메뉴 건너뛰기




Volumn 21, Issue 3, 1999, Pages 483-506

Sequence determinants of modified cobra venom neurotoxin which induce immune resistance to experimental allergic encephalomyelitis: Molecular mechanisms for immunologic action

Author keywords

Cobratoxin derivative; Experimental allergic encephalomyelitis; Immunosuppressive

Indexed keywords

CARDIOTOXIN; CYTOCHROME C; FREUND ADJUVANT; IODOACETAMIDE; MYELIN BASIC PROTEIN; NEUROTOXIN; SNAKE VENOM; SODIUM CHLORIDE; TRYPSIN;

EID: 0032820260     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.3109/08923979909007122     Document Type: Article
Times cited : (12)

References (54)
  • 1
    • 0014350129 scopus 로고
    • Protective action of the encephalitogen and other basic proteins in experimental allergic encephalomyelitis
    • Roboz-Einstein, E., Csejty, J., Davis, W. I. and Rauch, H. C., Protective action of the encephalitogen and other basic proteins in experimental allergic encephalomyelitis, Immunochem., 5:567, 1968.
    • (1968) Immunochem. , vol.5 , pp. 567
    • Roboz-Einstein, E.1    Csejty, J.2    Davis, W.I.3    Rauch, H.C.4
  • 2
    • 0343960597 scopus 로고
    • Chronic disseminated allergic encephalomyelitis in guinea pigs
    • Stone, S. H. and Lerner, E. M., Chronic disseminated allergic encephalomyelitis in guinea pigs, Ann. N.Y. Acad. Sci., 122:227, 1965.
    • (1965) Ann. N.Y. Acad. Sci. , vol.122 , pp. 227
    • Stone, S.H.1    Lerner, E.M.2
  • 3
    • 0001426187 scopus 로고
    • Encephalitogen-induced inhibition of experimental allergic encephalomyelitis: Prevention, suppression and therapy
    • Alvord, E. C., Jr., Shaw, C. M., Hruby, S. and Kies, M. W., Encephalitogen-induced inhibition of experimental allergic encephalomyelitis: prevention, suppression and therapy, Ann. N.Y. Acad. Sci., 122:333, 1965.
    • (1965) Ann. N.Y. Acad. Sci. , vol.122 , pp. 333
    • Alvord E.C., Jr.1    Shaw, C.M.2    Hruby, S.3    Kies, M.W.4
  • 4
    • 0345377565 scopus 로고
    • Protective effect of encephalitogenic factor in experimental allergic encephalomyelitis
    • Field, E. J. and Caspary, E. A., Protective effect of encephalitogenic factor in experimental allergic encephalomyelitis, Nature, 201:936, 1964.
    • (1964) Nature , vol.201 , pp. 936
    • Field, E.J.1    Caspary, E.A.2
  • 5
    • 0015914575 scopus 로고
    • Allergic encephalomyelitis: Characterization of the determinants for delayed type hypersensitivity
    • Hashim, G. A. and Shilling, F. J., Allergic Encephalomyelitis: Characterization of the determinants for delayed type hypersensitivity, Biochem. Biophys. Res. Comm., 50:589, 1973.
    • (1973) Biochem. Biophys. Res. Comm. , vol.50 , pp. 589
    • Hashim, G.A.1    Shilling, F.J.2
  • 6
    • 0017273621 scopus 로고
    • Suppression and reversal of allergic encephalomyelitis in guinea pigs with a non-encephalitogenic analogue of the tryptophan region of the myelin basic protein
    • Hashim, G. A., Sharpe, R. D. Carvalho, E. F. and Stevens, L. E., Suppression and reversal of allergic encephalomyelitis in guinea pigs with a non-encephalitogenic analogue of the tryptophan region of the myelin basic protein, J. Immunol., 116:126, 1976.
    • (1976) J. Immunol. , vol.116 , pp. 126
    • Hashim, G.A.1    Sharpe, R.D.2    Carvalho, E.F.3    Stevens, L.E.4
  • 7
    • 0018200453 scopus 로고
    • Myelin basic protein-structure, function and antigenic determinants
    • Hashim, G. A., Myelin basic protein-Structure, function and antigenic determinants, Immunol. Rev., 39:60, 1978.
