Calcifications in the abdominal aorta predict fractures in men: MINOS study

Journal of Bone and Mineral Research

Volumn 23, Issue 1, 2008, Pages 95-102

  Szulc, Pawel ^a,c   Kiel, Douglas P ^b   Delmas, Pierre D ^a  

^a UNIVERSITÉ DE LYON   (France)

^b HARVARD MEDICAL SCHOOL   (United States)

^c EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL AORTA; ADULT; ARTERY CALCIFICATION; ARTICLE; BODY MASS; BONE DENSITY; COMORBIDITY; DISEASE SEVERITY; FOREARM; FRAGILITY FRACTURE; HIP; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MORTALITY; RADIUS; RISK ASSESSMENT; RISK FACTOR; SMOKING;

AGED; AORTIC DISEASES; BONE DENSITY; CALCINOSIS; FOLLOW-UP STUDIES; FRACTURES, BONE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; OSTEOPOROSIS; PROSPECTIVE STUDIES;

EID: 37549000545     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070903     Document Type: Article

References (69)

1. Farhat GN, Cauley JA, Matthews KA, Newman AB, Johnston J, Mackey R, Edmundowicz D, Sutton-Tyrrell K 2006 Volumetric bone mineral density and vascular calcification in middle-aged women: The Study of Women's Health across the Nation. J Bone Miner Res 21:1839-1846.
2. Farhat GN, Strotmeyer ES, Newman AB, Sutton-Tyrrell K, Bauer DC, Harris T, Johnson KC, Taaffe DR, Cauley JA 2006 Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women: The Health, Aging, and Body Composition Study. Calcif Tissue Int 79:102-111.
3. Schulz E, Arfai K, Liu X, Sayre J, Gilsanz V 2004 Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89:4246-4253.
4. Hak AE, Pols HAP, van Hemert AM, Hofman A, Witteman JCM 2000 Progression of aortic calcification is associated with metacarpal bone loss during menopause: A population-based longitudinal study. Arterioscler Thromb Vasc Biol 20:1926-1931.
5. Tankó LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR 2005 Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 20:1912-1920.
6. Browner WS, Seelay DG, Vogt TM, Cummings SR 1991 Non-trauma mortality in elderly women with low bone mineral density. Study of Osteoporotic Fractures research group. Lancet 338:355-358.
7. Bagger YZ, Tankó LB, Alexandersen P, Qin G, Christiansen C 2006 Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J Intern Med 259:598-605.
8. Samelson EJ, Cupples LA, Broe KE, Hannan MT, O'Donnell CJ, Kiel DP 2007 Vascular calcification in middle-age and long term risk of hip fracture: The Framingham study. J Bone Miner Res 22:1449-1454.
9. Jørgensen L, Joakimsen O, Rosvold Bernsten GK, Heuch I, Jacobsen BK 2004 Low bone mineral density is related to echogenic carotid artery plaques: A population-based study. Am J Epidemiol 160:549-556.
10. Wong SYS, Kwok T, Woo J, Lynn H, Griffith JF, Leung J, Tang YYN, Leung PC 2005 Bone mineral density and the risk of peripheral arterial disease in men and women: Results from Mr. and Ms Os, Hong Kong. Osteoporos Int 16:1933-1938.
11. Latoche M, Pouilles JM, Ribot C, Bendayan P, Bernard J, Boccalon H, Mazieres B 1994 Comparison of the bone mineral content of the lower limbs in men with ischaemic atherosclerotic disease. Clin Rheumatol 13:611-614.
12. Magnus JH, Broussard DL 2005 Relationship between bone mineral density and myocardial infarction in US adults. Osteoporos Int 16:2053-2062.
13. Mussolino ME, Madans JH, Gillum RF 2003 Bone mineral density and mortality in women and men: The NHANES I epidemiologic follow-up study. Ann Epidemiol 13:692-697.
14. van der Klift M, Pols HAP, Geleijnse JM, van der Kuip DAM, Hofman A, de Laet CEDH 2002 Bone mineral density and mortality in elderly men and women: The Rotterdam study. Bone 30:643-648.
15. Trivedi DP, Khaw KT 2001 Bone mineral density at the hip predicts morality in elderly men. Osteoporos Int 12:259-265.
16. van der Klift M, Pols HAP, Hak AE, Witteman JCM, Hofman A, de Laet CEDH 2002 Bone mineral density and the risk of peripheral arterial disease: The Rotterdam study. Calcif Tissue Int 70:443-449.
17. Jørgensen L, Engstad T, Jacobsen BK 2001 Bone mineral density in acute stroke patients: Low bone mineral density may predict first stroke in women. Stroke 32:47-51.
18. Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O'Donnell CJ, Wilson PWF 2001 Bone loss and the progression of abdominal aortic calcification over a 25 year period: The Framingham Heart Study. Calcif Tissue Int 68:271-276.
