The role of stem cells in the post-MI patient

Current Heart Failure Reports

Volumn 4, Issue 4, 2007, Pages 198-203

  Meyer, Gerd P ^a   Wollert, Kai C ^b   Drexler, Helmut ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL MOTILITY; CELL POPULATION; CELL THERAPY; HEART INFARCTION; HEART MUSCLE PERFUSION; HUMAN; REVIEW; STEM CELL;

HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; STEM CELL TRANSPLANTATION; STEM CELLS; TREATMENT OUTCOME;

EID: 38049029702     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-007-0013-6     Document Type: Review

References (37)

1. Wollert KC, Drexler H: Clinical applications of stem cells for the heart. Circ Res 2005, 96:151-163.
2. Wagers AJ, Weissman IL: Plasticity of adult stem cells. Cell 2004, 116:639-648.
3. Orlic D, Kajstura J, Chimenti S, et al.: Bone marrow cells regenerate infarcted myocardium. Nature 2001, 410:701-705.
4. Torella D, Ellison GM, Mendez-Ferrer S, et al.: Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration. Nat Clin Pract Cardiovasc Med 2006, 3(Suppl 1):S8-S13.
5. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, et al.: Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 2003, 425:968-973.
6. Nygren JM, Jovinge S, Breitbach M, et al.: Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 2004, 10:494-501.
7. Murry CE, Soonpaa MH, Reinecke H, et al.: Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004, 428:664-668.
8. Balsam LB, Wagers AJ, Christensen JL, et al.: Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004, 428:668-673.
9. Kamihata H, Matsubara H, Nishiue T, et al.: Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation 2001, 104:1046-1052.
10. Kinnaird T, Stabile E, Burnett MS, et al.: Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 2004, 94:678-685.
11. Abdel-Latif A, Bolli R, Tleyjeh IM, et al.: Adult bone marrow-derived cells for cardiac repair. Arch Intern Med 2007, 167:989-997. This report, the most recent meta-analysis on stem cell therapy, includes 12 randomized controlled trials and six cohort studies.
12. Frangogiannis NG: The mechanistic basis of infarct healing. Antioxid Redox Signal 2006, 8:1907-1939.
13. Strauer BE, Brehm M, Zeus T, et al.: Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002, 106:1913-1918.
14. Hofmann M, Wollert KC, Meyer GP, et al.: Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 2005, 111:2198-2202. Stem cell labeling study demonstrating that only some intracoronary-administered cells are retained in the myocardium.
15. Orlic D, Kajstura J, Chimenti S, et al.: Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 2001, 98:10344-10349.
16. Ohtsuka M, Takano H, Zou Y, et al.: Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization. FASEB J 2004, 18:851-853.
17. Minatoguchi S, Takemura G, Chen XH, et al.: Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment. Circulation 2004, 109:2572-2580.
18. Harada M, Qin Y, Takano H, et al.: G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 2005, 11:305-311.
19. Wollert KC, Meyer GP, Lotz J, et al.: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004, 364:141-148. The first randomized, controlled trial on stem cell therapy after acute MI. At 6 months, improvement of global and regional left ventricular function was seen.
20. Schachinger V, Erbs S, Elsasser A, et al.: Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006, 355:1210-1221. The REPAIR-AMI trial: the largest benefit was seen in patients with poorer left ventricular ejection fraction at baseline.
21. Janssens S, Dubois C, Bogaert J, et al.: Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 2006, 367:113-121.
22. Lunde K, Solheim S, Aakhus S, et al.: Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med 2006, 355:1199-1209. This study and the study by Janssens et al. [21] did not find a benefit of stem cell therapy. Procedural issues and the timing of cell therapy may have played a role.
23. Meyer GP, Wollert KC, Lotz J, et al.: Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 2006, 113:1287-1294. The longest follow-up of a randomized trial of intracoronary bone marrow cell transfer so far. A catch-up phenomenon was observed in the control group, and a preserved beneficial effect was seen in the stem cell group.
24. Schaefer A, Meyer GP, Fuchs M, et al.: Impact of intracoronary bone marrow cell transfer on diastolic function in patients after acute myocardial infarction: results from the BOOST trial. Eur Heart J 2006, 27:929-935. Influence of stem cell therapy on diastolic left ventricular function from the randomized BOOST trial.
25. Schachinger V, Assmus B, Britten MB, et al.: Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOP-CARE-AMI Trial. J Am Coll Cardiol 2004, 44:1690-1699.
26. Assmus B, Honold J, Schachinger V, et al.: Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006, 355:1222-1232. Stem cells were transplanted into patients with chronic disease; unfractionated bone marrow cells provided the largest benefit.
27. Chen SL, Fang WW, Ye F, et al.: Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004, 94:92-95.
28. Vulliet PR, Greeley M, Halloran SM, et al.: Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet 2004, 363:783-784.
29. Mansour S, Vanderheyden M, De Bruyne B, et al.: Intra-coronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction. J Am Coll Cardiol 2006, 47:1727-1730.
30. Ince H, Petzsch M, Kleine HD, et al.: Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI). Circulation 2005, 112:3097-3106.
31. de Muinck ED, Simons M: Calling on reserves: granulocyte colony stimulating growth factor in cardiac repair. Circulation 2005, 112:3033-3035.
32. Zohlnhofer D, Ott I, Mehilli J, et al.: Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: a randomized controlled trial. JAMA 2006, 295:1003-1010. In this study of stem cell mobilization in patients with AMI and successful mechanical reperfusion, G-CSF had no influence on infarcr size or left ventricular function.
33. Ripa RS, Jorgensen E, Wang Y, et al.: Stem cell mobilization induced by subcutaneous granulocyte-colony stimulating factor to improve cardiac regeneration after acute ST-elevation myocardial infarction: result of the double-blind, randomized, placebo-controlled stem cells in myocardial infarction (STEMMI) trial. Circulation 2006, 113:1983-1992.
34. Bartunek J, Dimmeler S, Drexler H, et al.: The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur Heart J 2006, 27:1338-1340.
35. Sasaki K, Heeschen C, Aicher A, et al.: Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proc Natl Acad Sci U S A 2006, 103:14537-14541.
36. Kawamoto A, Murayama T, Kusano K, et al.: Synergistic effect of bone marrow mobilization and vascular endothelial growth factor-2 gene therapy in myocardial ischemia. Circulation 2004, 110:1398-1405.
37. Gnecchi M, He H, Liang OD, et al.: Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005, 11:367-368. This study provides insight into current concepts of how stem cells exhibit their protective effects.