Highly protective E2-CSFV vaccine candidate produced in the mammary gland of adenoviral transduced goats

Journal of Biotechnology

Volumn 133, Issue 3, 2008, Pages 370-376

  Toledo, Jorge R ^a   Sánchez, Oliberto ^a   Montesino, Raquel ^a   Farnos, Omar ^a   Rodríguez, Maria P ^a   Alfonso, Pastor ^b   Oramas, Nayrobis ^a   Rodríguez, Elsa ^a   Santana, Elaine ^a   Vega, Ernesto ^b   Ganges, Llilianne ^c   Frias, Maria T ^b   Cremata, José ^a   Barrera, Maritza ^b  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b National Centre for Animal and Plant Health CENSA   (Cuba)

^c INIA   (Spain)

Author keywords

Adenoviral transduction; CSFV; E2 glycoprotein; Goat milk; Mammary gland; Veterinary vaccine

Indexed keywords

ADENOVIRAL TRANSDUCTION; GOAT MILK; MAMMARY GLANDS; VETERINARY VACCINES;

CHELATION; DIMERS; GLYCOPROTEINS; MEDICAL PROBLEMS; SIGNAL TRANSDUCTION; VIRUSES;

VACCINES;

ADENOVIRUS VECTOR; GLYCOPROTEIN E2; HOMODIMER; MANNOSE OLIGOSACCHARIDE; MANNOSIDE; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG; VIRUS VACCINE;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FEMALE; GENE EXPRESSION; GLYCOSYLATION; GOAT; LD 50; MAMMARY GLAND; MILK; NONHUMAN; NUCLEOTIDE SEQUENCE; PESTIVIRUS; PRIORITY JOURNAL; PROTEIN PURIFICATION; SWINE DISEASE; VACCINATION; VETERINARY MEDICINE; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTION;

ADENOVIRIDAE; ANIMALS; BODY TEMPERATURE; CELL LINE; CLASSICAL SWINE FEVER; CLASSICAL SWINE FEVER VIRUS; DIMERIZATION; GLYCOSYLATION; GOATS; HISTIDINE; HUMANS; INJECTIONS, INTRAMUSCULAR; MAMMARY GLANDS, ANIMAL; MILK; OLIGOPEPTIDES; OLIGOSACCHARIDES; SWINE; TIME FACTORS; TRANSDUCTION, GENETIC; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES;

CAPRA HIRCUS; CLASSICAL SWINE FEVER VIRUS; SUIDAE;

EID: 37449022164     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2007.09.014     Document Type: Article

References (28)