    • (1978) Immunol. Rev. , vol.39 , pp. 60
    • Hashim, G.A.1
  • 8
    • 0004914712 scopus 로고
    • Prevention of allergic encephalomyelitis by prior injection of adjuvants
    • Kies, M. W. and Alvord, E. C., Jr., Prevention of allergic encephalomyelitis by prior injection of adjuvants, Nature, 182:1106, 1958.
    • (1958) Nature , vol.182 , pp. 1106
    • Kies, M.W.1    Alvord E.C., Jr.2
  • 9
    • 0021020031 scopus 로고
    • Effect of treatment with copolymer 1 (Cop-1) on the in vivo and in vitro manifestations of experimental allergic encephalomyelitis (EAE)
    • Lisak, R. P., Zweiman, B., Blanchard, N. and Borke L. B., Effect of treatment with copolymer 1 (Cop-1) on the in vivo and in vitro manifestations of experimental allergic encephalomyelitis (EAE), J. Neurol. Sci., 62:281, 1983.
    • (1983) J. Neurol. Sci. , vol.62 , pp. 281
    • Lisak, R.P.1    Zweiman, B.2    Blanchard, N.3    Borke, L.B.4
  • 10
    • 0020623136 scopus 로고
    • Antigen-induced suppression of mitogen responses and resistance to experimental allergic encephalomyelitis
    • Lyman, W. D., Kadish, A. S., Brosnan, C. F. and Raine, C. S., Antigen-induced suppression of mitogen responses and resistance to experimental allergic encephalomyelitis, Cell. Immunol., 78:43, 1983.
    • (1983) Cell. Immunol. , vol.78 , pp. 43
    • Lyman, W.D.1    Kadish, A.S.2    Brosnan, C.F.3    Raine, C.S.4
  • 11
    • 84907106772 scopus 로고
    • Bovine-derived spinal cord protein (SCP) protects guinea pigs from experimental allergic encephalomyelitis (EAE) - A confirmatory report
    • Montgomery, I. N. and Rauch, H. C., Bovine-derived spinal cord protein (SCP) protects guinea pigs from experimental allergic encephalomyelitis (EAE) - A confirmatory report, Immunol. Comm., 9:289, 1980.
    • (1980) Immunol. Comm. , vol.9 , pp. 289
    • Montgomery, I.N.1    Rauch, H.C.2
  • 12
    • 0020404224 scopus 로고
    • Intensive suppression of experimental allergic encephalomyelitis (EAE) by serum thymic factor and therapeutic implication for multiple sclerosis
    • Nagai, Y., Osanai, T. and Sakakibara, K., Intensive suppression of experimental allergic encephalomyelitis (EAE) by serum thymic factor and therapeutic implication for multiple sclerosis, Japan J. Exp. Med., 52:213, 1982.
    • (1982) Japan J. Exp. Med. , vol.52 , pp. 213
    • Nagai, Y.1    Osanai, T.2    Sakakibara, K.3
  • 13
    • 0019450951 scopus 로고
    • Inhibition of experimental allergic encephalomyelitis by carrier administered prior to challenge with encephalitogenic peptide-carrier conjugate
    • Rauch, H. C., Montgomey, I. N. and Swanborg, R. H., Inhibition of experimental allergic encephalomyelitis by carrier administered prior to challenge with encephalitogenic peptide-carrier conjugate, Eur. J. Immunol., 11:335, 1981.
    • (1981) Eur. J. Immunol. , vol.11 , pp. 335
    • Rauch, H.C.1    Montgomey, I.N.2    Swanborg, R.H.3
  • 14
    • 0016230572 scopus 로고
    • Induction and suppression of experimental allergic encephalomyelitis in non-human primates
    • Rauch, H. C. and Roboz-Einstein, E., Induction and suppression of experimental allergic encephalomyelitis in non-human primates, J. Neurol. Sci., 23:99, 1974.
