Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma

Molecular Therapy

Volumn 12, Issue 6, 2005, Pages 1176-1184

  Walther, Wolfgang ^a   Stein, Ulrike ^a   Fichtner, Iduna ^a   Kobelt, Dennis ^b   Aumann, Jutta ^b   Arlt, Franziska ^b   Schlag, Peter M ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Section of Pathology   (Germany)

Author keywords

Colon cancer; Cytosine deaminase; Jet injection; Nonviral gene therapy; Suicide gene

Indexed keywords

CYTOSINE DEAMINASE; FLUOROURACIL; MESSENGER RNA; NAKED DNA; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER PATIENT; COLON CARCINOMA; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; ESCHERICHIA COLI; GENE EXPRESSION; GENE TECHNOLOGY; GENE TRANSFER; HUMAN; HUMAN CELL; IN VIVO STUDY; JET INJECTION; JET INJECTOR; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; RNA ANALYSIS; SUICIDE GENE; SUICIDE GENE THERAPY; TUMOR MODEL;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYTOSINE DEAMINASE; ESCHERICHIA COLI; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

ANIMALIA; ESCHERICHIA COLI;

EID: 28444468416     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.07.700     Document Type: Article

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