Inhibition of protein kinase Cα improves myocardial β-adrenergic receptor signaling and ventricular function in a model of myocardial preservation

Journal of Thoracic and Cardiovascular Surgery

Volumn 135, Issue 1, 2008, Pages

  D'Souza, Karen M ^a   Petrashevskaya, Natalia N ^b   Merrill, Walter H ^a   Akhter, Shahab A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; PROTEIN KINASE C ALPHA; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; CRYSTALLOID; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; EX VIVO STUDY; HEART FUNCTION; HEART MUSCLE; HEART PRESERVATION; HEART PROTECTION; HEART TRANSPLANTATION; HEART VENTRICLE FUNCTION; HEMODYNAMICS; MEDICAL SCHOOL; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REPERFUSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UNITED STATES;

EID: 37549011353     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2007.08.035     Document Type: Article

References (25)

1. J.D. Molkentin G.W. Dorn II Cytoplasmic signaling pathways that regulate cardiac hypertrophy Annu Rev Physiol 63 2001 391 426
2. E.C. Dempsey A.C. Newton D. Mochley-Rosen A.P. Fields M.E. Reyland P.A. Insel Protein kinase C isozymes and the regulation of diverse cell responses Am J Physiol Lung Mol Physiol 279 2000 L429 L438
3. J.M. Pass J. Gao W.K. Jones W.B. Wead X. Wu J. Zhang Enhanced PKCβII translocation and PKCβII-RACK1 interactions in PKCϵ heart failure: a role for RACK1 Am J Physiol Heart Circ Physiol 281 2001 H2500 H2510
4. 2+]i J Mol Cell Cardiol 24 1992 937 948
5. J.E. Watson M. Karmazyn Concentration-dependent effects of protein kinase C-activating and –nonactivating phorbol esters on myocardial contractility, coronary resistance, energy metabolism, prostacyclin synthesis, and ultrastructure in isolated rat hearts: effects of amiloride Circ Res 69 1991 1114 1131
6. J.C. Braz K. Gregory A. Pathak W. Zhao B. Sahin R. Klevitsky PKCα regulates cardiac contractility and propensity towards heart failure Nat Med 10 2004 248 254
7. H.S. Hahn Y. Marreez A. Odley A. Sterbling M.G. Yussman C. Hilty Protein kinase Cα negatively regulates systolic and diastolic function in pathological hypertrophy Circ Res 93 2003 1111 1119
8. Y. Takeishi T. Jalili N.A. Ball R.A. Walsh Responses of cardiac protein kinase C isoforms to distinct pathological stimuli are differentially regulated Circ Res 85 1999 264 271
9. J.C. Stringham R.B. Love D. Welter C.C. Canver R.M. Mentzer Jr Impact of University of Wisconsin solution on clinical heart transplantation A comparison with Stanford solution for extended preservation Circulation 98 1998 II157 II161
10. W.M. Neethling J.J. van den Heever S. Cooper J.M. Meyer Interstitial pH during myocardial preservation: assessment of five methods of myocardial preservation Ann Thorac Surg 55 1993 420 426
11. + exchange inhibitor HOE-642 Circulation 102 2000 III319 III325
12. J.O. Hegge J.H. Southard R.A. Haworth Preservation of metabolic reserves and function after storage of myocytes in hypothermic UW solution Am J Physiol Cell Physiol 281 2001 C758 C772
13. B.Z. Simkovich K. Przyklenk R.A. Kloner Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review Cardiovasc Res 40 1998 9 22
14. C. Albert D. Ford Protein kinase C translocation and PKC dependent protein phosphorylation during myocardial ischemia Am J Physiol Heart Circ Physiol 276 1999 H642 H650
15. Y. Liu K. Ytrehus J.M. Downey Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium J Mol Cell Cardiol 26 1994 661 668
16. Y. Nishizuka Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C Science 258 1992 607 614
17. G. MacGowan C. Du D. Cowan C. Stamm F. McGowan R.J. Solaro Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites Am J Physiol Heart Circ Physiol 280 2000 H835 H843
18. V.O. Rybin S.F. Steinberg Protein kinase C isoform expression and regulation in the developing rat heart Circ Res 74 1994 299 309
19. V.O. Rybin S.F. Steinberg Do adult rat ventricular myocytes express protein kinase Cα? Am J Physiol Heart Circ Physiol 272 1997 H2485 H2491
20. 2+-sensitive isoforms in the failing human heart Circulation 99 1999 384 391
21. T.T. Chuang H. LeVine A. DeBlasi Phosphorylation and activation of β-adrenergic receptor kinase by protein kinase C J Biol Chem 270 1995 18660 18665
22. R. Winstel S. Freund C. Krasel E. Hoppe M. Lohse Protein kinase cross-talk: Membrane targeting of the β-adrenergic receptor kinase by protein kinase C Proc Natl Acad Sci U S A 93 1996 2105 2109
23. M.R. Bristow R. Ginsburg W. Minobe R.S. Cubicciotti W.S. Sageman K. Lurie Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts N Engl J Med 307 1982 205 211
24. M. Ungerer M. Bohm J.S. Elce E. Erdmann M.J. Lohse Altered expression of beta-adrenergic receptor kinase and beta-1 adrenergic receptors in the failing human heart Circulation 87 1993 454 463
25. M. Hambleton H. Hahn S.T. Pleger M.C. Kuhn R. Klevitsky A.N. Carr Pharmacological- and gene therapy-based inhibition of protein kinase Cα/β enhances cardiac contractility and attenuates heart failure Circulation 114 2006 574 582