Cardiovascular and neuroendocrine responses to exercise in hypoxia during impaired neural feedback from muscle

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 277, Issue 1 46-1, 1999, Pages

  Kjær, Michael ^a   Hanel, Birgitte ^b   Worm, Lars ^b   Perko, Grazyna ^b   Lewis, Steven F ^b   Sahlin, Kent ^b   Galbo, Henrik ^c   Secher, Niels H ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Copenhagen   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Altitude; Blood flow; Blood pressure; Cardiac output; Catecholamines; Epinephrine; Free fatty acids; Glucagon; Glucose production; Glucose uptake; Heart rate; Insulin; Lactate; Norepinephrine; Oxygen tension; Physical exertion; Pituitary hormones; Renin

Indexed keywords

CATECHOLAMINE; CORTICOTROPIN; CREATINE; CREATINE PHOSPHATE; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; INOSINE PHOSPHATE; INSULIN; LACTIC ACID; NORADRENALIN; RENIN;

ADULT; ARTICLE; EXERCISE; FEEDBACK SYSTEM; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HEART OUTPUT; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LEG BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MUSCLE CONTRACTION; NORMAL HUMAN; OXYGEN TENSION; PRIORITY JOURNAL;

EID: 0032806178     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1999.277.1.r76     Document Type: Article

References (38)

