메뉴 건너뛰기




Volumn 10, Issue 1, 2008, Pages 54-59

Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury

Author keywords

Brain derived nerve growth factor; Erectile dysfunction; Immunophilin ligands; Nerve regeneration; Neuroprotection; Neurotrophins; Postoperative complications; Prostate cancer; Radical prostatectomy; Stem cells

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; ARTEMIN; BONE MORPHOGENETIC PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLOSPORIN; CYCLOSPORIN A; ERYTHROPOIETIN; FK 1706; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GPI 1485; GROWTH DIFFERENTIATION FACTOR 5; HERPESVIRUS VECTOR; NEUROIMMUNOPHILIN; NEURONAL NITRIC OXIDE SYNTHASE; NEUROTROPHIN; NEUROTROPHIN 4; NEURTURIN; PARVOVIRUS VECTOR; PERSEPHIN; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; RAPAMYCIN; RECOMBINANT ERYTHROPOIETIN; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 37749038332     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.1111/j.1745-7262.2008.00368.x     Document Type: Review
Times cited : (38)

References (43)
  • 1
    • 33746700193 scopus 로고    scopus 로고
    • Neuromodulatory therapy to improve erectile function recovery outcomes after pelvic surgery
    • Burnett AL, Lue TF. Neuromodulatory therapy to improve erectile function recovery outcomes after pelvic surgery. J Urol 2006; 176: 882-7.
    • (2006) J Urol , vol.176 , pp. 882-887
    • Burnett, A.L.1    Lue, T.F.2
  • 2
    • 34249031564 scopus 로고    scopus 로고
    • Penile rehabilitation should become the norm for radical prostatectomy patients
    • Mulhall J P, Morgentaler A. Penile rehabilitation should become the norm for radical prostatectomy patients. J Sex Med 2007; 4: 538-43.
    • (2007) J Sex Med , vol.4 , pp. 538-543
    • Mulhall, J.P.1    Morgentaler, A.2
  • 3
    • 34447527303 scopus 로고    scopus 로고
    • Penile rehabilitation after radical prostatectomy: Where do we stand and where are we going?
    • Wang R. Penile rehabilitation after radical prostatectomy: Where do we stand and where are we going? J Sex Med 2007; 4: 1085-97.
    • (2007) J Sex Med , vol.4 , pp. 1085-1097
    • Wang, R.1
  • 4
    • 22144465483 scopus 로고    scopus 로고
    • The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function
    • Mulhall J, Land S, Parker M, Waters WB, Flanigan RC. The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2005; 2: 532-40.
    • (2005) J Sex Med , vol.2 , pp. 532-540
    • Mulhall, J.1    Land, S.2    Parker, M.3    Waters, W.B.4    Flanigan, R.C.5
  • 5
    • 0031805037 scopus 로고    scopus 로고
    • Is there a role of hypoxemia in penile fibrosis: A viewpoint presented to the Society for the Study of Impotence
    • Mooreland RB. Is there a role of hypoxemia in penile fibrosis: A viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 1998; 10: 113-20.
    • (1998) Int J Impot Res , vol.10 , pp. 113-120
    • Mooreland, R.B.1
  • 6
    • 25144458366 scopus 로고    scopus 로고
    • Radical prostatectomy: Long-term cancer control and recovery of sexual and urinary function ("trifecta")
    • Bianco FJ Jr, Scardino PT, Eastham JA. Radical prostatectomy: Long-term cancer control and recovery of sexual and urinary function ("trifecta"). Urology 2005; 66 (5 Suppl): 83-94.
    • (2005) Urology , vol.66 , Issue.5 SUPPL. , pp. 83-94
    • Bianco, F.J.1    Scardino, P.T.2    Eastham, J.A.3
  • 8
    • 33747700268 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 1
    • Bella AJ, Lin G, Tantiwongse K, Garcia M, Lin CS, Brant W, et al. Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 1. J Sex Med 2006; 3: 815-20.
