Reaction and strain engineering for improved stereo-selective whole-cell reduction of a bicyclic diketone

Applied Microbiology and Biotechnology

Volumn 77, Issue 5, 2008, Pages 1111-1118

  Johanson, Ted ^a   Carlquist, Magnus ^a   Olsson, Cecilia ^a   Rudolf, Andreas ^a,b   Frejd, Torbjörn ^a   Gorwa Grauslund, Marie F ^a  

^a LUND UNIVERSITY   (Sweden)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Bioreduction; Diastereoselectivity; Dicarbonyl; Process optimisation; Reductase; Substrate inhibition; Toxicity; Whole cell; Yeast

Indexed keywords

DIASTEREOSELECTIVITY; PROCESS OPTIMIZATION; SUBSTRATE INHIBITION;

CELL CULTURE; CONCENTRATION (PROCESS); REDUCTION; STEREOSELECTIVITY; TOXICITY; YEAST;

KETONES;

6 HYDROXYBICYCLO[2.2.2]OCTAN 2 ONE; BICYCLO[2.2.2]OCTANE 2,6 DIONE; DIKETONE; KETOL; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

GENE EXPRESSION; INHIBITION; KETONE; MODEL; OPTIMIZATION; PH; RECOMBINATION; REDUCTION; TOXICITY; YEAST;

ARTICLE; BIOENGINEERING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIASTEREOISOMER; ENANTIOMER; FUNGAL CELL; FUNGAL GENE; FUNGAL STRAIN; FUNGUS GROWTH; GENE OVEREXPRESSION; ISOLATION PROCEDURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PROCESS DESIGN; REACTION ANALYSIS; REDUCTION; SACCHAROMYCES CEREVISIAE; STEREOCHEMISTRY;

BICYCLO COMPOUNDS; HYDROGEN-ION CONCENTRATION; OXIDATION-REDUCTION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

SACCHAROMYCES CEREVISIAE;

EID: 37249019632     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-007-1240-1     Document Type: Article

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