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Volumn 189, Issue 24, 2007, Pages 9131-9135

Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket

Author keywords

[No Author keywords available]

Indexed keywords

DIVALENT CATION; GLYCOPROTEIN P; MEMBRANE PROTEIN;

EID: 37449027379     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01492-07     Document Type: Article
Times cited : (14)

References (11)
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    • Adler, J., and E. Bibi. 2005. Promiscuity in the geometry of electrostatic interactions between the Escherichia coli multidrug resistance transporter MdfA and cationic substrates. J. Biol. Chem. 280:2721-2729.
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    • Adler, J.1    Bibi, E.2
  • 2
    • 0345832205 scopus 로고    scopus 로고
    • Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA
    • Adler, J., O. Lewinson, and E. Bibi. 2004. Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA. Biochemistry 43:518-525.
    • (2004) Biochemistry , vol.43 , pp. 518-525
    • Adler, J.1    Lewinson, O.2    Bibi, E.3
  • 3
    • 0037599378 scopus 로고    scopus 로고
    • Analysis on distribution and genomic diversity of high-level antiseptic resistance genes qacA and qacB in human clinical isolates of Staphylococcus aureus
    • Alam, M. M., N. Kobayashi, N. Uehara, and N. Watanabe. 2003. Analysis on distribution and genomic diversity of high-level antiseptic resistance genes qacA and qacB in human clinical isolates of Staphylococcus aureus. Microb. Drug Resist. 9:109-121.
    • (2003) Microb. Drug Resist , vol.9 , pp. 109-121
    • Alam, M.M.1    Kobayashi, N.2    Uehara, N.3    Watanabe, N.4
  • 5
    • 0033558105 scopus 로고    scopus 로고
    • A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA
    • Edgar, R., and E. Bibi. 1999. A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA. EMBO J. 18:822-832.
    • (1999) EMBO J , vol.18 , pp. 822-832
    • Edgar, R.1    Bibi, E.2
  • 6
    • 0037135571 scopus 로고    scopus 로고
    • Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport of lipophilic cationic compounds
    • Mazurkiewicz, P., W. N. Konings, and G. J. Poelarends. 2002. Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport of lipophilic cationic compounds. J. Biol. Chem. 277:26081-26088.
    • (2002) J. Biol. Chem , vol.277 , pp. 26081-26088
    • Mazurkiewicz, P.1    Konings, W.N.2    Poelarends, G.J.3
  • 7
    • 0033524927 scopus 로고    scopus 로고
    • Bioenergetics of the staphylococcal multidrug export protein QacA: Identification of distinct binding sites for monovalent and divalent cations
    • Mitchell, B. A., I. T. Paulsen, M. H. Brown, and R. A. Skurray. 1999. Bioenergetics of the staphylococcal multidrug export protein QacA: identification of distinct binding sites for monovalent and divalent cations. J. Biol. Chem. 274:3541-3548.
    • (1999) J. Biol. Chem , vol.274 , pp. 3541-3548
    • Mitchell, B.A.1    Paulsen, I.T.2    Brown, M.H.3    Skurray, R.A.4
  • 8
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    • Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization
    • Murray, D. S., M. A. Schumacher, and R. G. Brennan. 2004. Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. J. Biol. Chem. 279:14365-14371.
    • (2004) J. Biol. Chem , vol.279 , pp. 14365-14371
    • Murray, D.S.1    Schumacher, M.A.2    Brennan, R.G.3
  • 9
    • 0029872148 scopus 로고    scopus 로고
    • Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: Membrane topology and identification of residues involved in substrate specificity
    • Paulsen, I. T., M. H. Brown, T. G. Littlejohn, B. A. Mitchell, and R. A. Skurray. 1996. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. Proc. Natl. Acad. Sci. USA 93:3630-3635.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3630-3635
    • Paulsen, I.T.1    Brown, M.H.2    Littlejohn, T.G.3    Mitchell, B.A.4    Skurray, R.A.5
  • 11
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    • Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA
    • Xu, Z., B. A. O'Rourke, R. A. Skurray, and M. H. Brown. 2006. Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA. J. Biol. Chem. 281:792-799.
    • (2006) J. Biol. Chem , vol.281 , pp. 792-799
    • Xu, Z.1    O'Rourke, B.A.2    Skurray, R.A.3    Brown, M.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.