Sodium butyrate alters erythropoietin glycosylation via multiple mechanisms

Biotechnology and Bioengineering

Volumn 99, Issue 1, 2008, Pages 201-213

  Crowell, Christopher K ^a   Qin, Qiang ^a   Grampp, Gustavo E ^a   Radcliffe, Richard A ^b   Rogers, Gary N ^a   Scheinman, Robert I ^b  

^a AMGEN INC   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Cell culture; Glycosylation; HT1080; Oligonucleotide micro arrays; Recombinant human erythropoietin (rHuEPO); Sodium butyrate

Indexed keywords

HT1080; OLIGONUCLEOTIDE MICRO-ARRAYS; RECOMBINANT HUMAN ERYTHROPOIETIN (RHUEPO); SODIUM BUTYRATE;

CELL CULTURE; NUCLEOTIDES; PROTEINS; SODIUM COMPOUNDS;

GLYCOSYLATION;

BETA 1,3 N ACETYLGLUCOSAMINYLTRANSFERASE 1; BETA 1,3 N ACETYLGLUCOSAMINYLTRANSFERASE 6; BUTYRIC ACID; CARBOHYDRATE DERIVATIVE; GALACTOSE 1 PHOSPHATE URIDYLYLTRANSFERASE; LACTOSE; POLYLACTOSAMINE; RECOMBINANT ERYTHROPOIETIN; SIALYLTRANSFERASE; SIALYLTRANSFERASE 4B; SLC17A5 PROTEIN; SUGAR NUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ARTICLE; CARBOHYDRATE ANALYSIS; CELL GROWTH; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; GLYCOBIOLOGY; HUMAN; HUMAN CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIALYLATION;

BUTYRATES; CELL LINE, TUMOR; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN, RECOMBINANT; FIBROSARCOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOSYLATION; HUMANS; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; PROTEIN ENGINEERING;

EID: 37549002545     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21539     Document Type: Article

References (36)

