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Volumn 8, Issue 17, 2007, Pages 2991-3008

The latest options and future agents for treating male hypogonadism

Author keywords

Androgen replacement therapy; Hypgonadism; SARMS; Testosterone

Indexed keywords

1,2,3,4 TETRAHYDROQUINOLINE DERIVATIVE; ANASTROZOLE; ANDARINE; ANDRIDIOL TESTOCAPS; ANDRIN; ANDROGEN RECEPTOR; ANDROSTANOLONE; AROMATASE INHIBITOR; BMS 564929; CLOMIFENE CITRATE; ENCLOMIFENE CITRATE; HYDANTOIN DERIVATIVE; LGD 2226; METHYLESTRENOLONE; OSTARINE; PLACEBO; PROPIONAMIDE DERIVATIVE; QUINOLINE DERIVATIVE; RECOMBINANT CHORIONIC GONADOTROPIN; S 40503; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TESTOSTERONE DERIVATIVE; TESTOSTERONE ENANTATE; TESTOSTERONE UNDECANOATE; TRESTOLONE; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG;

EID: 37349108187     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.8.17.2991     Document Type: Review
Times cited : (19)

References (103)
  • 1
    • 0029875771 scopus 로고    scopus 로고
    • Androgens in men - uses and abuses
    • BAGATELL CJ, BREMNER WJ: Androgens in men - uses and abuses. N. Engl. J. Med. (1996) 334(11):707-714.
    • (1996) N. Engl. J. Med , vol.334 , Issue.11 , pp. 707-714
    • BAGATELL, C.J.1    BREMNER, W.J.2
  • 2
    • 33645377272 scopus 로고    scopus 로고
    • Hypogonadism in men: An overview
    • Bagatell CJ, Bremner W Eds, Humana Press, New Jersey, US
    • PLYMATE SR: Hypogonadism in men: an overview. In: Androgens in Health and Disease. Bagatell CJ, Bremner W (Eds), Humana Press, New Jersey, US (2003):45-76.
    • (2003) Androgens in Health and Disease , pp. 45-76
    • PLYMATE, S.R.1
  • 3
    • 20344371508 scopus 로고    scopus 로고
    • Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations
    • NIESCHLAG E, SWERDLOFF R, BEHRE HM et al.: Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. Int. J. Androl. (2005) 28(3):125-127.
    • (2005) Int. J. Androl , vol.28 , Issue.3 , pp. 125-127
    • NIESCHLAG, E.1    SWERDLOFF, R.2    BEHRE, H.M.3
  • 4
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging
    • HARMAN SM, METIER EJ, TOBIN JD et al.: Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J. Clin. Endocrinol. Metab. (2001) 86(2):724-731.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , Issue.2 , pp. 724-731
    • HARMAN, S.M.1    METIER, E.J.2    TOBIN, J.D.3
  • 5
    • 0031001347 scopus 로고    scopus 로고
    • Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men
    • MORLEY JE, KAISER FE, PERRY HM III et al.: Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism (1997) 46(4):410-413.
    • (1997) Metabolism , vol.46 , Issue.4 , pp. 410-413
    • MORLEY, J.E.1    KAISER, F.E.2    PERRY III, H.M.3
  • 6
    • 0034976379 scopus 로고    scopus 로고
    • Effects of age on testicular function and consequences of testosterone treatment
    • SNYDER PJ: Effects of age on testicular function and consequences of testosterone treatment. J. Clin. Endocrinol. Metab. (2001) 86(6):2369-2372.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , Issue.6 , pp. 2369-2372
    • SNYDER, P.J.1
  • 7
    • 0034967072 scopus 로고    scopus 로고
    • Androgen replacement therapy in the aging male - a critical evaluation
    • VERMEULEN A: Androgen replacement therapy in the aging male - a critical evaluation. J. Clin. Endocrinol. Metab. (2001) 86(6):2380-2390.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , Issue.6 , pp. 2380-2390
    • VERMEULEN, A.1
  • 9
    • 0024419106 scopus 로고
    • Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men
    • PLYMATE SR, TENOVER JS, BREMNER WJ: Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy young and elderly men. J. Androl. (1989) 10(5):366-371.
    • (1989) J. Androl , vol.10 , Issue.5 , pp. 366-371
    • PLYMATE, S.R.1    TENOVER, J.S.2    BREMNER, W.J.3
  • 10
    • 0020635522 scopus 로고
    • Loss of circadian rhythmicity in blood testosterone levels with aging in normal men
    • BREMNER WJ, VITIELLO MV, PRINZ PN: Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J. Clin. Endocrinol. Metab. (1983) 56(6):1278-1281.
    • (1983) J. Clin. Endocrinol. Metab , vol.56 , Issue.6 , pp. 1278-1281
    • BREMNER, W.J.1    VITIELLO, M.V.2    PRINZ, P.N.3
  • 11
    • 0019759637 scopus 로고
    • Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
    • DUNN JF, NISULA BC, RODBARD D: Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J. Clin. Endocrinol. Metab. (1981) 53(1):58-68.
    • (1981) J. Clin. Endocrinol. Metab , vol.53 , Issue.1 , pp. 58-68
    • DUNN, J.F.1    NISULA, B.C.2    RODBARD, D.3
  • 12
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • VERMEULEN A, VERDONCK L, KAUFMAN JM: A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. (1999) 84(10):3666-3672.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , Issue.10 , pp. 3666-3672
    • VERMEULEN, A.1    VERDONCK, L.2    KAUFMAN, J.M.3
  • 13
    • 0031719992 scopus 로고    scopus 로고
    • The analog free testosterone assay: Are the results in men clinically useful?
    • WINTERS SJ, KELLEY DE, GOODPASTER B: The analog free testosterone assay: are the results in men clinically useful? Clin. Chem. (1998) 44(10):2178-2182.
    • (1998) Clin. Chem , vol.44 , Issue.10 , pp. 2178-2182
    • WINTERS, S.J.1    KELLEY, D.E.2    GOODPASTER, B.3
  • 14
    • 0037793319 scopus 로고    scopus 로고
    • Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men
    • DIVER MJ, IMTIAZ KE, AHMAD AM et al.: Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men. Clin. Endocrinol. (Oxf.) (2003) 58(6):710-717.
