Endotoxaemia modulates Toll-like receptors on leucocytes in humans

British Journal of Haematology

Volumn 121, Issue 4, 2003, Pages 653-656

  Marsik, Claudia ^a   Mayr, Florian ^a   Cardona, Francesco ^a   Derhaschnig, Ulla ^a   Wagner, Oswald F ^a   Jilma, Bernd ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Clinical trial; Endotoxin; Neutrophils; Toll like receptors 1, 2 and 4

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ESCHERICHIA COLI ENDOTOXIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; BOLUS INJECTION; CELL SUBPOPULATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTOXEMIA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; INFUSION; LEUKOCYTE CULTURE; MALE; MONOCYTE; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION;

ADULT; BACTERIAL TOXINS; ENDOTOXEMIA; ESCHERICHIA COLI; HUMANS; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MONOCYTES; NEUTROPHILS; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0038054131     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04350.x     Document Type: Article

References (11)

1. Guha, M. & Mackman, N. (2001) LPS induction of gene expression in human monocytes. Cell Signalling, 13, 85-94.
2. Hollenstein, U., Homoncik, M., Knobl, P., Pernerstorfer, T., Graggaber, J., Eichler, H.G., Handler, S. & Jilma, B. (2002) Acenocoumarol decreases tissue factor-dependent coagulation during systemic inflammation in humans. Clinical Pharmacolology and Therapeutics, 71, 368-374.
3. Homoncik, M., Blann, A.D., Hollenstein, U., Pernerstorfer, T., Eichler, H.G. & Jilma, B. (2000) Systemic inflammation increases shear stress-induced platelet plug formation measured by the PFA-100. British Journal of Haematology, 111, 1250-1252.
4. Jilma, B., Hergovich, N., Homoncik, M., Jilma-Stohlawetz, P., Kreuzer, C., Eichler, H.G., Zellner, M. & Pugin, J. (2000) Granulocyte colony-stimulating factor (G-CSF) downregulates its receptor (CD114) on neutrophils and induces gelatinase B release in humans. British Journal of Haematology, 111, 314-320.
5. Kurt-Jones, E.A., Mandell, L., Whitney, C., Padgett, A., Gosselin, K., Newburger, P.E. & Finberg, R.W. (2002) Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. Blood, 100, 1860-1868.
6. Mackman, N. (2000) Lipopolysaccharide induction of gene expression in human monocytic cells. Immunological Research, 21, 247-251.
7. Muzio, M., Bosisio, D., Polentarutti, N., D'Amico, G., Stoppacciaro, A., Mancinelli, R., van't Veer, C., Penton-Rol, G., Ruco, L.P., Allavena, P. & Mantovani, A. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. Journal of Immunology, 164, 5998-6004.
8. Sabroe, I., Jones, E.C., Usher, L.R., Whyte, M.K. & Dower, S.K. (2002) Toll-like receptor (TLR) 2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes m leukocyte lipopolysaccharide responses. Journal of Immunology, 168, 4701-4710.
9. Takeuchi, O. & Akira, S. (2001) Toll-like receptors; their physiological role and signal transduction system. International Immunopharmacology, 1, 625-635.
10. Visintin, A., Mazzoni, A., Spitzer, J.H., Wyllie, D.H., Dower, S.K. & Segal, D.M. (2001) Regulation of Toll-like receptors in human monocytes and dendritic cells. Journal of Immunology, 166, 249-255.
11. Wyllie, D.H., Kiss-Toth, E., Visintin, A., Smith, S.C., Boussouf, S., Segal, D.M., Duff, G.W. & Dower, S.K. (2000) Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. Journal of Immunology, 165, 7125-7132.