1. Adams, L., J. Garlick, A. Guz, K. Murphy, and S. J. G. Semple. Is the voluntary control of exercise in man necessary for the ventilatory response? J. Physiol. (Lond.) 355: 71-83, 1984.
2. Alam, M., and F. H. Smirk. Observations in man upon blood pressure raising reflex arising from voluntary muscles. J. Physiol. (Lond.) 89: 372-383, 1937.
3. Borg, G. Perceived exertion as indicator of somatic stress. Scared. J. Rehabil. Med. 2: 92-98, 1970.
4. Brooks, G. A., G. E. Butterfield, R. R. Wolfe, B. M. Groves, R. S. Mazzeo, J. R. Sutton, E. E. Wolfel, and J. T. Reeves. Increased dependence on blood glucose after acclimatization to 4300 m. J. Appl. Physiol. 70: 919-927, 1991.
5. Cartee, G. D., A. G. Douen, T. Ramlal, A. Klip, and J. O. Holloszy. Stimulation of glucose transport in skeletal muscle by hypoxia. J. Appl. Physiol. 70: 1593-1600, 1991.
6. o2 breathing in man. Am. J. Physiol. 251 (Endocrinol. Metab. 14): E209-E214, 1986.
7. Coote, J. H., S. M. Hilton, and J. F. Perez-Gonzalez. The reflex nature of the pressor response to muscular exercise. J. Physiol. (Lond.) 215: 789-804, 1971.
8. Fernandes, A., H. Galbo, M. Kjær, J. H. Mitchell, N. H. Secher, and S. N. Thomas. Cardiovascular and ventilatory responses to dynamic exercise during epidural anaesthesia in man. J. Physiol. (Lond.) 420: 281-293, 1990.
9. Freund, P. R., L. R. Rowell, T. H. Murphy, S. F. Hobbs, and S. H. Butler. Blockade of the pressor response to muscle ischemia by sensory nerve block in man. Am. J. Physiol. 237 (Heart Circ. Physiol. 6): H433-H439, 1979.
10. Galbo, H., N. J. Christensen, K. J. Mikines, B. Sonne, J. Hilsted, C. Hagen, and J. Fahrenkrug. The effect of fasting on the hormonal response to graded exercise. J. Clin. Endocrinol. Metab. 52: 1106-1112, 1981.
11. Galbo, H., M. Kjær, and N. H. Secher. Cardiovascular, ventilatory and catecholamine responses to maximal dynamic exercise in partially curarized man. J. Physiol. (Lond.) 389: 557-568, 1987.
12. Hetenyi, G., and K. H. Norwich. Validity of the rates of production and utilization of metabolites as determined by tracer methods in intact animals. Federation Proc. 33: 1841-1848, 1974.
13. Hill, J. M., J. G. Pickar, M. D. Parrish, and M. P. Kaufman. Effects of hypoxia on the discharge of group III and IV afferents in cats. J. Appl. Physiol. 73: 2524-2529, 1992.
14. Hornbein, T. F., S. C. Sørensen, and C. R. Parks. Role of muscle spindles in lower extremities in breathing during bicycle exercise. J. Appl. Physiol. 27: 467-479, 1969.
15. Katz, A., and K. Sahlin. Effect of decreased oxygen availability on NADH and lactate contents in human skeletal muscle during exercise. Acta Physiol. Scared. 131: 119-127, 1987.
16. Kjær, M., J. Bangsbo, G. Lortie, and H. Galbo. Hormonal response to exercise in humans: influence of hypoxia and physical training. Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R197-R203, 1988.
17. Kjær, M., K. Engfred, A. Fernandes, N. H. Secher, and H. Galbo. Regulation of hepatic glucose production during exercise in humans: role of sympathoadrenergic activity. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E275-E283, 1993.
18. Kæer, M., P. A. Farrell, N. J. Christensen, and H. Galbo. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J. Appl. Physiol. 61: 1693-1700, 1986.
19. Kjær, M., G. Perko, N. H. Secher, R. Boushel, N. Beyer, S. Pollack, A. Horn, A. Fernandes, T. Mohr, S. F. Lewis, and H. Galbo. Cardiovascular and ventilatory responses to electrically induced cycling with complete epidural anesthesia in humans. Acta Physiol. Scared. 151: 199-207, 1994.
20. Kjær, M., S. F. Pollack, T. Mohr, H. Weiss, G. W. Gleim, F. W. Bach, T. Nicolaisen, H. Galbo, and K. T. Ragnarsson. Regulation of glucose turnover and hormonal responses during electrical cycling in tetraplegic humans. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R191-R199, 1996.
21. Kjær, M., N. H. Secher, F. W. Bach, and H. Galbo. Role of motor center activity for hormonal changes and substrate mobilization in humans. Am. J. Physiol. 253 (Regulatory Integrative Comp. Physiol. 22): R687-R695, 1987.
22. Kjær, M., N. H. Secher, F. W. Bach, H. Galbo, D. R. Reeves, and J. H. Mitchell. Hormonal, metabolic, and cardiovascular responses to static exercise in humans: influence of epidural anesthesia. Am. J. Physiol. 261 (Endocrinol. Metab. 24): E214-E220, 1991.
23. Kjær, M., N. H. Secher, F. W. Bach, S. Sheikh, and H. Galbo. Hormonal and metabolic responses to exercise in humans: effect of sensory nervous blockade. Am. J. Physiol. 257 (Endocrinol. Metab. 20): E95-E101, 1989.
24. Kjær, M., N. H. Secher, J. Bangsbo, G. Perko, A. Horn, T. Mohr, and H. Galbo. Hormonal and metabolic responses to electrically induced cycling during epidural anesthesia in humans. J. Appl. Physiol. 80: 2156-2162, 1996.
25. Lowry, O. H., and J. V. Passonneau. A Flexible System of Enzymatic Analysis. New York: Academic, 1972.
26. McCloskey, D. I., and J. H. Mitchell. Reflex cardiovascular and respiratory responses originating in exercising muscle. J. Physiol. (Lond.) 224: 173-186, 1972.
27. Mitchell, J. H., W. C. Reardon, and D. I. McCloskey. Reflex effects on circulation and respiration from contracting skeletal muscle. Am. J. Physiol. 233 (Heart Circ. Physiol. 2): H374-H378, 1977.
28. Rowell, L. B. Human Cardiovascular Control. New York: Oxford University Press, 1993.
29. Rowell, L. B., J. R. Blackmon, and R. A. Bruce. Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man. J. Clin. Invest. 43: 1677-1690, 1964.
30. Rowell, L. B., J. R. Blackmon, M. A. Kenny, and P. Escourrou. Splanchnic vasomotor and metabolic adjustment to hypoxia and exercise in humans. Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H251-H258, 1984.
31. Sahlin, K., J. Gorski, and L. Edström. Influence of ATP turnover and metabolic changes on IMP formation and glycolysis in rat skeletal muscle. Am. J. Physiol. 259 (Cell Physiol. 28): C409-C412, 1990.
32. Savard, G., S. Strange, B. Kiens, B. Saltin, E. A. Richter, and N. J. Christensen. Norepinephrine spillover during exercise in active versus resting skeletal muscle in man. Acta Physiol. Scand. 131: 507-515, 1987.
33. Searls, D. R., D. G. Johnson, and R. F. Fregosi. Hypoxia potentiates exercise-induced sympathetic neural activation in humans. J. Appl. Physiol. 71: 1032-1040, 1992.
34. Steele, R., J. S. Wall, R. C. deBodo, and N. Altszuler. Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am. J. Physiol. 187: 15-24, 1956.
35. Steenberg, J., B. Ekblom, and R. Messin. Hemodynamic response to work at simulated altitude, 4000 m. J. Appl. Physiol. 21: 1589-1594, 1966.
36. Strange, S., N. H. Secher, J. A. Pawelczyk, J. A. Karpakka, N. J. Christensen, J. H. Mitchell, and B. Saltin. Neural control of cardiovascular responses and of ventilation during dynamic exercise in man. J. Physiol. (Lond.) 470: 693-704, 1993.
37. Sutton, J. R., K. T. Reeves, P. D. Wagner, B. M. Groves, A. Cymerman, M. K. Malconian, P. B. Rock, P. A. Young, S. D. Walter, and C. S. Houston. Operation Everest II: oxygen transport during exercise at extreme simulated exercise. J. Appl. Physiol. 64: 1309-1321, 1988.
38. Wagner, P. D., G. E. Gale, R. E. Moon, J. R. Torre-Bueno, B. W. Stolp, and H. A. Saltzman. Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J. Appl. Physiol. 61: 260-270, 1987.