    • (2003) Clin. Endocrinol. (Oxf.) , vol.58 , Issue.6 , pp. 710-717
    • DIVER, M.J.1    IMTIAZ, K.E.2    AHMAD, A.M.3
  • 15
    • 11244302480 scopus 로고    scopus 로고
    • Testosterone synthesis, transport, and metabolism
    • Bagatell CJ, Bremner WJ Eds, Humana Press, New Jersey, US
    • WINTERS SJ, CLARK BJ: Testosterone synthesis, transport, and metabolism. In: Androgens in Health and Disease. Bagatell CJ, Bremner WJ (Eds), Humana Press, New Jersey, US (2003):3-22.
    • (2003) Androgens in Health and Disease , pp. 3-22
    • WINTERS, S.J.1    CLARK, B.J.2
  • 17
    • 4544289803 scopus 로고    scopus 로고
    • Androgen replacement therapy: Present and future
    • GOOREN L, BUNCK JMC: Androgen replacement therapy: present and future. Drugs (2004) 64(17):1861-1891.
    • (2004) Drugs , vol.64 , Issue.17 , pp. 1861-1891
    • GOOREN, L.1    BUNCK, J.M.C.2
  • 18
    • 8744284557 scopus 로고    scopus 로고
    • Intramuscular testosterone undecanoate: Pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism
    • SCHUBERT M, MINNEMANN T, HUBLER D et al.: Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism. J. Clin. Endocrinol. Metab. (2004) 89(11):5429-5434.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , Issue.11 , pp. 5429-5434
    • SCHUBERT, M.1    MINNEMANN, T.2    HUBLER, D.3
  • 19
    • 0017128139 scopus 로고
    • Lymphatic absorption and metabolism of orally administered testosterone undecanoate In man
    • HORST HJ, HOLTJE WJ, DENNIS M et al.: Lymphatic absorption and metabolism of orally administered testosterone undecanoate In man. Klin. Wochenschr. (1976) 54(18):875-879.
    • (1976) Klin. Wochenschr , vol.54 , Issue.18 , pp. 875-879
    • HORST, H.J.1    HOLTJE, W.J.2    DENNIS, M.3
  • 20
    • 0027102382 scopus 로고
    • The effects of testosterone treatment on body composition and metabolism in middle-aged obese men
    • MARIN P, HOLMANG S, JONSSON L et al.: The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int. J. Obes. Relat. Metab. Disord. (1992) 16(12):991-997.
    • (1992) Int. J. Obes. Relat. Metab. Disord , vol.16 , Issue.12 , pp. 991-997
    • MARIN, P.1    HOLMANG, S.2    JONSSON, L.3
  • 21
    • 0038278875 scopus 로고    scopus 로고
    • Osteoporosis in male hypogonadism: Responses to androgen substitution differ among men with primary and secondary hypogonadism
    • SCHUBERT M, BULLMANN C, MINNEMANN T et al.: Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism. Horm. Res. (2003) 60(1):21-28.
    • (2003) Horm. Res , vol.60 , Issue.1 , pp. 21-28
    • SCHUBERT, M.1    BULLMANN, C.2    MINNEMANN, T.3
  • 22
    • 0028360993 scopus 로고
    • A ten-year safety study of the oral androgen testosterone undecanoate
    • GOOREN LJ: A ten-year safety study of the oral androgen testosterone undecanoate. J. Androl. (1994) 15(3):212-215.
    • (1994) J. Androl , vol.15 , Issue.3 , pp. 212-215
    • GOOREN, L.J.1
  • 23
    • 0019447704 scopus 로고
    • Androgen replacement with oral testosterone undecanoate in hypogonadal men: A double blind controlled study
    • SKAKKEBAEK NE, BANCROFT J, DAVIDSON DW, WARNER P: Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study. Clin. Endocrinol. (Oxf.) (1981) 14(1):49-61.
    • (1981) Clin. Endocrinol. (Oxf.) , vol.14 , Issue.1 , pp. 49-61
    • SKAKKEBAEK, N.E.1    BANCROFT, J.2    DAVIDSON, D.W.3    WARNER, P.4
  • 24
    • 0031022767 scopus 로고    scopus 로고
    • Testosterone supplementation for hypogonadal impotence: Assessment of biochemical measures and therapeutic outcomes
    • MORALES A, JOHNSTON B, HEATON JP, LUNDIE M: Testosterone supplementation for hypogonadal impotence: assessment of biochemical measures and therapeutic outcomes. J. Urol. (1997) 157(3):849-854.
    • (1997) J. Urol , vol.157 , Issue.3 , pp. 849-854
    • MORALES, A.1    JOHNSTON, B.2    HEATON, J.P.3    LUNDIE, M.4
  • 25
    • 0036220738 scopus 로고    scopus 로고
    • Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: A Phase II study
    • VON ECKARDSTEIN S, NIESCHLAG E: Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: a Phase II study. J. Androl. (2002) 23(3):419-425.
    • (2002) J. Androl , vol.23 , Issue.3 , pp. 419-425
    • VON ECKARDSTEIN, S.1    NIESCHLAG, E.2
  • 26
    • 0033014486 scopus 로고    scopus 로고
    • Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: Phase I studies
    • BEHRE HM, ABSHAGEN K, OETTEL M et al.: Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: Phase I studies. Eur. J. Endocrinol. (1999) 140(5):414-419.
    • (1999) Eur. J. Endocrinol , vol.140 , Issue.5 , pp. 414-419
    • BEHRE, H.M.1    ABSHAGEN, K.2    OETTEL, M.3
  • 27
    • 0032422573 scopus 로고    scopus 로고
    • A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men
    • ZHANG GY, GU YQ, WANG XH et al.: A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men. J. Androl. (1998) 19(6):761-768.