    • (2006) J Sex Med , vol.3 , pp. 815-820
    • Bella, A.J.1    Lin, G.2    Tantiwongse, K.3    Garcia, M.4    Lin, C.S.5    Brant, W.6
  • 9
    • 34247347022 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: New experimental paradigms
    • Valentine H, Chen Y, Guo Y, McCormick J, Wu Y, Sezen SF, et al. Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: New experimental paradigms. Eur Urol 2007; 51: 1724-31.
    • (2007) Eur Urol , vol.51 , pp. 1724-1731
    • Valentine, H.1    Chen, Y.2    Guo, Y.3    McCormick, J.4    Wu, Y.5    Sezen, S.F.6
  • 10
    • 8144228785 scopus 로고    scopus 로고
    • The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury
    • Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, et al. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int 2004; 94: 904-9.
    • (2004) BJU Int , vol.94 , pp. 904-909
    • Bochinski, D.1    Lin, G.T.2    Nunes, L.3    Carrion, R.4    Rahman, N.5    Lin, C.S.6
  • 11
    • 33745254222 scopus 로고    scopus 로고
    • Structural effects and potential changes in growth factor signaling in penis-projecting autonomic neurons after axotomy
    • Palma CA, Keast JR. Structural effects and potential changes in growth factor signaling in penis-projecting autonomic neurons after axotomy. BMC Neurosci 2006; 7: 41.
    • (2006) BMC Neurosci , vol.7 , pp. 41
    • Palma, C.A.1    Keast, J.R.2
  • 12
    • 34548297591 scopus 로고    scopus 로고
    • Daily administration of phosphodiesterase type 5 inhibitors for urological and nonurological indications
    • Bella AJ, DeYoung L, al-Numi M, Brock GB. Daily administration of phosphodiesterase type 5 inhibitors for urological and nonurological indications. Eur Urol 2007; 52: 990-1005.
    • (2007) Eur Urol , vol.52 , pp. 990-1005
    • Bella, A.J.1    DeYoung, L.2    al-Numi, M.3    Brock, G.B.4
  • 13
    • 34247357886 scopus 로고    scopus 로고
    • Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: New experimental paradigms
    • Mulhall J. Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: New experimental paradigms. Eur Urol 2007; 51: 1488-9.
    • (2007) Eur Urol , vol.51 , pp. 1488-1489
    • Mulhall, J.1
  • 14
    • 33747638627 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 2
    • Lin G, Bella AJ, Lue T, Lin CS. Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 2. J Sex Med 2006; 3: 821-9.
    • (2006) J Sex Med , vol.3 , pp. 821-829
    • Lin, G.1    Bella, A.J.2    Lue, T.3    Lin, C.S.4
  • 15
    • 0042411135 scopus 로고    scopus 로고
    • The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model
    • Hsieh PS, Bochinski DJ, Lin GT, Nunes L, Lin CS, Lue TF. The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model. BJU Int 2003; 92: 470-5.
    • (2003) BJU Int , vol.92 , pp. 470-475
    • Hsieh, P.S.1    Bochinski, D.J.2    Lin, G.T.3    Nunes, L.4    Lin, C.S.5    Lue, T.F.6
  • 16
    • 34250735626 scopus 로고    scopus 로고
    • Upregulation of penile brain-derived neurotrophic factor (BDNF) and activation of the JAK/STAT signaling pathway in the major pelvic ganglion of the rat following cavernous nerve transection
    • Bella AJ, Lin G, Garcia MM, Tantiwonge T, Lin CS, Brant WO, et al. Upregulation of penile brain-derived neurotrophic factor (BDNF) and activation of the JAK/STAT signaling pathway in the major pelvic ganglion of the rat following cavernous nerve transection. Eur Urol 2007; 52: 574-81.
    • (2007) Eur Urol , vol.52 , pp. 574-581
    • Bella, A.J.1    Lin, G.2    Garcia, M.M.3    Tantiwonge, T.4    Lin, C.S.5    Brant, W.O.6
  • 17
    • 18844412425 scopus 로고    scopus 로고
    • Neurotrophin-3 is a target derived neurotrophic factor for penile erection-inducing neurons
    • Hiltunen JO, Laurikainen A, Klinge E, Saarma M. Neurotrophin-3 is a target derived neurotrophic factor for penile erection-inducing neurons. Neuroscience 2005; 133: 51-8.
