메뉴 건너뛰기




Volumn 27, Issue 6 B, 2007, Pages 3963-3971

Regulation of pyruvate kinase type M2 by A-raf: A possible glycolytic stop or go mechanism

Author keywords

A Raf; Glutaminolysis; M2 PK; Pyruvate kinase; Serinolysis; Tumor metabolome

Indexed keywords

A RAF KINASE; GLUTAMINE; PYRUVATE KINASE; PYRUVATE KINASE ISOENZYME M 2; SERINE; UNCLASSIFIED DRUG;

EID: 37549020279     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (50)

References (40)
  • 1
    • 0000069903 scopus 로고
    • New perspectives on carbohydrate metabolism in tumor cells
    • Beitner R ed, Boca Raton, CRC Press, pp
    • Eigenbrodt E, Fister P and Reinacher M: New perspectives on carbohydrate metabolism in tumor cells. In: Regulation of Carbohydrate Metabolism. Beitner R (ed.). Boca Raton, CRC Press, pp. 141-179, 1985.
    • (1985) Regulation of Carbohydrate Metabolism , pp. 141-179
    • Eigenbrodt, E.1    Fister, P.2    Reinacher, M.3
  • 2
    • 0031311965 scopus 로고    scopus 로고
    • Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells
    • Guminska M, Ignacak J, Kedryna T and Stachurska MB: Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells. Acta Biochim Pol 44: 711-724, 1997.
    • (1997) Acta Biochim Pol , vol.44 , pp. 711-724
    • Guminska, M.1    Ignacak, J.2    Kedryna, T.3    Stachurska, M.B.4
  • 3
    • 0031819240 scopus 로고    scopus 로고
    • Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet
    • Hacker HJ, Steinberg P and Bannasch P: Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet. Carcinogenesis 19: 99-107, 1998.
    • (1998) Carcinogenesis , vol.19 , pp. 99-107
    • Hacker, H.J.1    Steinberg, P.2    Bannasch, P.3
  • 4
    • 0019487346 scopus 로고
    • Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-PK) in tumors of chicken and rat
    • Reinacher M and Eigenbrodt E: Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-PK) in tumors of chicken and rat. Virchows Arch B Cell Pathol Incl Mol Pathol 37: 79-88, 1981.
    • (1981) Virchows Arch B Cell Pathol Incl Mol Pathol , vol.37 , pp. 79-88
    • Reinacher, M.1    Eigenbrodt, E.2
  • 5
    • 0002853229 scopus 로고
    • Pyruvate kinase in selected human tumors
    • Pretlow TG and Pretlow TP eds, San Diego, Academic Press, pp
    • Staal GEJ and Rijksen G: Pyruvate kinase in selected human tumors. In: Biochemical and Molecular Aspects of Selected Cancers. Pretlow TG and Pretlow TP (eds.). San Diego, Academic Press, pp. 313-337, 1993.
    • (1993) Biochemical and Molecular Aspects of Selected Cancers , pp. 313-337
    • Staal, G.E.J.1    Rijksen, G.2
  • 6
    • 0024261927 scopus 로고
    • Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus
    • Presek P, Reinacher M and Eigenbrodt E: Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus. FEBS Lett 242: 194-198, 1988.
    • (1988) FEBS Lett , vol.242 , pp. 194-198
    • Presek, P.1    Reinacher, M.2    Eigenbrodt, E.3
  • 7
    • 0026000507 scopus 로고
    • In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate
    • Ashizawa K, Willingham MC, Liang CM and Cheng SY: In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate. J Biol Chem 266: 16842-16846, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 16842-16846
    • Ashizawa, K.1    Willingham, M.C.2    Liang, C.M.3    Cheng, S.Y.4
  • 8
    • 0035874480 scopus 로고    scopus 로고
    • Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: Role of pyruvate kinase type M2 and the glycolytic-enzyme complex
    • Mazurek S, Zwerschke W, Jansen-Durr P and Eigenbrodt E: Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex. Biochem J 356: 247-256, 2001.
    • (2001) Biochem J , vol.356 , pp. 247-256
    • Mazurek, S.1    Zwerschke, W.2    Jansen-Durr, P.3    Eigenbrodt, E.4
  • 9
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • Mazurek S, Boschek CB, Hugo F and Eigenbrodt E: Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15: 300-308, 2005.
