Stereochemical criteria for prediction of the effects of proline mutations on protein stability

PLoS Computational Biology

Volumn 3, Issue 12, 2007, Pages 2465-2475

  Bajaj, Kanika ^a   Madhusudhan, M S ^b   Adkar, Bharat V ^a   Chakrabarti, Purbani ^a   Ramakrishnan, C ^a   Sali, Andrej ^b   Varadarajan, Raghavan ^a,c  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINO ACIDS; CHAINS; DECISION TREES; ENZYMES; FORECASTING; HYDROGEN BONDS; STABILITY CRITERIA;

AMINO ACID RESIDUES; IN-VIVO; MAIN CHAINS; MODEL PROTEINS; NATURALLY OCCURRING; POLYPEPTIDES CHAINS; PROPERTY; PROTEIN STABILITY; PROTEIN THERMODYNAMIC STABILITY; VIVO ACTIVITY;

DIHEDRAL ANGLE;

ARABINOSE; LYSOZYME; PROLINE; BACTERIAL PROTEIN; BACTERIAL TOXIN; CCDB PROTEIN, PLASMID F; UNCLASSIFIED DRUG;

ARTICLE; HYDROGEN BOND; MUTATIONAL ANALYSIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; STEREOCHEMISTRY; THERMODYNAMICS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; METHODOLOGY; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BACTERIAL TOXINS; COMPUTER SIMULATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; SEQUENCE ANALYSIS, PROTEIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37849003218     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0030241     Document Type: Article

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