Relationships between cytoprotection and mutation prevention by WR-1065

Military Medicine

Volumn 167, Issue 2 SUPPL., 2002, Pages 51-53

  Grdina, David J ^a   Murley, Jeffrey S ^a   Kataoka, Yasushi ^a   Epperly, William ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; AMIFOSTINE; ANTIOXIDANT; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MYC PROTEIN; RADIOPROTECTIVE AGENT; THYMIDINE KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; CANCER PREVENTION; CARCINOGENESIS; CELL PROTECTION; CELL SURVIVAL; CHO CELL; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GENE MUTATION; MUTAGENESIS; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RADIATION INJURY; RADIATION PROTECTION;

EID: 0036177173     PISSN: 00264075     EISSN: None     Source Type: Journal    
DOI: 10.1093/milmed/167.suppl_1.51     Document Type: Conference Paper

References (14)

1. News and product notes
2. Radioprotective effects of amifostine
3. Radioprotectants
4. Mechanism of action of aminothiol radioprotectors
5. Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721), protect DNA against neutron-induced strand breakage
6. Activation of NFκB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells
7. Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065
8. Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine
9. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase-IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells
10. Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action
11. Protection against late effects of radiation by S-2-(3-aminopropylamino)ethyl-phosphorothioic acid
12. Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278
13. The radioprotector WR1065 reduces radiation-induced mutations at the HGPRT locus in V79 cells
14. Antimutagenic effects of amifostine: Clinical implications