    • (2005) Neuroscience , vol.133 , pp. 51-58
    • Hiltunen, J.O.1    Laurikainen, A.2    Klinge, E.3    Saarma, M.4
  • 18
    • 18544367145 scopus 로고    scopus 로고
    • The additive erectile recovery effect of brain-derived neurotrophic factor combined with vascular endothelial growth factor in a rat model or neurogenic impotence
    • Chen KC, Minor TX, Rahman NU, Ho HC, Nunes L, Lue TF. The additive erectile recovery effect of brain-derived neurotrophic factor combined with vascular endothelial growth factor in a rat model or neurogenic impotence. BJU Int 2005; 95: 1077-80.
    • (2005) BJU Int , vol.95 , pp. 1077-1080
    • Chen, K.C.1    Minor, T.X.2    Rahman, N.U.3    Ho, H.C.4    Nunes, L.5    Lue, T.F.6
  • 19
    • 22044438251 scopus 로고    scopus 로고
    • Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats
    • Mitsui T, Fischer I, Shumsky JS, Murray M. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Exp Neurol 2005; 194: 410-31.
    • (2005) Exp Neurol , vol.194 , pp. 410-431
    • Mitsui, T.1    Fischer, I.2    Shumsky, J.S.3    Murray, M.4
  • 21
    • 34548451681 scopus 로고    scopus 로고
    • Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury
    • Kato R, Wolfe D, Coyle CH, Huang S, Wechuck JB, Goins WF, et al. Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury. Gene Ther 2007; 14: 1344-52.
    • (2007) Gene Ther , vol.14 , pp. 1344-1352
    • Kato, R.1    Wolfe, D.2    Coyle, C.H.3    Huang, S.4    Wechuck, J.B.5    Goins, W.F.6
  • 23
    • 33746891485 scopus 로고    scopus 로고
    • The effect of intracavernous growth differentiation factor-5 in a rat model of cavernous nerve injury
    • Fandel T, Bella AJ, Tantiwongse K, Garcia M, Nunes L, Thuroff JW, et al. The effect of intracavernous growth differentiation factor-5 in a rat model of cavernous nerve injury. BJU Int 2006; 98: 632-36.
    • (2006) BJU Int , vol.98 , pp. 632-636
    • Fandel, T.1    Bella, A.J.2    Tantiwongse, K.3    Garcia, M.4    Nunes, L.5    Thuroff, J.W.6
  • 24
    • 20044376614 scopus 로고    scopus 로고
    • The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurons: Relevance to Parkinson's disease treatment
    • Sullivan AM, O'Keeffe GW. The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurons: relevance to Parkinson's disease treatment. J Anat 2005; 207: 219-26.
    • (2005) J Anat , vol.207 , pp. 219-226
    • Sullivan, A.M.1    O'Keeffe, G.W.2
  • 25
    • 37749040169 scopus 로고    scopus 로고
    • Intracavernous growth differentiation factor-5 therapy enhances the recovery of erectile function in a rat model of cavernous nerve injury
    • (Abstract 670)
    • Fandel TM, Bella AJ, Lin G, Tantiwongse K, Banie L, Thurhoff JW, et al. Intracavernous growth differentiation factor-5 therapy enhances the recovery of erectile function in a rat model of cavernous nerve injury. J Urol 2007; 177: 225 (Abstract 670).
    • (2007) J Urol , vol.177 , pp. 225
    • Fandel, T.M.1    Bella, A.J.2    Lin, G.3    Tantiwongse, K.4    Banie, L.5    Thurhoff, J.W.6
  • 26
    • 33748349205 scopus 로고    scopus 로고
    • Healos/recombinant human growth and differentiation factor-5 induces posterolateral lumbar fusion in a New Zealand white rabbit model
    • Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, et al. Healos/recombinant human growth and differentiation factor-5 induces posterolateral lumbar fusion in a New Zealand white rabbit model. Spine 2006; 31: 2180-8.
    • (2006) Spine , vol.31 , pp. 2180-2188
    • Magit, D.P.1    Maak, T.2    Trioano, N.3    Raphael, B.4    Hamouria, Q.5    Polzhofer, G.6
  • 27
    • 0034775552 scopus 로고    scopus 로고
    • Immunophilin ligand FK 506 is neuroprotective for penile innervation
    • Sezen SF, Hoke A, Burnett AL, Snyder SH. Immunophilin ligand FK 506 is neuroprotective for penile innervation. Nat Med 2001; 710: 1073-4.
