High-level expression of human lactoferrin in the milk of goats by using replication-defective adenoviral vectors

Protein Expression and Purification

Volumn 53, Issue 1, 2007, Pages 225-231

  Han, Zeng Sheng ^a,b   Li, Qing Wang ^a,b   Zhang, Zhi Ying ^b,c   Xiao, Bo ^a,d   Gao, Da Wei ^b   Wu, Shu Yun ^a   Li, Jian ^b   Zhao, Hong Wei ^b   Jiang, Zhong Liang ^a   Hu, Jian Hong ^a  

^a NORTHWEST A F UNIVERSITY   (China)

^b YANSHAN UNIVERSITY   (China)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^d LUDONG UNIVERSITY   (China)

Author keywords

Goats; Human lactoferrin; Mammary gland; Milk; Recombinant adenovirus; Recombinant protein

Indexed keywords

COLLAGENASE; COMPLEMENTARY DNA; LACTOFERRIN; RECOMBINANT PROTEIN; VIRUS DNA;

ADENOVIRUS; ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; DNA REPLICATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; GOAT; HISTOLOGY; HUMAN; METABOLISM; MILK; MOLECULAR WEIGHT; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; UDDER; VIROLOGY; VIRUS CELL TRANSFORMATION; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL LINE; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; COLLAGENASES; DNA REPLICATION; DNA, COMPLEMENTARY; DNA, VIRAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; GENETIC VECTORS; GOATS; HUMANS; LACTOFERRIN; MAMMARY GLANDS, ANIMAL; MILK; MOLECULAR WEIGHT; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; TRANSFECTION;

ADENOVIRIDAE; ANIMALIA; CAPRA HIRCUS;

EID: 33847144886     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pep.2006.11.019     Document Type: Article

References (35)

