Enhanced PKCβII translocation and PKCβII-RACK1 interactions in PKCε-induced heart failure: A role for RACK1

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 6 50-6, 2001, Pages

  Pass, Jason M ^a   Jiuming, G A O ^a   Keith Jones, W ^b   Wead, William B ^a   Xin, W U ^a   Zhang, J U N ^b   Baines, Christopher P ^a   Bolli, Roberto ^a   Zheng, Y U Ting ^a   Joshua, Irving G ^b   Ping, Peipei ^a,c  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c Cardiology Research   (United States)

Author keywords

Cardiac phenotype; Hypertrophy; Protein protein interactions

Indexed keywords

MUTANT PROTEIN; PROTEIN KINASE C; RECEPTOR FOR ACTIVATED C KINASE 1; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME POLYMORPHISM; HEART FAILURE; HEART HYPERTROPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

EID: 0035662009     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.6.h2500     Document Type: Article

References (47)

1. The role of anchoring protein RACK1 in PKC activation in the aging rat brain
2. RACK1 is upregulated in angiogenesis and human carcinomas
3. The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: An overview
4. 2+-sensitive isoforms in the failing human heart
5. + production
6. Pharmacologic modulation of protein kinase C isozymes: The role of RACKs and subcellular localization
7. Transgenic Gαq overexpression induces cardiac contractile failure in mice
8. Hormonal influences on cardiac myosin ATPase activity and myosin isoenzyme distribution
9. Sustained in vivo cardiac protection by a rationally designed peptide that causes ε protein kinase C translocation
10. A parallel modulation of receptor for activated C kinase 1 and protein kinase C-α and -β isoforms in brains of morphine-treated rats
11. Cardiac expression of PKCε alters the activity of the myofilaments and increases fetal gene expression before the onset of cardiac hypertrophy
12. Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat
13. PKC translocation without changes in Gαq and PLC-β protein abundance in cardiac hypertrophy and failure
14. Cardiac physiology in transgenic mice
15. Ablation of the murine α-myosin heavy chain gene leads to dosage effects and functional deficits in the heart
16. Genetically engineered mice: Model systems for left ventricular failure
17. Expression of a constitutively activated mutant of the β-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the β-myosin heavy chain isogene
18. 1-adrenergic agonist and activated β-protein kinase C in hypertrophy of cardiac myocytes
19. 1-adrenergic induction of the skeletal α-actin promoter during cardiac myocyte hypertrophy. Transcriptional enhancer factor-1 and protein kinase C as conserved transducers of the fetal program in cardiac growth
20. Rack1 a receptor for activated protein kinase C, interacts with integrin β subunit
21. 2+-activated tension development in single adult cardiac myocytes
22. Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: A role in β protein kinase C mediated signal transduction
23. Cardiotrophic effects of protein kinase Cε: Analysis by in vivo modulation of PKCε translocation
24. The PTPμ protein tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts
25. Protein kinase C and myocardial biology and function
26. Calcineurin signaling and muscle remodeling
27. PKCε activation induces dichotomous cardiac phenotypes and modulates PKCε-RACK interactions and RACK expression
28. The molecular and cellular pathophysiology of heart failure
29. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits
30. Functional proteomic analysis of protein kinase Cε signaling complexes in the normal heart and during cardioprotection
31. Ischemic preconditioning induces selective translocation of protein kinase C isoforms ε and η in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity
32. A receptor for activated C kinase is upregulated by angiotensin II and colocalizes with protein kinase C β in adult cardiomyocytes
33. RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro
34. Coordinated movement of RACK1 with activated βIIPKC
35. 2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo
36. An autoregulatory region in protein kinase C: The pseudoanchoring site
37. Left ventricular isomyosins in normal and hypertrophied rat and human hearts
38. β-protein kinase C and hypertrophic signaling in human heart failure
39. Tissue-specific regulation of the α-myosin heavy chain gene promoter in transgenic mice
40. Pathogenesis of dilated cardiomyopathy: Molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice
41. In vivo phosphorylation of cardiac troponin I by protein kinase Cβ2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse hearts
42. Transgenic overexpression of constitutively active protein kinase Cε causes concentric cardiac hypertrophy
43. Use of functional proteomics to investigate PKCε-mediated cardioprotection: The signaling module hypothesis
44. Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy
45. ε-protein kinase C in pathological myocardial hypertrophy: Analysis by combined transgenic expression of translocation modifiers and Gαq
46. The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform
47. Activation of PKCε induces hypertrophy and heart failure in a dose-dependent fashion