Expression level of thymidylate synthase mRNA reflects 5-fluorouracil sensitivity with low dose and long duration in primary colorectal cancer

Cancer Chemotherapy and Pharmacology

Volumn 61, Issue 4, 2008, Pages 587-594

  Okumura, Kenji ^a   Mekata, Eiji ^a   Shiomi, Hisanori ^a   Naitoh, Hiroyuki ^a   Abe, Hajime ^a   Endo, Yoshihiro ^a   Kurumi, Yoshimasa ^a   Tani, Tohru ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

5 FU metabolic enzymes; Chemosensitivity; Colorectal cancer; Low dose 5 FU

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; MESSENGER RNA; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG SENSITIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; ANTIMETABOLITES; COLLAGEN; COLORECTAL NEOPLASMS; DIHYDROURACIL DEHYDROGENASE (NADP); FEMALE; FLUOROURACIL; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

EID: 38049008970     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0511-y     Document Type: Article

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