    • (1998) J. Androl , vol.19 , Issue.6 , pp. 761-768
    • ZHANG, G.Y.1    GU, Y.Q.2    WANG, X.H.3
  • 28
    • 0033304555 scopus 로고    scopus 로고
    • Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men
    • DOBS AS, MEIKLE AW, ARVER S et al.: Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men. J. Clin. Endocrinol. Metab. (1999) 84(10):3469-3478.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , Issue.10 , pp. 3469-3478
    • DOBS, A.S.1    MEIKLE, A.W.2    ARVER, S.3
  • 29
    • 0026676634 scopus 로고
    • The effects of exogenous testosterone on sexuality and mood of normal men
    • ANDERSON RA, BANCROFT J, WU FC: The effects of exogenous testosterone on sexuality and mood of normal men. J. Clin. Endocrinol. Metab. (1992) 75(6):1503-1507.
    • (1992) J. Clin. Endocrinol. Metab , vol.75 , Issue.6 , pp. 1503-1507
    • ANDERSON, R.A.1    BANCROFT, J.2    WU, F.C.3
  • 30
    • 23844468548 scopus 로고    scopus 로고
    • Nebido: A long-acting injectable testosterone for the treatment of male hypogonadism
    • HARLE L, BASARIA S, DOBS AS: Nebido: a long-acting injectable testosterone for the treatment of male hypogonadism. Expert Opin. Pharmacother. (2005) 6(10):1751-1759.
    • (2005) Expert Opin. Pharmacother , vol.6 , Issue.10 , pp. 1751-1759
    • HARLE, L.1    BASARIA, S.2    DOBS, A.S.3
  • 31
    • 0033383771 scopus 로고    scopus 로고
    • Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men
    • NIESCHLAG E, BUCHTER D, VON ECKARDSTEIN S et al.: Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men. Clin. Endocrinol. (Oxf.) (1999) 51(6):757-763.
    • (1999) Clin. Endocrinol. (Oxf.) , vol.51 , Issue.6 , pp. 757-763
    • NIESCHLAG, E.1    BUCHTER, D.2    VON ECKARDSTEIN, S.3
  • 32
    • 37349035837 scopus 로고    scopus 로고
    • ZITZMANN M: Long-term experience of more than 8 years with a novel formulation of testosterone undecanoate (Nebido) in substitution therapy of hypogonadal men aging male. The 5th World Conference on the Aging Male. Salzburg, Austria (9-12 February 2006).
    • ZITZMANN M: Long-term experience of more than 8 years with a novel formulation of testosterone undecanoate (Nebido) in substitution therapy of hypogonadal men "aging male". The 5th World Conference on the Aging Male. Salzburg, Austria (9-12 February 2006).
  • 33
    • 0028868688 scopus 로고
    • Pharmacokinetics of a single dose of buccal testosterone
    • KIM S, SNIPES W, HODGEN GD, ANDERSON F: Pharmacokinetics of a single dose of buccal testosterone. Contraception (1995) 52(5):313-316.
    • (1995) Contraception , vol.52 , Issue.5 , pp. 313-316
    • KIM, S.1    SNIPES, W.2    HODGEN, G.D.3    ANDERSON, F.4
  • 34
    • 2442551637 scopus 로고    scopus 로고
    • A comparison of a novel testosterone bioadhesive buccal system, striant, with a testosterone adhesive patch in hypogonadal males
    • KORBONITS M, SLAWIK M, CULLEN D et al.: A comparison of a novel testosterone bioadhesive buccal system, striant, with a testosterone adhesive patch in hypogonadal males. J. Clin. Endocrinol. Metab. (2004) 89(5):2039-2043.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , Issue.5 , pp. 2039-2043
    • KORBONITS, M.1    SLAWIK, M.2    CULLEN, D.3
  • 35
    • 2542466641 scopus 로고    scopus 로고
    • Short-term pharmacokinetic comparison of a novel testosterone buccal system and a testosterone gel in testosterone deficient men
    • DOBS AS, MATSUMOTO AM, WANG C, KIPNES MS: Short-term pharmacokinetic comparison of a novel testosterone buccal system and a testosterone gel in testosterone deficient men. Curr. Med. Res. Opin. (2004) 20(5):729-738.
    • (2004) Curr. Med. Res. Opin , vol.20 , Issue.5 , pp. 729-738
    • DOBS, A.S.1    MATSUMOTO, A.M.2    WANG, C.3    KIPNES, M.S.4
  • 36
    • 0029870714 scopus 로고    scopus 로고
    • Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system
    • ARVER S, DOBS AS, MEIKLE AW et al.: Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J. Urol. (1996) 155(5):1604-1608.
    • (1996) J. Urol , vol.155 , Issue.5 , pp. 1604-1608
    • ARVER, S.1    DOBS, A.S.2    MEIKLE, A.W.3
  • 37
    • 0031469651 scopus 로고    scopus 로고
    • Long-term efficacy and safety of a permeation-enhanced testosterone transdermal system in hypogonadal men
    • ARVER S, DOBS AS, MEIKLEA W et al.: Long-term efficacy and safety of a permeation-enhanced testosterone transdermal system in hypogonadal men. Clin. Endocrinol. (Oxf.) (1997) 47(6):727-737.
    • (1997) Clin. Endocrinol. (Oxf.) , vol.47 , Issue.6 , pp. 727-737
    • ARVER, S.1    DOBS, A.S.2    MEIKLEA, W.3
  • 38
    • 0029930211 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of a permeation-enhanced testosterone transdermal system in hypogonadal men: Influence of application site - a clinical research center study
    • MEIKLE AW, ARVER S, DOBS AS et al.: Pharmacokinetics and metabolism of a permeation-enhanced testosterone transdermal system in hypogonadal men: influence of application site - a clinical research center study. J. Clin. Endocrinol. Metab. (1996) 81(5):1832-1840.
    • (1996) J. Clin. Endocrinol. Metab , vol.81 , Issue.5 , pp. 1832-1840
    • MEIKLE, A.W.1    ARVER, S.2    DOBS, A.S.3
  • 39
    • 0033941520 scopus 로고    scopus 로고
    • Testosterone supplementation for erectile dysfunction: Results of a meta-analysis
    • JAIN P, RADEMAKER AW, MCVARY KT: Testosterone supplementation for erectile dysfunction: results of a meta-analysis. J. Urol. (2000) 164(2):371-375.
