메뉴 건너뛰기




Volumn 5, Issue 4, 2007, Pages 171-178

The antimutagenic and cytoprotective effects of amifostine: The role of p53

Author keywords

Amifostine; Cytoprotective and antimutagenic compounds; Tumour suppressor p53; WR 1065; WR 2721

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; ACETYLCYSTEINE; AMIFOSTINE; ANTINEOPLASTIC AGENT; BIS[2 (3 AMINOPROPYLAMINO)ETHYL] DISULFIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1; GLUTATHIONE; MESNA; PROTEIN P53; RAZOXANE; REACTIVE OXYGEN METABOLITE;

EID: 37549052483     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.32725/jab.2007.023     Document Type: Review
Times cited : (13)

References (53)
  • 2
    • 0037268373 scopus 로고    scopus 로고
    • Chemical radioprotection: A critical review of amifostine as a cytoprotector in radiotherapy
    • Andreassen CN, Grau C, Lindegaard J C: Chemical radioprotection: a critical review of amifostine as a cytoprotector in radiotherapy. Semin. Radiat. Oncol. 13:62-72, 2003.
    • (2003) Semin. Radiat. Oncol , vol.13 , pp. 62-72
    • Andreassen, C.N.1    Grau, C.2    Lindegaard, J.C.3
  • 3
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • Appella E, Anderson CW: Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268:2764-2772, 2001.
    • (2001) Eur. J. Biochem , vol.268 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 4
    • 0023679159 scopus 로고
    • Uptake of WR-2721 derivatives by cells in culture: Identification of the transported form of the drug
    • Calabro-Jones PM, Aguilera JA, Ward JF, Smoluk GD, Fahey RC: Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Cancer Res. 48:3634-3640, 1988.
    • (1988) Cancer Res , vol.48 , pp. 3634-3640
    • Calabro-Jones, P.M.1    Aguilera, J.A.2    Ward, J.F.3    Smoluk, G.D.4    Fahey, R.C.5
  • 5
    • 0029048855 scopus 로고
    • The oxidative stress response
    • Camhi SL, Lee P, Choi AM: The oxidative stress response. New Horiz. 3:170-182, 1995.
    • (1995) New Horiz , vol.3 , pp. 170-182
    • Camhi, S.L.1    Lee, P.2    Choi, A.M.3
  • 6
    • 0033038974 scopus 로고    scopus 로고
    • The preclinical basis for broad-spectrum selective, cytoprotection of normal tissues from cytotoxic therapies by amifostine
    • Capizzi RL: The preclinical basis for broad-spectrum selective, cytoprotection of normal tissues from cytotoxic therapies by amifostine. Semin. Oncol. 26:3-21, 1999.
    • (1999) Semin. Oncol , vol.26 , pp. 3-21
    • Capizzi, R.L.1
  • 7
    • 0034998360 scopus 로고    scopus 로고
    • Amifostine: An update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome
    • Culy CR, Spencer CM: Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome. Drugs 61:641-684, 2001.
    • (2001) Drugs , vol.61 , pp. 641-684
    • Culy, C.R.1    Spencer, C.M.2
  • 8
    • 0023815322 scopus 로고
    • Influence of WR2721 on DNA cross-linking by nitrogen mustard in normal mouse bone marrow and leukemia cells in vivo
    • DeNeve WJ, Everett CK, Suminski JE, Valeriote FA: Influence of WR2721 on DNA cross-linking by nitrogen mustard in normal mouse bone marrow and leukemia cells in vivo. Cancer Res. 48:6002-6005, 1988.
    • (1988) Cancer Res , vol.48 , pp. 6002-6005
    • DeNeve, W.J.1    Everett, C.K.2    Suminski, J.E.3    Valeriote, F.A.4
  • 9
    • 0032510341 scopus 로고    scopus 로고
    • Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast
    • Flaman JM, Robert V, Lenglet S, Moreau V, Iggo R, Frebourg T: Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast. Oncogene 16:1369-1372, 1998.