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 10
    • 0028209999 scopus 로고
    • Enzymes as RNA-binding proteins: A role for (di)nucleotide-binding domains?
    • Hentze MW: Enzymes as RNA-binding proteins: a role for (di)nucleotide-binding domains? Trends Biochem Sci 19: 101-103, 1994.
    • (1994) Trends Biochem Sci , vol.19 , pp. 101-103
    • Hentze, M.W.1
  • 11
    • 0028816615 scopus 로고
    • Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold)
    • Nagy E and Rigby WF: Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold). J Biol Chem 270: 2755-2763, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 2755-2763
    • Nagy, E.1    Rigby, W.F.2
  • 12
    • 0032797579 scopus 로고    scopus 로고
    • Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells
    • Mazurek S, Eigenbrodt E, Failing K and Steinberg P: Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells. J Cell Physiol 181: 136-146, 1999.
    • (1999) J Cell Physiol , vol.181 , pp. 136-146
    • Mazurek, S.1    Eigenbrodt, E.2    Failing, K.3    Steinberg, P.4
  • 13
    • 0031730047 scopus 로고    scopus 로고
    • Metabolic characteristics of different malignant cancer cell lines
    • Mazurek S, Grimm H, Wilker S, Leib S and Eigenbrodt E: Metabolic characteristics of different malignant cancer cell lines. Anticancer Res 18: 3275-3282, 1998.
    • (1998) Anticancer Res , vol.18 , pp. 3275-3282
    • Mazurek, S.1    Grimm, H.2    Wilker, S.3    Leib, S.4    Eigenbrodt, E.5
  • 16
    • 0030028069 scopus 로고    scopus 로고
    • The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells
    • Goossens V, Grooten J and Fiers W: The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells. J Biol Chem 271: 192-196, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 192-196
    • Goossens, V.1    Grooten, J.2    Fiers, W.3
  • 18
    • 0034212427 scopus 로고    scopus 로고
    • Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells
    • Lobo C, Ruiz-Bellido MA, Aledo JC, Marquez J, Nunez De Castro I and Alonso FJ: Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells. Biochem J 348: 257-261, 2000.
    • (2000) Biochem J , vol.348 , pp. 257-261
    • Lobo, C.1    Ruiz-Bellido, M.A.2    Aledo, J.C.3    Marquez, J.4    Nunez De Castro, I.5    Alonso, F.J.6
  • 22
    • 85047697320 scopus 로고    scopus 로고
    • ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf
    • Mercer K, Chiloeches A, Huser M, Kiernan M, Marais R and Pritchard C: ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf. Oncogene 21: 347-355, 2002.
    • (2002) Oncogene , vol.21 , pp. 347-355
    • Mercer, K.1    Chiloeches, A.2    Huser, M.3    Kiernan, M.4    Marais, R.5    Pritchard, C.6
  • 23
    • 0030133927 scopus 로고    scopus 로고
    • Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene
    • Pritchard CA, Bolin L, Slattery R, Murray R and McMahon M: Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Curr Biol 6: 614-617, 1996.
    • (1996) Curr Biol , vol.6 , pp. 614-617
    • Pritchard, C.A.1    Bolin, L.2    Slattery, R.3    Murray, R.4    McMahon, M.5
  • 26
    • 33745327045 scopus 로고    scopus 로고
    • Back to the roots: The remarkable RAF oncogene story
    • Zebisch A and Troppmair J: Back to the roots: the remarkable RAF oncogene story. Cell Mol Life Sci 63: 1314-1330, 2006.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1314-1330
    • Zebisch, A.1    Troppmair, J.2
  • 27
    • 0024208064 scopus 로고
    • Activation of a cytosolic serine protein kinase by epidermal growth factor
    • Giugni TD, Chen K and Cohen S: Activation of a cytosolic serine protein kinase by epidermal growth factor. J Biol Chem 263: 18988-18995, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 18988-18995
    • Giugni, T.D.1    Chen, K.2    Cohen, S.3
  • 28