    • (1974) J. Neurol. Sci. , vol.23 , pp. 99
    • Rauch, H.C.1    Roboz-Einstein, E.2
  • 16
    • 0015407980 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by chemically modified encephalitogen
    • Roboz-Einstein, E., Chao, L.-P. and Csejty, J., Suppression of experimental allergic encephalomyelitis by chemically modified encephalitogen, Immunochem., 9:1013, 1972.
    • (1972) Immunochem. , vol.9 , pp. 1013
    • Roboz-Einstein, E.1    Chao, L.-P.2    Csejty, J.3
  • 17
    • 0343876714 scopus 로고
    • Suppression of experimental "allergic" encephalomyelitis in guinea pigs by encephalitogenic proteins extracted from homologous brain
    • Shaw, C. M., Fahlberg, W. J., Kies, M. W. and Alvord, E. C., Jr., Suppression of experimental "allergic" encephalomyelitis in guinea pigs by encephalitogenic proteins extracted from homologous brain, J. Exp. Med., 111:171, 1960.
    • (1960) J. Exp. Med. , vol.111 , pp. 171
    • Shaw, C.M.1    Fahlberg, W.J.2    Kies, M.W.3    Alvord E.C., Jr.4
  • 18
    • 0015402679 scopus 로고
    • Antigen-induced inhibition of experimental allergic encephalomyelitis. 1. Inhibition in guinea pigs injected with non-encephalitogenic modified myelin basic protein
    • Swanborg, R. H., Antigen-induced inhibition of experimental allergic encephalomyelitis. 1. Inhibition in guinea pigs injected with non-encephalitogenic modified myelin basic protein, J. Immunol., 109:540, 1972.
    • (1972) J. Immunol. , vol.109 , pp. 540
    • Swanborg, R.H.1
  • 19
    • 0016431331 scopus 로고
    • Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein
    • Swanborg, R. H., Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein, J. Immunol., 114:191, 1975.
    • (1975) J. Immunol. , vol.114 , pp. 191
    • Swanborg, R.H.1
  • 20
    • 0015103005 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide
    • Teitelbaum, D., Meshorer, A., Hirshfeld, T., Arnon, R. and Sela, M., Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide, Eur. J. Immunol., 1:242, 1971.
    • (1971) Eur. J. Immunol. , vol.1 , pp. 242
    • Teitelbaum, D.1    Meshorer, A.2    Hirshfeld, T.3    Arnon, R.4    Sela, M.5
  • 21
    • 0017286723 scopus 로고
    • Molecular requirements involved in suppression of EAE by synthetic basic copolymers of amino acids
    • Webb, C., Teitelbaum, D., Herz, A., Arnon, R. and Sela, M., Molecular requirements involved in suppression of EAE by synthetic basic copolymers of amino acids, Immunochem., 13:333, 1976.
    • (1976) Immunochem. , vol.13 , pp. 333
    • Webb, C.1    Teitelbaum, D.2    Herz, A.3    Arnon, R.4    Sela, M.5
  • 22
    • 0023927111 scopus 로고
    • Suppression of experimental autoimmune encephalitis by the oral administration of myelin basic protein
    • Bitar, D. M., and Whitaker, C. C., Suppression of experimental autoimmune encephalitis by the oral administration of myelin basic protein, Cell. Immunol., 112:364, 1988.
    • (1988) Cell. Immunol. , vol.112 , pp. 364
    • Bitar, D.M.1    Whitaker, C.C.2
  • 23
    • 0023858086 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments
    • Higgens, P. J. and Weiner, H. L., Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments, J. Immunol., 140:440, 1988.
    • (1988) J. Immunol. , vol.140 , pp. 440
    • Higgens, P.J.1    Weiner, H.L.2
  • 24
    • 0024524088 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein
    • Lider, O., Santos, L. M. B., Lee, C. S. Y., Higgins, P. J. and Weiner, H. L. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. J. Immunol. 1989; 142, 748-752.