1. Agresti A, Bianchi ME. 2003. HMGB proteins and gene expression. Curr Opin Genet Dev 13(2):170-178.
2. Ahringer J. 2000. NuRD and SIN3 histone deacetylase complexes in development. Trends Genet 16(8):351-356.
3. Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc B 57:289-300.
4. Candido EP, Reeves R, Davie JR. 1978. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14(1):105-113.
5. Chotigeat W, Watanapokasin Y, Mahler S, Gray PP. 1994. Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase for hFSH produced by recombinant CHO cells. Cytotechnology 15(1-3):217-221.
6. Chung BS, Jeong YT, Chang KH, Kim JS, Kim JH. 2001. Effect of sodium butyrate on glycosylation of recombinant erythropoietin. J Microbiol Biotechnol 11(6):1087-1092.
7. Davie JR. 2003. Inhibition of histone deacetylase activity by butyrate. J Nutr 133 (Suppl 7): 2485S-2493S.
8. Fisher JW. 2003. Erythropoietin: Physiology and pharmacology update. Exp Biol Med (Maywood) 228(1):1-14.
9. Goochee CF, Gramer MJ, Andersen DC, Bahr JB, Rasmussen JR. 1991. The oligosaccharides of glycoproteins: Bioprocess factors affecting oligosaccharide structure and their effect on glycoprotein properties. Bio/Technology 9(12):1347-1355.
10. Graber SE, Krantz SB. 1989. Erythropoietin: Biology and clinical use. Hematol Oncol Clin North Am 3(3):369-400.
11. Hendrick V, Winnepenninckx P, Abdelkafi C, Vandeputte O, Cherlet M, Marique T, Renemann G, Loa A, Kretzmer G, Werenne J. 2001. Increased productivity of recombinant tissular plasminogen activator (t-PA) by butyrate and shift of temperature: A cell cycle phases analysis. Cytotechnology 36(1-3):71-83.
12. Iacomino G, Tecce MF, Grimaldi C, Tosto M, Russo GL. 2001. Transcriptional response of a human colon adenocarcinoma cell line to sodium butyrate. Biochem Biophys Res Commun 285(5):1280-1289.
13. Jenkins N, Parekh RB, James DC. 1996. Getting the glycosylation right: Implications for the biotechnology industry. Nat Biotechnol 14(8):975-981.
14. Kim NS, Lee GM. 2000. Overexpression of bcl-2 inhibits sodium butyrate-induced apoptosis in Chinese hamster ovary cells resulting in enhanced humanized antibody production. Biotechnol Bioeng 71(3):184-193.
15. Kornfeld R, Kornfeld S. 1985. Assembly of asparagine-linked oligosaccharides. Annu Rev Biochem 54:631-664.
16. Kruh J. 1982. Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 42(2):65-82.
17. Laubach VE, Garvey EP, Sherman PA. 1996. High-level expression of human inducible nitric oxide synthase in Chinese hamster ovary cells and characterization of the purified enzyme. Biochem Biophys Res Commun 218(3):802-807.
18. Litvak DA, Evers BM, Hwang KO, Hellmich MR, Ko TC, Townsend CM, Jr. 1998. Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21Waf1/Cip1 and p27Kip1. Surgery 124(2):161-169; discussion 169-170.
19. Mimura Y, Lund J, Church S, Dong S, Li J, Goodall M, Jefferis R. 2001. Butyrate increases production of human chimeric IgG in CHO-K1 cells whilst maintaining function and glycoform profile. J Immunol Methods 247:205-216.
20. Munshi N, Agalioti T, Lomvardas S, Merika M, Chen G, Thanos D. 2001. Coordination of a transcriptional switch by HMGI(Y) acetylation. Science 293(5532):1133-1136.
21. Murrell MP, Yarema KJ, Levchenko A. 2004. The systems biology of glycosylation. Chembiochem 5(10):1334-1347.
22. Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DG. 2003. Butyrate modulates gene and protein expression in human intestinal endothelial cells. Biochem Biophys Res Commun 309(3):512-519.
23. Palermo DP, DeGraaf ME, Marotti KR, Rehberg E, Post LE. 1991. Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. J Biotechnol 19(1):35-47.
24. Prasad KN, Sinha PK. 1976. Effect of sodium butyrate on mammalian cells in culture: A review. In Vitro 12(2):125-132.
25. Rabelo FL, Ropert C, Ramos MG, Bonjardim CA, Gazzinelli RT, Alvarez-Leite JI. 2003. Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrate. Biochem Biophys Res Commun 303(3):968-972.
26. Rasheed S, Nelson-Rees WA, Toth EM, Arnstein P, Gardner MB. 1974. Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer 33(4):1027-1033.
27. Rijcken WRP, Overdijk B, Van Den Eijnden DH, Ferwerda W. 1993. Pyrimidine nucleotide metabolism in rat hepatocytes: Evidence for compartmentation of nucleotide pools. Biochem J 293(1):207-213.
28. Ryll T, Wagner R. 1991. Improved ion-pair high-performance liquid chromatographic method for the quantification of a wide variety of nucleotides and sugar-nucleotides in animal cells. J Chromatogr A 570(1):77-88.
29. Santell L, Ryll T, Etcheverry T, Santoris M, Dutina G, Wang A, Gunson J, Warner TG. 1999. Aberrant metabolic sialylation of recombinant proteins expressed in Chinese hamster ovary cells in high productivity cultures. Biochem Biophys Res Commun 258(1):132-137.
30. Sasaki K, Kurata-Miura K, Ujita M, Angata K, Nakagawa S, Sekine S, Nishi T, Fukuda M. 1997. Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis. Proc Natl Acad Sci USA 94(26):14294-14299.
31. Sealy L, Chalkley R. 1978. The effect of sodium butyrate on histone modification. Cell 14(1):115-121.
32. Sung YH, Song YJ, Lim SW, Chung JY, Lee GM. 2004. Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells. J Biotechnol 112(3):323-335.
33. Tabuchi Y, Arai Y, Kondo T, Takeguchi N, Asano S. 2002. Identification of genes responsive to sodium butyrate in colonic epithelial cells. Biochem Biophys Res Commun 293(4):1287-1294.
34. Van den Steen P, Rudd PM, Dwek RA, Opdenakker G. 1998. Concepts and principles of O-linked glycosylation. Crit Rev Biochem Mol Biol 33(3):151-208.
35. Walker GE, Wilson EM, Powell D, Oh Y. 2001. Butyrate, a histone deacetylase inhibitor, activates the human IGF binding protein-3 promoter in breast cancer cells: Molecular mechanism involves an Sp1/Sp3 multiprotein complex. Endocrinology 142(9):3817-3827.
36. Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T. 1999. A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. Proc Natl Acad Sci USA 96(2):406-411.