Validation of transgenic mice harboring the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing

Toxicology Letters

Volumn 102-103, Issue , 1998, Pages 473-478

  Yamamoto, Satoshi ^a,b   Urano, Koji ^a   Nomura, Tatsuji ^a  

^a CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^b BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

c Ha ras human; Carcinogenicity testing; Chemical carcinogenesis; rasH2 mouse; Transgenic mouse

Indexed keywords

1,1,2 TRICHLOROETHANE; 2 IMIDAZOLIDINETHIONE; ACRYLIC ACID ETHYL ESTER; BENZENE; CARCINOGEN; CYCLOSPORIN; DIOXANE; FURFURAL; MUTAGENIC AGENT;

ANIMAL MODEL; BIOASSAY; CARCINOGEN TESTING; CONFERENCE PAPER; DOSE RESPONSE; DOSE TIME EFFECT RELATION; KNOCKOUT MOUSE; METHODOLOGY; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL;

ANIMALS; CARCINOGENICITY TESTS; GENES, RAS; HUMANS; MICE; MICE, TRANSGENIC;

ANIMALIA; MUS MUSCULUS; SALMONELLA;

EID: 0032440863     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00341-5     Document Type: Conference Paper

References (8)

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2. ICH Harmonised Triparite Guideline, 1997. Testing for carcinogenicity of pharmaceuticals for human use. In: D'Arcy, P.F., Harron, D.W.G. (Eds.), Proceedings of The Fourth International Conference on Harmonisation Brussels 1997, Queen's University of Belfast, N. Ireland, pp. 949, 23-1-23-7.
3. Mitsumori, K., Wakana, S., Yamamoto, S., Kodama, Y., Yasuhara, K., Nomura, T., Hayashi, Y., Maronpot, R.R., 1998a. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses on the induced tumors. Mol. Carcinogen. 20, 307.
4. Mitsumori, K., Koizumi, H., Nomura, T., Yamamoto, S., 1998b. Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for 6-month carcinogenicity studies. Pathol. Toxicol. (in press).
5. Saitoh, A., Kimura, M., Takahashi, R., Yokoyama, M., Nomura, T., Izawa, M., Sekiya, T., Nishimura, S., Katsuki, M., 1990. Most tumors in transgenic mice with human c-Ha-ras gene contained somatically activated transgenes. Oncogene 5, 1195-1200.
6. Yamamoto, S., Mitsumori, K., Kodama, Y., Matsunuma, N., Manabe, S., Okamiya, H., Suzuki, H., Fukuda, T., Sakamaki, Y., Sunaga, M., Nomura, G., Hioki, K., Wakana, S., Nomura, T., Hayashi, Y., 1996. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring human prototype c-Ha-ras gene than in control nontransgenic mice. Carcinogenesis 17, 2455-2461.
7. Yamamoto, S., Hayashi, Y., Mitsumori, K., Nomura, T., 1997. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene. Lab. Anim. Sci. 47, 121-126.
8. Yamamoto, S., Urano, K., Koizumi, H., Wakana, S., Hioki, K., Mitsumori, K., Kurokawa, Y., Hayashi, Y., Nomura, T., 1998. Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. Environ. Health Perspect. 106, 57-69.