Structure and quantum chemical analysis of NAD+-dependent isocitrate dehydrogenase: Hydride transfer and co-factor specificity

Proteins: Structure, Function and Genetics

Volumn 70, Issue 1, 2008, Pages 63-71

  Imada, Katsumi ^a,b   Tamura, Takashi ^c   Takenaka, Ryo ^c   Kobayashi, Issei ^c   Namba, Keiichi ^a,b   Inagaki, Kenji ^c  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Chemolithotrophic bacterium; Crystal structure; Decarboxylating dehydrogenase; Hydride migration; Semi empirical molecular orbital calculation

Indexed keywords

ADENOSINE; ADENOSINE RIBOSE; AMIDE; ASPARTIC ACID; BACTERIAL ENZYME; CARBON; CITRIC ACID; HYDRIDE; HYDROGEN; HYDROXYL GROUP; ISOCITRATE DEHYDROGENASE; ISOPROPYLMALATE DEHYDROGENASE; MALATE DEHYDROGENASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RIBOSE; UNCLASSIFIED DRUG;

ACIDITHIOBACILLUS THIOOXIDANS; ALGORITHM; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMOLITHOTROPH; COFACTOR SPECIFICITY; CRYSTAL STRUCTURE; DENSITY; ELECTRON; ELECTRON DENSITY; ENZYME ACTIVE SITE; HYDRIDE TRANSFER; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE; QUANTUM CHEMISTRY; SEMI EMPIRICAL MOLECULAR ORBITAL CALCULATION;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HYDROGEN; HYDROGEN BONDING; ISOCITRATE DEHYDROGENASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAD; PROTEIN CONFORMATION; QUANTUM THEORY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

ACIDITHIOBACILLUS THIOOXIDANS; BACTERIA (MICROORGANISMS);

EID: 37349078630     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21486     Document Type: Article

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