S2 deletion variants of human PRL receptors demonstrate that extracellular domain conformation can alter conformation of the intracellular signaling domain

Biochemistry

Volumn 47, Issue 1, 2008, Pages 479-489

  Tan, Dunyong ^a   Huang, Kuang Tzu ^a   Ueda, Eric ^a   Walker, Ameae M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; LIGANDS;

CANCEROUS HUMAN CELLS; HUMAN BREAST; PROSTATE;

PROTEINS;

BETA CASEIN; GREEN FLUORESCENT PROTEIN; LIGAND; LUCIFERASE; PROLACTIN; PROLACTIN RECEPTOR;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CARBOXY TERMINAL SEQUENCE; CELL COUNT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; ENERGY TRANSFER; GREEN FLUORESCENT PROTEINS; HUMANS; LUCIFERASES; LUMINESCENT MEASUREMENTS; MICROSCOPY, CONFOCAL; PROLACTIN; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PROLACTIN; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 37849052434     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7013882     Document Type: Article

References (32)

1. Nevalainen, M. T., Valve, E. M., Ingleton, P. M., Nurmi, M., Martikainen, P. M., and Harkonen, P. L. (1997) Prolactin and prolactin receptors are expressed and functioning in human prostate. J. Clin. Invest. 99, 618-627.
2. Neville, M. C., McFadden, T. B., and Forsyth, I. (2002) Hormonal regulation of mammary differentiation and milk secretion. J. Mammary Gland Biol. Neoplasia 7, 49-66.
3. Goffin, V., Binart, N., Touraine, P., and Kelly, A. P. (2002) Prolactin: the new biology of an old hormone. Annu. Rev. Physiol. 64, 47-67.
4. Hu, Z., Zhuang, L., Maria, L., and Dufau, M. L. (1996) Multiple and tissue-specific promoter control of gonadal and non-gonadal prolactin receptor gene expression. J. Biol. Chem. 271, 10242-10246.
5. Nagano, M., and Kelly, P. A. (1994) Tissue distribution and regulation of rat prolactin receptor gene expression. Quantitative analysis by polymerase chain reaction. J. Biol. Chem. 269, 13337-13345.
6. Cosman, D. (1993) The hematopoietin receptor superfamily. Cytokine 5, 95-106.
7. Bole-Feysot, C., Goffin, V., Edery, M., Binart, N., and Kelly, P. A. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr. Rev. 19, 225-268.
8. Tan, D., Johnson, D. A., Wu, W., Zeng, L., Chen, Y. H., Chen, W. Y., Vonderhaar, B. K., and Walker, A. M. (2005) Unmodified prolactin (PRL) and S179D PRL-initiated bioluminescence resonance energy transfer between homo- and hetero-pairs of long and short human PRL receptors in living human cells. Mol. Endocrinol. 19, 1291-1303.
9. Langenheim, J. F., Tan, D., Walker, A. M., and Chen, W. Y. (2005) Two wrongs can make a right: dimers of prolactin and growth hormone receptor antagonists behave as agonists. Mol. Endocrinol. 19, 1291-1303.
10. Goffin, V., and Kelly, P. A. (1997) The prolactin/growth hormone receptor family: structure/ function relationships. J. Mammary Gland Biol. Neoplasia 2, 7-17.
11. Christinger, H. W., Elkins, P. A., Sandowski, Y., Sakal, E., Gertler, A., Kossiakoff, A. A., and de Vos, A. M. (1998) Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor. Acta Crystallogr., Sect. D: Biol. Crystallogr. 54, 1408-1411.
12. Gourdou, I., Gabou, L., Paly, J. A., Kermabon, A. Y., Belair, L., and Djiane, J. (1996) Development of a constitutively active mutant form of the prolactin receptor, a member of the cytokine receptor family. Mol. Endocrinol. 10, 45-56.
13. Lee, R. C., Walters, J. A., Reyland, M. E., and Anderson, S. M. (1999) Constitutive activation of the prolactin receptor results in the induction of growth factor-independent proliferation and constitutive activation of signaling molecules. J. Biol. Chem. 274, 10024-10034.
