Preconditioning in the absence or presence of sustained ischemia modulates myocardial Cx43 protein levels and gap junction distribution

Canadian Journal of Physiology and Pharmacology

Volumn 79, Issue 5, 2001, Pages 371-378

  Daleau, P ^a   Boudriau, S ^a   Michaud, M ^a   Jolicoeur, C ^a   Kingma J G , Jr ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Connexin43; Gap junction; Heart; Ischemic preconditioning; Reperfusion

Indexed keywords

CONNEXIN 43; HEART ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; GAP JUNCTION; HEART ARRHYTHMIA; HEART HEMODYNAMICS; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; TIME;

EID: 0034872137     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y01-004     Document Type: Article

References (45)

1. Delayed myocardial protection following ischaemic preconditioning
2. Rapid turnover of connexin43 in the adult rat heart
3. Stability of the cytoskeleton contributes to preconditioning-induced cardioprotection
4. The survival of embryonic cardiomyocytes transplanted into damaged host rat myocardium
5. Intracellular Ca2+, intercellular electrical coupling, and mechanical activity in ischemic rabbit papillary muscle. Effects of preconditioning and metabolic blockade
6. Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts
7. Failure of AICA riboside to limit infarct size during acute myocardial infarction in rabbits
8. Stretch-induced protection shares a common mechanism with ischemic preconditioning in rabbit heart
9. Alterations of intercellular junctions induced by hypoxia in canine myocardium
10. Heterogeneous loss of connexin43 protein in ischemic dog hearts
11. Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers
12. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle
13. Cardiac adaptation to ischemia-reperfusion injury
14. Medical and cellular implications of stunning, hibernation and preconditioning. An NHLBI workshop
15. Degradation of connexin43 gap junctions involves both the proteasome and the lysosome
16. Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes
17. Analyzing phorbol ester effects on gap junctional communication: A dramatic inhibition of assembly
18. The low-molecular weight heparin: Enoxaparin reduces infarct size when given at reperfusion in untreated and streptokinase-treated dogs
19. Remodeling of ventricular conduction pathways in healed canine infarct border zones
20. Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43
21. How to identify and quantify an underperfused zone
22. A filter paper dye-binding assay for quantitative determination of proteins without interference from reducing agents or detergents
23. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
24. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode
25. Ischemic preconditioning is not prevented by inhibition of endothelium-derived nitric oxide
26. Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium
27. Disturbed connexin 43 gap junction distribution correlates with the location of reentrant circuits of the epicardial border zone of healing canine infarcts that cause ventricular tachycardia
28. Regional ischemic preconditioning protects remote virgin myocardium from subsequent coronary occlusion
29. Increased protein synthesis is necessary for the development of late preconditioning against myo-cardial stunning
30. Propagation of cardiomyocyte hypercontracture by passage of Na+ through gap junctions
31. Preconditioning of ischemic myocardium: Peperfusion-induced arrhythmias
32. Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy
33. The discontinuous nature of propagation in normal canine cardiac muscle. Evidence of recurrent discontinuities of intracellular resistance that affect the membrane currents
34. Effect of cellular uncoupling by heptanol on conduction in infarcted myocardium
35. ATP directly affects junctional conductance between paired ventricular myocytes isolated from guinea pig hearts
36. In vitro, rapid assembly of gap junctions is induced by cytoskeleton disruptors
37. Direct association of the gap junction protein connexin43 with ZO-1 in cardiac myocytes
38. Does nitric oxide play a role in ischemic preconditioning?
39. Lidocaine reduces infarct size in the rabbit model of myocardial reperfusion injury and inhibits neutrophil activation in vitro
40. Regulation of connexin43 gap junctional intercellular communication by mitogen-activated protein kinase
41. Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart
42. Action potential transfer in cell pairs isolated from adult rat and guinea pig ventricles
43. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment
44. A "Second window of protection" or delayed preconditioning phenomenon: Future horizons for myocardial protection?
45. v-src induced gating of connexin 43 gap junction channels