    • (1989) J. Immunol. , vol.142 , pp. 748-752
    • Lider, O.1    Santos, L.M.B.2    Lee, C.S.Y.3    Higgins, P.J.4    Weiner, H.L.5
  • 25
    • 0025266658 scopus 로고
    • Oral tolerance in experimental autoimmune encephalomyelitis: Serum and salivary antibody responses
    • Fuller, K. A., Pearl, D. and Whitacre, C. C., Oral tolerance in experimental autoimmune encephalomyelitis: serum and salivary antibody responses, J. Neuroimmunol., 28:15, 1990.
    • (1990) J. Neuroimmunol. , vol.28 , pp. 15
    • Fuller, K.A.1    Pearl, D.2    Whitacre, C.C.3
  • 26
    • 0026042008 scopus 로고
    • Oral tolerance in experimental autoimmune encephalomyelitis III. Evidence for clonal anergy
    • Whitacre, C. C., Gienapp, I. E., Orosz, C. G. and Bitar, D. M., Oral tolerance in experimental autoimmune encephalomyelitis III. Evidence for clonal anergy, J. Immunol., 147:2155, 1991.
    • (1991) J. Immunol. , vol.147 , pp. 2155
    • Whitacre, C.C.1    Gienapp, I.E.2    Orosz, C.G.3    Bitar, D.M.4
  • 28
    • 0345377560 scopus 로고
    • Correlation of experimental allergic encephalomyelitis with delayed-type skin sensitivity to specific homologous encephalitogen
    • Shaw, C., Alvord, E. C., Jr., Kaku, J. and Kies, M. W., Correlation of experimental allergic encephalomyelitis with delayed-type skin sensitivity to specific homologous encephalitogen, Ann. N.Y. Acad. Sci., 122:318, 1965.
    • (1965) Ann. N.Y. Acad. Sci. , vol.122 , pp. 318
    • Shaw, C.1    Alvord E.C., Jr.2    Kaku, J.3    Kies, M.W.4
  • 29
    • 0020693270 scopus 로고
    • Experimental allergic encephalomyelitis: Prevention with a nontoxic derivative of a cobra neurotoxin
    • Hudson, R. A. Montgomery, I. N. and Rauch, H. C., Experimental allergic encephalomyelitis: prevention with a nontoxic derivative of a cobra neurotoxin, Mol. Immunol., 20:229, 1983.
    • (1983) Mol. Immunol. , vol.20 , pp. 229
    • Hudson, R.A.1    Montgomery, I.N.2    Rauch, H.C.3
  • 30
    • 0019408124 scopus 로고
    • Purification and characterization of the cardiotoxins from the venom of Thailand cobra, Naja naja siamensis
    • Zusman, N., Cafmeyer, N. and Hudson, R. A., Purification and characterization of the cardiotoxins from the venom of Thailand cobra, Naja naja siamensis, Comp. Biochem. Physiol., 69B:345, 1981.
    • (1981) Comp. Biochem. Physiol. , vol.69 B , pp. 345
    • Zusman, N.1    Cafmeyer, N.2    Hudson, R.A.3
  • 31
    • 0021990771 scopus 로고
    • Affinity-dependent cross-linking to neurotoxin sites of the acetylcholine receptor mediated by catechol oxidation
    • Nickoloff, B. J., Grimes, M., Wohlfeil, E. R. and Hudson, R. A., Affinity-dependent cross-linking to neurotoxin sites of the acetylcholine receptor mediated by catechol oxidation, Biochemistry, 24:999, 1985.
    • (1985) Biochemistry , vol.24 , pp. 999
    • Nickoloff, B.J.1    Grimes, M.2    Wohlfeil, E.R.3    Hudson, R.A.4
  • 32
    • 0345346100 scopus 로고
    • The preparation and enzymatic hydrolysis of reduced and S-carboxymethylated proteins
    • Crestfield, A. M., Moore, S. and Stein, W. H., The preparation and enzymatic hydrolysis of reduced and S-carboxymethylated proteins, J. Biol. Chem., 238:622, 1963.