19. Samelson EJ, Kiel DP, Broe KE, Zhang Y, Cupples LA, Hannan MT, Wilson PWF, Levy D, Williams SA, Vaccarino V 2004 Metacarpal cortical area and risk of coronary heart disease. The Framingham Study. Am J Epidemiol 159:589-595.
20. Allison MA, Criqui MH, Wright CM 2004 Patterns and risk factors for systemic calcified atherosclerosis. Arterioscler Thromb Vasc Biol 24:331-336.
21. Witteman JCM, Kok FJ, van Saase JLCM, Valkenburg HA 1986 Aortic calcification as a predictor of cardiovascular mortality. Lancet 2:1120-1122.
22. Wilson PWF, Kauppila LI, O'Donnell CJ, Kiel DP, Hannan M, Polak JM, Cupples LA 2001 Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation 103:1529-1534.
23. Szulc P, Marchand F, Duboeuf F, Delmas PD 2000 Crosssectional assessment of age-related bone loss in men: The MINOS study. Bone 26:123-129.
24. Szulc P, Dubeouf F, Marchand F, Delmas PD 2004 Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: The MINOS study. Am J Clin Nutr 80:496-503.
25. Szulc P, Munoz F, Dubeouf F, Marchand F, Delmas PD 2005 Bone mineral density predicts osteoporotic fractures in elderly men: The MINOS study. Osteoporos Int 16:1184-1192.
26. Szulc P, Munoz F, Marchand F, Delmas PD 2001 Semiquantitative evaluation of prevalent vertebral deformities in men and their relationship with osteoporosis: The MINOS study. Osteoporos Int 12:302-310.
27. Szulc P, Uusi-Rasi K, Claustrat B, Marchand F, Beck TJ, Delmas PD 2004 Role of sex steroids in the regulation of bone morphology in men. The MINOS study. Osteoporos Int 15:909-917.
28. Kauppila LI, Polak JF, Cupples LA, Hannan MT, Kiel DP, Wilson PWF 1997 New indices to classify location, severity, and progression of calcific lesions in the abdominal aorta: A 25-year follow-up study. Atherosclerosis 132:245-250.
29. Szulc P, Munoz F, Dubeouf F, Marchand F, Delmas PD 2006 Low width of tubular bones is associated with increased risk of fragility fracture in elderly men - the MINOS study. Bone 38:595-602.
30. Mazzini MJ, Schulze PC 2006 Proatherogenic pathways leading ot vascular calcifications. Eur J Radiol 57:384-389.
31. Hak AE, Witteman JCM, de Jong FH, Geerlings MI, Hofman A, Pols HAP 2002 Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: The Rotterdam study. J Clin Endocrinol Metab 87:3632-3639.
32. Hruska KA, Mathew S, Saab G 2005 Bone morphogenetic proteins in vascular calcifications. Circ Res 97:105-114.
33. Schoppet M, Preissner KT, Hofbauer LC 2002 RANK ligand and osteoprotegerin: Paracrine regulators of bone metabolism and vascular function. Arterioscler Thromb Vasc Biol 22:549-553.
34. Browner WS, Lui LY, Cummings SR 2001 Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women. J Clin Endocrinol Metab 86:631-637.
35. Grundy SM, Brewer HB, Cleeman JI, Smith SC Jr, Lenfant C 2004 Definition of metabolic syndrome. Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation 109:433-438.
36. von Muhlen D, Safii S, Jassal SK, Svartberq J, Barrett-Connor E 2007 Associations between the metabolic syndrome and bone health in older men and women: The Rancho Bernardo Study. Osteoporos Int 18:1337-1344.
37. Katz R, Wong ND, Kronmal R, Takasu J, Shavelle DM, Probstfield JL, Bertoni AG, Budoff MJ, O'Brien KD 2006 Features of the metabolic syndrome and diabetes mellitus as predictors of aortic valce calcification in the multi-ethnic study of atherosclerosis. Circulation 113:2113-2119.
38. Tankó L, Bagger YZ, Qin G, Alexandersen P, Larsen PJ, Christiansen C 2005 Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women. Circulation 111:1883-1890.
39. Muller M, Grobbee DE, den Tonkelaar I, Lamberts SWJ, van der Schouw YT 2005 Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metab 90:2618-2623.
40. Szulc P, Claustrat B, Marchand F, Delmas PD 2003 Increased risk of falls and increased bone resorption in elderly men with partial androgen deficiency: The MINOS study. J Clin Endocrinol Metab 88:5240-5247.
41. Fink HA, Ewing SK, Ensrud KE, Barrett-Connor E, Taylor BC, Cauley JA, Orwoll ES 2006 Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men. J Clin Endocrinol Metab 91:3908-3915.
42. Stanley HL, Schmitt BP, Poses RM, Deiss WP 1991 Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 39:766-771.
43. Jackson JA, Riggs MW, Spiekerman AM 1992 Testosterone deficiency as a risk factor for hip fractures in men: A case-control study. Am J Med Sci 304:4-8.
44. Cappuccio FP, Meilahn E, Zmuda JM, Cauley JA 1999 High blood pressure and bone-mineral loss in elderly white women: A prospective study. Lancet 354:971-975.
