Prolactin and prolactin receptors are expressed and functioning in human prostate

Journal of Clinical Investigation

Volumn 99, Issue 4, 1997, Pages 618-627

  Nevalainen, Marja T ^a   Valve, Eeva M ^a   Ingleton, Patricia M ^b   Nurmi, Martti ^c   Martikainen, Paula M ^c   Härkönen, Pirkko L ^a,c  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

human prostate; prolactin effects; prolactin expression; prolactin receptors

Indexed keywords

PROLACTIN RECEPTOR;

ARTICLE; CELL PROLIFERATION; CROSS LINKING; DNA SYNTHESIS INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OSMOREGULATION; PRIORITY JOURNAL; PROSTATE DISEASE; RECEPTOR GENE; REPRODUCTION; RNA PROCESSING;

EID: 0031030299     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119204     Document Type: Article

References (75)

1. Sinha, Y.N. 1995. Structural variants of prolactin: occurrence and physiological significance. Endocr. Rev. 16:354-369.
2. Wallis, M. 1988. Mechanism of action of prolactin. In Hormones and Their Actions. Part II. B.A. Cooke, R.J.B. King, and H.J. van der Molen, editors. Elsevier, Amsterdam. 295-319.
3. Guyette, W.A., R.A. Matusik, and J.M. Rosen. 1979. Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression. Cell. 17:1013-1023.
4. Lesueur, L., M. Edery, S. Ali, J. Paly, P.A. Kelly, and J. Djiane. 1991. Comparison of long and short forms of the prolactin receptor on prolactin induced milk protein gene transcription. Proc. Natl. Acad. Sci. USA. 88:824-828.
5. Yu-Lee, L. 1990. Prolactin stimulates transcription of growth-related genes in Nb2 T lymphoma cells. Mol. Cell. Endocrinol. 68:21-28.
6. Stevens, A.M., and L. Yu-Lee. 1994. Multiple prolactin-responsive elements mediate G1 and S phase expression of the interferon regulatory factor-1 gene. Mol. Endocrinol. 8:345-355.
7. Clevenger, C.V., A.L. Sillman, J. Hanley-Hyde, and M.B. Prystowsky. 1992. Requirement for prolactin during cell cycle regulated gene expression in cloned T-lymphocytes. Endocrinology. 130:3216-3222.
8. Costello, L.C., and R.B. Franklin. 1994. Effects of prolactin on the prostate. Prostate. 24:162-166.
9. Reiter, E., S. Lardinois, M. Klug, B. Sente, B. Hennuy, M. Bruyninx, J. Closset, and G. Hennen. 1995. Androgen-independent effects of prolactin on the different lobes of the immature rat prostate. Mol. Cell. Endocrinol. 112: 113-122.
10. Perez-Villamil, B., E. Bordiu, and M. Puente-Cueva. 1991. Involvement of physiological prolactin levels in growth and prolactin receptor content of prostate glands and testes in developing male rats. J. Endocrinol. 132:449-459.
11. Rui, H., and K. Purvis. 1987. Prolactin selectively stimulates ornithine decarboxylase in the lateral lobe of the rat prostate. Mol. Cell. Endocrinol. 50: 89-97.
12. Nevalainen, M.T., E.M. Valve, S.I. Mäkelä, M. Bläuer, P.J. Tuohimaa, and P.L. Härkönen. 1991. Estrogen and prolactin regulation of rat dorsal and lateral prostate in organ culture. Endocrinology. 129:612-622.
13. Price, D. 1963. Comparative aspects of development and structure in the prostate. Natl. Cancer Inst. Monogr. 12:351-369.
14. Wilson, J.D. 1980. The pathogenesis of benign prostatic hyperplasia. Am. J. Med. 68:745-756.
15. Sissom, J.F., M.L. Eigenbrodt, and J.C. Porter. 1988. Anti-growth action on mouse mammary and prostate glands of a monoclonal antibody to prolactin receptor. Am. J. Pathol. 133:589-595.
