HNO induces DNA deletions in the yeast S. cerevisiae

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 638, Issue 1-2, 2008, Pages 83-89

  Sobol, Zhanna ^a,b   Cook, Natalie M ^a   Schiestl, Robert H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anaerobic; Angeli's salt; CAN mutation; DEL assay; DNA deletions; Genotoxicity; HNO; Interchromosomal recombination; Intrachromosomal recombination; Yeast

Indexed keywords

ACETYLCYSTEINE; CANAVANINE; DNA; DNA BASE; NITROGEN DERIVATIVE; NITROXYL; OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; GENE DELETION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENOTOXICITY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; WHOLE CELL; YEAST;

ACETYLCYSTEINE; ANAEROBIOSIS; DNA, FUNGAL; MUTAGENICITY TESTS; NITRITES; NITROGEN OXIDES; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SEQUENCE DELETION;

SACCHAROMYCES CEREVISIAE;

EID: 37849031005     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2007.08.018     Document Type: Article

References (30)

1. Fukuto J.M., Dutton A.S., and Houk K.N. The chemistry and biology of nitroxyl (HNO): a chemically unique species with novel and important biological activity. Chembiochem 6 (2005) 612-619
2. Fukuto J.M., Bartberger M.D., Dutton A.S., Paolocci N., Wink D.A., and Houk K.N. The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide. Chem. Res. Toxicol. 18 (2005) 790-801
3. Ignarro L.J. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J. Physiol. Pharmacol. 53 (2002) 503-514
4. Fukuto J.M., Chiang K., Hszieh R., Wong P., and Chaudhuri G. The pharmacological activity of nitroxyl: a potent vasodilator with activity similar to nitric oxide and/or endothelium-derived relaxing factor. J. Pharmacol. Exp. Ther. 263 (1992) 546-551
5. Lee M.J., Nagasawa H.T., Elberling J.A., and DeMaster E.G. Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase. J. Med. Chem. 35 (1992) 3648-3652
6. DeMaster E.G., Redfern B., and Nagasawa H.T. Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide. Biochem. Pharmacol. 55 (1998) 2007-2015
7. Wink D.A., Feelisch M., Fukuto J., Chistodoulou D., Jourd'heuil D., Grisham M.B., Vodovotz Y., Cook J.A., Krishna M., DeGraff W.G., Kim S., Gamson J., and Mitchell J.B. The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO. Arch. Biochem. Biophys. 351 (1998) 66-74
8. Ohshima H., Gilibert I., and Bianchini F. Induction of DNA strand breakage and base oxidation by nitroxyl anion through hydroxyl radical production. Free Radic. Biol. Med. 26 (1999) 1305-1313
9. Chazotte-Aubert L., Oikawa S., Gilibert I., Bianchini F., Kawanishi S., and Ohshima H. Cytotoxicity and site-specific DNA damage induced by nitroxyl anion (NO(-)) in the presence of hydrogen peroxide. Implications for various pathophysiological conditions. J. Biol. Chem. 274 (1999) 20909-20915
10. Fedeli D., Damiani E., Greci L., Littarru G.P., and Falcioni G. Nitroxide radicals protect against DNA damage in rat epithelial cells induced by nitric oxide, nitroxyl anion and peroxynitrite. Mutat. Res. 535 (2003) 117-125
11. Hughes M.N., and Cammack R. Synthesis, chemistry, and applications of nitroxyl ion releasers sodium trioxodinitrate or Angeli's salt and Piloty's acid. Methods Enzymol. 301 (1999) 279-287
12. Shinyashiki M., Lopez B.E., Rodriguez C.E., and Fukuto J.M. Yeast model systems for examining nitrogen oxide biochemistry/signaling. Methods Enzymol. 396 (2005) 301-316
13. Schiestl R.H., Gietz R.D., Mehta R.D., and Hastings P.J. Carcinogens induce intrachromosomal recombination in yeast. Carcinogenesis 10 (1989) 1445-1455
14. Schiestl R.H. Nonmutagenic carcinogens induce intrachromosomal recombination in yeast. Nature 337 (1989) 285-288
15. Schiestl R.H., Gietz R.D., Hastings P.J., and Wintersberger U. Interchromosomal and intrachromosomal recombination in rad 18 mutants of Saccharomyces cerevisiae. Mol. Gen. Genet. 222 (1990) 25-32
16. Schiestl R.H., and Prakash S. RAD1, an excision repair gene of Saccharomyces cerevisiae, is also involved in recombination. Mol. Cell Biol. 8 (1988) 3619-3626
17. Bishop A.J., and Schiestl R.H. Role of homologous recombination in carcinogenesis. Exp. Mol. Pathol. 74 (2003) 94-105
18. Brennan R.J., and Schiestl R.H. Detecting carcinogens with the yeast DEL assay. Methods Mol. Biol. 262 (2004) 111-124
19. Whelan W.L., Gocke E., and Manney T.R. The CAN1 locus of Saccharomyces cerevisiae: fine-structure analysis and forward mutation rates. Genetics 91 (1979) 35-51
20. Smith P.A., and Hein G.E. The alleged role of nitroxyl in certain reactions of aldehydes and alkyl halides. J. Am. Chem. Soc. 82 (1960) 5731-5740
21. Kirpnick Z., Homiski M., Rubitski E., Repnevskaya M., Howlett N., Aubrecht J., and Schiestl R.H. Yeast DEL assay detects clastogens. Mutat. Res. 582 (2005) 116-134
22. Galli A., and Schiestl R.H. Cell division transforms mutagenic lesions into deletion-recombinagenic lesions in yeast cells. Mutat. Res. 429 (1999) 13-26
23. Galli A., and Schiestl R.H. Effects of DNA double-strand and single-strand breaks on intrachromosomal recombination events in cell-cycle-arrested yeast cells. Genetics 149 (1998) 1235-1250
24. Tishkoff D.X., Filosi N., Gaida G.M., and Kolodner R.D. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 88 (1997) 253-263
25. Sobol Z., Engel M.E., Rubitski E., Ku W.W., Aubrecht J., and Schiestl R.H. Genotoxicity profiles of common alkyl halides and esters with alkylating activity. Mutat. Res. 633 (2007) 80-94
26. Doetsch P.W., Morey N.J., Swanson R.L., and Jinks-Robertson S. Yeast base excision repair: interconnections and networks. Prog. Nucleic Acid Res. Mol. Biol. 68 (2001) 29-39
27. Gellon L., Barbey R., Auffret van der Kemp P., Thomas D., and Boiteux S. Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae. Mol. Genet. Genomics 265 (2001) 1087-1096
28. Gal A., and Wogan G.N. Mutagenesis associated with nitric oxide production in transgenic SJL mice. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 15102-15107
29. Tamir S., Burney S., and Tannenbaum S.R. DNA damage by nitric oxide. Chem. Res. Toxicol. 9 (1996) 821-827
30. Spek E.J., Vuong L.N., Matsuguchi T., Marinus M.G., and Engelward B.P. Nitric oxide-induced homologous recombination in Escherichia coli is promoted by DNA glycosylases. J. Bacteriol. 184 (2002) 3501-3507