    • (1963) J. Biol. Chem. , vol.238 , pp. 622
    • Crestfield, A.M.1    Moore, S.2    Stein, W.H.3
  • 33
    • 0025888320 scopus 로고
    • Synthesis and characterization of a heterobifunctional mercurial cross-linking agent: Incorporation into cobratoxin and interaction with the nicotinic acetylcholine receptor
    • Wohlfeil, E. R. and Hudson, R. A., Synthesis and characterization of a heterobifunctional mercurial cross-linking agent: incorporation into cobratoxin and interaction with the nicotinic acetylcholine receptor, Biochemistry, 30:7231, 1991.
    • (1991) Biochemistry , vol.30 , pp. 7231
    • Wohlfeil, E.R.1    Hudson, R.A.2
  • 34
    • 24844481301 scopus 로고
    • Basic proteins from acidic extracts of bovine spinal cord - Isolation and characterization
    • Nakao, A., Davis, W. J. and Einstein, E. R., Basic proteins from acidic extracts of bovine spinal cord - Isolation and characterization, Biochim. Biophys. Acta, 130:163, 1965.
    • (1965) Biochim. Biophys. Acta , vol.130 , pp. 163
    • Nakao, A.1    Davis, W.J.2    Einstein, E.R.3
  • 35
    • 0020032697 scopus 로고
    • Application of high performance liquid chromatography to the preparation of encephalitogenic myelin basic protein
    • Hinman, C. L., Rauch, H. and Pfeiffer, R., Application of high performance liquid chromatography to the preparation of encephalitogenic myelin basic protein, Life Sci., 30:989, 1982.
    • (1982) Life Sci. , vol.30 , pp. 989
    • Hinman, C.L.1    Rauch, H.2    Pfeiffer, R.3
  • 36
    • 0019205503 scopus 로고
    • Enzyme-linked immunoadsorbent assays for myelin basic protein and antibodies to myelin basic protein
    • Groome, N. P., Enzyme-linked immunoadsorbent assays for myelin basic protein and antibodies to myelin basic protein, J. Neurochem., 35:1409, 1980.
    • (1980) J. Neurochem. , vol.35 , pp. 1409
    • Groome, N.P.1
  • 37
    • 0023093137 scopus 로고
    • Experimental allergic encephalomyelitis in mice: Presence of myelin basic protein in cerebrospinal fluid
    • Rauch, H. C., Montgomery, I. N., Hinman, C. L. and Harb, W., Experimental allergic encephalomyelitis in mice: Presence of myelin basic protein in cerebrospinal fluid, J Neuroimmunol., 15:73, 1987.
    • (1987) J Neuroimmunol. , vol.15 , pp. 73
    • Rauch, H.C.1    Montgomery, I.N.2    Hinman, C.L.3    Harb, W.4
  • 38
    • 0015226272 scopus 로고
    • Isolation of the principal neurotoxins of two Naja naja subspecies
    • Karlsson, E., Arnberg, H. and Eaker, D., Isolation of the principal neurotoxins of two Naja naja subspecies, Eur. J. Biochem., 21:1, 1971.
    • (1971) Eur. J. Biochem. , vol.21 , pp. 1
    • Karlsson, E.1    Arnberg, H.2    Eaker, D.3
  • 39
    • 0020046166 scopus 로고
    • Effects of purified cardiotoxins from the Thailand cobra (Naja naja siamensis) on isolated skeletal and cardiac muscle preparation
    • Harvey, A. L., Marshall, R. J. and Karlsson, E., Effects of purified cardiotoxins from the Thailand cobra (Naja naja siamensis) on isolated skeletal and cardiac muscle preparation, Toxicon, 20:379, 1982.
    • (1982) Toxicon , vol.20 , pp. 379
    • Harvey, A.L.1    Marshall, R.J.2    Karlsson, E.3
  • 41
    • 0031664697 scopus 로고    scopus 로고
    • Molecular mimicry and immune-mediated diseases
    • Oldstone, M. B. A. Molecular mimicry and immune-mediated diseases, FASEB J., 12;1255, 1998.
    • (1998) FASEB J. , vol.12 , pp. 1255
    • Oldstone, M.B.A.1
  • 42
    • 0018186898 scopus 로고
    • Structure and function of snake venom alpha-neurotoxins
    • Tsernoglou, D., Petsko, G. A. and Hudson, R. A., Structure and function of snake venom alpha-neurotoxins, Molec. Pharmacol., 14:710, 1978.