1. Cammuso C., Porter C., Nims S., Gaucher D., Melican D., Bombard S., Hawkins N., O'Coin A., Ricci C., Brayman C., Buzzell N., Ziomek C., and Gavin W. Hormonal induced lactation in transgenic goats. Anim. Biotechnol. 11 (2000) 1-17
2. Clark A.J. The mammary gland as a bioreactor: expression, processing, and production of recombinant proteins. J. Mammary Gland Biol. Neoplasia 3 (1998) 337-350
3. Diaz de Arce H., Nunez J.I., Ganges L., Barreras M., Frias M.T., and Sobrino F. Molecular epidemiology of classical swine fever in Cuba. Virus Res. 64 (1999) 61-67
4. Diaz de Arce H., Ganges L., Barrera M., Naranjo D., Sobrino F., Frias M.T., and Nunez J.I. Origin and evolution of viruses causing classical swine fever in Cuba. Virus Res. 112 (2005) 123-131
5. Dong X.N., and Chen Y.H. Marker vaccine strategies and candidate CSFV marker vaccines. Vaccine 25 (2007) 205-230
6. Edmunds T., Van Patten S.M., Pollock J., Hanson E., Bernasconi R., Higgins E., Manavalan P., Ziomek C., Meade H., McPherson J.M., and Cole E.S. Transgenically produced human antithrombin: structural and functional comparison to human plasma-derived antithrombin. Blood 91 (1998) 4561-4571
7. Ferreira T.B., Alves P.M., Aunins J.G., and Carrondo M.J. Use of adenoviral vectors as veterinary vaccines. Gene Ther. 1 (2005) S73-S83
8. Ganges L., Barrera M., Nunez J.I., Blanco I., Frias M.T., Rodríguez F., and Sobrino F. A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge. Vaccine 23 (2005) 3741-3752
9. Graham F.L., Smiley J., Russel W.C., and Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus 5. J. Gen. Virol. 36 (1977) 59-72
10. Han Z.S., Li Q.W., Zhang Z.Y., Xiao B., Gao D.W., Wu S.Y., Li J., Zhao H.W., Jiang Z.L., and Hu J.H. High-level expression of human lactoferrin in the milk of goats by using replication-defective adenoviral vectors. Protein Expr Purif. 53 (2006) 225-231
11. He T.C., Zhou S., da Costa L.T., Yu J., Kinzler K.W., and Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 2509-2514
12. Houdebine L.M. Transgenic animal bioreactors. Transgenic Res. 9 (2000) 305-320
13. Moennig V. Introduction to classical swine fever: virus, disease and control policy. Vet. Microbiol. 73 (2000) 93-102
14. Niemann H., and Kues W. Application of transgenesis in livestock for agriculture and biomedicine. Anim. Reprod. Sci. 79 (2003) 291-317
15. Niemann H., Kues W., and Carnwath J.W. Transgenic farm animals: present and future. Rev. Sci. Tech. 24 (2005) 285-298
16. OIE, 2004. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2004 consulted October 30, 2006: http://www.oie.int/eng/normes/mmanual/A_00036.htm.
17. Risatti G.R., Borca M.V., Kutish G.F., Lu Z., Holinka L.G., French R.A., Tulman E.R., and Rock D.L. The E2 glycoprotein of classical swine fever virus is a virulence determinant in swine. J. Virol. 79 (2005) 3787-3796
18. Robl J.M., Wang Z., Kasinathan P., and Kuroiwa Y. Transgenic animal production and animal biotechnology. Theriogenology 67 (2007) 127-133
19. Rumenapf T., Stark R., Meyers G., and Thiel H.-J. Structural proteins of hog cholera virus expressed by vaccinia virus: further characterization and induction of protective immunity. J. Virol. 65 (1991) 589-597
20. Sanchez O., Toledo J.R., Rodríguez M.P., and Castro F.O. Adenoviral vector mediates high expression levels of human growth hormone in the milk of mice and goats. J. Biotechnol. 114 (2004) 89-97
21. Sanchez, O., Barrera, M., Rodríguez, M.P., Frias, M.T., Figueroa, N.E., Naranjo, P., Montesino, R., Farnos, O., Castell, S., Venereo, A., Ganges, L., Borroto, C., Toledo, J.R., 2007. Classical swine fever virus E2 glycoprotein antigen produced in adenovirally transduced PK-15 cells confers complete protection in pigs upon viral challenge. Vaccine, in press.
22. Toledo J.R., Sanchez O., Montesino R., García G., Montañez M., Zamora P.A., Rodríguez M.P., and Cremata J. High expression level of recombinant human erythropoietin in the milk of non-transgenic goats. J. Biotechnol. 123 (2006) 225-235
23. Van Berkel P.H., Welling M.M., Geerts M., van Veen H.A., Ravensbergen B., Salaheddine M., Pauwels E.K., Pieper F., Nuijens J.H., and Nibbering P.H. Large scale production of recombinant human lactoferrin in the milk of transgenic cows. Nat. Biotechnol. 20 (2002) 484-487
24. van Rijn P.A., Miedema G.K., Wensvoort G., van Gennip H.G., and Moormann R.J. Antigenic structure of envelope glycoprotein E1 of hog cholera virus. J. Virol. 68 (1994) 3934-3942
25. van Oirschot J.T. Diva vaccines that reduce virus transmission. J. Biotechnol. 73 (1999) 195-205
26. van Oirschot J.T. Vaccinology of classical swine fever: from lab to field. Vet. Microbiol. 96 (2003) 367-384
27. Wensvoort G., Terpstra C., Boonstra J., Bloemraad M., and Van Zaane D. Production of monoclonal antibodies against swine fever virus and their use in laboratory diagnosis. Vet. Microbiol. 12 (1986) 101-108
28. Wheeler M.B. Production of transgenic livestock: promise fulfilled. J. Anim. Sci. 81 (2003) 32-37