Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA

Molecular Therapy

Volumn 16, Issue 1, 2008, Pages 178-186

  Stein, Ulrike ^a   Walther, Wolfgang ^a   Stege, Alexandra ^b   Kaszubiak, Alexander ^b   Fichtner, Iduna ^a   Lage, Hermann ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CANCER RESISTANCE; CHEMOSENSITIVITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; EXPRESSION VECTOR; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; JET INJECTION; MOUSE; MULTIDRUG RESISTANCE; NEOPLASM; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; REVERSAL REACTION; TUMOR VOLUME;

MUS;

EID: 37549014128     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/sj.mt.6300304     Document Type: Article

References (33)

1. Lage, H (2003). ABC-transporters: Implications on drug resistance from microorganisms to human cancers. Int J Antimicrob Agents 22: 188-199.
2. Stein, U and Walther, W (2006). Current Opinion article: Reversal of ABC transporter-mediated multidrug resistance in cancer: A realistic option? Am J Cancer 5: 285-297.
3. Szakacs, G, Paterson, JK, Ludwig, JA, Booth-Genthe, C and Gottesman, MM (2006). Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5: 219-234.
4. Marie, JP, Zhou, DC, Gurbuxani, S, Legrand, O and Zittoun R (1996). MDR1/ P-glycoprotein in haematological neoplasms. Eur J Cancer 32A 1034-1038.
5. Goldstein, LJ (1996). MDR1 gene expression in solid tumours. Eur J Cancer 32A: 1039-1050.
6. Lage, H (2005). Potential applications of RNA interference technology in the treatment of cancer. Future Oncol 1: 103-113.
7. Lage, H (2006). MDR1/P-glycoprotein (ABCB1) as target for RNA interference-mediated reversal of multidrug resistance. Curr Drug Targets 7: 813-821.
8. Yamamoto, M and Curiel, DT (2005). Cancer gene therapy. Technol Cancer Res Treat 4: 315-330.
9. Herweijer, H and Wolff, JA (2003). Progress and prospects: Naked DNA gene transfer and therapy. Gene Ther 10: 453-458.
10. Niidome, T and Huang, L (2002). Gene therapy progress and prospects: nonviral vectors. Gene Ther 9: 1647-1652.
11. Furth, PA, Kerr, D and Wall, R (1995). Gene transfer by jet injection into differentiated tissues of living animals and in organ culture. Mol Biotechnol 4: 121-127.
12. Walther, W, Stein, U, Fichtner, I, Malcherek, L, Lemm, M and Schlag, PM (2001). Non-viral in vivo gene delivery into tumors using a novel low volume jet-injection technology. Gene Ther 8: 173-180.
13. Walther, W, Stein, U, Fichtner, I, Schlag, PM (2004). Low-volume jet injection for efficient nonviral in vivo gene transfer. Mol Biotechnol 28: 121-128.
14. Walther, W, Stein, U, Fichtner, I, Kobelt, D, Aumann, J, Arlt, F et al. (2005). Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma. Mol Ther 12: 1176-1184.
15. Walther, W, Minow, T, Martin, R, Fichtner, I, Schlag, PM and Stein, U (2006). Uptake, biodistribution and time course of naked plasmid DNA trafficking after intratumoral in vivo jet injection. Hum Gene Ther 17: 611-624.
16. Nieth, C, Priebsch, A, Stege, A and Lage, H (2003). Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi). FEBS Lett 545: 144-150.
17. Muratovska, A and Eccles, MR (2004). Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett 558: 63-68.
18. Soutschek, J, Akinc, A, Bramlage, B, Charisse, K, Constien, R, Donoghue, M et al. (2004). Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432: 173-178.
19. Janouskova, O, Nellessen, T, Stokrova, J, Jinoch, P and Smahel M (2003). Delivery of recombinant adeno-associated virus by jet-injection. Int J Mol Med 12: 687-691.
20. Elbashir, SM, Harborth, J, Lendeckel, W, Yalcin, A, Weber, K and Tuschl, T (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
21. Harborth, J, Elbashir, SM, Bechert, K, Tuschl, T and Weber, K (2001). Identification of essential genes in cultured mammalian cells using small interfering RNAs. J Cell Sci 114: 4557-4565.
22. Kowalski, P, Surowiak, P and Lage, H (2005). Reversal of different drug-resistant phenotypes by an autocatalytic multitarget multiribozyme directed against the transcripts of the ABC-transporters MDR1/P-gp, MRP2 and BCRP. Mol Ther 11: 508-522.
23. Kretschmer-Kazemi Far, R and Sczakiel, G (2003). The activity of siRNA in mammalian cells is related to structural target accessibility: A comparison with antisense oligonucleoticles. Nucleic Acids Res 31: 4417-4424.
24. Matema, V, Stege, A, Surowiak, P, Priebsch, A and Lage, H (2006). RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells. Biochem Biophys Res Comm 348: 153-157.
25. Priebsch, A, Rompe, F, Tönnies, H, Kowalski, P, Surowiak, P, Stege, A et al. (2006). Complete reversal of ABCG2-depending atypical multidrug resistance by RNA interference in human carcinoma cells. Oligonucleotides 16: 263-274.
26. Stege, A, Priebsch, A, Nieth, C and Lage, H (2004). Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference. Cancer Gene Ther 11: 699-706.
27. Shi, Z, Liang, YJ, Chen, ZS, Wang, XW, Wang, XH, Ding, Y et al. (2006). Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo. Cancer Biol Ther 5: 39-47.
28. Pichler, A, Zelcer, N, Prior, JL, Kuil, AJ and Piwnica-Worms, D (2005). In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res 11: 4487-4494.
29. Matsui, Y, Kobayashi, N, Nishikawa, M and Takakura, Y (2005). Sequence-specific suppression of mdr1 a/1 b expression in mice via RNA interference. Pharm Res 22: 2091-2098.
30. Widmaier, R, Wildner, GP, Papsdorf, G and Graffi, I (1974). Über eine neue, in vitro unbegrenzt wachsende Zellinie MaTu von Mamma-Tumorzellen des Menschen. Arch Geschwulstforsch 44: 1-10.
31. Stein, U, Walther, W, Lemm, M, Naundorf, H and Fichtner, I (1997). Development and characterisation of novel human multidrug resistant mammary carcinoma lines in vitro and in vivo. Int J Cancer 72: 885-891.
32. T method. Methods 25: 402-408.
33. Stein, U, Jürchott, K, Schläfke, M and Hohenberger, P (2002). Expression of multidrug resistance genes MVP, MDR1 and MRP1 determined sequentially before, during, and after hyperthermic isolated limb perfusion of soft tissue sarcoma and melanoma patients. J Clin Oncol 20: 3282-3292.