Discovery of a series of aminopiperidines as novel iNOS inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 1, 2008, Pages 336-343

  Bourdonnec, Bertrand Le ^a   Leister, Lara K ^a   Ajello, Christopher A ^a   Cassel, Joel A ^a   Seida, Pamela R ^a   O'Hare, Heather ^a   Gu, Minghua ^a   Chu, Guo Hua ^a   Tuthill, Paul A ^a   DeHaven, Robert N ^a   Dolle, Roland E ^a  

^a ADOLOR CORPORATION   (United States)

Author keywords

Aminopiperidines; Inhibitors; iNOS

Indexed keywords

AMINOPIPERIDINE DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; NITRIC OXIDE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD FLOW; BLOOD PRESSURE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; REACTION ANALYSIS; STRUCTURE ANALYSIS;

AMINES; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37549058422     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.073     Document Type: Article

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