TGF-β1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis

Neuroscience Letters

Volumn 430, Issue 1, 2008, Pages 81-86

  Salins, Pradeep ^a,c   He, Yang ^a,c   Olson, Kelly ^a,c   Glazner, Gordon ^a,c   Kashour, Tarek ^a,b   Amara, Francis ^a,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b ST BONIFACE GENERAL HOSPITAL   (Canada)

^c St Boniface Research Centre   (Canada)

Author keywords

catenin; Apoptosis; Smad7; TGF 1; Transgenic mice

Indexed keywords

BETA CATENIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; AMYLOID BETA PROTEIN; CATNB PROTEIN, MOUSE; SMAD7 PROTEIN, MOUSE; T CELL FACTOR PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN REGION; CELL CULTURE; CONTROLLED STUDY; DNA BINDING; GENE ACTIVITY; IMMUNOPRECIPITATION; MOUSE; NERVE CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSGENIC MOUSE; ANIMAL; BRAIN; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BETA CATENIN; BLOTTING, WESTERN; BRAIN; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; MICE; MICE, TRANSGENIC; NEURONS; SMAD7 PROTEIN; TCF TRANSCRIPTION FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 37549066655     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.10.025     Document Type: Article

References (23)

1. Amara F.M., Junaid A., Clough R., and Liang B. TGF-β1 regulation of Alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization. Brain Res. Mol. Brain. Res. 71 (1999) 42-49
2. Barker N., Morin P., and Clevers H. The Yin-Yang of TCF/β-catenin signaling. Adv. Cancer. Res. 77 (2000) 1-24
3. Chao C.C., Hu S., Kravitz F.H., Tsang M., Anderson W.R., and Peterson P.K. Transforming growth factor-β protects human neurons against β-amyloid-induced injury. Mol. Chem. Neuropathol. 23 (1994) 159-178
4. Chishti M.A., Yang D.S., Janus C., Phinney A.L., Horne P., Pearson J., Strome R., Zuker N., Loukides J., French J., Turner S., Lozza G., Grilli M., Kunicki S., Morissette C., Paquette J., Gervais F., Bergeron C., Fraser P.E., Carlson G.A., George-Hyslop P.S., and Westaway D. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 276 (2001) 21562-21570
5. Christian S.L., Sims P.V., and Gold M.R. The B cell antigen receptor regulates the transcriptional activator beta-catenin via protein kinase C-mediated inhibition of glycogen synthase kinase-3. J. Immunol. 169 (2002) 758-769
6. De Ferrari G.V., Chacón M.A., Barría M.I., Garrido J.L., Godoy J.A., Olivares G., Reyes A.E., Alvarez A., Bronfman M., and Inestrosa N.C. Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils. Mol. Psychiatry 8 (2003) 195-208
7. Dennler S., Goumans M.J., and ten Dijke P. Transforming growth factor beta signal transduction. J. Leukoc. Biol. 71 (2002) 731-740
8. Edlund S., Lee S.-Y., Grimsby S., Zhang S., Asperton P., Heldin C.-H., and Landström M. Interaction between Smad7 and β-catenin: importance for transforming growth factor- β-induced apoptosis. Mol. Cell. Biol. 25 (2005) 1475-1488
9. Ebisawa T., Fukuchi M., Murakami G., Chiba T., Tanaka K., Imamura T., and Miyazono K. Smurf1 interacts with transforming growth factor-beta type 1 receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276 (2001) 12477-12480
10. Fujii M., Takeda K., Imamura T., Aoki H., Sampath T.K., Enomoto S., Kawabata M., Kato M., Ichijo H., and Miyazono K. Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol. Biol. Cell 11 (1999) 3801-3813
11. Flanders K.C., Lippa C.F., Smith T.W., Pollen D.A., and Sporn M.B. Altered expression of transforming growth factor- β in Alzheimer's disease. Neurology 45 (1995) 1561-1569
12. Jiang Y., Zhou X.D., Liu Y.K., Huang X.W., Zhao Y., Xue Q., Sun R.X., Chen J., and Wu X. Antisense Tcf inhibits the neoplastic growth of liver cancer cells. J. Cancer Res. Clin. Oncol. 11 (2004) 671-678
13. Kim K., Pang M.K., Evans M., and Hay E.D. Overexpression of β-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol. Biol. Cell 11 (2000) 3509-3523
14. Landström M., Heldin M.N., Bu S., Hermansson A., Itoh S., ten Dijke P., and Heldin C. Smad7 mediates TGF-β1 induced apoptosis in prostatic carcinoma cells. Curr. Biol. 10 (2000) 535-538
15. Oloumi A., McPhee T., and Dedhar S. Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim. Biophys. Acta 169 (2004) 11-15
16. Rota E., Bellone G., Rocca P., Bergamasco B., Emanuelli G., and Ferrero P. Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients. Neurol. Sci. 27 (2006) 33-39
17. Salins P., Shawesh S., He Y., Dibrov A., Kashour T., Arthur G., and Amara F. Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci. Lett. 412 (2007) 211-216
18. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron 6 (1991) 487-498
19. Shi Y., and Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
20. Shuster N., and Krieglstein K. Mechanisms of TGF-β-mediated apoptosis. Cell Tissue. Res. 307 (2002) 1-14
21. Smale G., Nichols N.R., Brady D.R., Finch C.E., and Horton Jr. W.E. Evidence for apoptotic cell death in Alzheimer's disease. Exp. Neurol. 133 (1995) 225-230
22. Stine W.B., Dahlgren K.N., Krafft G.A., and LaDu M.J. In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J. Biol. Chem. 278 (2003) 11612-11622
23. Zhang Z., Hartmann H., Do V.M., Abramowski D., Sturchler-Pierrat C., Staufenbiel M., Sommer B., van de Wetering M., Clevers H., Saftig P., De Strooper B., He X., and Yankner B.A. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395 (1998) 698-702