Comparison of the growth-promoting effects of testosterone and 7-α-methyl-19-nor-testosterone (MENT) on the prostate and levator ani muscle of LPB-Tag transgenic mice

Prostate

Volumn 66, Issue 4, 2006, Pages 369-376

  Shao, T C ^a,c   Li, H L ^a   Kasper, S ^b   Matusik, R ^b   Ittmann, M ^a   Cunningham, G R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Levator ani muscle; LPB Tag; MENT; Prostate; Testosterone; Transgenic mice

Indexed keywords

CYCLINE; DNA; KI 67 ANTIGEN; TESTOSTERONE; TRESTOLONE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; IMMUNOHISTOCHEMISTRY; LEVATOR ANI MUSCLE; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; TISSUE GROWTH; TRANSGENIC MOUSE;

ANIMALS; CONTRACEPTIVE AGENTS, MALE; DNA; ESTRENES; FEMALE; HORMONE REPLACEMENT THERAPY; MALE; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; PROSTATIC NEOPLASMS; TESTIS; TESTOSTERONE;

EID: 33644779101     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.20354     Document Type: Article

References (31)

1. Morali G, Lemus AE, Munguia R, Arteaga M, Perez-Palacios G, Sundaram K, Kumar N, Bardin CW. Induction of male sexual behavior in the rat by 7 alpha-methyl-19-nortestosterone, an androgen that does not undergo 5 alpha-reduction. Biol Reprod 1993;49:577-581.
2. Ogawa S, Robbins A, Kumar N, Pfaff DW, Sundaram K, Bardin CW. Effects of testosterone and 7 alpha-methyl-19-nortestosterone (MENT) on sexual and aggressive behaviors in two inbred strains of male mice. Horm Behav 1996;30:74-84.
3. Kumar N, Didolkar AK, Monder C, Bardin CW, Sundaram K. The biological activity of 7 alpha-methyl-19-nortestosterone is not amplified in male reproductive tract as is that of testosterone. Endocrinology 1992;130:3677-3683.
4. Wood RI, Bean AR, Sundaram K, Kumar N, Bardin CW. 7 alpha-methyl-19- nortestosterone facilitates sexual behavior in the male Syrian hamster. Horm Behav 1996;30:131-137.
5. Limonta P, Ladizhenskaya A, Gunsalus GL, Bardin CW, Thau RB. Regulation of pituitary gonadotropin-releasing hormone receptors by androgens in the male rabbit. Endocrinology 1986;118:340-347.
6. Kumar N, Suvisaari J, Tsong YY, Aguillaume C, Bardin CW, Lahteenmaki P, Sundaram K. Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys. J Androl 1997;18:352-358.
7. Cummings DE, Kumar N, Bardin CW, Sundaram K, Bremner WJ. Prostate-sparing effects in primates of the potent androgen 7alpha-methyl-19-nortestosterone: A potential alternative to testosterone for androgen replacement and male contraception. J Clin Endocrinol Metab 1998;83:4212-4219.
8. Ramachandra SG, Ramesh V, Krishnamurthy HN, Kumar N, Sundaram K, Hardy MP, Rao AJ. Effect of chronic administration of 7alpha-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata). Reproduction 2002;124:301-309.
9. Kumar N, Suvisaari J, Tsong YY, Aguillaume C, Bardin CW, Lahteenmaki P, Sundaram K. Pharmacokinetics of 7 alpha-methyl-19-nortestosterone in men and cynomolgus monkeys. J Androl 1997;18:352-358.
10. Noe G, Suvisaari J, Martin C, Moo-Young AJ, Sundaram K, Saleh SI, Quintero E, Croxatto HB, Lahteenmaki P. Gonadotrophin and testosterone suppression by 7α-methyl-19-nortestosterone acetate administered by subdermal implant to healthy men. Hum Reprod 1999;14:2200-2206.
11. von Eckardstein S, Noe G, Brache V, Nieschlag E, Croxatto H, Alvarez F, Moo-Young A, Sivin I, Kumar N, Small M, Sundaram K. International Committee for Contraception Research, The Population Council, a clinical trial of 7 alpha-methyl-19-nortestosterone implants for possible use as a long-acting contraceptive for men. J Clin Endocrinol Metab 2003;88:5232-5239.