    • (1998) Oncogene , vol.16 , pp. 1369-1372
    • Flaman, J.M.1    Robert, V.2    Lenglet, S.3    Moreau, V.4    Iggo, R.5    Frebourg, T.6
  • 10
    • 0036177173 scopus 로고    scopus 로고
    • Relationships between cytoprotection and mutation prevention by WR-1065
    • Grdina DJ, Murley JS, Kataoka Y, Epperly W: Relationships between cytoprotection and mutation prevention by WR-1065. Mil. Med. 167:51-53, 2002a.
    • (2002) Mil. Med , vol.167 , pp. 51-53
    • Grdina, D.J.1    Murley, J.S.2    Kataoka, Y.3    Epperly, W.4
  • 11
    • 0036916372 scopus 로고    scopus 로고
    • Radioprotectants: Current status and new directions
    • Grdina DJ, Murley JS, Kataoka Y: Radioprotectants: current status and new directions. Oncology 63:2-10, 2002b.
    • (2002) Oncology , vol.63 , pp. 2-10
    • Grdina, D.J.1    Murley, J.S.2    Kataoka, Y.3
  • 12
    • 0027361046 scopus 로고
    • Redox modulation of p53 conformation and sequence-specific DNA binding in vitro
    • Hainaut P, Milner J: Redox modulation of p53 conformation and sequence-specific DNA binding in vitro. Cancer Res. 53:4469-4473, 1993.
    • (1993) Cancer Res , vol.53 , pp. 4469-4473
    • Hainaut, P.1    Milner, J.2
  • 14
    • 37549035972 scopus 로고    scopus 로고
    • downloaded 28th February 2007
    • http://www.drugs.com, downloaded 28th February 2007.
  • 15
    • 0034037475 scopus 로고    scopus 로고
    • Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines
    • Kataoka Y, Murley JS, Patel R, Grdina DJ: Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. Int. J. Radiat. Biol. 76:633-639, 2000.
    • (2000) Int. J. Radiat. Biol , vol.76 , pp. 633-639
    • Kataoka, Y.1    Murley, J.S.2    Patel, R.3    Grdina, D.J.4
  • 16
    • 1642558247 scopus 로고    scopus 로고
    • Amifostine: Is there evidence of tumour protection?
    • Koukourakis MI: Amifostine: is there evidence of tumour protection? Semin. Oncol. 30:18-30, 2003.
    • (2003) Semin. Oncol , vol.30 , pp. 18-30
    • Koukourakis, M.I.1
  • 18
    • 0037430041 scopus 로고    scopus 로고
    • p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection
    • Lee E, Gerhold M, Palmer MW, Christen RD: p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. Br. J. Cancer. 88:754-759, 2003.
    • (2003) Br. J. Cancer , vol.88 , pp. 754-759
    • Lee, E.1    Gerhold, M.2    Palmer, M.W.3    Christen, R.D.4
  • 19
    • 0031410502 scopus 로고    scopus 로고
    • Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine
    • Liu SC, Murley JS, Woloschak, Grdina DJ: Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine. Carcinogenesis 18:2457-2459, 1997.
    • (1997) Carcinogenesis , vol.18 , pp. 2457-2459
    • Liu, S.C.1    Murley, J.S.2    Woloschak3    Grdina, D.J.4
  • 20
    • 20544452533 scopus 로고    scopus 로고
    • Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53
    • Mann K, Hainaut P: Aminothiol WR1065 induces differential gene expression in the presence of wild-type p53. Oncogene 24:3964-3975, 2005.
    • (2005) Oncogene , vol.24 , pp. 3964-3975
    • Mann, K.1    Hainaut, P.2
  • 21
    • 0035859006 scopus 로고    scopus 로고
    • Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay
    • Maurici D, Monti P, Campomenosi P, North S, Frebourg T, Fronza G, Hainaut P: Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene 20:3533-3540, 2001.