    • (2000) J. Urol , vol.164 , Issue.2 , pp. 371-375
    • JAIN, P.1    RADEMAKER, A.W.2    MCVARY, K.T.3
  • 40
    • 0031799313 scopus 로고    scopus 로고
    • Use of topical corticosteroid pretreatment to reduce the incidence and severity of skin reactions associated with testosterone transdermal therapy
    • WILSON DE, KAIDBURY K, BOIKE SC, JORKASKY DK: Use of topical corticosteroid pretreatment to reduce the incidence and severity of skin reactions associated with testosterone transdermal therapy. Clin. Ther. (1998) 20(2):299-306.
    • (1998) Clin. Ther , vol.20 , Issue.2 , pp. 299-306
    • WILSON, D.E.1    KAIDBURY, K.2    BOIKE, S.C.3    JORKASKY, D.K.4
  • 41
    • 0034453061 scopus 로고    scopus 로고
    • Pharmacokinetics of transdermal testosterone gel in hypogonadal men: Application of gel at one site versus four sites: a general clinical research center study
    • WANG C, BERMAN N, LONGSTRETH JA et al.: Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a general clinical research center study. J. Clin. Endocrinol. Metab. (2000) 85(3):964-969.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , Issue.3 , pp. 964-969
    • WANG, C.1    BERMAN, N.2    LONGSTRETH, J.A.3
  • 42
    • 17744374771 scopus 로고    scopus 로고
    • Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men
    • SWERDLOFF RS, WANG C, CUNNINGHAM G et al.: Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J. Clin. Endocrinol. Metab. (2000) 85(12):4500-4510.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , Issue.12 , pp. 4500-4510
    • SWERDLOFF, R.S.1    WANG, C.2    CUNNINGHAM, G.3
  • 43
    • 0012619789 scopus 로고    scopus 로고
    • AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function
    • STEIDLE C, SCHWARTZ S, JACOBY K et al.: AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function. J. Clin. Endocrinol. Metab. (2003) 88(6):2673-2681.
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , Issue.6 , pp. 2673-2681
    • STEIDLE, C.1    SCHWARTZ, S.2    JACOBY, K.3
  • 44
    • 2442543161 scopus 로고    scopus 로고
    • Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men
    • WANG C, CUNNINGHAM G, DOBS A et al.: Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J. Clin. Endocrinol. Metab. (2004) 89(5):2085-2098.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , Issue.5 , pp. 2085-2098
    • WANG, C.1    CUNNINGHAM, G.2    DOBS, A.3
  • 45
    • 0035725618 scopus 로고    scopus 로고
    • Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men
    • WANG C, SWERDLOFF RS, IRANMANESH A et al.: Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. Clin. Endocrinol. (Oxf.) (2001) 54(6):739-750.
    • (2001) Clin. Endocrinol. (Oxf.) , vol.54 , Issue.6 , pp. 739-750
    • WANG, C.1    SWERDLOFF, R.S.2    IRANMANESH, A.3
  • 46
    • 0037223737 scopus 로고    scopus 로고
    • Testosterone gel supplementation for men with refractory depression: A randomized, placebo-controlled trial
    • POPE HG Jr, COHANE GH, KANAYAMA G et al.: Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial. Am. J. Psychiatry (2003) 160(1):105-111.
    • (2003) Am. J. Psychiatry , vol.160 , Issue.1 , pp. 105-111
    • POPE Jr, H.G.1    COHANE, G.H.2    KANAYAMA, G.3
  • 47
    • 0036274222 scopus 로고    scopus 로고
    • Interpersonal testosterone transfer after topical application of a newly developed testosterone gel preparation
    • ROLF C, KNIE U, LEMMNITZ G, NIESCHLAG E: Interpersonal testosterone transfer after topical application of a newly developed testosterone gel preparation. Clin. Endocrinol. (Oxf.) (2002) 56(5):637-641.
    • (2002) Clin. Endocrinol. (Oxf.) , vol.56 , Issue.5 , pp. 637-641
    • ROLF, C.1    KNIE, U.2    LEMMNITZ, G.3    NIESCHLAG, E.4
  • 48
    • 0038410330 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetic profiles of the new testosterone topical gel formulation, Testim, compared to AndroGel
    • MARBURY T, HAMILL E, BACHAND R et al.: Evaluation of the pharmacokinetic profiles of the new testosterone topical gel formulation, Testim, compared to AndroGel. Biopharm. Drug Dispos. (2003) 24(3):115-120.
    • (2003) Biopharm. Drug Dispos , vol.24 , Issue.3 , pp. 115-120
    • MARBURY, T.1    HAMILL, E.2    BACHAND, R.3
  • 49
    • 0037236825 scopus 로고    scopus 로고
    • A novel testosterone gel formulation normalizes androgen levels in hypogonadal men, with improvements in body composition and sexual function
    • MCNICHOLAS TA, DEAN JD, MULDER H et al.: A novel testosterone gel formulation normalizes androgen levels in hypogonadal men, with improvements in body composition and sexual function. BJU Int. (2003) 91(1):69-74.
    • (2003) BJU Int , vol.91 , Issue.1 , pp. 69-74
    • MCNICHOLAS, T.A.1    DEAN, J.D.2    MULDER, H.3
  • 50
    • 0034456450 scopus 로고    scopus 로고
    • Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men
    • WANG C, SWERDLOFF RS, IRANMANESH A et al.: Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J. Clin. Endocrinol. Metab. (2000) 85(8):2839-2853.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , Issue.8 , pp. 2839-2853
    • WANG, C.1    SWERDLOFF, R.S.2    IRANMANESH, A.3
  • 51
    • 0033304913 scopus 로고    scopus 로고
    • Selective androgen receptor modulators (SARMs): A novel approach to androgen therapy for the new millennium
    • NEGRO-VILAR A: Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium. J. Clin. Endocrinol. Metab. (1999) 84(10):3459-3462.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , Issue.10 , pp. 3459-3462
    • NEGRO-VILAR, A.1
  • 52
    • 0034856883 scopus 로고    scopus 로고
    • Testosterone supplementation in older men: A rational idea whose time has not yet come
    • BHASIN S, BUCKWALTER JG: Testosterone supplementation in older men: a rational idea whose time has not yet come. J. Androl. (2001) 22(5):718-731.