16. Nakamura, A., T. Shirai, K. Ogawa, S. Wada, N.A. Fujimoto, A. Ito, and N. Ito. 1990. Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis. Cancer Lett. 53:151-157.
17. Webber, M.M. 1981. Polypeptide hormones and the prostate. In The Prostatic Cell: Structure and Function. Part B. G.P. Murphy, A.A. Sandberg, and J.P. Karr, editors. Alan R. Liss, Inc., New York. 63-88.
18. Thomas, J.A., and M. Manadhar. 1975. Effects of prolactin and/or testosterone on nucleic acid levels in prostate glands of normal and castrated rats. J. Endocrinol. 65:149-150.
19. Walvoord, D.J., M.I. Resnick, and J.T. Grayhack. 1976. Effects of testosterone, dihydrotestosterone, estradiol, and prolactin on the weight and citric acid content of the lateral lobe of the rat prostate. Invest. Urol. 14:60-65.
20. Jones, R., P.R. Riding, and M.G. Parker. 1983. Effects of prolactin on testosterone-induced growth and protein synthesis in rat accessory sex glands. J. Endocrinol. 96:407-416.
21. Prins, G.S. 1987. Prolactin influence cytosol and nuclear androgen receptors in the ventral, dorsal, and lateral lobes of rat prostate. Endocrinology. 120:1457-1464.
22. Kelly, P.A., J. Djiane, M.C. Postel-Vinay, and M. Edery. 1991. The prolactin/growth hormone receptor family. Endocr. Rev. 12:235-251.
23. Bazan, J.F. 1990. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA. 87:6934-6938.
24. Thoreau, E., B. Petridou, P. Kelly, J. Djiane, and J.P. Mornon. 1991. Structural symmetry of extracellular domain of the cytokine/growth hormone/ prolactin receptor family and interferon receptors revealed by hydrophobic cluster analysis. FEBS Lett. 282:26-31.
25. Shirota, M., D. Banville, S. Ali, C. Jolicoeur, J.M. Boutin, M. Edery, J. Djiane, and P.A. Kelly. 1990. Expression of two forms of prolactin receptor in rat ovary and liver. Mol. Endocrinol. 4:1136-1143.
26. Ali, S., I. Pellegrini, and P.A. Kelly. 1991. A prolactin-dependent immune cell line (Nb2) expresses a mutant form of prolactin receptor. J. Biol. Chem. 266:20110-20117.
27. fyn is associated with prolactin (Prl) receptor and is activated by Prl stimulation of T-lymphocytes. Mol. Endocrinol. 8:674-681.
28. Clevenger, C.V., T. Torigoe, and J.C. Reed. 1994. Prolactin induces rapid phosphorylation and activation of prolactin receptor-associated RAF-1 kinase in a T-cell line. J. Biol. Chem. 269:5559-5565.
29. Boutin, J.M., M. Edery, M. Shirota, C. Jolicoeur, L. Lesueur, S. Ali, D. Gould, J. Djiane, and P.A. Kelly. 1989. Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells. Mol. Endocrinol. 3:1455-1461.
30. Clevenger, C.V., W.P. Chang, W. Ngo, T.L.M. Pasha, K.T. Montone, and J.E. Tomaszewski. 1995. Expression of prolactin and prolactin receptor in human breast carcinoma: evidence for an autocrine/paracrine loop. Am. J. Pathol. 146:695-705.
31. Das, R., and B.K. Vonderhaar. 1995. Transduction of prolactin's growth signal through both long and short forms of the prolactin receptor. Mol. Endocrinol. 9:1750-1759.
32. Nagano, M., and P.A. Kelly. 1994. Tissue distribution and regulation of rat prolactin receptor gene expression. J. Biol. Chem. 269:13337-13345.
33. Ouhtit, A., G. Morel, and P.A. Kelly. 1993. Visualization of gene expression of short and long forms of prolactin receptor in rat reproductive tissues. Biol. Reprod. 49:528-536.
34. Ouhtit, A., P.A. Kelly, and G. Morel. 1994. Visualization of gene expression of short and long forms of prolactin receptor in rat digestive tissues. Am. J. Physiol. 266:G807-G815.
