Upregulation of Penile Brain-Derived Neurotrophic Factor (BDNF) and Activation of the JAK/STAT Signalling Pathway in the Major Pelvic Ganglion of the Rat After Cavernous Nerve Transection

European Urology

Volumn 52, Issue 2, 2007, Pages 574-581

  Bella, Anthony J ^a   Lin, Guiting ^a   Garcia, Maurice M ^a   Tantiwongse, Kavirach ^a   Brant, William O ^a   Lin, Ching Shwun ^a   Lue, Tom F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Animal model; Brain derived neurotrophic factor; Impotence; Janus kinase; Nerve regeneration; Neuroprotective agents

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; JANUS KINASE; MESSENGER RNA; NEUROTROPHIN 3; PROTEIN; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN;

ANIMAL TISSUE; ARTICLE; CORPUS CAVERNOSUM; ENZYME ACTIVATION; GANGLION; IMMUNOHISTOCHEMISTRY; MALE; MODULATION; NERVE FIBER TRANSECTION; NERVE REGENERATION; NONHUMAN; PELVIS; PENIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; SURVIVAL; UPREGULATION;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; GANGLIA, PARASYMPATHETIC; IMMUNOENZYME TECHNIQUES; JANUS KINASE 1; JANUS KINASES; MALE; PENIS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 34250735626     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2006.10.043     Document Type: Article

References (21)

1. Dubbelman Y.D., Dohle G.R., and Schröder F.H. Sexual function before and after radical retropubic prostatectomy: a systematic review of prognostic indicators for a successful outcome. Eur Urol 50 (2006) 711-720
2. Stone N.N., and Stock R.G. Complications following permanent prostate brachytherapy. Eur Urol 41 (2002) 427-433
3. May F., Vroeman M., Matiasek K., et al. Nerve replacement strategies for cavernous nerves. Eur Urol 48 (2005) 372-378
4. Yamauchi K., Osuka K., Takayasu M., et al. Activation of JAK/STAT signalling in neurons following spinal cord injury in mice. J Neurochem 96 (2006) 1060-1070
5. Mousavi K., Parry D.J., and Jasmin B.J. BDNF rescues myosin heavy chain IIb muscle fibres after neonatal nerve injury. Am J Physiol Cell Physiol 287 (2004) C22-C29
6. Bakircioglu M.E., Lin C.-S., Fan P., et al. The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence. J Urol 165 (2001) 2103-2109
7. Hsieh P.S., Bochinski D.J., Lin G.T., et al. The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model. BJU Int 92 (2003) 470-475
8. Lin G., Chen K.C., Hsieh P.S., et al. Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia. BJU Int 92 (2003) 631-635
9. Bella A., Lin G., Tantiwongse K., et al. Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: part 1. J Sex Med 3 (2006) 815-820
10. Lin G., Bella A., Lue T., et al. Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: Part 2. J Sex Med 3 (2006) 821-827
11. Hiltunen J.O., Laurikainen A., Klinge E., and Saarma M. Neurotrophin-3 is a target derived neurotrophic factor for penile erection-inducing neurons. Neuroscience 133 (2005) 51-58
12. Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
13. Chin Y.E., Kitagawa M., Su W.C., et al. Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1. Science 272 (1996) 719-722
14. Liu K.D., Gaffen S.L., and Goldsmith M.A. JAK/STAT signalling by cytokine receptors. Curr Opin Immunol 10 (1998) 271-278
15. Darnell Jr. J.E., Kerr I.M., and Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994) 1415-1421
16. Sheu J.Y., Kulhanek D.J., and Eckenstein F.P. Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transection in the rat. Exp Neurol 166 (2000) 392-402
17. Symes A., Gearan T., Eby J., et al. Integration of JAK-STAT and AP-1 signaling pathways at the vasoactive intestinal peptide cytokine response element regulates ciliary neurotrophic factor-dependent transcription. J Biol Chem 272 (1997) 9648-9654
18. Symes A., Lewis S., Corpus L., et al. STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines. Mol Endocrin 8 (1994) 1750-1763
19. Coffer P., Lutticken C., Vanpuijenbroek A., et al. Transcriptional regulation of the junb promoter - analysis of STAT-mediated signal transduction. Oncogene 10 (1995) 985-994
20. Schaefer T.S., Sanders L.K., and Nathans D. Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. Proc Natl Acad Sci USA 92 (1995) 9097-9101
21. Valentino L., and Pierre J. JAK/STAT signal transduction: regulators and implication in hematological malignancies. Biochem Pharmacol 71 (2006) 713-721