    • (2001) J. Androl , vol.22 , Issue.5 , pp. 718-731
    • BHASIN, S.1    BUCKWALTER, J.G.2
  • 53
    • 26844496083 scopus 로고    scopus 로고
    • Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats
    • GAO W, REISER PJ, COSS CC et al.: Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology (2005) 146(11):4887-4897.
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4887-4897
    • GAO, W.1    REISER, P.J.2    COSS, C.C.3
  • 54
    • 0036121239 scopus 로고    scopus 로고
    • Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile
    • ROSEN J, NEGRO-VILAR A: Novel, non-steroidal, selective androgen receptor modulators (SARMs) with anabolic activity in bone and muscle and improved safety profile. J. Musculoskelet. Neuro. Interact. (2002) 2(3):222-224.
    • (2002) J. Musculoskelet. Neuro. Interact , vol.2 , Issue.3 , pp. 222-224
    • ROSEN, J.1    NEGRO-VILAR, A.2
  • 56
    • 4444371195 scopus 로고    scopus 로고
    • Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis
    • HANADA K, FURUYA K, YAMAMOTO N et al.: Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. Biol. Pharm. Bull. (2003) 26(11):1563-1569.
    • (2003) Biol. Pharm. Bull , vol.26 , Issue.11 , pp. 1563-1569
    • HANADA, K.1    FURUYA, K.2    YAMAMOTO, N.3
  • 57
    • 0842325914 scopus 로고    scopus 로고
    • Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators
    • MARHEFKA CA, GAO W, CHUNG K et al.: Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators. J. Med. Chem. (2004) 47(4):993-998.
    • (2004) J. Med. Chem , vol.47 , Issue.4 , pp. 993-998
    • MARHEFKA, C.A.1    GAO, W.2    CHUNG, K.3
  • 58
    • 0037371461 scopus 로고    scopus 로고
    • Pharmacodynamics of selective androgen receptor modulators
    • YIN D, GAO W, KEARBEY JD et al.: Pharmacodynamics of selective androgen receptor modulators. J. Pharmacol. Exp. Ther. (2003) 304(3):1334-1340.
    • (2003) J. Pharmacol. Exp. Ther , vol.304 , Issue.3 , pp. 1334-1340
    • YIN, D.1    GAO, W.2    KEARBEY, J.D.3
  • 59
    • 0037222170 scopus 로고    scopus 로고
    • Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor
    • YIN D, HE Y, PERERA MA et al.: Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor. Mol. Pharmacol. (2003) 63(1):211-223.
    • (2003) Mol. Pharmacol , vol.63 , Issue.1 , pp. 211-223
    • YIN, D.1    HE, Y.2    PERERA, M.A.3
  • 60
    • 0032492668 scopus 로고    scopus 로고
    • EDWARDS JP, WEST SJ, POOLEY CL et al.: New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino [3,2-g] quinolinone. Bioorg. Med. Chem. Lett. (1998) 8(7):745-750.
    • EDWARDS JP, WEST SJ, POOLEY CL et al.: New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino [3,2-g] quinolinone. Bioorg. Med. Chem. Lett. (1998) 8(7):745-750.
  • 61
    • 33747163669 scopus 로고    scopus 로고
    • Asylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer
    • HWANG DJ, YANG J, XU H et al.: Asylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer. Bioorg. Med. Chem. (2006).
    • (2006) Bioorg. Med. Chem
    • HWANG, D.J.1    YANG, J.2    XU, H.3
  • 62
    • 33646156657 scopus 로고    scopus 로고
    • Selective androgen receptor modulators in drug discovery: Medicinal chemistry and therapeutic potential
    • CADILLA R, TURNBULL P: Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential. Curr. Top. Med. Chem. (2006) 6(3):245-270.
    • (2006) Curr. Top. Med. Chem , vol.6 , Issue.3 , pp. 245-270
    • CADILLA, R.1    TURNBULL, P.2
  • 63
    • 33645703903 scopus 로고    scopus 로고
    • Therapeutic potential of the SARMs: Revisiting the androgen receptor for drug discovery
    • SEGAL S, NARAYANAN R, DALTON JT: Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery. Expert Opin. Investig. Drugs (2006) 15(4):377-387.
    • (2006) Expert Opin. Investig. Drugs , vol.15 , Issue.4 , pp. 377-387
    • SEGAL, S.1    NARAYANAN, R.2    DALTON, J.T.3
  • 64
    • 22544467523 scopus 로고    scopus 로고
    • Discovery and therapeutic promise of selective androgen receptor modulators
    • CHEN J, KIM J, DALTON JT: Discovery and therapeutic promise of selective androgen receptor modulators. Mol. Interv. (2005) 5(3):173-188.
    • (2005) Mol. Interv , vol.5 , Issue.3 , pp. 173-188
    • CHEN, J.1    KIM, J.2    DALTON, J.T.3
  • 65
    • 3042866315 scopus 로고    scopus 로고
    • Prostate-sparing effects in primates of the potent androgen 7α-methyl-19-nortestosterone: A potential alternative to testosterone for androgen replacement and male contraception
    • CUMMINGS DE, KUMAR N, BARDIN CW et al.: Prostate-sparing effects in primates of the potent androgen 7α-methyl-19-nortestosterone: a potential alternative to testosterone for androgen replacement and male contraception. J. Clin Endocrinol. Metab. (1998) 83(12):4212-4219.
    • (1998) J. Clin Endocrinol. Metab , vol.83 , Issue.12 , pp. 4212-4219
    • CUMMINGS, D.E.1    KUMAR, N.2    BARDIN, C.W.3
  • 66
    • 0033237648 scopus 로고    scopus 로고
    • 7α-Methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men
    • ANDERSON RA, MARTIN CW, KUNG AW et al.: 7α-Methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men. J. Clin. Endocrinol. Metab. (1999) 84(10):3556-3562.
    • (1999) J. Clin. Endocrinol. Metab , vol.84 , Issue.10 , pp. 3556-3562
    • ANDERSON, R.A.1    MARTIN, C.W.2    KUNG, A.W.3
  • 67
    • 0030610958 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of 7α-methyl-19-nortestosterone after intramuscular administration in healthy men
    • SUVISAARI J, SUNDARAM K, NOE G et al.: Pharmacokinetics and pharmacodynamics of 7α-methyl-19-nortestosterone after intramuscular administration in healthy men. Hum. Reprod. (1997) 12(5):967-973.