    • (2001) Nat Med , vol.710 , pp. 1073-1074
    • Sezen, S.F.1    Hoke, A.2    Burnett, A.L.3    Snyder, S.H.4
  • 28
    • 34447498964 scopus 로고    scopus 로고
    • FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms
    • Lagoda G, Jin L, Lehrfeld TJ, Liu T, Burnett AL. FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms. J Sex Med 2007; 4: 908-16.
    • (2007) J Sex Med , vol.4 , pp. 908-916
    • Lagoda, G.1    Jin, L.2    Lehrfeld, T.J.3    Liu, T.4    Burnett, A.L.5
  • 29
  • 30
    • 3042739759 scopus 로고    scopus 로고
    • Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells
    • Tanaka K, Asanuma M, Ogawa N. Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells. Neurochem Res 2004; 29: 1529-36.
    • (2004) Neurochem Res , vol.29 , pp. 1529-1536
    • Tanaka, K.1    Asanuma, M.2    Ogawa, N.3
  • 31
    • 33745244235 scopus 로고    scopus 로고
    • Erectile recovery effect of FK1706 following a bilateral cavernous nerve crush injury in a rat model
    • Hayashi N, Minor TX, Carrion R, Price RD, Nunes L, Lue TF. Erectile recovery effect of FK1706 following a bilateral cavernous nerve crush injury in a rat model. J Urol 2006; 176: 824-9.
    • (2006) J Urol , vol.176 , pp. 824-829
    • Hayashi, N.1    Minor, T.X.2    Carrion, R.3    Price, R.D.4    Nunes, L.5    Lue, T.F.6
  • 32
    • 0037063708 scopus 로고    scopus 로고
    • The non-immunosuppressive immunophilin ligand GPI-1046 potently stimulated regenerating axon growth from adult mouse dorsal root ganglia cultured in Matrigel
    • Khan Z, Ferrari F, Kasper M, Tonge DA, Steiner JP, Hamilton GS, et al. The non-immunosuppressive immunophilin ligand GPI-1046 potently stimulated regenerating axon growth from adult mouse dorsal root ganglia cultured in Matrigel. Neuro-science 2002; 114: 601-9.
    • (2002) Neuro-science , vol.114 , pp. 601-609
    • Khan, Z.1    Ferrari, F.2    Kasper, M.3    Tonge, D.A.4    Steiner, J.P.5    Hamilton, G.S.6
  • 34
    • 33947101455 scopus 로고    scopus 로고
    • FK1706 enhances functional recovery following bilateral cavernous nerve crush injury in a rat model
    • Bella AJ, Hayashi N, Carrion R, Price R, Lue TF. FK1706 enhances functional recovery following bilateral cavernous nerve crush injury in a rat model. J Sex Med 2007; 4: 341-47.
    • (2007) J Sex Med , vol.4 , pp. 341-347
    • Bella, A.J.1    Hayashi, N.2    Carrion, R.3    Price, R.4    Lue, T.F.5
  • 35
    • 0346848798 scopus 로고    scopus 로고
    • Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury
    • Burnett AL, Becker RE. Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury. J Urol 2004; 171: 495-500.
    • (2004) J Urol , vol.171 , pp. 495-500
    • Burnett, A.L.1    Becker, R.E.2
  • 36
    • 37749054920 scopus 로고    scopus 로고
    • Neuromodulation to preserve erectile function after radical prostatectomy: Results from the GPI 1485 neuroimmunophilin ligand clinical trial
    • (Abstract 1162)
    • Burnett AL, McCullough AR, Smith JA Jr, Montie JE, Walsh PC, Steiner JP. Neuromodulation to preserve erectile function after radical prostatectomy: Results from the GPI 1485 neuroimmunophilin ligand clinical trial. J Urol 2007; 177: 383-4 (Abstract 1162).