    • (1978) Molec. Pharmacol. , vol.14 , pp. 710
    • Tsernoglou, D.1    Petsko, G.A.2    Hudson, R.A.3
  • 43
    • 0027371744 scopus 로고
    • NMR solution structure of an α-bungarotoxin/nicotinic acetylcholine receptor peptide complex
    • Basus, V. J., Song, G. and Hawrot, E., NMR solution structure of an α-bungarotoxin/nicotinic acetylcholine receptor peptide complex, Biochemistry, 32:12290, 1993.
    • (1993) Biochemistry , vol.32 , pp. 12290
    • Basus, V.J.1    Song, G.2    Hawrot, E.3
  • 44
    • 0001765604 scopus 로고
    • Chemistry of protein toxins in snake venoms
    • edited by C. Y. Lee, Springer-Verlag, Berlin
    • Karlsson, E., Chemistry of protein toxins in snake venoms, In Handbook of Experimental Pharmacology, edited by C. Y. Lee, Vol. 52, p. 159, Springer-Verlag, Berlin, 1979.
    • (1979) Handbook of Experimental Pharmacology , vol.52 , pp. 159
    • Karlsson, E.1
  • 46
    • 0022369377 scopus 로고
    • Neuroimmunomodulation of homeostasis and host defense
    • Waksman, B., Neuroimmunomodulation of homeostasis and host defense, J. Immunol., 135:862s, 1985.
    • (1985) J. Immunol. , vol.135
    • Waksman, B.1
  • 47
    • 0021846352 scopus 로고
    • Primary structure of six antimicrobial peptides of rabbit peritoneal neutrophils
    • Selsted, M. E., Brown, D. M., Delange, R. J., Harwig, S. S. L. and Lehrer, R. I., Primary structure of six antimicrobial peptides of rabbit peritoneal neutrophils, J. Biol. Chem., 260:4579, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 4579
    • Selsted, M.E.1    Brown, D.M.2    Delange, R.J.3    Harwig, S.S.L.4    Lehrer, R.I.5
  • 48
    • 0024468234 scopus 로고
    • Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides
    • Howell, M. D., Winters, S. T., Olee, T., Powell, H. C., Carlo, D. J. and Brostoff, S. W., Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides, Science, 246:668, 1989.
    • (1989) Science , vol.246 , pp. 668
    • Howell, M.D.1    Winters, S.T.2    Olee, T.3    Powell, H.C.4    Carlo, D.J.5    Brostoff, S.W.6
  • 49
    • 0025969733 scopus 로고
    • T -cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis
    • Offner, H., Hashim, G. A. and Vandenbark, A. A., T -Cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis, Science, 251:430, 1991.
    • (1991) Science , vol.251 , pp. 430
    • Offner, H.1    Hashim, G.A.2    Vandenbark, A.A.3
  • 52
    • 0025138302 scopus 로고
    • T-cells responsive to myelin basic protein in patients with multiple sclerosis
    • Allegretta, M., Nicklas, J. A., Sriram, S. and Albertine, R. J. T-cells responsive to myelin basic protein in patients with multiple sclerosis, Science, 247:718, 1990.
    • (1990) Science , vol.247 , pp. 718
    • Allegretta, M.1    Nicklas, J.A.2    Sriram, S.3    Albertine, R.J.4
  • 53
    • 0027056539 scopus 로고
    • Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy
    • Gaur, A., Wiers, B., Liu, A. Rothbard, J. Fathman, C. G. Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy, Science, 258:1491, 1992.
    • (1992) Science , vol.258 , pp. 1491
    • Gaur, A.1    Wiers, B.2    Liu, A.3    Rothbard, J.4    Fathman, C.G.5
  • 54
    • 0026488690 scopus 로고
    • Structural basis of antigenic specificity and design of new vaccines
    • Arnon, R. and van Regenmortel, M. H. V., Structural basis of antigenic specificity and design of new vaccines, FASEB J., 6:3265, 1992.
    • (1992) FASEB J. , vol.6 , pp. 3265
    • Arnon, R.1    Van Regenmortel, M.H.V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.