    • (1997) Hum. Reprod , vol.12 , Issue.5 , pp. 967-973
    • SUVISAARI, J.1    SUNDARAM, K.2    NOE, G.3
  • 68
    • 0038578277 scopus 로고    scopus 로고
    • Evidence for tissue selectivity of the synthetic androgen 7α-methyl-19-nortestosterone in hypogonadal men
    • ANDERSON RA, WALLACE AM, SATTAR N et al.: Evidence for tissue selectivity of the synthetic androgen 7α-methyl-19-nortestosterone in hypogonadal men. J. Clin. Endocrinol. Metab. (2003) 88(6):2784-2793.
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , Issue.6 , pp. 2784-2793
    • ANDERSON, R.A.1    WALLACE, A.M.2    SATTAR, N.3
  • 69
    • 33644779101 scopus 로고    scopus 로고
    • Comparison of the growth-promoting effects of testosterone and 7-α-methyl-19-nor-testosterone (MENT) on the prostate and levator ani muscle of LPB-tag transgenic mice
    • SHAO TC, LI HL, KASPER S et al.: Comparison of the growth-promoting effects of testosterone and 7-α-methyl-19-nor-testosterone (MENT) on the prostate and levator ani muscle of LPB-tag transgenic mice. Prostate (2006) 66(4):369-376.
    • (2006) Prostate , vol.66 , Issue.4 , pp. 369-376
    • SHAO, T.C.1    LI, H.L.2    KASPER, S.3
  • 70
    • 18044387619 scopus 로고    scopus 로고
    • Bone and muscle protective potential of the prostate-sparing synthetic androgen 7α-methyl-19-nortestosterone: Evidence from the aged orchidectomized male rat model
    • VENKEN K, BOONEN S, VAN HERCK E et al.: Bone and muscle protective potential of the prostate-sparing synthetic androgen 7α-methyl-19-nortestosterone: evidence from the aged orchidectomized male rat model. Bone (2005) 36(4):663-670.
    • (2005) Bone , vol.36 , Issue.4 , pp. 663-670
    • VENKEN, K.1    BOONEN, S.2    VAN HERCK, E.3
  • 71
    • 0027217774 scopus 로고
    • Transdermal dihydrotestosterone therapy and its effects on patients with microphallus
    • CHOI SK, HAN SW, KIM DH, DE LIGNIERES B: Transdermal dihydrotestosterone therapy and its effects on patients with microphallus. J. Urol. (1993) 150(2 Part 2):657-660.
    • (1993) J. Urol , vol.150 , Issue.2 PART 2 , pp. 657-660
    • CHOI, S.K.1    HAN, S.W.2    KIM, D.H.3    DE LIGNIERES, B.4
  • 72
    • 0032454317 scopus 로고    scopus 로고
    • Dihydrotestosterone: A rationale for its use as a non-aromatizable androgen replacement therapeutic agent
    • SWERDLOFF RS, WANG C: Dihydrotestosterone: a rationale for its use as a non-aromatizable androgen replacement therapeutic agent. Baillieres Clin. Endocrinol. Metab. (1998) 12(3):501-506.
    • (1998) Baillieres Clin. Endocrinol. Metab , vol.12 , Issue.3 , pp. 501-506
    • SWERDLOFF, R.S.1    WANG, C.2
  • 73
    • 85047681812 scopus 로고    scopus 로고
    • Should the nonaromatizable androgen dihydrotestosterone be considered as an alternative to testosterone in the treatment of the andropause?
    • WANG C, SWERDLOFF RS: Should the nonaromatizable androgen dihydrotestosterone be considered as an alternative to testosterone in the treatment of the andropause? J. Clin. Endocrinol. Metab. (2002) 87(4): 1462-1466.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , Issue.4 , pp. 1462-1466
    • WANG, C.1    SWERDLOFF, R.S.2
  • 74
    • 0000313051 scopus 로고    scopus 로고
    • Percutaneous dihydrotestosterone (DHT) treatment
    • Nieschlag E, Behre HM, Eds, Springer Verlag, Berlin
    • SCHAISON G, COUZINET B: Percutaneous dihydrotestosterone (DHT) treatment. In: Testosterone: Action, Deficiency, Substitution. Nieschlag E, Behre HM, (Eds), Springer Verlag, Berlin (1998):423-436.
    • (1998) Testosterone: Action, Deficiency, Substitution , pp. 423-436
    • SCHAISON, G.1    COUZINET, B.2
  • 75
    • 0027249032 scopus 로고
    • Transdermal dihydrotestosterone treatment of 'andropause'
    • DE LIGNIERES B: Transdermal dihydrotestosterone treatment of 'andropause'. Ann. Med. (1993) 25(3):235-241.
    • (1993) Ann. Med , vol.25 , Issue.3 , pp. 235-241
    • DE LIGNIERES, B.1
  • 76
    • 0034847204 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency
    • LY LP, JIMENEZ M, ZHUANG TN et al.: A double-blind, placebo-controlled, randomized clinical trial of transdermal dihydrotestosterone gel on muscular strength, mobility, and quality of life in older men with partial androgen deficiency. J. Clin. Endocrinol. Metab. (2001) 86(9):4078-4088.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , Issue.9 , pp. 4078-4088
    • LY, L.P.1    JIMENEZ, M.2    ZHUANG, T.N.3
  • 77
    • 0036280902 scopus 로고    scopus 로고
    • The effects of transdermal dihydrotestosterone in the aging male: A prospective, randomized, double blind study
    • KUNELIUS P, LUKKARINEN O, HANNUKSELA ML et al.: The effects of transdermal dihydrotestosterone in the aging male: a prospective, randomized, double blind study. J. Clin. Endocrinol. Metab. (2002) 87(4):1467-1472.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , Issue.4 , pp. 1467-1472
    • KUNELIUS, P.1    LUKKARINEN, O.2    HANNUKSELA, M.L.3
  • 78
    • 1642364154 scopus 로고    scopus 로고
    • Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels
    • LEDER BZ, ROHRER JL, RUBIN SD et al.: Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels. J. Clin. Endocrinol. Metab. (2004) 89(3):1174-1180.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , Issue.3 , pp. 1174-1180
    • LEDER, B.Z.1    ROHRER, J.L.2    RUBIN, S.D.3
  • 79
    • 0034970468 scopus 로고    scopus 로고
    • The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men
    • TAXEL P, KENNEDY DG, FALL PM et al.: The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men. J. Clin. Endocrinol. Metab. (2001) 86(6):2869-2874.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , Issue.6 , pp. 2869-2874
    • TAXEL, P.1    KENNEDY, D.G.2    FALL, P.M.3
  • 80
    • 0036144667 scopus 로고    scopus 로고
    • RAMAN JD, SCHLEGEL PN: Aromatase inhibitors for male infertility. J. Urol. (2002) 167(2 Part 1)):624-629.
    • RAMAN JD, SCHLEGEL PN: Aromatase inhibitors for male infertility. J. Urol. (2002) 167(2 Part 1)):624-629.
  • 81
    • 0024515141 scopus 로고
    • Testosterone replacement with transdermal therapeutic systems. Physiological serum testosterone and elevated dihydrotestosterone levels
    • CUNNINGHAM GR, CORDERO E, THORNBY JI: Testosterone replacement with transdermal therapeutic systems. Physiological serum testosterone and elevated dihydrotestosterone levels. JAMA (1989) 261(17):2525-2530.
    • (1989) JAMA , vol.261 , Issue.17 , pp. 2525-2530
    • CUNNINGHAM, G.R.1    CORDERO, E.2    THORNBY, J.I.3
  • 82
    • 0028824137 scopus 로고
    • Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: Double blind placebo-controlled trial with clomiphene citrate
    • GUAY AT, BANSAL S, HEATLEY GJ: Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate. J. Clin. Endocrinol. Metab. (1995) 80(12):3546-3552.
    • (1995) J. Clin. Endocrinol. Metab , vol.80 , Issue.12 , pp. 3546-3552
    • GUAY, A.T.1    BANSAL, S.2    HEATLEY, G.J.3
  • 83
    • 0041670895 scopus 로고    scopus 로고
    • Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: Who does and does not benefit?
    • GUAY AT, JACOBSON J, PEREZ JB et al.: Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit? Int. J. Impot. Res. (2003) 15(3):156-165.
    • (2003) Int. J. Impot. Res , vol.15 , Issue.3 , pp. 156-165
    • GUAY, A.T.1    JACOBSON, J.2    PEREZ, J.B.3
  • 84
    • 28544441542 scopus 로고    scopus 로고
    • Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism
    • SHABSIGH A, KANG Y, SHABSIGH R et al.: Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism. J. Sex. Med. (2005) 2(5):716-721.
    • (2005) J. Sex. Med , vol.2 , Issue.5 , pp. 716-721
    • SHABSIGH, A.1    KANG, Y.2    SHABSIGH, R.3
  • 85
    • 0000535221 scopus 로고
    • Idiopathic hypogonadotropic hypogonadism with anosmia (Kallmann's syndrome)
    • CHRISTENSEN RB, MATSUMOTO AM, BREMNER WJ: Idiopathic hypogonadotropic hypogonadism with anosmia (Kallmann's syndrome). Endocrinologist (1992) 2(5):332-340.
    • (1992) Endocrinologist , vol.2 , Issue.5 , pp. 332-340
    • CHRISTENSEN, R.B.1    MATSUMOTO, A.M.2    BREMNER, W.J.3
  • 86
    • 0024027001 scopus 로고
    • Hypogonadotropic hypogonadal men respond less well to androgen substitution treatment than hypergonadotropic hypogonadal men
    • GOOREN L: Hypogonadotropic hypogonadal men respond less well to androgen substitution treatment than hypergonadotropic hypogonadal men. Arch. Sex. Behav. (1988) 17(3):265-270.
    • (1988) Arch. Sex. Behav , vol.17 , Issue.3 , pp. 265-270
    • GOOREN, L.1
  • 87
    • 0018071062 scopus 로고
    • Maintenance of spermatogenesis induced by HMG treatment by means of continuous HCG treatment in hypogonadotrophic men
    • JOHNSEN SG: Maintenance of spermatogenesis induced by HMG treatment by means of continuous HCG treatment in hypogonadotrophic men. Acta Endocrinol. (Copenh.) (1978) 89(4):763-769.
    • (1978) Acta Endocrinol. (Copenh.) , vol.89 , Issue.4 , pp. 763-769
    • JOHNSEN, S.G.1
  • 88
    • 0026688575 scopus 로고
    • Therapy with human chorionic gonadotrophin alone induces spermatogenesis in men with isolated hypogonadotrophic hypogonadism - long-term follow-up
    • VICARI E, MONGIOI A, CALOGERO AE et al.: Therapy with human chorionic gonadotrophin alone induces spermatogenesis in men with isolated hypogonadotrophic hypogonadism - long-term follow-up. Int. J. Androl. (1992) 15(4):320-329.
    • (1992) Int. J. Androl , vol.15 , Issue.4 , pp. 320-329
    • VICARI, E.1    MONGIOI, A.2    CALOGERO, A.E.3
  • 89
    • 0036317130 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled, randomized clinical trial of recombinant human chorionic gonadotropin on muscle strength and physical function and activity in older men with partial age-related androgen deficiency
    • LIU PY, WISHART SM, HANDELSMAN DJ: A double-blind, placebo-controlled, randomized clinical trial of recombinant human chorionic gonadotropin on muscle strength and physical function and activity in older men with partial age-related androgen deficiency. J. Clin. Endocrinol. Metab. (2002) 87(7):3125-3135.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , Issue.7 , pp. 3125-3135
    • LIU, P.Y.1    WISHART, S.M.2    HANDELSMAN, D.J.3
  • 90
    • 0025935923 scopus 로고
    • Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization
    • JENSTER G, VAN DER KORPUT HA, VAN VROONHOVEN C et al.: Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Mol. Endocrinol. (1991) 5(10):1396-1404.
