Caspase-3 is related to infarct growth after human ischemic stroke

Neuroscience Letters

Volumn 430, Issue 1, 2008, Pages 1-6

  Rosell, A ^a   Cuadrado, E ^a   Alvarez Sabin J ^a   Hernandez Guillamon M ^a   Delgado, P ^a   Penalba, A ^a   Mendioroz, M ^a   Rovira, A ^b   Fernandez Cadenas I ^a   Ribo M ^a   Molina, C A ^a   Montaner, J ^a  

^a Neurovascular Research Laboratory   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Caspase 3; Diffussion weighted images; Ischemic stroke

Indexed keywords

CASPASE 3; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGED; ARTICLE; BRAIN INFARCTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

AGED; BIOLOGICAL MARKERS; BRAIN; BRAIN INFARCTION; CASPASE 3; DIFFUSION MAGNETIC RESONANCE IMAGING; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; STROKE;

EID: 37649003511     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.05.006     Document Type: Article

References (22)

1. Blandini F., Sinforiani E., Pacchetti C., Samuele A., Bazzini E., Zangaglia R., Nappi G., and Martignoni E. Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease. Neurology 66 (2006) 529-534
2. Didenko V.V., Ngo H., Minchew C.L., Boudreaux D.J., Widmayer M.A., and Baskin D.S. Caspase-3-dependent and -independent apoptosis in focal brain ischemia. Mol. Med. 8 (2002) 347-352
3. Faubel S., and Edelstein C.L. Caspases as drug targets in ischemic organ injury. Curr. Drug Targets Immune. Endocr. Metabol. Disord. 5 (2005) 269-287
4. Ferrer I., Friguls B., Dalfó E., Justicia C., and Planas A.M. Caspase-dependent and caspase-independent sgnalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat. Neuropath. Appl. Neurobiol. 29 (2003) 472-481
5. Ferrer I., and Planas A.M. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J. Neuropathol. Exp. Neurol. 62 (2003) 329-339
6. Guglielmo M.A., Chan P.T., Cortez S., Stopa E.G., McMillan P., Johanson C.E., Epstein M., and Doberstein C.E. The temporal profile and morphologic features of neuronal death in human stroke resemble those observed in experimental forebrain ischemia: the potential role of apoptosis. Neurol. Res. 20 (1998) 283-296
7. Hou S.T., and MacManus J.P. Molecular mechanisms of cerebral ischemia-induced neuronal death. Int. Rev. Cytol. 221 (2002) 93-148
8. Kerr L.E., McGregor A.L., Amet L.E., Asada T., Spratt C., Allsopp T.E., Harmar A.J., Shen S., Carlson G., Logan N., Kelly J.S., and Sharkey J. Mice overexpressing human caspase-3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia. Cell Death Differ. 11 (2004) 1102-1111
9. Kilic E., Kilic U., Yulug B., Hermann D.M., and Reiter R.J. Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator. J. Pineal. Res. 36 (2004) 171-176
10. Le D.A., Wu Y., Huang Z., Matsushita K., Plesnila N., Augustinack J.C., Hyman B.T., Yuan J., Kuida K., Flavell R.A., and Moskowitz M.A. Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 15188-15193
11. Liot G., Roussel B.D., Lebeurrier N., Benchenane K., Lopez-Atalaya J.P., Vivien D., and Ali C. Tissue-type plasminogen activator rescues neurones from serumdeprivation-induced apoptosis through a mechanism independentof its proteolytic activity. J. Neurochem. 98 (2006) 1458-1464
12. Liu D., Cheng T., Guo H., Fernandez J.A., Griffin J.H., Song X., and Zlokovic B.V. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat. Med. 10 (2004) 1379-1383
13. Love S. Apoptosis and brain ischaemia. Prog. Neuropsychopharmacol. Biol. Psychiatry 27 (2003) 267-282
14. Love S., Barber R., Srinivasan A., and Wilcock G.K. Activation of caspase-3 in permanent and transient brain ischaemia in man. Neuroreport 11 (2000) 2495-2499
15. Love S., Barber R., and Wilcock G.K. Neuronal death in brain infarcts in man. Neuropathol. Appl. Neurobiol. 26 (2000) 55-66
16. Ma J., Endres M., and Moskowitz M.A. Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice. Br. J. Pharmacol. 124 (1998) 756-762
17. Manabat C., Han B.H., Wendlad M., Derugin N., Fox C.K., Choi J., Holtzman D.M., Ferriero D.M., and Vexler Z.S. Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke 34 (2003) 207-213
18. Qi J.P., Wu A.P., Wang D.S., Wang L.F., Li S.X., and Xu F.L. Correlation between neuronal injury and caspase-3 after focal ischemia in human hippocampus. Chin. Med. J. 117 (2004) 1507-1512
19. Rosell A., Alvarez-Sabín J., Arenillas J.F., Rovira A., Delgado P., Fernandez-Cadenas I., Penalba A., Molina C.A., and Montaner J. A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke. Stroke 36 (2005) 1415-1420
20. Sairanen T., Karjalainen-Lindsberg M.L., Paetau A., Ijas P., and Lindsberg P.J. Apoptosis dominant in the periinfarct area of human ischaemic stroke: a possible target of antiapoptotic treatments. Brain 129 (2006) 189-199
21. Ünal-Çevik I., Kilinç M., Can A., Gursoy-Ozdemir Y., and Dalkara T. Apoptotic and necrotic death mechanisms are concomitantly activated in the same cell after cerebral ischemia. Stroke 35 (2004) 2189-2194
22. Yakovlev A.G., and Faden A.I. Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies. NeuroRx. 1 (2004) 5-16