Pancreatic endocrine and exocrine cell ontogeny from renal capsule-transplanted embryonic stem cells in streptozocin-injured mice

Journal of Histochemistry and Cytochemistry

Volumn 56, Issue 1, 2008, Pages 33-44

  Kodama, Maho ^a   Takeshita, Fumitaka ^a   Kanegasaki, Shiro ^b   Ochiya, Takahiro ^a   Quinn, Gary ^a,b  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b Central Laboratory   (Japan)

Author keywords

Diabetes; Differentiation; Embryonic stem cells; Hormone; Pancreas; Pancreatic cells; Pancreatogenesis; Regeneration

Indexed keywords

AMYLASE; GLUCAGON; INSULIN; ISL 1 PROTEIN; NGN3 PROTEIN; NKX6 1 PROTEIN; PROTEIN DERIVATIVE; SOMATOSTATIN; STREPTOZOCIN; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL DAMAGE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDOCRINE CELL; EXOCRINE CELL; FEMALE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; KIDNEY CAPSULE; MOUSE; NONHUMAN; ONTOGENY; PANCREAS; PANCREAS CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL TRANSPLANTATION; TUMOR VOLUME;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; FEMALE; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; KIDNEY; MICE; MICE, NUDE; PANCREAS, EXOCRINE; PLURIPOTENT STEM CELLS; REGENERATION; STREPTOZOCIN;

MUS; MUS MUSCULUS;

EID: 37249030984     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.7A7278.2007     Document Type: Article

References (43)

1. Alpert S, Hanahan D, Teitelman G (1988) Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53:295-308
2. Apelqvist A, Li H, Sommer L, Beams P, Anderson DJ, Honjo T, Hrabe de Angelis M, et al. (1999) Notch signalling controls pancreatic cell differentiation. Nature 400:877-881
3. Beattie GM, Butler C, Hayek A (1994) Morphology and function of cultured human fetal pancreatic cells transplanted into athymic mice: a longitudinal study. Cell Transplant 3:421-425
4. Bonner-Weir S, Trent DF, Zmachinski CJ, Clore ET, Weir GC (1981) Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone. Metabolism 30:914-918
5. Brolen GK, Heins N, Edsbagge J, Semb H (2005) Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing β-cell-like cells. Diabetes 54:2867-2874
6. Cardinal JW, Allan DJ, Cameron DP (1999) Poly(ADP-ribose)polymerase activation determines strain sensitivity to streptozotocin-induced β cell death in inbred mice. J Mol Endocrinol 22:65-70
7. Chang A, Diani AR (1985) Chemically and hormonally induced diabetes mellitus. In Volk B, Arquilla ER, eds. The Diabetic Pancreas. New York, Plenum, 415-438
8. Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46
9. Edlund H (2002) Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat Rev Genet 3:524-532
10. Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G (1997) Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138:1750-1762
11. Gradwohl G, Dierich A, LeMeur M, Guillemot F (2000) neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611
12. Gu D, Lee MS, Krahl T, Sarvetnick N (1994) Transitional cells in the regenerating pancreas. Development 120:1873-1881
13. Gu D, Sarvetnick N (1993) Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 118:33-46
14. Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457
15. Guz Y, Nasir I, Teitelman G (2001) Regeneration of pancreatic β cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 142:4956-4968
16. Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M (2005) NKX6 transcription factor activity is required for α- and β-cell development in the pancreas. Development 132:3139-3149
17. Herrera PL (2000) Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317-2322
18. Herrera PL, Huarte J, Sanvito F, Meda P, Orci L, Vassalli JD (1991) Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene. Development 113:1257-1265
19. Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, et al. (2000a) Independent development of pancreatic α- and β-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49:163-176
20. Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, et al. (2000b) Control of endodermal endocrine development by Hes-1. Nat Genet 24:36-44
21. Jensen JN, Cameron E, Garay MV, Starkey TW, Gianani R, Jensen J (2005) Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology 128:728-741
22. Kahan BW, Jacobson LM, Hullett DA, Ochoada JM, Oberley TD, Lang KM, Odorico JS (2003) Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes 52:2016-2024
23. Kim SK, Hebrok M, Melton DA (1997) Notochord to endoderm signaling is required for pancreas development. Development 124:4243-4252
24. Lehv M, Fitzgerald PJ (1968) Pancreatic acinar cell regeneration. IV. Regeneration after resection. Am J Pathol 53:513-535
25. Like AA, Rossini AA (1976) Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193:415-417
26. Lipsett M, Finegood DT (2002) β-cell neogenesis during prolonged hyperglycemia in rats. Diabetes 51:1834-1841
27. Micallef SJ, Janes ME, Knezevic K, Davis RP, Elefanty AG, Stanley EG (2005) Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes 54:301-305
28. Michalopoulos GK, DeFrances MC (1997) Liver regeneration. Science 276:60-66
29. Movassat J, Beattie GM, Lopez AD, Hayek A (2002) Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells. J Clin Endocrinol Metab 87:4775-4781
30. Movassat J, Beattie GM, Lopez AD, Portha B, Hayek A (2003) Keratinocyte growth factor and β-cell differentiation in human fetal pancreatic endocrine precursor cells. Diabetologia 46:822-829
31. Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259
32. Oster A, Jensen J, Serup P, Galante P, Madsen OD, Larsson LI (1998) Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1). J Histochem Cytochem 46:707-715
33. Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, et al. (2005) Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol 288:487-501
34. Pictet R, Rutter WJ (1972) Development of the embryonic pancreas. In Steiner DF, Steiner FN, eds. Handbook of Physiology. Washington, DC, American Physiological Society, 25-66
35. Rose MI, Crisera CA, Colen KL, Connelly PR, Longaker MT, Gittes GK (1999) Epithelio-mesenchymal interactions in the developing mouse pancreas: morphogenesis of the adult architecture. J Pediatr Surg 34:774-779
36. Rosenberg L, Brown RA, Duguid WP (1983) A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. J Surg Res 35:63-72
37. Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, et al. (2000) Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas. Development 127:5533-5540
38. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, et al. (2000) Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127:3533-3542
39. Slack JM (1995) Developmental biology of the pancreas. Development 121:1569-1580
40. Stanger BZ, Tanaka AJ, Melton DA (2007) Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445:886-891
41. Takeshita F, Kodama M, Yamamoto H, Ikarashi Y, Ueda S, Teratani T, Yamamoto Y, et al. (2006) Streptozotocin-induced partial β cell depletion in nude mice without hyperglycaemia induces pancreatic morphogenesis in transplanted embryonic stem cells. Diabetologia 49:2948-2958
42. Trucco M (2005) Regeneration of the pancreatic β cell. J Clin Invest 115:5-12
43. Yamamoto H, Quinn G, Asari A, Yamanokuchi H, Teratani T, Terada M, Ochiya T (2003) Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology 37:983-993