Reduction of neuromuscular activity is required for the rescue of motoneurons from naturally occurring cell death by nicotinic-blocking agents

Journal of Neuroscience

Volumn 20, Issue 16, 2000, Pages 6117-6124

  Oppenheim, Ronald W ^a   Prevette, David ^a   D'Costa, Anselem ^a   Wang, Siwei ^a   Houenou, Lucien J ^a   Michael McIntosh, J ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Acetylcholine; Activity; Cell death; Chicken; Embryo; Motoneurons; Nicotinic receptors; Spinal cord

Indexed keywords

ALPHA BUNGAROTOXIN; CURARE; NICOTINIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL DEATH; CHICKEN; CONTROLLED STUDY; EMBRYO; MOTONEURON; NEUROMUSCULAR SYSTEM; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 0034663169     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-16-06117.2000     Document Type: Article

References (59)

1. Blockade of neuromuscular activity by the GABA(A) agonist muscimol promotes the survival of motoneurons in the chick embryo
2. Survival in vitro of motoneurons identified or purified by novel antibody-based methods is selectively enhanced by muscle-derived factors
3. Peripheral target regulation of the development and survival of spinal sensory and motor neurons in the chick embryo
4. A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors
5. Cell death of motoneurons in the chick embryo spinal cord
6. Neuron death in vertebrate development: In vivo methods
7. Nicotinic receptor subtypes in the developing chick brain: Appearance of a species containing the α4, β2 and α5 gene products
8. Expression of neuronal acetylcholine receptor genes in vertebrate skeletal muscle during development
9. The regulation of intramuscular nerve branching during normal development and following activity blockade
10. The regulation of synaptogenesis during normal development and following activity blockade
11. Mechanisms of insulin-like growth factor regulation of programmed cell death of developing avian motoneurons
12. Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture
13. Interactions between spinal cord stimulation and activity blockade in the regulation of synaptogenesis and motoneuron survival in the chick embryo
14. Cell death in the development of the lateral motor column of the chick embryo
15. A series of normal stages in the development of the chick embryo
16. Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro
17. Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord
18. The nicotinic blocking agents D-tubocurare and α-bungarotoxin save motoneurons from naturally occurring death in the absence of neuromuscular blockade
19. Regulation of putative muscle-derived neurotrophic factors by muscle activity and innervation: In vivo and in vitro studies
20. Differential targeting of nicotinic acetylcholine receptors by novel αA-conotoxins
21. α-Conotoxin ImI exhibits sub-type specific nicotinic acetylcholine receptor blockade: Preferential inhibition of homomeric α7 and α9 receptors
22. Distribution of the α7 nicotinic acetylcholine receptor subunit in the developing chick cerebellum
23. Developmental expression of neuronal and muscle nicotinic receptor subunits in chick spinal cord and limb-bud muscle
24. The relationship of intramuscular nerve branching and synaptogenesis to motoneuron survival
25. Activation pattern of embryonic chick hind-limb muscles following blockade of activity and motoneuron cell death
26. Nicotinic acetylcholine receptors in health and disease
27. Survival effects of depolarization on chick motoneurons in vitro
28. α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release
29. Cholinergic and GABAergic inputs drive patterned spontaneous motoneuron activity before target contact
30. The role of supraspinal input in embryonic motility
31. Muscle activity and motor neuron death in the spinal cord of the chick embryo
32. The neurotrophic theory and naturally occurring motoneuron death
33. Cell death during development of the nervous system
34. Neurotrophic survival molecules for motoneurons; An embarrassment of riches
35. Aspects of naturally occurring motoneuron death in the chick spinal cord during embryonic development
36. Electrical stimulation of hindlimb increases neuronal cell death in the chick embryo
37. Cell death of motoneurons in the chick embryo spinal cord
38. The development of motoneurons in the embryonic spinal cord of the mouse mutant muscular dysgenesis (mdg/mdg): Survival, morphology, and biochemical differentiation
39. Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor
40. Cell death of motoneurons in the chick embryo spinal cord: Acetylcholine receptors and synaptogenesis in skeletal muscle following the reduction of motoneuron death by neuromuscular blockade
41. Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo
42. The rescue of avian motoneurons by activity blockade at the neuromuscular junction
43. Neuromuscular development in the avian paralytic mutant crooked neck dwarf (cn/cn): Further evidence for the role of neuromuscular activity in motoneuron survival
44. Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents
45. Neuromuscular blockade increases motoneuron survival during normal cell death in the chick embryo
46. Cell death of motoneurons in the chick embryo spinal cord: Evidence that a functional neuromuscular interaction is involved in the regulation of naturally occurring cell death and the stabilization of synapses
47. Fast retrograde effects on neuronal death and dendritic organization in development: The role of calcium influx
48. 125I]-α-bungarotoxin binding co-varies with motoneuron density during apoptosis
49. Exogenously administered alpha-bungarotoxin binds to embryonic chick spinal cord: Implications for the toxin-induced arrest of naturally occurring motoneuron death
50. Development of the blood-brain barrier
51. Nicotinic receptors in the development and modulation of synapses
52. The diversity of neuronal nicotinic acetylcholine receptors
53. Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by phosphatidylinositol-3 kinase- and MAPK-independent pathways
54. Structural and histochemical features of the avian blood-brain barrier
55. Chronic application of curare does not increase the level of motoneuron survival promoting activity in limb muscle extracts during the naturally occurring motoneuron cell death period
56. Reduction of intramuscular nerve branching and synaptogenesis is correlated with decreased motoneuron survival
57. Neuromuscular activity blockade induced by muscimol and D-tubocurarine differentially affects the survival of embryonic chick motoneurons
58. Megacystic, mydriasis, and ion channel defect in mice lacking the α3 neuronal nicotinic acetylcholine receptor
59. Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous system