Repeated simulated ischemia and protection against gap junctional uncoupling

Cell Communication and Adhesion

Volumn 14, Issue 5, 2007, Pages 239-249

  Sundset, R ^a,b   Ytrehus, K ^b   Zhang, Y ^a   Saffitz, J E ^a   Yamada, K A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Connexin43; Coupling; Gap junction; Ischemia; Preconditioning

Indexed keywords

CONNEXIN 43;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; GAP JUNCTION; HEART CELL CULTURE; HEART INFARCTION PREVENTION; HEART MUSCLE ISCHEMIA; IMMUNOBLOTTING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANIMALS, NEWBORN; CELL COMMUNICATION; CELLS, CULTURED; CONNEXIN 43; CONNEXINS; CYTOPROTECTION; GAP JUNCTIONS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; ISOQUINOLINES; MYOCARDIAL ISCHEMIA; MYOCARDIUM; MYOCYTES, CARDIAC; PHOSPHORYLATION; RATS; RATS, WISTAR;

RATTUS;

EID: 37849016364     PISSN: 15419061     EISSN: 15435180     Source Type: Journal    
DOI: 10.1080/15419060701821149     Document Type: Article

References (48)

1. Baxter, G. F., Goma, F. M. and Yellon, D. M. (1997) Characterisation of the infarct-limiting effect of delayed preconditioning: Timecourse and dose-dependency studies in rabbit myocardium. Basic Res Cardiol, 92, pp. 159-167.
2. Boengler, K., Dodoni, G., Rodriguez-Sinovas, A., Cabestrero, A., Ruiz-Meana, M., Gres, P., Konietzka, I., Lopez-Iglesias, C., Garcia-Dorado, D., Lisa, F Di, Heusch, G. and Schulz, R. (2005) Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res, 67, pp. 234-244.
3. Boengler, K., Konietzka, I., Buechert, A., Heinen, Y., Garcia-Dorado, D., Heusch, G. and Schulz, R. (2007) Loss of ischemic preconditioning's cardioprotection in aged mouse hearts is associated with reduced gap junctional and mitochondrial levels of connexin43. Am J Physiol Heart Circ Physiol, 292, pp. H1764-H1769.
4. Bolli, R. (2000) The late phase of preconditioning. Circ Res, 87, pp. 972-983.
5. Cinca, J., Warren, M., Carreno, A., Tresanchez, M., Armadans, L., Gomez, P. and Soler, J Soler (1997) Changes in myocardial electrical impedance induced by coronary artery occlusion in pigs with and without preconditioning: Correlation with local ST-segment potential and ventricular arrhythmias. Circulation, 96, pp. 3079-3086.
6. Cohen, M. V., Baines, C. P. and Downey, J. M. (2000) Ischemic preconditioning: From adenosine receptor to KATP channel. Annu Rev Physiol, 62, pp. 79-109.
7. Cruciani, V. and Mikalsen, S. O. (1999) Stimulated phosphorylation of intracellular connexin43. Exp Cell Res, 251, pp. 285-298.
8. Daleau, P., Boudriau, S., Michaud, M., Jolicoeur, C. and Kingma, J GJ (2001) Preconditioning in the absence or presence of sustained ischemia modulates myocardial Cx43 protein levels and gap junction distribution. Can J Physiol Pharmacol, 79, pp. 371-378.
9. + entry. J Mol Cell Cardiol, 30, pp. 829-835.
10. Esumi, K., Nishida, M., Shaw, D., Smith, T. W. and Marsh, J. D. (1991) NADH measurements in adult rat myocytes during simulated ischemia. Am J Physiol, 260, pp. H1743-H1752.
11. Fast, V. G., Darrow, B. J., Saffitz, J. E. and Kleber, A. G. (1996) Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuities. Circ Res, 79, pp. 115-127.
12. Dorado, D Garcia, Sinovas, A Rodriguez and Meana, M Ruiz (2004) Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion. Cardiovasc Res, 61, pp. 386-401.
13. Dorado, D Garcia, Meana, M Ruiz, Padilla, F., Sinovas, A Rodriguez and Mirabet, M. (2002) Gap junction-mediated intercellular communication in ischemic preconditioning. Cardiovasc Res, 55, pp. 456-465.
14. Goodenough, D. A., Goliger, J. A. and Paul, D. L. (1996) Connexins, connexons, and intercellular communication. Annu Rev Biochem, 65, pp. 475-502.
15. Heinzel, F. R., Luo, Y., Li, X., Boengler, K., Buechert, A., García-Dorado, D., Lisa, F Di, Schulz, R. and Heusch, G. (2005) Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res, 97, pp. 583-586.
16. Jain, S. K., Schuessler, R. B. and Saffitz, J. E. (2003) Mechanisms of delayed electrical uncoupling induced by ischemic preconditioning. Circ Res, 92, pp. 1138-1144.
17. Juhaszova, M., Zorov, D. B., Kim, S. H., Pepe, S., Fu, Q., Fishbein, K. W., Ziman, B. D., Wang, S., Ytrehus, K., Antos, C. L., Olson, E. N. and Sollott, S. J. (2004) Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest, 113, pp. 1535-1549.
18. Lerner, D. L., Beardslee, M. A. and Saffitz, J. E. (2001) The role of altered intercellular coupling in arrhythmias induced by acute myocardial ischemia. Cardiovasc Res, 50, pp. 263-269.
19. Li, G., Whittaker, P., Yao, M., Kloner, R. A. and Przyklenk, K. (2002) The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts. Cardiovasc Pathol, 11, pp. 158-165.
20. Liu, Y., Ren, G., O'Rourke, B., Marban, E. and Seharaseyon, J. (2001) Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. Mol Pharmacol, 59, pp. 225-230.
21. Kaszala, K., Vegh, A., Papp, J. G. and Parratt, J. R. (1996) Time course of the protection against ischaemia and reperfusion-induced ventricular arrhythmias resulting from brief periods of cardiac pacing. J Mol Cell Cardiol, 28, pp. 2085-2095.
22. Kwak, B. R. and Jongsma, H. J. (1996) Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions. Mol Cell Biochem, 157, pp. 93-99.
23. Lampe, P. D., Broek, E M Ten, Burt, J. M., Kurata, W. E., Johnson, R. G. and Lau, A. F. (2000) Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol, 149, pp. 1503-1512.
24. Li, H., Brodsky, S., Kumari, S., Valiunas, V., Brink, P., Kaide, J., Nasjletti, A. and Goligorsky, M. S. (2002) Paradoxical overexpression and translocation of connexin43 in homocysteine-treated endothelial cells. Am J Physiol Heart Circ Physiol, 282, pp. H2124-H2133.
25. Li, X., Heinzel, K., Boengler, R., Schulz, R. and Heusch, G. (2004) Role of connexin43 in ischemic preconditioning does not involve intercellular communication through gap junctions. J Mol Cell Cardiol, 36, pp. 161-163.
26. Miura, T., Ohnuma, Y., Kuno, A., Tanno, M., Ichikawa, Y., Nakamura, Y., Yano, T., Miki, T., Sakamoto, J. and Shimamoto, K. (2004) Protective role of gap junctions in preconditioning against myocardial infarction. Am J Physiol Heart Circ Physiol, 286, pp. H214-H221.
27. Murry, C. E., Jennings, R. B. and Reimer, K. A. (1986) Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation, 74, pp. 1124-1136.
28. Nagy, J. I., Li, W. E., Roy, C., Doble, B. W., Gilchrist, J. S., Kardami, E. and Hertzberg, E. L. (1997) Selective monoclonal antibody recognition and cellular localization of an unphosphorylated form of connexin43. Exp Cell Res, 236, pp. 127-136.
29. Padilla, F., Dorado, D Garcia, Sinovas, A Rodriguez, Meana, M Ruiz, Inserte, J. and Soler, J Soler (2003) Protection afforded by ischemic preconditioning is not mediated by effects on cell-to-cell electrical coupling during myocardial ischemia-reperfusion. Am J Physiol Heart Circ Physiol, 285, pp. H1909-H1916.
30. + exchange. Am J Physiol, 265, pp. H2017-H2026.
31. Piot, C. A., Padmanaban, D., Ursell, P. C., Sievers, R. E. and Wolfe, C. L. (1997) Ischemic preconditioning decreases apoptosis in rat hearts in vivo. Circulation, 96, pp. 1598-1604.
32. Punn, A., Mockridge, J. W., Farooqui, S., Marber, M. S. and Heads, R. J. (2000) Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes. Biochem J, 350, pp. 891-899.
33. Rizvi, A., Tang, X. L., Qiu, Y., Xuan, Y. T., Takano, H., Jadoon, A. K. and Bolli, R. (1999) Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning. Am J Physiol, 277, pp. H874-H884.
34. Rodriguez-Sinovas, A., Boengler, K., Cabestrero, A., Gres, P., Morente, M., Ruiz-Meana, M., Konietzka, I., Miró, E., Totzeck, A., Heusch, G., Schulz, R. and Garcia-Dorado, D. (2006) Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. Circ Res, 99, pp. 93-101.
35. Meana, M Ruiz, Dorado, D Garcia, Hofstaetter, B., Piper, H. M. and Soler, J Soler (1999) Propagation of cardiomyocyte hypercontracture by passage of Na(+) through gap junctions. Circ Res, 85, pp. 280-287.
36. Saez, J. C., Berthoud, V. M., Moreno, A. P. and Spray, D. C. (1993) Gap junctions. Multiplicity of controls in differentiated and undifferentiated cells and possible functional implications. Adv Second Messenger Phosphoprotein Res, 27, pp. 163-198.
37. Saez, J. C., Nairn, A. C., Czernik, A. J., Fishman, G. I., Spray, D. C. and Hertzberg, E. L. (1997) Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions. J Mol Cell Cardiol, 29, pp. 2131-2145.
38. Schulz, R., Gres, P., Skyschally, A., Duschin, A., Belosjorow, S., Konietzka, I. and Heusch, G. (2003) Ischemic preconditioning preserves connexin 43 phosphorylation during ischemia in pig hearts in vivo. FASEB J, 17, pp. 1355-1357.
39. Schulz, R. and Heusch, G. (2004) Connexin 43 and ischemic preconditioning. Cardiovasc Res, 62, pp. 335-344.
40. Schwanke, U., Konietzka, I., Duschin, A., Li, X., Schulz, R. and Heusch, G. (2002) No ischemic preconditioning in heterozygous connexin43-deficient mice. Am J Physiol Heart Circ Physiol, 283, pp. H1740-H1742.
41. Schwanke, U., Li, X., Schulz, R. and Heusch, G. (2003) No ischemic preconditioning in heterozygous connexin 43-deficient mice - a further in vivo study. Basic Res Cardiol, 98, pp. 181-182.
42. Solan, J. L., Fry, M. D., Broek, E M Ten and Lampe, P. D. (2003) Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. J Cell Sci, 116, pp. 2203-2211.
43. Tang, X. L., Qiu, Y., Park, S. W., Sun, J. Z., Kalya, A. and Bolli, R. (1996) Time course of late preconditioning against myocardial stunning in conscious pigs. Circ Res, 79, pp. 424-434.
44. Tan, H. L., Mazon, P., Verberne, H. J., Sleeswijk, M. E., Coronel, R., Opthof, T. and Janse, M. J. (1993) Ischaemic preconditioning delays ischaemia induced cellular electrical uncoupling in rabbit myocardium by activation of ATP sensitive potassium channels. Cardiovasc Res, 27, pp. 644-651.
45. TenBroek, E. M., Lampe, P. D., Solan, J. L., Reynhout, J. K. and Johnson, R. G. (2001) Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP. J Cell Biol, 155, pp. 1307-1318.
46. Verheule, S., van Kempen, M. J., Welscher, P H te, Kwak, B. R. and Jongsma, H. J. (1997) Characterization of gap junction channels in adult rabbit atrial and ventricular myocardium. Circ Res, 80, pp. 673-681.
47. Cramer, B J Warn, Lampe, P. D., Kurata, W. E., Kanemitsu, M. Y., Loo, L. W., Eckhart, W. and Lau, A. F. (1996) Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem, 271, pp. 3779-3786.
48. Zhuang, J., Yamada, K. A., Saffitz, J. E. and Kleber, A. G. (2000) Pulsatile stretch remodels cell-to-cell communication in cultured myocytes. Circ Res, 87, pp. 316-322.