45. Metz JA, Morris CD, Roberts LA, McClung MR, McCarron DA 1999 Blood pressure and calcium intake are related to bone density in adult males. Br J Nutr 81:383-388.
46. Mussolino ME, Gillum RF 2006 Bone mineral density and hypertension prevalence in postmenopausal women: Results from the Third National Health and Nutrition Examination Survey. Ann Epidemiol 16:395-399.
47. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL 2001 Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res 16:182-188.
48. Towler DA, Bidder M, Latifi T, Coleman T, Semenkovich CF 1998 Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. J Biol Chem 273:30427-30434.
49. Corwin RL, Hartman TJ, Maczuga SA, Graubard BI 2006 Dietary saturated fat intake is inversely associated with bone density in humans: Analysis of NHANES III. J Nutr 136:159-165.
50. Whiting SJ, Boyle JL, Thompson A, Mirwald RL, Faulkner RA 2002 Dietary protein, phosphorus and potassium are beneficial to bone mineral density in adult men consuming adequate dietary calcium. J Am Coll Nutr 21:402-409.
51. Raggi P, Giachelli C, Bellasi A 2007 Interaction of vascular and bone disease in patients with normal renal function and patients undergoing dialysis. Nat Clin Pract Cardiovasc Med 4:26-33.
52. London GM, Marty C, Marchais SJ, Guerin AP, Metivier F, de Vernejoul MC 2004 Arterial calcifications and bone histomorphometry in end-stage renal disease. J Am Soc Nephrol 15:1943-1951.
53. Cunningham J, Danese M, Olson K, Klassen P, Chertow GM 2005 Effects of the calcimimetic cinacalcet HCl on cardiovascular disease, fracture, and health-related quality of life in secondary hyperparathyroidism. Kidney Int 68:1793-1800.
54. Shao JS, Cheng SL, Charlton-Kachigian N, Loewy AP, Towler DA 2003 Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice. J Biol Chem 278:50195-50202.
55. van Meurs JBJ, Dhonukshe-Rutten RAM, Pluijm SMF, van der Klift M, de Jonge R, Lindemans J, de Groot LCPGM, Hofman A, Witterman JCM, van Leeuven JPTM, Breteler MMB, Lips P, Pols HAP, Uitterlinden AG 2004 Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033-2041.
56. Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K 2005 Homocysteine as a predictive factor for hip fracture in stroke patients. Bone 36:721-726.
57. Sato Y, Iwamoto J, Kanoko T, Satoh K 2005 Homocysteine as a predictive factor for hip fracture in elderly women with Parkinson's disease. Am J Med 118:1250-1255.
58. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, Hannan MT, Cupples LA, Kiel DP 2004 Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 350:2042-2049.
59. Chambers JC, Obeid OA, Refsum H, Ueland P, Hackett D, Hooper J, Turner RM, Thompson SG, Kooner JS 2000 Plasma homocysteine concentrations and risk of coronary heart disease in UK Indian Asian and European men. Lancet 355:523-527.
60. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE 1997 Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337:230-236.
61. Hirose N, Arai Y, Ishii T, Tushima M, Li J 2001 Association of mild hyperhomocysteinemia with aortic calcification in hypercholesterolemic patients. J Atheroscler Thromb 8:91-94.
62. Raposo B, Rodriguez C, Martinez-Gonzalez J, Badimon L 2004 High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells. Atherosclerosis 177:1-8.
63. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GH 1996 Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta 1315:159-162.
64. Li J, Chai S, Tang C, Du J 2003 Homocysteine potentiates calcification of cultured rat aortic smooth muscle cells. Life Sci 74:451-461.
65. Kannus P, Sievänen H, Palvanen M, Järvinen T, Parkkari J 2005 Prevention of falls and consequent injuries in edlerly people. Lancet 366:1885-1893.
66. Lawlor DA, Patel R, Ebrahim S 2003 Association between falls in elderly women and chronic diseases and drug use: Cross sectional study. BMJ 327:712-717.
67. de Carle AJ, Kohn R 2001 Risk factors for falling in a psychogeriatric unit. Int J Geriatr Psychiatry 16:762-767.
68. Schwartz AV, Hillier TA, Sellmeyer DE, Resnick HE, Gregg E, Ensrud KE, Schreiner PJ, Margolis KL, Cauley JA, Nevitt MC, Black DM, Cummings SR 2002 Older women with diabetes have a higher risk of falls: A prospective study. Diabetes Care 25:1749-1754.
69. Poór G, Atkinson EJ, O'Fallon WM, Melton LJ III 1995 Predictors of hip fractures in elderly men. J Bone Miner Res 10:1900-1907.