35. Lobie, P.E., J. Garcia-Aragon, and M.J. Waters. 1993. Prolactin receptor expression in the gastrointestinal tract: characterization of the prolactin receptor of gastric mucosa. J. Endocrinol. 139:371-381.
36. Nevalainen, M.T., E.M. Valve, P.M. Ingleton, and P.L. Härkönen. 1996. Expression and hormone regulation of prolactin receptors in rat dorsal and lateral prostate. Endocrinology. 137:3078-3088.
37. Sabharwal, P., R. Glaser, W. Lafuse, S. Varma, Q. Liu, S. Arkins, R. Kooijman, L. Kutz, K.W. Kelley, and W.B. Malarkey. 1992. Prolactin synthesized and secreted by human peripheral mononuclear cells: an autocrine growth factor for lymphoproliferation. Proc. Natl. Acad. Sci. USA. 89:7713-7716.
38. Hooghe, R., M. Delhase, P. Vergani, A. Malur, and E.L. Hooghe-Peters. 1993. Growth hormone and prolactin are paracrine growth and differentiation factors in the haemopoietic system. Immunol. Today. 14:212-214.
39. Wu, H., R. Devi, and W. Malarkey. 1996. Expression and localization of prolactin messenger ribonucleic acid in the human immune system. Endocrinology. 137:349-353.
40. Handwerger, S., R.G. Richards, and E. Markoff. 1992. The physiology of decidual prolactin and other decidual protein hormones. Trends Endocrinol. Metab. 3:91-95.
41. Mershon, J., W. Sali, N. Mitchner, and N. Ben-Jonathan. 1995. Prolactin is a local growth factor in rat mammary tumors. Endocrinology. 136:3619-3623.
42. Ginsburg, E., and B.K. Vonderhaar. 1995. Prolactin synthesis and secretion by human breast cancer cells. Cancer Res. 55:2591-2595.
43. McKeehan, W.L., P.S. Adams, and D. Fast. 1987. Different hormonal requirements for androgen-independent growlh of normal and tumor epithelial cells from rat prostate. In Vitro Cell. Dev. Biol. 23:147-152.
44. Nevalainen, M.T., E.M. Valve, W. Ping, M. Nurmi, P.L. Härkönen, and P.M. Martikainen. 1993. Hormone regulation of human prostate in organ culture. Cancer Res 53:5199-5207.
45. Martikainen, P.M., P.L. Härkönen, T. Vanhala, S.I. Mäkelä, M. Viljanen, and J.J.O. Suominen. 1987. Multihormonal control of synthesis and secretion of prostatein in cultured rat ventral prostate. Endocrinology. 121:604-611.
46. Martikainen, P. 1987. Maintenance of adult rat ventral prostate in organ culture. Anat. Rec: 218:166-174.
47. Johansson, R. 1975. RNA, protein and DNA synthesis stimulated by testosterone, insulin and prolactin in the rat ventral prostate cultured in chemically defined medium. Acta Endocrinol. 80:761-764.
48. Chang, S.M., and L.W.K. Chung. 1989. Interaction between prostatic fibroblasts and epithelial cells in culture: role of androgen. Endocrinology. 125: 2719-2727.
49. Cunha, G.R., N. Hayashi, and Y.C. Wong. 1991. Regulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchyme. In Prostate Cancer. L.M. Franks and J.T. Isaacs, editors. Cold Spring Harbor Laboratory Press. Cancer Surveys. 11:73-89.
50. Burton, K. 1956. A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 62:315-323.
51. SAS Institute Inc. 1990. SAS/STAT Users Guide, Version 6, 4th Edition, Vols. 1 and 2. SAS Institute Inc., Cary, NC.
52. Sternberger, L.A. 1974. Immunocytochemistry. Prentice-Hall, Englewood Cliffs, NJ.
53. Danks, J.A., A.J. Devlin, P.M.W. Ho, H. Diefenbach-Jagger, D.M. Power, A.V.M. Canario, T.J. Martin, and P.M. Ingleton. 1993. Parathyroid hormone-related protein is a factor in normal fish pituitary. Gen. Comp. Endocrinol. 92:201-212.