1. Lonnerdal B., and Iyer S. Lactoferrin: molecular structure and biological function. Annu. Rev. Nutr. 15 (1995) 93-110
2. Vorland L.H. Lactoferrin: a multifunctional glycoprotein. APMIS 107 (1999) 971-981
3. Togawa J., Nagase H., Tanaka K., Inamori M., Nakajima A., Ueno N., Saito T., and Sekihara H. Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. J. Gastroenterol. Hepatol. 17 (2002) 1291-1298
4. Liang Q., and Richardson T. Expression and characterized of human lactoferrin in yeast Saccharomyces cerevisiae. J. Agric. Food Chem. 41 (1993) 1800-1807
5. Mitra A., and Zhang Z. Expression of a human lactoferrin cDNA in tobacco cells produces antibacterial protein(s). Plant Physiol. 106 (1994) 977-981
6. Legrand D., Salmon V., Coddeville B., Benaissa M., Plancke Y., and Spik G. Structural determination of two N-linked glycans isolated from recombinant human lactoferrin expressed in BHK cells. FEBS Lett. 365 (1995) 57-60
7. Salmon V., Legrand D., Georges B., Slomianny M.C., Coddeville B., and Spik G. Characterization of human lactoferrin produced in the baculovirus expression system. Protein Expr. Purif. 9 (1997) 203-210
8. Salmon V., Legrand D., Slomianny M.C., el Yazidi I., Spik G., Gruber V., Bournat P., Olagnier B., Mison D., Theisen M., and Merot B. Production of human lactoferrin in transgenic tobacco plants. Protein Expr. Purif. 13 (1998) 127-135
9. Ward P.P., Piddington C.S., Cunningham G.A., Zhou X., Wyatt R.D., and Conneely O.M. A system for production of commercial quantities of human lactoferrin: a broad-spectrum natural antibiotic. Biotechnology (NY) 13 (1995) 498-503
10. van Berkel P.H., Welling M.M., Geerts M., van Veen H.A., Ravensbergen B., Salaheddine M., Pauwels E.K., Pieper F., Nuijens J.H., and Nibbering P.H. Large-scale production of recombinant human lactoferrin in the milk of transgenic cows. Nat. Biotechnol. 20 (2002) 484-487
11. Patton S., Welsch U., and Singh S. Intramammary infusion technique for genetic engineering of the mammary gland. J. Dairy Sci. 67 (1984) 1323-1326
12. Yang J., Tsukamoto T., Popnikolov N., Guzman R.C., Chen X., Yang J.H., and Nandi S. Adenoviral-mediated gene transfer into primary human and mouse mammary epithelial cells in vitro and in vivo. Cancer Lett. 98 (1995) 9-17
13. Wagner K.U., Wall R.J., St-Onge L., Gruss P., Wynshaw-Boris A., Garrett L., Li M., Furth P.A., and Hennighausen L. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 25 (1997) 4323-4330
14. Jeng M.H., Kao C., Sivaraman L., Krnacik S., Chung L.W., Medina D., Conneely O.M., and Malley B.W.O. Reconstitution of estrogen-dependent transcriptional activation of an adenoviral target gene in select regions of the rat mammary gland. Endocrinology 39 (1998) 2916-2925
15. Fan W., Plaut K., Bramley A.J., Barlow J.W., Mischler S.A., and Kerr D.E. Persistency of adenoviral-mediated lysostaphin expression in goat mammary glands. J. Dairy. Sci. 87 (2004) 602-608
16. Russell T.D., Fischer A., Beeman N.E., Freed E.F., Neville M.C., and Schaack J. Transduction of the mammary epithelium with adenovirus vectors in vivo. J. Virol. 77 (2003) 5801-5809
17. Sanchez O., Toledo J.R., Rodriguez M.P., and Castro F.O. Adenoviral vector mediates high expression levels of human growth hormone in the milk of mice and goats. J. Biotechnol. 114 (2004) 89-97
18. Toledo J.R., Sanchez O., Montesino S.R., Fernandez G.Y., Rodriguez M.P., and Cremata J.A. Differential in vitro and in vivo glycosylation of human erythropoietin expressed in adenovirally transduced mouse mammary epithelial cells. Biochim. Biophys. Acta. 1726 (2005) 48-56
19. Toledo J.R., Sanchez O., Segui R.M., Garcia G., Montanez M., Zamora P.A., Rodriguez M.P., and Cremata J.A. High expression level of recombinant human erythropoietin in the milk of non-transgenic goats. J. Biotechnol. 123 (2006) 225-235
20. Liu T., Zhang Y.Z., and Wu X.F. High level expression of functionally active human lactoferrin in silkworm larvae. J. Biotechnol. 118 (2005) 246-256
21. Archer J.S., Kennan W.S., Gould M.N., and Bremel R.D. Human growth hormone (hGH) secretion in milk of goats after direct transfer of the hGH gene into the mammary gland by using replication-defective retrovirus vectors. Proc. Natl. Acad. Sci. USA 91 (1994) 6840-6844
22. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., and Struhl K. Current Protocols in Molecular Biology (1993), Greene Publishing Associates Inc., New York
23. Sambrook J., Fritsch E.F., and Maniatis T. In: Nolan C. (Ed). Molecular Cloning: A Laboratory Manual (1989), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
24. He T.C., Zhou S., da Costa L.T., Yu J., Kinzler K.W., and Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95 (1998) 2509-2514
25. Rees S., Coote J., Stables J., Goodson S., Harris S., and Lee M.G. Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic-resistant cells to express recombinant protein. Biotechniques 20 (1996) 102-104 106, 108-110
26. Hurwitz D.R., and Chinnadurai G. Evidence that a second tumor antigen coded by adenovirus early gene region E1a is required for efficient cell transformation. Proc. Natl. Acad. Sci. USA 82 (1985) 163-767
27. Wall R.J., Hawk H.W., and Nel N. Making transgenic livestock: genetic engineering on a large scale. J. Cell. Biochem. 49 (1992) 113-120
28. Schnieke A.E., Kind A.J., Ritchie W.A., Mycock K., Scott A.R., Ritchie M., Wilmut I., Colman A., and Campbell K.H. Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278 (1997) 2130-2133
29. Merrick A.F., Shewring L.D., Sawyer G.J., Gustafsson K.T., and Fabre J.W. Comparison of adenovirus gene transfer to vascular endothelial cells in cell culture, organ culture, and in vivo. Transplantation 62 (1996) 1085-1089
30. Morsy M.A., Gu M., Motzel S., Zhao J., Lin J., Su Q., Allen H., Franlin L., Parks R.J., Graham F.L., Kochanek S., Bett A.J., and Caskey C.T. An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc. Natl. Acad. Sci. USA 95 (1998) 7866-7871
31. Howell J.M., Lochmuller H., O'Hara A., Fletcher S., Kakulas B.A., Massie B., Nalbantoglu J., and Karpati G. High-level dystrophin expression after adenovirus-mediated dystrophin minigene transfer to skeletal muscle of dystrophic dogs: prolongation of expression with immunosuppression. Hum. Gene Ther. 9 (1998) 629-634
32. Hens J.R., Amstutz M.D., Schanbacher F.L., and Mather I.H. Introduction of the human growth hormone gene into the guinea pig mammary gland by in vivo transfection promotes sustained expression of human growth hormone in the milk throughout lactation. Biochim. Biophys. Acta 1523 (2000) 161-171
33. Connelly S., Gardner J.M., McClelland A., and Kaleko M. High-level tissue-specific expression of functional human factor VIII in mice. Hum. Gene Ther. 7 (1996) 183-195
34. Ye X., Robinson M.B., Batshaw M.L., Furth E.E., Smith I., and Wilson J.M. Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vector. J. Biol. Chem. 271 (1996) 3639-3646
35. Kreppel F., and Kochanek S. Long-term transgene expression in proliferating cells mediated by episomally maintained high-capacity adenovirus vectors. J. Virol. 78 (2004) 9-22