14. Sakal, E., Elberg, G., and Gertler, A. (1997) Direct evidence that lactogenic hormones induce homodimerization of membrane-anchored prolactin receptor in intact Nb2-11C rat lymphoma cells. FEBS Lett. 410, 289-292.
15. Qazi, A. M., Tsai-Morris, C. H., and Dufau, M. L. (2006) Ligand-independent homo- and heterodimerization of human prolactin receptor variants: inhibitory action of the short forms by heterodimerization. Mol. Endocrinol. 20, 1912-1923.
16. Gadd, S. L., and Clevenger, C. V. (2006) Ligand-independent dimerization of the human prolactin receptor isoforms: functional implications. Mol. Endocrinol. 20, 2734-2746.
17. Brown, R. J., Adams, J. J., Pelekanos, R. A., Wan, Y., McKinstry, W. J., Palethorpe, K., Seeber, R. M., Monks, T. A., Eidne, K. A., Parker, M. W., and Waters, M. J. (2005) Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat. Struct. Mol. Biol. 12, 814-821.
18. Constantinescu, S. N., Keren, T., Socolovsky, M., Nam, H., Henis, Y. I., and Lodish, H. F. (2001) Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc. Natl. Acad. Sci. U.S.A. 98, 4379-4384.
19. Chen, T. J., Kuo, C. B., Tsai, K. F., Liu, J. W., Chen, D. Y., and Walker, A. M. (1998) Development of recombinant human prolactin receptor antagonists by molecular mimicry of the phosphorylated hormone. Endocrinology 139, 609-616.
20. Huang, K. T., Chen, Y. H., and Walker, A. M. (2004) Inaccuracies in MTS assays: major distorting effects of medium, serum albumin, and fatty acids. BioTechniques 37, 406-412.
21. Wu, W., Ginsburg, E., Vonderhaar, B. K., and Walker, A. M. (2005) S179D prolactin increases vitamin D receptor and p21 through upregulation of short 1b prolactin receptor in human prostate cancer cells. Cancer Res. 65, 7509-7515.
22. Rozakis-Adcock, M., and Kelly, P. A. (1992) Identification of ligand binding determinants of the prolactin receptor. J. Biol. Chem. 267, 7428-7433.
23. Watson, C. J., and Burdon, T. G. (1996) Prolactin signal transduction mechanisms in the mammary gland: the role of the Jak/Stat pathway. Rev. Reprod. 1, 1-5.
24. Walker, A. M. (2005) Prolactin receptor antagonists. Curr. Opin. Invest. Drugs 6, 378-385.
25. Seubert, N., Royer, Y., Staerk, J., Kubatzky, K. F., Moucadel, V., Krishnakumar, S., Smith, S. O., and Constantinescu, S. N. (2003) Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol. Cell 12, 1239-1250.
26. Brockman, J. L., and Schuler, L. A. (2005) Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter. Mol. Cell. Endocrinol. 239, 45-53.
27. Huang, L. J., Constantinescu, S. N., and Lodish, H. E. (2001) The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. MoL Cell 8, 1327-1338.
28. Elkins, P. A., Christinger, H. W., Sandowski, Y., Sakal, E., Gertler, A., de Vos, A. M., and Kossiakoff, A. A. (2000) Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nat. Struct. Biol. 7, 808-815.
29. Xu, X., Kreye, E., Kuo, C. B., and Walker, A. M. (2001) A molecular mimic of phosphorylated prolactin markedly reduced tumor incidence and size when DU145 human prostate cancer cells were grown in nude mice. Cancer Res. 61, 6098-6114.
30. Ginsburg, E., and Vonderhaar, B. K. (1995) Prolactin synthesis and secretion by human breast cancer cells. Cancer Res. 55, 2591-2595.
31. Kline, J. B., Rycyzyn, M. A., and Clevenger, C. V. (2002) Characterization of a novel and functional human prolactin receptor isoform (delta S1PRLr) containing only one extracellular fibronectin-like domain. Mol. Endocrinol. 16, 2310-2322.
32. Jackson, I. J. (1991) A reappraisal of non-consensus mRNA splice sites. Nucleic Acids Res. 19, 3795-3798.