54. Ben-David, M., T. Kadar, and A.V. Schally. 1986. Micromethod for the determination of free and total prolactin receptors: measurement of receptor levels in normal and malignant mammary and prostate tissues. Proc. Natl. Acad. Sci. USA. 83:8375-8379.
55. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
56. Salacinski, P.R.P., C. McLean, J.E.C. Sykes, V.V. Clement-Jones, and P.J. Lowry. 1981. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3a,6a-dipenyl glycoluril (IODO-GEN®). Anal. Biochem. 117:136-146.
57. 4. Nature (Lond.). 227:680-685.
58. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
59. Boutin, J.M., C. Jolicoeur, H. Okamura, J. Gagnon, M. Edery, M. Shirota, D. Banville, I. Dusanter-Fourt, J. Djiane, and P.A. Kelly. 1988. Cloning and expression of the rat prolactin receptor, a member of the growth hormone/ prolactin receptor gene family. Cell. 53:69-77.
60. Feinberg, A.P., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
61. Mellanen, P., H. Minn, R. Grenman, and P. Härkönen. 1994. Expression of glucose transporters in head-and-neck tumors. Int. J. Cancer. 56:622-629.
62. Sakaguchi, K., T. Ohkubo, M. Tanaka, H. Ushiro, and K. Nakashima. 1994. Differential regulation of prolactin receptor mRNA expression in rat liver and kidney by testosterone and oestradiol. J. Endocrinol. 143:383-392.
63. Fields, K., E. Kulig, and R.V. Lloyd. 1993. Detection of prolactin messenger RNA in mammary and other normal and neoplastic tissues by polymerase chain reaction. Lab. Invest. 68:354-359.
64. Gubbins, E.J., R.A. Maurer, M. Lagrimini, C.R. Erwin, and J.E. Donelson. 1980. Structure of the rat prolactin gene. J. Biol. Chem. 255:8655-8662.
65. Rui, H., I. Brekke, P.A. Torjesen, and K. Purvis. 1986. Homologous up-regulation of the prolactin receptor in rat prostatic explants. Mol. Cell. Endocrinol. 46:53-57.
66. Franklin, R.B., and L.C. Costello. 1990. Prolactin directly stimulates citrate production and mitochondrial aspartate aminotransferase of prostate epithelial cells. Prostate. 17:13-18.
67. Bostwick, D.G., M.B. Amin, P. Dundore, W. Marsh, and D.S. Schultz. 1993. Architectural patterns of high-grade prostatic intraepithelial neoplasia. Hum. Pathol. 24:298-310.
68. Page, D.L., T.J. Anderson, and L.W. Rogers. 1987. Carcinoma in situ (CIS). In Diagnostic Histopathology of the Breast. D.L. Page and T.J. Anderson, editors. Churchill Livingstone, Edinburgh-London-Melbourne-New York. 158-171.
69. Fuh, G., and J. A. Wells. 1995. Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J. Biol. Chem. 270:13133-13137.
70. Hu, Z.Z., and M. Dufau. 1991. Multiple and differential regulation of ovarian prolactin receptor messenger RNAs and their expression. Biochem. Biophys. Res. Commun. 181:219-225.
71. Abrahamssom, P.-A. 1996. Neuroendocrine differentiation and hormone-refractory prostate cancer. Prostate. 6:3-8.
72. Bonkhoff, H., U. Stein, and K. Remberger. 1995. Endocrine-paracrine cell types in the prostate and prostatic adenocarcinoma are postmitotic cells. Hum. Pathol. 26:167-170.
73. Aprikian, A.G., C. Cordon-Cardo, W.R. Fair, and V.E. Reuter. 1993. Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma. Cancer (Phila.). 71:3952-3965.
74. Bonkhoff, H., U. Stein, and K. Remberger. 1993. Androgen receptor status in endocrine-paracrine cell types of the normal, hyperplastic, and neoplastic human prostate. Virchows Archiv. A Pathol Anat. 423:291-294.
75. Santágnese, P.A. 1992. Neuroendocrine differentiation in human prostatic carcinoma. Hum. Pathol. 23:287-296.