    • (1991) Mol. Endocrinol , vol.5 , Issue.10 , pp. 1396-1404
    • JENSTER, G.1    VAN DER KORPUT HA, V.A.N.2    VROONHOVEN, C.3
  • 91
    • 0025582865 scopus 로고
    • Molecular basis of androgen insensitivity
    • discussion 38-42
    • FRENCH FS, LUBAHN DB, BROWN TR et al.: Molecular basis of androgen insensitivity. Recent Prog. Horm. Res. (1990):461-438; discussion 38-42.
    • (1990) Recent Prog. Horm. Res , pp. 461-438
    • FRENCH, F.S.1    LUBAHN, D.B.2    BROWN, T.R.3
  • 92
    • 0025957233 scopus 로고
    • Transcriptional activation and nuclear targeting signals of the human androgen receptor
    • SIMENTAL JA, SAR M, LANE MV et al.: Transcriptional activation and nuclear targeting signals of the human androgen receptor. J. Biol. Chem. (1991) 266(1):510-518.
    • (1991) J. Biol. Chem , vol.266 , Issue.1 , pp. 510-518
    • SIMENTAL, J.A.1    SAR, M.2    LANE, M.V.3
  • 93
    • 0028033594 scopus 로고
    • The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function
    • CHAMBERLAIN NL, DRIVER ED, MIESFELD RS: The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res. (1994) 22(15):3181-3186.
    • (1994) Nucleic Acids Res , vol.22 , Issue.15 , pp. 3181-3186
    • CHAMBERLAIN, N.L.1    DRIVER, E.D.2    MIESFELD, R.S.3
  • 94
    • 0027366138 scopus 로고
    • Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy
    • MHATRE AN, TRIPIRO MA, KAUFMAN M et al.: Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy. Nat. Genet. (1993) 5(2):184-188.
    • (1993) Nat. Genet , vol.5 , Issue.2 , pp. 184-188
    • MHATRE, A.N.1    TRIPIRO, M.A.2    KAUFMAN, M.3
  • 95
    • 0029856398 scopus 로고    scopus 로고
    • Reduced androgen receptor gene expression with first exon CAG repeat expansion
    • CHOONG CS, KEMPPAINEN JA, ZHOU ZX, WILSON EM: Reduced androgen receptor gene expression with first exon CAG repeat expansion. Mol. Endocrinol. (1996) 10(12):1527-1535.
    • (1996) Mol. Endocrinol , vol.10 , Issue.12 , pp. 1527-1535
    • CHOONG, C.S.1    KEMPPAINEN, J.A.2    ZHOU, Z.X.3    WILSON, E.M.4
  • 96
    • 0035724191 scopus 로고    scopus 로고
    • The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males
    • ZITZMANN M, BRUNE M, KORNMANN B et al.: The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males. Clin. Endocrinol. (Oxf.) (2001) 55(5):649-657.
    • (2001) Clin. Endocrinol. (Oxf.) , vol.55 , Issue.5 , pp. 649-657
    • ZITZMANN, M.1    BRUNE, M.2    KORNMANN, B.3
  • 97
    • 0034752252 scopus 로고    scopus 로고
    • The CAG repeat polymorphism in the AR gene affects high density lipoprotein cholesterol and arterial vasoreactivity
    • ZITZMANN M, BRUNE M, KORNMANN B et al.: The CAG repeat polymorphism in the AR gene affects high density lipoprotein cholesterol and arterial vasoreactivity. J. Clin. Endocrinol. Metab. (2001) 86(10):4867-4873.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , Issue.10 , pp. 4867-4873
    • ZITZMANN, M.1    BRUNE, M.2    KORNMANN, B.3
  • 98
    • 0037280752 scopus 로고    scopus 로고
    • The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men
    • ZITZMANN M, GROMOLL J, VON ECKARDSTEIN A, NIESCHLAG E: The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men. Diabetologia (2003) 46(1):31-39.
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 31-39
    • ZITZMANN, M.1    GROMOLL, J.2    VON ECKARDSTEIN, A.3    NIESCHLAG, E.4
  • 99
    • 10344248169 scopus 로고    scopus 로고
    • X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients
    • ZITZMANN M, DEPENBUSCH M, GROMOLL J, NIESCHLAG E: X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients. J. Clin. Endocrinol. Metab. (2004) 89(12):6208-6217.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , Issue.12 , pp. 6208-6217
    • ZITZMANN, M.1    DEPENBUSCH, M.2    GROMOLL, J.3    NIESCHLAG, E.4
  • 100
    • 11144269092 scopus 로고    scopus 로고
    • Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men
    • WALSH S, ZMUDA JM, CAULEY JA et al.: Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men. J. Appl. Physiol. (2005) 98(1):132-137.
    • (2005) J. Appl. Physiol , vol.98 , Issue.1 , pp. 132-137
    • WALSH, S.1    ZMUDA, J.M.2    CAULEY, J.A.3
  • 101
    • 24344490751 scopus 로고    scopus 로고
    • Androgen receptor CAGn repeat length influences phenotype of 47, XXY (Klinefelter) syndrome
    • ZINN AR, RAMOS P, ELDER FF et al.: Androgen receptor CAGn repeat length influences phenotype of 47, XXY (Klinefelter) syndrome. J. Clin. Endocrinol. Metab. (2005) 90(9):5041-5046.
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , Issue.9 , pp. 5041-5046
    • ZINN, A.R.1    RAMOS, P.2    ELDER, F.F.3
  • 102
    • 1642294242 scopus 로고    scopus 로고
    • Hypogonadism in elderly men - what to do until the evidence comes
    • SNYDER PJ: Hypogonadism in elderly men - what to do until the evidence comes. N. Engl. J. Med. (2004) 350(5):440-442.
    • (2004) N. Engl. J. Med , vol.350 , Issue.5 , pp. 440-442
    • SNYDER, P.J.1
  • 103
    • 0242390083 scopus 로고    scopus 로고
    • Managing the risks of prostate disease during testosterone replacement therapy in older men: Recommendations for a standardized monitoring plan
    • BHASIN S, SINGH AB, MAC RP et al.: Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan. J. Androl. (2003) 24(3):299-311.
    • (2003) J. Androl , vol.24 , Issue.3 , pp. 299-311
    • BHASIN, S.1    SINGH, A.B.2    MAC, R.P.3


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