    • (2001) Oncogene , vol.20 , pp. 3533-3540
    • Maurici, D.1    Monti, P.2    Campomenosi, P.3    North, S.4    Frebourg, T.5    Fronza, G.6    Hainaut, P.7
  • 22
    • 37549062284 scopus 로고    scopus 로고
    • MedImmune Oncology, Inc, Ethyol Monograph. Package Insert, Gaithersburg, MD 2005
    • MedImmune Oncology, Inc.: Ethyol Monograph. Package Insert, Gaithersburg, MD 2005.
  • 23
    • 0029129978 scopus 로고
    • Degradation of 2-(3- aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells
    • Meier T, Issels RD: Degradation of 2-(3- aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells. Biochem. Pharmacol. 50:489-496, 1995.
    • (1995) Biochem. Pharmacol , vol.50 , pp. 489-496
    • Meier, T.1    Issels, R.D.2
  • 24
    • 0028877982 scopus 로고
    • Flexibility: The key to p53 function?
    • Milner J: Flexibility: The key to p53 function? Trends Biochem. Sci. 20:49-51, 1995.
    • (1995) Trends Biochem. Sci , vol.20 , pp. 49-51
    • Milner, J.1
  • 25
    • 0035870129 scopus 로고    scopus 로고
    • c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells
    • Minet E, Michel G, Mottet D, Piret JP, Barbieux A, Raes M, Michiels C: c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells. Exp. Cell. Res. 265:114-124, 2001.
    • (2001) Exp. Cell. Res , vol.265 , pp. 114-124
    • Minet, E.1    Michel, G.2    Mottet, D.3    Piret, J.P.4    Barbieux, A.5    Raes, M.6    Michiels, C.7
  • 26
    • 0032532296 scopus 로고    scopus 로고
    • Mammalian cell polyamine homeostasis is altered by the radioprotector WR1065
    • Mitchell JL, Rupert J, Leyser A, Judd GG: Mammalian cell polyamine homeostasis is altered by the radioprotector WR1065. Biochem. J. 335:329-334, 1998.
    • (1998) Biochem. J , vol.335 , pp. 329-334
    • Mitchell, J.L.1    Rupert, J.2    Leyser, A.3    Judd, G.G.4
  • 27
    • 0031473153 scopus 로고    scopus 로고
    • WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to ebanges in enzyme activity and cell cycle progression in CHO AA8 cells
    • Murley JS, Constantinou A, Kamath NS, Grdina DJ: WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to ebanges in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 30:283-294, 1997.
    • (1997) Cell Prolif , vol.30 , pp. 283-294
    • Murley, J.S.1    Constantinou, A.2    Kamath, N.S.3    Grdina, D.J.4
  • 28
    • 0028844805 scopus 로고
    • The effects of cycloheximide and WR-1065 on radiation-induced repair processes: A mechanism for chemoprevention
    • Murley JS, Grdina DJ: The effects of cycloheximide and WR-1065 on radiation-induced repair processes: A mechanism for chemoprevention. Carcinogenesis 16:2699-2705, 1995.
    • (1995) Carcinogenesis , vol.16 , pp. 2699-2705
    • Murley, J.S.1    Grdina, D.J.2
  • 29
    • 0035874637 scopus 로고    scopus 로고
    • Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells
    • Murley JS, Kataoka Y, Hallahan DE, Roberts JC, Grdina DJ: Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radic. Biol. Med. 30:1426-1439, 2001.
    • (2001) Free Radic. Biol. Med , vol.30 , pp. 1426-1439
    • Murley, J.S.1    Kataoka, Y.2    Hallahan, D.E.3    Roberts, J.C.4    Grdina, D.J.5
  • 30
    • 0034708220 scopus 로고    scopus 로고
    • The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through, a p53-dependent pathway
    • North S, El-Ghissassi F, Pluquet O, Verhaegh G, Hainaut P: The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through, a p53-dependent pathway. Oncogene, 19:1206-1214, 2000.
    • (2000) Oncogene , vol.19 , pp. 1206-1214
    • North, S.1    El-Ghissassi, F.2    Pluquet, O.3    Verhaegh, G.4    Hainaut, P.5
  • 31
    • 0036191959 scopus 로고    scopus 로고
    • Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1
    • North S, Pluquet O, Maurici D, El-Ghissassi F, Hainaut P: Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1. Mol. Carcinog. 33:181-188, 2002.