    • 0026623266 scopus 로고
    • Phosphorylation of pyruvate kinase type K is restricted to the dimeric form
    • Weernink PA, Rijksen G, Mascini EM and Staal GE: Phosphorylation of pyruvate kinase type K is restricted to the dimeric form. Biochim Biophys Acta 1121: 61-68, 1992.
    • (1992) Biochim Biophys Acta , vol.1121 , pp. 61-68
    • Weernink, P.A.1    Rijksen, G.2    Mascini, E.M.3    Staal, G.E.4
  • 29
    • 0025353389 scopus 로고
    • Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5′-monophosphate-independent protein kinase
    • Weernink PA, Rijksen G, van der Heijden MC and Staal GE: Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5′-monophosphate-independent protein kinase. Cancer Res 50: 4604-4610, 1990.
    • (1990) Cancer Res , vol.50 , pp. 4604-4610
    • Weernink, P.A.1    Rijksen, G.2    van der Heijden, M.C.3    Staal, G.E.4
  • 30
    • 34147116745 scopus 로고    scopus 로고
    • Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase
    • Siwko S and Mochly-Rosen D: Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase. Int J Biochem Cell Biol 39: 978-987, 2007.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 978-987
    • Siwko, S.1    Mochly-Rosen, D.2
  • 31
    • 7544235811 scopus 로고    scopus 로고
    • Regulating cell survival by controlling cellular energy production: Novel functions for ancient signaling pathways?
    • Kuznetsov AV, Janakiraman M, Margreiter R and Troppmair J: Regulating cell survival by controlling cellular energy production: novel functions for ancient signaling pathways? FEBS Lett 577: 1-4, 2004.
    • (2004) FEBS Lett , vol.577 , pp. 1-4
    • Kuznetsov, A.V.1    Janakiraman, M.2    Margreiter, R.3    Troppmair, J.4
  • 32
    • 18444374405 scopus 로고    scopus 로고
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davies N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais S, Marshall CJ, Wooster R, Stratton MR and Futreal PA: Mutations of the BRAF gene in human cancer. Nature 417: 949-954, 2002.
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davies N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais S, Marshall CJ, Wooster R, Stratton MR and Futreal PA: Mutations of the BRAF gene in human cancer. Nature 417: 949-954, 2002.
  • 34
  • 36
    • 0035328521 scopus 로고    scopus 로고
    • Active Ras induces heterodimerization of c-Raf and B-Raf
    • Weber CK, Slupsky JR, Kalmes HA and Rapp UR: Active Ras induces heterodimerization of c-Raf and B-Raf. Cancer Res 61: 3595-3598, 2001.
    • (2001) Cancer Res , vol.61 , pp. 3595-3598
    • Weber, C.K.1    Slupsky, J.R.2    Kalmes, H.A.3    Rapp, U.R.4
  • 37
    • 23444440323 scopus 로고    scopus 로고
    • A-Raf and Raf-1 work together to influence transient ERK phosphorylation and G1/S cell cycle progression
    • Mercer K, Giblett S, Oakden A, Brown J, Marais R and Pritchard C: A-Raf and Raf-1 work together to influence transient ERK phosphorylation and G1/S cell cycle progression. Oncogene 24: 5207-5217, 2005.
    • (2005) Oncogene , vol.24 , pp. 5207-5217
    • Mercer, K.1    Giblett, S.2    Oakden, A.3    Brown, J.4    Marais, R.5    Pritchard, C.6
  • 38
    • 33749635119 scopus 로고    scopus 로고
    • Raf kinases: Oncogenesis and drug discovery
    • Schreck R and Rapp UR: Raf kinases: oncogenesis and drug discovery. Int J Cancer 119: 2261-2271, 2006.
    • (2006) Int J Cancer , vol.119 , pp. 2261-2271
    • Schreck, R.1    Rapp, U.R.2
  • 40
    • 21844468220 scopus 로고    scopus 로고
    • Structural basis of tumor M2 allosteric regulation and catalysis
    • Dombrauckas JD, Santarsiero BD and Mesecar AD: Structural basis of tumor M2 allosteric regulation and catalysis. Biochemistry 44: 9417-9429, 2005.
    • (2005) Biochemistry , vol.44 , pp. 9417-9429
    • Dombrauckas, J.D.1    Santarsiero, B.D.2    Mesecar, A.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.