    • (2007) J Urol , vol.177 , pp. 383-384
    • Burnett, A.L.1    McCullough, A.R.2    Smith Jr., J.A.3    Montie, J.E.4    Walsh, P.C.5    Steiner, J.P.6
  • 37
    • 18844421337 scopus 로고    scopus 로고
    • Nonimmuno-suppressant immunophilin ligand GPI-1046 does not promote in vitro growth of prostate cancer cells
    • Burnett AL, Kramer MF, Dalrymple S, Isaacs JT. Nonimmuno-suppressant immunophilin ligand GPI-1046 does not promote in vitro growth of prostate cancer cells. Urology 2005; 65: 1003-7.
    • (2005) Urology , vol.65 , pp. 1003-1007
    • Burnett, A.L.1    Kramer, M.F.2    Dalrymple, S.3    Isaacs, J.T.4
  • 38
    • 35148857245 scopus 로고    scopus 로고
    • Erythropoetin receptor expression in the human urogenital tract: Immunolocalization in the prostate, neurovascular bundle, and penis
    • Liu T, Allaf ME, Lagoda G, Burnett AL. Erythropoetin receptor expression in the human urogenital tract: Immunolocalization in the prostate, neurovascular bundle, and penis. BJU Int 2007; 100: 1103-6.
    • (2007) BJU Int , vol.100 , pp. 1103-1106
    • Liu, T.1    Allaf, M.E.2    Lagoda, G.3    Burnett, A.L.4
  • 39
    • 27544450744 scopus 로고    scopus 로고
    • Erythropoetin promotes the recovery of erectile function following cavernous nerve injury
    • Allaf ME, Hoke A, Burnett AL. Erythropoetin promotes the recovery of erectile function following cavernous nerve injury. J Urol 2005; 174: 2060-4.
    • (2005) J Urol , vol.174 , pp. 2060-2064
    • Allaf, M.E.1    Hoke, A.2    Burnett, A.L.3
  • 40
    • 8144228785 scopus 로고    scopus 로고
    • The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury
    • Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, et al. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int 2005; 94: 904-9.
    • (2005) BJU Int , vol.94 , pp. 904-909
    • Bochinski, D.1    Lin, G.T.2    Nunes, L.3    Carrion, R.4    Rahman, N.5    Lin, C.S.6
  • 41
    • 34447531567 scopus 로고    scopus 로고
    • Adult bone marrow stem cells isolated by the p75 nerve growth factor receptor into the corpora cavernosa promoted recovery of erectile function in cavernous nerve injury
    • (Abstract OR-008)
    • Kendirci M, Spees JL, Trost L, Whitney MJ, Prockop DJ, Hellstrom WJ. Adult bone marrow stem cells isolated by the p75 nerve growth factor receptor into the corpora cavernosa promoted recovery of erectile function in cavernous nerve injury. J Sex Med 2006; 3 (Suppl 5): 384 (Abstract OR-008).
    • (2006) J Sex Med , vol.3 , Issue.SUPPL. 5 , pp. 384
    • Kendirci, M.1    Spees, J.L.2    Trost, L.3    Whitney, M.J.4    Prockop, D.J.5    Hellstrom, W.J.6
  • 42
    • 33847711835 scopus 로고    scopus 로고
    • Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction
    • Bivalacqua TJ, Deng W, Kendirci M, Usta MF, Robinson C, Taylor BK, et al. Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. Am J Physiol Heart Circ Physiol 2007; 292: H1278-90.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Bivalacqua, T.J.1    Deng, W.2    Kendirci, M.3    Usta, M.F.4    Robinson, C.5    Taylor, B.K.6
  • 43
    • 37749041098 scopus 로고    scopus 로고
    • Adult adipose tissue derived stem cells enhance neurite outgrowth from the major pelvic ganglion of the rat
    • (Abstract 2.01)
    • Bella AJ, Garcia MM, Lin G, Fandel TM, Brant WO, Lue TF. Adult adipose tissue derived stem cells enhance neurite outgrowth from the major pelvic ganglion of the rat. CUAJ 2007; 1: 200 (Abstract 2.01).
    • (2007) CUAJ , vol.1 , pp. 200
    • Bella, A.J.1    Garcia, M.M.2    Lin, G.3    Fandel, T.M.4    Brant, W.O.5    Lue, T.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.