti, A., Smart, E. J., Anderson, R. G. W., Xu, S., and Kriger, M. (1997). Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acid acylated and colocalizes with plasma membrane caveolae. J. Biol. Chem. 272, 13242-13249.
27. Graf, G. A., Connell, P. M., van der Westhuyzen, D. R. and Smart, E. J. (1999). The class B, type I scavenger receptor promotes the selective uptake of high density lipoprotein cholesterol ethers into caveolae. J. Biol. Chem. 274, 12043-12048.
28. Schnitzer, J. E., McIntosh, D. P., Dvorak, A. M., Liu, J., and Oh, P. (1995). Separation of caveolae from associated microdomains of GPI-anchored proteins. Science 269, 1435-1439.
29. yes controlsymeric IgA transcytosis in vivo. Mol. Cell 4, 627-632.
30. Vergés, M., Havel, R. J., and Mostov, K. E. (1999). A tubular endosomal fraction from rat liver: Biochemical evidence of receptor sorting by default. Proc. Natl. Acad. Sci. USA 96, 10146-10151.
31. Pol, A., Calvo, M., Lu, A., and Enrich, C. (2000). EGF triggers caveolin redistribution from the plasma membrane to the early/sorting endocytic compartment of hepatocytes. Cell Signal. 12, 537-540.
32. Calvo, M., Tebar, F., Lopez-Iglesias, C., and Enrich, C. (2001). Morphological and functional characterization of caveolae from liver hepatocytes. Hepatology 33, 1259-1269.
33. Mercader, J., Gómez-Angelats, M., del Santo, B., Casado, J., Felipe, A., and Pastor-Anglada, M. (1996). Nucleoside uptake in rat liver parenchymal cells. Biochem. J. 317, 835-842.
34. Ruiz-Montasell, B., Martinez-Mas, J. V., Enrich, C., Casado, F. J., Felipe, A., and Pastor-Anglada, M. (1993). Early induction of Na(+)-dependent uridine uptake in the regenerating rat liver. FEBS Lett. 316, 85-88.
35. del Santo, B., Tarafa, G., Felipe, A., Casado, F. J. and Pastor-Anglada, M. (2001). Developmental regulation of the concentrative nucleoside transporters CNT1 and CNT2 in rat liver. J. Hepatol. 34, 873-880.
36. Pol, A., Calvo, M.,and Enrich, C. (1998). Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment. FEBS Lett. 441, 34-38.
37. Enrich, C., Pol, A., Calvo, M., Pons, M.,and Jäckle, S. (1999). Dissection of the multifunctional "receptor-recycling" endocytic compartment of hepatocytes. Hepatology 30, 1115-1120.
38. Calvo, M., Pol, A., Lu, A., Ortega, D., Pons, M., Blasi, J., and Enrich, C. (2000). Cellubrevin is present in the basolateral endocytic compartment of hepatocytes and follows the transcytotic pathway after IgA internalization. J. Biol. Chem. 275, 7910-7917.
39. Anderson, R. G. W. (1998). The caveolae membrane system. Annu. Rev. Biochem. 67, 199-225.
40. Enrich, C., Jäckle, S., and Havel, R. J. (1996). The polymeric immunoglobulin receptor is the major calmodulin-binding protein in an endosome fraction from rat liver enriched in recycling receptors. Hepatology 24, 226-232.