    • (2002) Mol. Carcinog , vol.33 , pp. 181-188
    • North, S.1    Pluquet, O.2    Maurici, D.3    El-Ghissassi, F.4    Hainaut, P.5
  • 32
    • 0034645061 scopus 로고    scopus 로고
    • c-Jun activation-dependent tumourigenic transformation induced paradoxically by overexpression or block of S- adenosylmethionine decarboxylase
    • Paasinen-Sohns A, Kielosto M, Kaariainen E, Eloranta T, Laine A, Janne OA, Birrer MJ, Holtta E: c-Jun activation-dependent tumourigenic transformation induced paradoxically by overexpression or block of S- adenosylmethionine decarboxylase. J. Cell. Biol. 151:801-810, 2000.
    • (2000) J. Cell. Biol , vol.151 , pp. 801-810
    • Paasinen-Sohns, A.1    Kielosto, M.2    Kaariainen, E.3    Eloranta, T.4    Laine, A.5    Janne, O.A.6    Birrer, M.J.7    Holtta, E.8
  • 33
    • 33746238959 scopus 로고    scopus 로고
    • Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53
    • Pataer A, Fanale MA, Roth JA, Swisher SG, Hunt KK: Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53. Cancer Gene Ther. 13:806-814, 2006.
    • (2006) Cancer Gene Ther , vol.13 , pp. 806-814
    • Pataer, A.1    Fanale, M.A.2    Roth, J.A.3    Swisher, S.G.4    Hunt, K.K.5
  • 34
    • 0012549224 scopus 로고    scopus 로고
    • The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase
    • Pluquet O, North S, Bhoumik A, Dimas K, Ronai Z, Hainaut P: The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J. Biol. Chem. 278:11879-11887, 2003a.
    • (2003) J. Biol. Chem , vol.278 , pp. 11879-11887
    • Pluquet, O.1    North, S.2    Bhoumik, A.3    Dimas, K.4    Ronai, Z.5    Hainaut, P.6
  • 35
    • 0037378392 scopus 로고    scopus 로고
    • Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity
    • Pluquet O, North S, Richard MJ, Hainaut P: Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity. Biochem. Pharmacol. 65:1129-1137, 2003b.
    • (2003) Biochem. Pharmacol , vol.65 , pp. 1129-1137
    • Pluquet, O.1    North, S.2    Richard, M.J.3    Hainaut, P.4
  • 36
    • 0033569769 scopus 로고    scopus 로고
    • Functional interaction between GCN5 and polyamines: A new role for core histone acetylation
    • Pollard KJ, Samuels ML, Crowley KA, Hansen JC, Peterson CL: Functional interaction between GCN5 and polyamines: A new role for core histone acetylation. EMBO J. 18: 5622-5633, 1999.
    • (1999) EMBO J , vol.18 , pp. 5622-5633
    • Pollard, K.J.1    Samuels, M.L.2    Crowley, K.A.3    Hansen, J.C.4    Peterson, C.L.5
  • 37
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C, Hall PA: The p53 pathway. J. Pathol. 187:112-126, 1999.
    • (1999) J. Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 38
    • 0033582918 scopus 로고    scopus 로고
    • In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients
    • Provinciali M, Ciavattini A, Di Stefano G, Argentati K, Garzetti GG: In vivo amifostine (WR-2721) prevents chemotherapy-induced apoptosis of peripheral blood lymphocytes from cancer patients. Life Sci. 64:1525-1532, 1999.
    • (1999) Life Sci , vol.64 , pp. 1525-1532
    • Provinciali, M.1    Ciavattini, A.2    Di Stefano, G.3    Argentati, K.4    Garzetti, G.G.5
  • 39
    • 0026588374 scopus 로고
    • N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death
    • Ramakrishnan N, Catravas GN: N-(2-mercaptoethyl)-1,3-propanediamine (WR-1065) protects thymocytes from programmed cell death. J. Immunol. 148:1817-1821, 1992.