12. Suvisaari J, Moo-Young A, Juhakoski A, Elomaa K, Saleh SI, Lahteenmaki P. Pharmacokinetics of 7 alpha-methyl-19-nortestosterone (MENT) delivery using subdermal implants in healthy men. Contraception 1999;60:299-303.
13. Sundaram K, Kumar N, Bardin CW. 7 alpha-methyl-nortestosterone (MENT): The optimal androgen for male contraception. Ann Med 1993;25:199-205.
14. Sundaram K, Kumar N, Bardin CW. 7 alpha-Methyl-19-nortestosterone: An ideal androgen for replacement therapy. Recent Prog Horm Res 1994;49:373-376.
15. Anderson RA, Martin CW, Kung AW, Everington D, Pun TC, Tan KC, Bancroft J, Sundaram K, Moo-Young AJ, Baird DT. 7Alpha-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men. J Clin Endocrinol Metab 1999;84:3556-3562.
16. Anderson RA, Wallace AM, Sattar N, Kumar N, Sundaram K. Evidence for tissue selectivity of the synthetic androgen 7 alpha-methyl-19-nortestosterone in hypogonadal men. J Clin Endocrinol Metab 2003;88:2784-2793.
17. Kumar N, Crozat A, Li F, Catterall JF, Bardin CW, Sundaram K. 7alpha-methyl-19-nortestosterone, a synthetic androgen with high potency: Structure-activity comparisons with other androgens. J Steroid Biochem Mol Biol 1999;71:213-222.
18. Markiewicz L, Gurpide E. Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays. Methods Find Exp Clin Pharmacol 1997;19:215-222.
19. Beri R, Kumar N, Savage T, Benalcazar L, Sundaram K. Estrogenic and progestational activity of 7alpha-methyl-19-nortestosterone, a synthetic androgen. J Steroid Biochem Mol Biol 1998;67:275-283.
20. de Gooyer ME, Oppers-Tiemissen HM, Leysen D, Verheul HA, Kloosterboer HJ. Tibolone is not converted by human aromatase to 7alpha-methyl-17alpha- ethynylestradiol (7alpha-MEE): Analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS. Steroids 2003;68:235-243.
21. LaMorte A, Kumar N, Bardin CW, Sundaram K. Aromatization of 7 alpha-methyl-19-nortestosterone by human placental microsomes in vitro. J Steroid Biochem Mol Biol 1994;48:297-304.
22. Agarwal AK, Monder C. In vitro metabolism of 7 alpha-methyl-19- nortestosterone by rat liver, prostate, and epididymis. Endocrinology 1988;123:2187-2193.
23. Sundaram K, Kumar N, Monder C, Bardin CW. Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens. J Steroid Biochem Mol Biol 1995;53:253-257.
24. Kasper S, Sheppard PC, Yan Y, Pettigrew N, Borowsky AD, Prins GS, Dodd JG, Duckworth ML, Matusik RJ. Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: A model for prostate cancer. Lab Invest 1998;78:319-333.
25. Corrected and republished in: Lab Invest 1998;78:i-xv.
26. Yan Y, Sheppard PC, Kasper S, Lin L, Hoare S, Kapoo A, Dodd JG, Duckwotyh ML, Matsusik RJ. A large fragment of the probasin promoter targets high level of transgene expression to the prostate of transgenic mice. Prostate 1997;32:129-139.
27. Schneider WC. Phosphorous compounds in animal tissue I. Extraction and estimation of deoxypentose nucleic acid and of pentose nucleic acid. J Biol Chem 1945;161:293-303.
28. Shao TC, Kong A, Cunningham GR. Effects of 4-MAPC, a 5 alpha-reductase inhibitor, and cyproterone acetate on regrowth of the rat ventral prostate. Prostate 1994;24:212-220.
29. Burton K. A study of the conditions and mechanisms of the diphenylamine reaction for the colorimentric estimation of deoxyribonucleic acid. Biochem J 1956;62:315-323.
30. Negro-Vilar A. Selective androgen receptor modulators (SARMs): A novel approach to androgen therapy for the new millennium. J Clin Endocrinol Metab 1999;84:3459-3462.
31. Bandivdekar AH, Karp R, Sundaram K, Kumar N. The antigonadotropic action of testosterone but not 7alpha-methyl-19-nortestosterone is attenuated through the 5alpha-reductase pathway in the castrated male rat pituitary gland. J Androl 2000;21:268-275.