Helicobacter pylori infection affects Toll-like receptor 4 expression in human gastric mucosa

Hepato-Gastroenterology

Volumn 54, Issue 79, 2007, Pages 1941-1944

  Asahi, Kayoko ^a,c   Hai, Ying Fu ^a   Hayashi, Yujiro ^a   Eguchi, Hiroshi ^a   Murata, Hiroaki ^a   Tsujii, Masahiko ^a   Tsuji, Shingo ^a   Tanimura, Hirohisa ^b   Kawano, Sunao ^a  

^a OSAKA UNIVERSITY   (Japan)

^b Osaka Kaisei Hospital   (Japan)

^c NONE   (Japan)

Author keywords

Helicobacter pylori (H. pylori); MD 2; Toll like receptor 4 (TLR4)

Indexed keywords

MESSENGER RNA; PROTEIN MD 2; TOLL LIKE RECEPTOR 4;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ERADICATION THERAPY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH BIOPSY; STOMACH MUCOSA;

AGED; FEMALE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ANTIGEN 96; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 4;

EID: 37749041203     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Blaser MJ, Parsonnet J: Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest 1994; 94:4-8.
2. Akira S, Takeda K, Kashio T: Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001; 2:675-680.
3. Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr.: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388:394-397.
4. Kawahara T, Kuwano Y, Teshima-Kondo S, Kawai T, Nikawa T, Kishi K, Rokutan K: Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection. J Med Invest 2001; 48:190-197.
5. Su B, Ceponis PJ, Lebel S, Huynh H, Sherman PM: Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells. Infect Immun 2003; 71:3496-3502.
6. Ishihara S, Rumi MA, Kadowaki Y, Ortega-Cava CF, Yuki T, Yoshino N, Miyaoka Y, Kazumori H, Ishimura N, Amano Y, Kinoshita Y: Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol 2004; 173:1406-1416.
7. Backhed F, Rokbi B, Torstensson E, Zhao Y, Nilsson C, Seguin D, Normark S, Buchan AMJ, Richter-Dahlfors A: Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4. J Infect Dis 2003; 187:829-836.
8. Marsik C, Mayr F, Cardona F, Derhaschnig U, Wagner OF, Jilma B: Endotoxaemia modulates Toll-like receptor on lecocytes in human. Br J Haematol 2003; 121:653-656.
9. Genta RM, Graham DY: Comparison of biopsy sites for histopathologic diagnosis of Helicobacter pylori: a topographic study of H. pylori density and distribution. Gastrointest Endosc 1994; 40:342-345.
10. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K: MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 1999; 189:1777-1782.
11. Smith MF Jr, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB: Toll-like receptor (TLR)2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem 2003; 278:32552-32560.
12. Ohara T, Morishita T, Suzuki H, Hibi T: Heterozygous Thr135 Ala polymorphism at leucin-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinoma. Int J Mol Med 2006; 18:59-63.