    • (1992) J. Immunol , vol.148 , pp. 1817-1821
    • Ramakrishnan, N.1    Catravas, G.N.2
  • 41
    • 0032734957 scopus 로고    scopus 로고
    • The potential of amifostine: From cytoprotectant to therapeutic agent
    • Santini V, Giles FJ: The potential of amifostine: from cytoprotectant to therapeutic agent. Haematologica 84:1035-1042, 1999.
    • (1999) Haematologica , vol.84 , pp. 1035-1042
    • Santini, V.1    Giles, F.J.2
  • 42
    • 8244222299 scopus 로고    scopus 로고
    • Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage
    • Savoye C, Swenberg C, Hugot S, Sy D, Sabattier R, Charlier M, Spotheim-Maurizot M: Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. Int. J. Radiat. Biol. 71:193-202, 1997.
    • (1997) Int. J. Radiat. Biol , vol.71 , pp. 193-202
    • Savoye, C.1    Swenberg, C.2    Hugot, S.3    Sy, D.4    Sabattier, R.5    Charlier, M.6    Spotheim-Maurizot, M.7
  • 43
  • 44
    • 0035005458 scopus 로고    scopus 로고
    • Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs
    • Shen H, Chen ZJ, Zilfou JT, Hopper E, Murphy M, Tew KD: Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J. Pharmacol. Exp. Ther. 297:1067-1073, 2001.
    • (2001) J. Pharmacol. Exp. Ther , vol.297 , pp. 1067-1073
    • Shen, H.1    Chen, Z.J.2    Zilfou, J.T.3    Hopper, E.4    Murphy, M.5    Tew, K.D.6
  • 46
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
    • Toledo F, Wahl GM: Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 6:909-923, 2006.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 909-923
    • Toledo, F.1    Wahl, G.M.2
  • 47
    • 34547648771 scopus 로고    scopus 로고
    • Amifostine (Ethyol): Pharmacokinetic and pharmacodynamic effects in vivo
    • van der Vijgh WJ, Korst AE: Amifostine (Ethyol): Pharmacokinetic and pharmacodynamic effects in vivo. Eur. J. Cancer 32:S26-S30, 1996.
    • (1996) Eur. J. Cancer , vol.32
    • van der Vijgh, W.J.1    Korst, A.E.2
  • 48
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X: Live or let die: the cell's response to p53. Nat. Rev. Cancer 2:594-604, 2002.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 49
    • 0037075898 scopus 로고    scopus 로고
    • Activation of the p53 tumour suppressor protein
    • Vousden KH: Activation of the p53 tumour suppressor protein. Biochim. Biophys. Acta 1602:47-59, 2002.
    • (2002) Biochim. Biophys. Acta , vol.1602 , pp. 47-59
    • Vousden, K.H.1
  • 51
    • 0028889590 scopus 로고
    • Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065
    • Woloschak G E, Paunesku T, Chang-Liu CM, Grdina DJ: Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065. Cancer Res. 55:4788-4792, 1995.
    • (1995) Cancer Res , vol.55 , pp. 4788-4792
    • Woloschak, G.E.1    Paunesku, T.2    Chang-Liu, C.M.3    Grdina, D.J.4
  • 52
    • 0014468075 scopus 로고
    • Differential chemoprotection of normal and malignant tissues
    • Yuhas JM, Storer JB: Differential chemoprotection of normal and malignant tissues. J. Natl. Cancer Inst. 42:331-335, 1969.
    • (1969) J. Natl. Cancer Inst , vol.42 , pp. 331-335
    • Yuhas, J.M.1    Storer, J.B.2
  • 53
    • 0026486828 scopus 로고
    • Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065
    • Zhang X, Lai PP, Taylor YC: Differential radioprotection of cultured human diploid fibroblasts and fibrosarcoma cells by WR1065. Int. J. Radiat. Oncol. Biol. Phys. 24:713-719, 1992.
    • (1992) Int. J. Radiat. Oncol. Biol. Phys , vol.24 , pp. 713-719
    • Zhang, X.1    Lai, P.P.2    Taylor, Y.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.